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Protein

Ribonucleoprotein PTB-binding 1

Gene

Raver1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoprotein PTB-binding 1
Alternative name(s):
Protein raver-1
Gene namesi
Name:Raver1
Synonyms:Kiaa1978
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919016. Raver1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000814882 – 748Ribonucleoprotein PTB-binding 1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineBy similarity1
Modified residuei14PhosphoserineCombined sources1
Modified residuei469PhosphothreonineCombined sources1
Modified residuei480PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CW46.
PaxDbiQ9CW46.
PeptideAtlasiQ9CW46.
PRIDEiQ9CW46.

PTM databases

iPTMnetiQ9CW46.
PhosphoSitePlusiQ9CW46.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSMUSG00000010205.
CleanExiMM_RAVER1.
GenevisibleiQ9CW46. MM.

Interactioni

Subunit structurei

Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1.2 Publications

Protein-protein interaction databases

BioGridi214910. 7 interactors.
DIPiDIP-44609N.
IntActiQ9CW46. 4 interactors.
MINTiMINT-1707126.
STRINGi10090.ENSMUSP00000111150.

Structurei

Secondary structure

1748
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 64Combined sources4
Helixi72 – 78Combined sources7
Turni79 – 81Combined sources3
Beta strandi84 – 90Combined sources7
Turni91 – 94Combined sources4
Beta strandi95 – 102Combined sources8
Helixi103 – 113Combined sources11
Beta strandi116 – 120Combined sources5
Beta strandi122 – 127Combined sources6
Beta strandi684 – 686Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WI6NMR-A61-135[»]
3ZZYX-ray1.40C/D496-507[»]
3ZZZX-ray1.55C/D680-692[»]
ProteinModelPortaliQ9CW46.
SMRiQ9CW46.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CW46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 130RRM 1PROSITE-ProRule annotationAdd BLAST72
Domaini132 – 210RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini221 – 299RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni307 – 401Interaction with PTBP11 PublicationAdd BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 60Nuclear localization signalSequence analysisAdd BLAST16
Motifi743 – 746Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi432 – 629Pro-richAdd BLAST198

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJBP. Eukaryota.
ENOG410ZP6I. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ9CW46.
OMAiFSHPREP.
OrthoDBiEOG091G04CT.
PhylomeDBiQ9CW46.
TreeFamiTF331660.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CW46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADVSVTHR PPLSPEAEAE AETPETVDRR APEQELPPLD PEEIRKRLEH
60 70 80 90 100
TERQFRNRRK ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL
110 120 130 140 150
LNGEQAEAAI NTFHQSRLRE RELSVQLQPT DALLCVANLP PSLTQAQFEE
160 170 180 190 200
LVRPFGSLER CFLVYSERTG HSKGYGFAEY MKKDSAARAK SDLLGKPLGP
210 220 230 240 250
RTLYVHWTDA GQLTPALLHS RCLCVDHLPP GFSDVDALRR ALSVVYTPTF
260 270 280 290 300
CQLACGQDGQ LKGFAVLEYE TAEMAEAAQE RADGQALGDS HLRVSFCAPG
310 320 330 340 350
PPGRSMLAAL IAAQATALNR GKGLLPEPNL LQLLNNLGPS ASLQLLLNPL
360 370 380 390 400
LHGGASGKQG LLGAPPAMPL LSGPALSTAL LQLALQSQSQ NQSQGQKKPG
410 420 430 440 450
ILGDSPLGTL QAGAQPSNSL LGELSAGGGL APELPPRRGK PQPLLPPLLG
460 470 480 490 500
PSGGDREPMG LGPPATQLTP PPAPVGLRGS NHRGLPKDSG PLPTPPGVSL
510 520 530 540 550
LGEPPKDYRI PLNPYLNLHS LLPSSNLAGK ETRGWGGSGR GRRPAEPPLP
560 570 580 590 600
SPAVPGGGSG SNNGNKAFQM KSRLLSPIAS NRLPPEPGLP DSYGFDYPTD
610 620 630 640 650
VGPRRLFSHP REPTLGAHGP SRHKMSPPPS SFNEPRSGGG SGGPLSHFYS
660 670 680 690 700
GSPTSYFTSG LQAGLKQSHL NKAVGSSPMG SSEGLLGLGP GPNGHSHLLK
710 720 730 740
TPLGGQKRSF SHLLPSPEPS PEGSYVGQHS QGLGGHYADS YLKRKRIF
Length:748
Mass (Da):79,382
Last modified:January 24, 2006 - v2
Checksum:iB0D775F14BD5B214
GO
Isoform 2 (identifier: Q9CW46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-270: LACGQDGQLKGFAVLEYE → TCVIMASLELRDPPAFSS
     271-748: Missing.

