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Protein

Receptor protein serine/threonine kinase

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • activation of MAPKK activity Source: MGI
  • angiogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • artery morphogenesis Source: MGI
  • blastocyst development Source: MGI
  • cell motility Source: MGI
  • cellular response to transforming growth factor beta stimulus Source: MGI
  • collagen fibril organization Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • endothelial cell migration Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • germ cell migration Source: MGI
  • heart development Source: MGI
  • in utero embryonic development Source: MGI
  • kidney development Source: MGI
  • lens development in camera-type eye Source: MGI
  • male gonad development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of endothelial cell proliferation Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • neuron fate commitment Source: MGI
  • palate development Source: MGI
  • parathyroid gland development Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • peptidyl-threonine phosphorylation Source: MGI
  • pharyngeal system development Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of cell growth Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cellular component movement Source: MGI
  • positive regulation of filopodium assembly Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of SMAD protein import into nucleus Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • post-embryonic development Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of protein binding Source: MGI
  • regulation of protein ubiquitination Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to cholesterol Source: MGI
  • signal transduction Source: MGI
  • skeletal system development Source: MGI
  • skeletal system morphogenesis Source: MGI
  • thymus development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9CVP4.

Expressioni

Gene expression databases

BgeeiQ9CVP4.
ExpressionAtlasiQ9CVP4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000230587.
HOVERGENiHBG104975.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CVP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA IAHRDLKSKN
60 70 80 90 100
ILVKKNGTCC IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI
110 120 130 140 150
NMKHFESFKR ADIYAMGLVF WEIARRCSIG GIHEDYQLPY YDLVPSDPSV
160 170 180 190 200
EEMRKVVCEQ KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI
210
KKTLSQLSQQ EGIKM
Length:215
Mass (Da):24,353
Last modified:June 1, 2001 - v1
Checksum:i52E9ACE05F802F2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007125 mRNA. Translation: BAB24865.1.
UniGeneiMm.197552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007125 mRNA. Translation: BAB24865.1.
UniGeneiMm.197552.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Chemistry

BindingDBiQ9CVP4.

Proteomic databases

PRIDEiQ9CVP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Phylogenomic databases

HOGENOMiHOG000230587.
HOVERGENiHBG104975.

Miscellaneous databases

ChiTaRSiTgfbr1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CVP4.
ExpressionAtlasiQ9CVP4. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ9CVP4_MOUSE
AccessioniPrimary (citable) accession number: Q9CVP4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.