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Protein

Golgin subfamily A member 1

Gene

Golga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure. May play a role in acrosome formation and spermatogenesis.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 1
Alternative name(s):
Golgin-97
Gene namesi
Name:Golga1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924149. Golga1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Golgin subfamily A member 1PRO_0000190053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei36 – 361PhosphoserineCombined sources
Modified residuei41 – 411PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei50 – 501PhosphoserineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CW79.
PaxDbiQ9CW79.
PeptideAtlasiQ9CW79.
PRIDEiQ9CW79.

PTM databases

iPTMnetiQ9CW79.
PhosphoSiteiQ9CW79.

Expressioni

Developmental stagei

Present in the acrosome of spermatids up to the late cap-stage, but not in mature spermatozoa.

Gene expression databases

BgeeiENSMUSG00000026754.
CleanExiMM_GOLGA1.
ExpressionAtlasiQ9CW79. baseline and differential.
GenevisibleiQ9CW79. MM.

Interactioni

Subunit structurei

Binds RAB6A.By similarity

Protein-protein interaction databases

IntActiQ9CW79. 4 interactions.
MINTiMINT-1783053.
STRINGi10090.ENSMUSP00000037735.

Structurei

3D structure databases

ProteinModelPortaliQ9CW79.
SMRiQ9CW79. Positions 684-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini679 – 72850GRIPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili50 – 648599Sequence analysisAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG17. Eukaryota.
ENOG410ZJU1. LUCA.
GeneTreeiENSGT00530000064371.
HOGENOMiHOG000246957.
HOVERGENiHBG051751.
InParanoidiQ9CW79.
KOiK16731.
OMAiQMHQLQA.
OrthoDBiEOG091G02ME.
PhylomeDBiQ9CW79.
TreeFamiTF326001.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CW79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFAKLKKKIA EETAVAQRPG GTTRIPRSVS KESVASMGAD SGDDFASDGS
60 70 80 90 100
SSREDLSSQL LRRNEQIRKL EARLSDYAEQ VRNLQKIKEK LEIALEKHQD
110 120 130 140 150
SSMRKFQEQN ETFQASRAKM AEGLALALAR KDQEWSEKME QLEKDKRFLT
160 170 180 190 200
SQLQEVKNQS LSLFQKRDEI DELEGFQQQE ISKVKHMLLK KEECLGKMEQ
210 220 230 240 250
ELDARTRELN RTQEELVTSN QLSSDLNERL EELQRHCSTL EEQRDHLTAS
260 270 280 290 300
KAGAEHKIVV LEQKEQELQA IIQQHSIDLQ KVTAETQEKE KVITHLQEKV
310 320 330 340 350
IFLEKRLEQN LSGEDHVQEL LKEKTVAEQN LEDTRQQLLA ARNSHTKALY
360 370 380 390 400
LLETRVKDLE RSLQAAEEQL SQSRNVVADQ EAQIQKLITT NQENSLSQQQ
410 420 430 440 450
VLALEQHCRE RIHALEAQIE ALEQTRVADQ IASEQGMLQL QQENVALKES
460 470 480 490 500
RNECEHSLQH HQLELKKLKD EWSQREIVSV AMAQALEEVR KQREEFQQQA
510 520 530 540 550
TELTAIIEEK NQSLCEKDEA LLQKEQELRQ LEKGHSSALL QMHKLQRELE
560 570 580 590 600
ALKTCKAQEA MPATTGEDCL PLQGQEPLVI SKAMQNSEYE LPAAEGTPNG
610 620 630 640 650
EVGASDLKQL QKEKQDLEQQ LIEKNKIMKQ MQQRMLELKK TLQKELKIRP
660 670 680 690 700
DSELFEVREK TGPEIPNMAP SVTNNTDLTD AREINFEYLK HVVLKFMSCR
710 720 730 740 750
ESEAFHLIKA VSVLLNFSQE EENMLKETLE YKMSWFGSKP TPKGSIRPSI

