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Q9CVP4

- Q9CVP4_MOUSE

UniProt

Q9CVP4 - Q9CVP4_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: MGI
  4. transforming growth factor beta binding Source: MGI
  5. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. angiogenesis Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. artery morphogenesis Source: MGI
  5. blastocyst development Source: MGI
  6. collagen fibril organization Source: MGI
  7. embryonic cranial skeleton morphogenesis Source: MGI
  8. endothelial cell migration Source: MGI
  9. epithelial to mesenchymal transition Source: Ensembl
  10. germ cell migration Source: MGI
  11. heart development Source: MGI
  12. in utero embryonic development Source: MGI
  13. kidney development Source: MGI
  14. lens development in camera-type eye Source: MGI
  15. male gonad development Source: MGI
  16. negative regulation of apoptotic process Source: MGI
  17. negative regulation of endothelial cell proliferation Source: MGI
  18. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  19. neuron fate commitment Source: MGI
  20. palate development Source: MGI
  21. parathyroid gland development Source: MGI
  22. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  23. peptidyl-serine phosphorylation Source: Ensembl
  24. peptidyl-threonine phosphorylation Source: Ensembl
  25. pharyngeal system development Source: MGI
  26. positive regulation of apoptotic signaling pathway Source: Ensembl
  27. positive regulation of cell growth Source: Ensembl
  28. positive regulation of cell proliferation Source: Ensembl
  29. positive regulation of cellular component movement Source: Ensembl
  30. positive regulation of filopodium assembly Source: MGI
  31. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  32. positive regulation of protein kinase B signaling Source: Ensembl
  33. positive regulation of SMAD protein import into nucleus Source: Ensembl
  34. positive regulation of transcription, DNA-templated Source: Ensembl
  35. post-embryonic development Source: MGI
  36. regulation of gene expression Source: MGI
  37. regulation of protein binding Source: MGI
  38. regulation of protein ubiquitination Source: Ensembl
  39. skeletal system development Source: MGI
  40. skeletal system morphogenesis Source: MGI
  41. thymus development Source: MGI
  42. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
  4. receptor complex Source: Ensembl
  5. tight junction Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9CVP4.

Expressioni

Gene expression databases

BgeeiQ9CVP4.
ExpressionAtlasiQ9CVP4. baseline and differential.
GenevestigatoriQ9CVP4.

Interactioni

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000230587.
HOVERGENiHBG104975.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CVP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA IAHRDLKSKN
60 70 80 90 100
ILVKKNGTCC IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI
110 120 130 140 150
NMKHFESFKR ADIYAMGLVF WEIARRCSIG GIHEDYQLPY YDLVPSDPSV
160 170 180 190 200
EEMRKVVCEQ KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI
210
KKTLSQLSQQ EGIKM
Length:215
Mass (Da):24,353
Last modified:June 1, 2001 - v1
Checksum:i52E9ACE05F802F2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007125 mRNA. Translation: BAB24865.1.
UniGeneiMm.197552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007125 mRNA. Translation: BAB24865.1 .
UniGenei Mm.197552.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9CVP4.

Proteomic databases

PRIDEi Q9CVP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98728. Tgfbr1.

Phylogenomic databases

HOGENOMi HOG000230587.
HOVERGENi HBG104975.

Miscellaneous databases

ChiTaRSi TGFBR1. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q9CVP4.
ExpressionAtlasi Q9CVP4. baseline and differential.
Genevestigatori Q9CVP4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ9CVP4_MOUSE
AccessioniPrimary (citable) accession number: Q9CVP4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)