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Protein

Actin-related protein 2/3 complex subunit 2

Gene

Arpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:Arpc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923959. Arpc2.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: MGI
  • cell leading edge Source: MGI
  • cytoplasm Source: MGI
  • endosome Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • Golgi apparatus Source: MGI
  • muscle cell projection membrane Source: MGI
  • neuron projection Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Actin-related protein 2/3 complex subunit 2PRO_0000124034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysineBy similarity
Modified residuei295 – 2951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CVB6.
MaxQBiQ9CVB6.
PaxDbiQ9CVB6.
PeptideAtlasiQ9CVB6.
PRIDEiQ9CVB6.

PTM databases

iPTMnetiQ9CVB6.
PhosphoSiteiQ9CVB6.

Expressioni

Tissue specificityi

Expressed in hippocampal neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000006304.
CleanExiMM_ARPC2.
ExpressionAtlasiQ9CVB6. baseline and differential.
GenevisibleiQ9CVB6. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.1 Publication

Protein-protein interaction databases

BioGridi218272. 2 interactions.
IntActiQ9CVB6. 7 interactions.
MINTiMINT-1857921.
STRINGi10090.ENSMUSP00000006467.

Structurei

3D structure databases

ProteinModelPortaliQ9CVB6.
SMRiQ9CVB6. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
GeneTreeiENSGT00390000016794.
HOVERGENiHBG050580.
InParanoidiQ9CVB6.
KOiK05758.
OMAiFPRHFAN.
OrthoDBiEOG091G0BUH.
TreeFamiTF315006.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CVB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPEPG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNATARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,357
Last modified:July 25, 2006 - v3
Checksum:i6A5D8500D641DB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008777 mRNA. Translation: BAB25889.2.
AK152356 mRNA. Translation: BAE31148.1.
BC115750 mRNA. Translation: AAI15751.1.
CCDSiCCDS35612.1.
RefSeqiNP_083987.1. NM_029711.1.
XP_006496380.1. XM_006496317.1.
UniGeneiMm.337038.

Genome annotation databases

EnsembliENSMUST00000006467; ENSMUSP00000006467; ENSMUSG00000006304.
ENSMUST00000113820; ENSMUSP00000109451; ENSMUSG00000006304.
GeneIDi76709.
KEGGimmu:76709.
UCSCiuc007bln.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008777 mRNA. Translation: BAB25889.2.
AK152356 mRNA. Translation: BAE31148.1.
BC115750 mRNA. Translation: AAI15751.1.
CCDSiCCDS35612.1.
RefSeqiNP_083987.1. NM_029711.1.
XP_006496380.1. XM_006496317.1.
UniGeneiMm.337038.

3D structure databases

ProteinModelPortaliQ9CVB6.
SMRiQ9CVB6. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218272. 2 interactions.
IntActiQ9CVB6. 7 interactions.
MINTiMINT-1857921.
STRINGi10090.ENSMUSP00000006467.

PTM databases

iPTMnetiQ9CVB6.
PhosphoSiteiQ9CVB6.

Proteomic databases

EPDiQ9CVB6.
MaxQBiQ9CVB6.
PaxDbiQ9CVB6.
PeptideAtlasiQ9CVB6.
PRIDEiQ9CVB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006467; ENSMUSP00000006467; ENSMUSG00000006304.
ENSMUST00000113820; ENSMUSP00000109451; ENSMUSG00000006304.
GeneIDi76709.
KEGGimmu:76709.
UCSCiuc007bln.1. mouse.

Organism-specific databases

CTDi10109.
MGIiMGI:1923959. Arpc2.

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
GeneTreeiENSGT00390000016794.
HOVERGENiHBG050580.
InParanoidiQ9CVB6.
KOiK05758.
OMAiFPRHFAN.
OrthoDBiEOG091G0BUH.
TreeFamiTF315006.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

ChiTaRSiArpc2. mouse.
PROiQ9CVB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006304.
CleanExiMM_ARPC2.
ExpressionAtlasiQ9CVB6. baseline and differential.
GenevisibleiQ9CVB6. MM.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CVB6
Secondary accession number(s): Q3U870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.