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Protein

Iron-sulfur protein NUBPL

Gene

Nubpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 828ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur protein NUBPL
Alternative name(s):
Nucleotide-binding protein-like
Gene namesi
Name:Nubpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1924076. Nubpl.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionSequence analysisAdd
BLAST
Chaini39 – 319281Iron-sulfur protein NUBPLPRO_0000184951Add
BLAST

Proteomic databases

EPDiQ9CWD8.
MaxQBiQ9CWD8.
PaxDbiQ9CWD8.
PeptideAtlasiQ9CWD8.
PRIDEiQ9CWD8.

PTM databases

iPTMnetiQ9CWD8.
PhosphoSiteiQ9CWD8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035142.
CleanExiMM_NUBPL.
ExpressionAtlasiQ9CWD8. baseline and differential.
GenevisibleiQ9CWD8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044292.

Structurei

3D structure databases

ProteinModelPortaliQ9CWD8.
SMRiQ9CWD8. Positions 43-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3022. Eukaryota.
COG0489. LUCA.
GeneTreeiENSGT00390000009735.
HOGENOMiHOG000079916.
HOVERGENiHBG051027.
InParanoidiQ9CWD8.
KOiK03593.
OMAiVKDRDIH.
OrthoDBiEOG091G0D7U.
TreeFamiTF323196.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CWD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTWRRLLLF GGVSLRGGGA ATVPPRGCRA LGCGRQLLGA ESEALKQRRT
60 70 80 90 100
QIMSRGLPKQ KPIEGVREVI VVASGKGGVG KSTTAVNLAL ALAANDSSKA
110 120 130 140 150
VGLLDVDVYG PSIPKMMNLR GNPELSPNNL MRPLLNYGIA CMSMGFLVEE
160 170 180 190 200
TAPLVWRGLM VMSAIEKLLR QVDWGQLDYL VVDMPPGTGD VQLSVSQNIP
210 220 230 240 250
ISGAVIVSTP QDIALMDAHK GAEMFRKVNV PVLGLVQNMS VFQCPKCKHK
260 270 280 290 300
THIFGADGAR KLAQTLDLDV LGDVPLHLSI REASDMGQPV VFSQPGSDEA
310
KAYLHIASEV VRRLKSSPE
Length:319
Mass (Da):34,139
Last modified:July 27, 2011 - v2
Checksum:i5455BB7F2F1F8713
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921F → L in BAB27209 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010827 mRNA. Translation: BAB27209.1.
AK152377 mRNA. Translation: BAE31166.1.
BC062175 mRNA. Translation: AAH62175.1.
CCDSiCCDS36442.2.
RefSeqiNP_084036.2. NM_029760.2.
UniGeneiMm.244781.

Genome annotation databases

EnsembliENSMUST00000040090; ENSMUSP00000044292; ENSMUSG00000035142.
GeneIDi76826.
KEGGimmu:76826.
UCSCiuc007nnh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010827 mRNA. Translation: BAB27209.1.
AK152377 mRNA. Translation: BAE31166.1.
BC062175 mRNA. Translation: AAH62175.1.
CCDSiCCDS36442.2.
RefSeqiNP_084036.2. NM_029760.2.
UniGeneiMm.244781.

3D structure databases

ProteinModelPortaliQ9CWD8.
SMRiQ9CWD8. Positions 43-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044292.

PTM databases

iPTMnetiQ9CWD8.
PhosphoSiteiQ9CWD8.

Proteomic databases

EPDiQ9CWD8.
MaxQBiQ9CWD8.
PaxDbiQ9CWD8.
PeptideAtlasiQ9CWD8.
PRIDEiQ9CWD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040090; ENSMUSP00000044292; ENSMUSG00000035142.
GeneIDi76826.
KEGGimmu:76826.
UCSCiuc007nnh.2. mouse.

Organism-specific databases

CTDi80224.
MGIiMGI:1924076. Nubpl.

Phylogenomic databases

eggNOGiKOG3022. Eukaryota.
COG0489. LUCA.
GeneTreeiENSGT00390000009735.
HOGENOMiHOG000079916.
HOVERGENiHBG051027.
InParanoidiQ9CWD8.
KOiK03593.
OMAiVKDRDIH.
OrthoDBiEOG091G0D7U.
TreeFamiTF323196.

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CWD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035142.
CleanExiMM_NUBPL.
ExpressionAtlasiQ9CWD8. baseline and differential.
GenevisibleiQ9CWD8. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUBPL_MOUSE
AccessioniPrimary (citable) accession number: Q9CWD8
Secondary accession number(s): Q6P6K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.