Show »
Length:270
Mass (Da):30,392
Checksum:i99A147002C2EDA9F
GO

Sequence cautioni

The sequence BAB23670 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → K in BAB23670 (PubMed:11724819).Curated1
Sequence conflicti397Missing in BAD90266 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017037253 – 270LACGQ…VLEYE → TCVIMASLELRDPPAFSS in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017038271 – 748Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275472 mRNA. Translation: AAP33691.1.
AK004919 mRNA. Translation: BAB23670.1. Different initiation.
AK039928 mRNA. Translation: BAC30481.1.
AK084478 mRNA. Translation: BAC39194.1.
AK220434 mRNA. Translation: BAD90266.1.
BC043698 mRNA. Translation: AAH43698.1.
BC108392 mRNA. Translation: AAI08393.1.
CCDSiCCDS40550.1. [Q9CW46-1]
RefSeqiNP_082187.1. NM_027911.3. [Q9CW46-1]
UniGeneiMm.196137.

Genome annotation databases

EnsembliENSMUST00000115487; ENSMUSP00000111150; ENSMUSG00000010205. [Q9CW46-1]
GeneIDi71766.
KEGGimmu:71766.
UCSCiuc009okd.2. mouse. [Q9CW46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275472 mRNA. Translation: AAP33691.1.
AK004919 mRNA. Translation: BAB23670.1. Different initiation.
AK039928 mRNA. Translation: BAC30481.1.
AK084478 mRNA. Translation: BAC39194.1.
AK220434 mRNA. Translation: BAD90266.1.
BC043698 mRNA. Translation: AAH43698.1.
BC108392 mRNA. Translation: AAI08393.1.
CCDSiCCDS40550.1. [Q9CW46-1]
RefSeqiNP_082187.1. NM_027911.3. [Q9CW46-1]
UniGeneiMm.196137.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WI6NMR-A61-135[»]
3ZZYX-ray1.40C/D496-507[»]
3ZZZX-ray1.55C/D680-692[»]
ProteinModelPortaliQ9CW46.
SMRiQ9CW46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214910. 7 interactors.
DIPiDIP-44609N.
IntActiQ9CW46. 4 interactors.
MINTiMINT-1707126.
STRINGi10090.ENSMUSP00000111150.

PTM databases

iPTMnetiQ9CW46.
PhosphoSitePlusiQ9CW46.

Proteomic databases

EPDiQ9CW46.
PaxDbiQ9CW46.
PeptideAtlasiQ9CW46.
PRIDEiQ9CW46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115487; ENSMUSP00000111150; ENSMUSG00000010205. [Q9CW46-1]
GeneIDi71766.
KEGGimmu:71766.
UCSCiuc009okd.2. mouse. [Q9CW46-1]

Organism-specific databases

CTDi125950.
MGIiMGI:1919016. Raver1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJBP. Eukaryota.
ENOG410ZP6I. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ9CW46.
OMAiFSHPREP.
OrthoDBiEOG091G04CT.
PhylomeDBiQ9CW46.
TreeFamiTF331660.

Miscellaneous databases

ChiTaRSiRaver1. mouse.
EvolutionaryTraceiQ9CW46.
PROiQ9CW46.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010205.
CleanExiMM_RAVER1.
GenevisibleiQ9CW46. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAVR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CW46
Secondary accession number(s): Q5DTT6
, Q811K0, Q8C3Z1, Q8CA14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.