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Protein

Iron-sulfur protein NUBPL

Gene

Nubpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 82ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur protein NUBPL
Alternative name(s):
Nucleotide-binding protein-like
Gene namesi
Name:Nubpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1924076 Nubpl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000018495139 – 319Iron-sulfur protein NUBPLAdd BLAST281

Proteomic databases

EPDiQ9CWD8
MaxQBiQ9CWD8
PaxDbiQ9CWD8
PeptideAtlasiQ9CWD8
PRIDEiQ9CWD8

PTM databases

iPTMnetiQ9CWD8
PhosphoSitePlusiQ9CWD8

Expressioni

Gene expression databases

BgeeiENSMUSG00000035142
CleanExiMM_NUBPL
ExpressionAtlasiQ9CWD8 baseline and differential
GenevisibleiQ9CWD8 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CWD8, 1 interactor
STRINGi10090.ENSMUSP00000044292

Structurei

3D structure databases

ProteinModelPortaliQ9CWD8
SMRiQ9CWD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3022 Eukaryota
COG0489 LUCA
GeneTreeiENSGT00390000009735
HOGENOMiHOG000079916
HOVERGENiHBG051027
InParanoidiQ9CWD8
KOiK03593
OMAiPMLNGII
OrthoDBiEOG091G0D7U
TreeFamiTF323196

Family and domain databases

CDDicd02037 MRP-like, 1 hit
HAMAPiMF_02040 Mrp_NBP35, 1 hit
InterProiView protein in InterPro
IPR019591 Mrp/NBP35_ATP-bd
IPR000808 Mrp_CS
IPR027417 P-loop_NTPase
IPR033756 YlxH/NBP35
PfamiView protein in Pfam
PF10609 ParA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01215 MRP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CWD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTWRRLLLF GGVSLRGGGA ATVPPRGCRA LGCGRQLLGA ESEALKQRRT
60 70 80 90 100
QIMSRGLPKQ KPIEGVREVI VVASGKGGVG KSTTAVNLAL ALAANDSSKA
110 120 130 140 150
VGLLDVDVYG PSIPKMMNLR GNPELSPNNL MRPLLNYGIA CMSMGFLVEE
160 170 180 190 200
TAPLVWRGLM VMSAIEKLLR QVDWGQLDYL VVDMPPGTGD VQLSVSQNIP
210 220 230 240 250
ISGAVIVSTP QDIALMDAHK GAEMFRKVNV PVLGLVQNMS VFQCPKCKHK
260 270 280 290 300
THIFGADGAR KLAQTLDLDV LGDVPLHLSI REASDMGQPV VFSQPGSDEA
310
KAYLHIASEV VRRLKSSPE
Length:319
Mass (Da):34,139
Last modified:July 27, 2011 - v2
Checksum:i5455BB7F2F1F8713
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292F → L in BAB27209 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010827 mRNA Translation: BAB27209.1
AK152377 mRNA Translation: BAE31166.1
BC062175 mRNA Translation: AAH62175.1
CCDSiCCDS36442.2
RefSeqiNP_084036.2, NM_029760.2
UniGeneiMm.244781

Genome annotation databases

EnsembliENSMUST00000040090; ENSMUSP00000044292; ENSMUSG00000035142
GeneIDi76826
KEGGimmu:76826
UCSCiuc007nnh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNUBPL_MOUSE
AccessioniPrimary (citable) accession number: Q9CWD8
Secondary accession number(s): Q6P6K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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