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Q9CVP4

- Q9CVP4_MOUSE

UniProt

Q9CVP4 - Q9CVP4_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: MGI
    5. transforming growth factor beta binding Source: MGI
    6. transforming growth factor beta receptor activity, type I Source: Ensembl

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. angiogenesis Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. artery morphogenesis Source: MGI
    5. blastocyst development Source: MGI
    6. collagen fibril organization Source: MGI
    7. embryonic cranial skeleton morphogenesis Source: MGI
    8. endothelial cell migration Source: MGI
    9. epithelial to mesenchymal transition Source: Ensembl
    10. germ cell migration Source: MGI
    11. heart development Source: MGI
    12. in utero embryonic development Source: MGI
    13. kidney development Source: MGI
    14. lens development in camera-type eye Source: MGI
    15. negative regulation of apoptotic process Source: MGI
    16. negative regulation of endothelial cell proliferation Source: MGI
    17. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    18. neuron fate commitment Source: MGI
    19. palate development Source: MGI
    20. parathyroid gland development Source: MGI
    21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    22. peptidyl-serine phosphorylation Source: Ensembl
    23. peptidyl-threonine phosphorylation Source: Ensembl
    24. pharyngeal system development Source: MGI
    25. positive regulation of apoptotic signaling pathway Source: Ensembl
    26. positive regulation of cell growth Source: Ensembl
    27. positive regulation of cell proliferation Source: Ensembl
    28. positive regulation of cellular component movement Source: Ensembl
    29. positive regulation of filopodium assembly Source: MGI
    30. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    31. positive regulation of protein kinase B signaling Source: Ensembl
    32. positive regulation of SMAD protein import into nucleus Source: Ensembl
    33. positive regulation of transcription, DNA-templated Source: Ensembl
    34. post-embryonic development Source: MGI
    35. regulation of gene expression Source: MGI
    36. regulation of protein binding Source: MGI
    37. regulation of protein ubiquitination Source: Ensembl
    38. skeletal system development Source: MGI
    39. skeletal system morphogenesis Source: MGI
    40. thymus development Source: MGI
    41. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Tgfbr1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98728. Tgfbr1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: MGI
    4. receptor complex Source: Ensembl
    5. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9CVP4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CVP4.
    BgeeiQ9CVP4.
    GenevestigatoriQ9CVP4.

    Interactioni

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000230587.
    HOVERGENiHBG104975.
    InParanoidiQ9CVP4.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9CVP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA IAHRDLKSKN    50
    ILVKKNGTCC IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI 100
    NMKHFESFKR ADIYAMGLVF WEIARRCSIG GIHEDYQLPY YDLVPSDPSV 150
    EEMRKVVCEQ KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI 200
    KKTLSQLSQQ EGIKM 215
    Length:215
    Mass (Da):24,353
    Last modified:June 1, 2001 - v1
    Checksum:i52E9ACE05F802F2D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007125 mRNA. Translation: BAB24865.1.
    UniGeneiMm.197552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007125 mRNA. Translation: BAB24865.1 .
    UniGenei Mm.197552.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9CVP4.

    Proteomic databases

    PRIDEi Q9CVP4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98728. Tgfbr1.

    Phylogenomic databases

    HOGENOMi HOG000230587.
    HOVERGENi HBG104975.
    InParanoidi Q9CVP4.

    Miscellaneous databases

    ChiTaRSi TGFBR1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CVP4.
    Bgeei Q9CVP4.
    Genevestigatori Q9CVP4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ9CVP4_MOUSE
    AccessioniPrimary (citable) accession number: Q9CVP4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)