Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9CVP4 (Q9CVP4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Tgfbr1 MGI 98728
OrganismMus musculus (Mouse) EMBL BAB24865.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length215 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from mutant phenotype PubMed 11285230. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 16845371. Source: MGI

artery morphogenesis

Inferred from mutant phenotype PubMed 17078885. Source: MGI

blastocyst development

Inferred from direct assay PubMed 9921650. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 15993878. Source: MGI

embryo development

Inferred from mutant phenotype PubMed 14729481PubMed 16344855. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 16806156. Source: MGI

endothelial cell migration

Inferred from mutant phenotype PubMed 11285230. Source: MGI

epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

germ cell migration

Inferred from mutant phenotype PubMed 15993878. Source: MGI

heart development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 11285230PubMed 14729481PubMed 17078885. Source: MGI

kidney development

Inferred from genetic interaction PubMed 16845371. Source: MGI

lens development in camera-type eye

Inferred from mutant phenotype PubMed 11641223. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16806156PubMed 17078885. Source: MGI

negative regulation of endothelial cell proliferation

Inferred from genetic interaction PubMed 21832243. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

neuron fate commitment

Inferred from mutant phenotype PubMed 15744664. Source: MGI

palate development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

parathyroid gland development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

positive regulation of SMAD protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular component movement

Inferred from electronic annotation. Source: Ensembl

positive regulation of filopodium assembly

Inferred from mutant phenotype PubMed 16806156. Source: MGI

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of protein binding

Inferred from mutant phenotype PubMed 16601693. Source: MGI

regulation of protein ubiquitination

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from genetic interaction PubMed 16845371. Source: MGI

skeletal system morphogenesis

Inferred from genetic interaction PubMed 16845371. Source: MGI

thymus development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 14580334PubMed 15820682. Source: MGI

   Cellular_componentcaveola

Inferred from sequence orthology PubMed 17878231. Source: MGI

membrane raft

Inferred from sequence orthology PubMed 17878231. Source: MGI

receptor complex

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

transforming growth factor beta binding

Inferred from physical interaction PubMed 17878231. Source: MGI

transforming growth factor beta receptor activity, type I

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta-activated receptor activity

Inferred from direct assay PubMed 15820682. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAB24865.1

Sequences

Sequence LengthMass (Da)Tools
Q9CVP4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 52E9ACE05F802F2D

FASTA21524,353
        10         20         30         40         50         60 
FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA IAHRDLKSKN ILVKKNGTCC 

        70         80         90        100        110        120 
IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI NMKHFESFKR ADIYAMGLVF 

       130        140        150        160        170        180 
WEIARRCSIG GIHEDYQLPY YDLVPSDPSV EEMRKVVCEQ KLRPNIPNRW QSCEALRVMA 

       190        200        210 
KIMRECWYAN GAARLTALRI KKTLSQLSQQ EGIKM 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB24865.1.
Tissue: Testis EMBL BAB24865.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007125 mRNA. Translation: BAB24865.1.
UniGeneMm.197552.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9CVP4.

Proteomic databases

PRIDEQ9CVP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:98728. Tgfbr1.

Phylogenomic databases

HOGENOMHOG000230587.
HOVERGENHBG104975.
InParanoidQ9CVP4.

Gene expression databases

ArrayExpressQ9CVP4.
BgeeQ9CVP4.
GenevestigatorQ9CVP4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTGFBR1. mouse.
SOURCESearch...

Entry information

Entry nameQ9CVP4_MOUSE
AccessionPrimary (citable) accession number: Q9CVP4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)