ID   Q9CV93_MOUSE            Unreviewed;       725 AA.
AC   Q9CV93;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:BAB26024.1};
DE   Flags: Fragment;
GN   Name=Muc5b {ECO:0000313|MGI:MGI:1921430};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB26024.1};
RN   [1] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RA   Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T.,
RA   Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T.,
RA   Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y.,
RA   Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A.,
RA   Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C.,
RA   Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K.,
RA   Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M.,
RA   Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T.,
RA   Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAB26024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26024.1};
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAB26024.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   EMBL; AK009011; BAB26024.1; -; mRNA.
DR   RefSeq; NP_083077.2; NM_028801.2.
DR   AlphaFoldDB; Q9CV93; -.
DR   DNASU; 74180; -.
DR   GeneID; 74180; -.
DR   KEGG; mmu:74180; -.
DR   AGR; MGI:1921430; -.
DR   CTD; 727897; -.
DR   MGI; MGI:1921430; Muc5b.
DR   OrthoDB; 2872912at2759; -.
DR   BioGRID-ORCS; 74180; 3 hits in 77 CRISPR screens.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR   GO; GO:0043030; P:regulation of macrophage activation; IMP:MGI.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF371; MUCIN-5B; 1.
DR   Pfam; PF08742; C8; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00832; C8; 1.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00214; VWC; 2.
DR   SMART; SM00216; VWD; 1.
DR   SUPFAM; SSF57603; FnI-like domain; 1.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 1.
DR   Genevisible; Q9CV93; MM.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00039}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          45..232
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   DOMAIN          386..456
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          493..557
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          623..715
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|PROSITE:PS01225"
FT   REGION          228..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        654..708
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT   DISULFID        658..710
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAB26024.1"
SQ   SEQUENCE   725 AA;  78873 MW;  F2D96B2CAB7552E4 CRC64;
     ARCQGNNQII LLEPEPVDNV TCANRHLPIK VWDQEPCHFH YECECFCSGW GHSHYLTFDG
     TSYTFLDNCT SVLMREIHPR HGNLSILAHS YYCGATTNVT SCPRALSVYY NSMEIILTIS
     TTESGKDESL IIWDQMWIRS GFSKNGVTVS LSGATTMSVN ISTIGTIITF DGNIFQIWLP
     YRYFSSNTEG QCGTCTNSQI DDCRRPDGTI ASDCQDMAKE WLVPGNSSSS CLAQPSPLPS
     TTPQTPVSST LTSTPCPSAP LCELMLSQVF AECHRLIPPD AFFRSCVSDH CNANITDMLC
     QSLEAYAALC RAQGVCTNWR NATGGLCDLS CPPTKEYRPC GPLHPASCNS RTQDSTTGML
     AEGCFCPENQ LLFNSRMDIC VSECPCVGPD GLPKFPGEHW ISNCQACVCE PGSVSVQCEP
     VKCESQDKPP QCTEAGFVTV TWPSADNPCC PETLCVCNST TCPKSLPTCE PGYELVQTHE
     NSSCCPSYSC RPRLCTYNDT IYGVGTTFPG GPCHTCTCLS DGDQEPKVEC KETNCTTSCP
     QGFKYTLVPE QCCGECLQNA CLTPEGHAVQ PNETWVNSPV DNCTAYHCMA ENGVYVLTPI
     PTSCPDVSNC TGTLRKTGCC YSCEKEDSST CQVHVNATVL RYKGCETEVN ITFCEGSCSG
     ISKYSMEAQA MERQCTCCQE SKVHDVAVTM QCPDGTVIQH TYTHIDECNC APACSSLPGT
     SMIAS
//