SNPRIPWS
Length:758
Mass (Da):87,338
Last modified:July 3, 2003 - v2
Checksum:i5F2AECF0D91784D2
GO
Isoform 2 (identifier: Q9CW79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-101: DYAEQVRNLQKIKEKLEIALEKHQDS → A

Note: No experimental confirmation available.
Show »
Length:733
Mass (Da):84,300
Checksum:i37C05CBFBA0ADE08
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 10126DYAEQ…KHQDS → A in isoform 2. 1 PublicationVSP_007726Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844588 Genomic DNA. Translation: CAM46066.1.
BC043090 mRNA. Translation: AAH43090.1.
BC053068 mRNA. Translation: AAH53068.1.
AK002954 mRNA. Translation: BAB22477.1.
CCDSiCCDS16016.1. [Q9CW79-1]
CCDS71049.1. [Q9CW79-2]
RefSeqiNP_001277578.1. NM_001290649.1. [Q9CW79-2]
NP_084069.1. NM_029793.2. [Q9CW79-1]
UniGeneiMm.131098.

Genome annotation databases

EnsembliENSMUST00000039165; ENSMUSP00000037735; ENSMUSG00000026754. [Q9CW79-1]
ENSMUST00000112850; ENSMUSP00000108471; ENSMUSG00000026754. [Q9CW79-2]
ENSMUST00000184996; ENSMUSP00000139001; ENSMUSG00000026754. [Q9CW79-1]
GeneIDi76899.
KEGGimmu:76899.
UCSCiuc008job.2. mouse. [Q9CW79-1]
uc008joc.2. mouse. [Q9CW79-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844588 Genomic DNA. Translation: CAM46066.1.
BC043090 mRNA. Translation: AAH43090.1.
BC053068 mRNA. Translation: AAH53068.1.
AK002954 mRNA. Translation: BAB22477.1.
CCDSiCCDS16016.1. [Q9CW79-1]
CCDS71049.1. [Q9CW79-2]
RefSeqiNP_001277578.1. NM_001290649.1. [Q9CW79-2]
NP_084069.1. NM_029793.2. [Q9CW79-1]
UniGeneiMm.131098.

3D structure databases

ProteinModelPortaliQ9CW79.
SMRiQ9CW79. Positions 684-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CW79. 4 interactions.
MINTiMINT-1783053.
STRINGi10090.ENSMUSP00000037735.

PTM databases

iPTMnetiQ9CW79.
PhosphoSiteiQ9CW79.

Proteomic databases

MaxQBiQ9CW79.
PaxDbiQ9CW79.
PeptideAtlasiQ9CW79.
PRIDEiQ9CW79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039165; ENSMUSP00000037735; ENSMUSG00000026754. [Q9CW79-1]
ENSMUST00000112850; ENSMUSP00000108471; ENSMUSG00000026754. [Q9CW79-2]
ENSMUST00000184996; ENSMUSP00000139001; ENSMUSG00000026754. [Q9CW79-1]
GeneIDi76899.
KEGGimmu:76899.
UCSCiuc008job.2. mouse. [Q9CW79-1]
uc008joc.2. mouse. [Q9CW79-2]

Organism-specific databases

CTDi2800.
MGIiMGI:1924149. Golga1.

Phylogenomic databases

eggNOGiENOG410IG17. Eukaryota.
ENOG410ZJU1. LUCA.
GeneTreeiENSGT00530000064371.
HOGENOMiHOG000246957.
HOVERGENiHBG051751.
InParanoidiQ9CW79.
KOiK16731.
OMAiQMHQLQA.
OrthoDBiEOG091G02ME.
PhylomeDBiQ9CW79.
TreeFamiTF326001.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ9CW79.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026754.
CleanExiMM_GOLGA1.
ExpressionAtlasiQ9CW79. baseline and differential.
GenevisibleiQ9CW79. MM.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CW79
Secondary accession number(s): A3KGQ9, Q80YB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.