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Protein

Ubiquitin carboxyl-terminal hydrolase FAM188A

Gene

Fam188a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. May have pro-apoptotic function.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51NucleophileBy similarity1
Active sitei286Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase FAM188A (EC:3.4.19.12)
Alternative name(s):
Protein CARP
Gene namesi
Name:Fam188a
Synonyms:Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914210. Fam188a.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175621 – 444Ubiquitin carboxyl-terminal hydrolase FAM188AAdd BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CV28.
PaxDbiQ9CV28.
PeptideAtlasiQ9CV28.
PRIDEiQ9CV28.

PTM databases

iPTMnetiQ9CV28.
PhosphoSitePlusiQ9CV28.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026767.
CleanExiMM_2310047O13RIK.
ExpressionAtlasiQ9CV28. baseline and differential.
GenevisibleiQ9CV28. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028105.

Structurei

3D structure databases

ProteinModelPortaliQ9CV28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2871. Eukaryota.
ENOG410XSGV. LUCA.
GeneTreeiENSGT00530000063283.
HOGENOMiHOG000031396.
HOVERGENiHBG061682.
InParanoidiQ9CV28.
OMAiYGQLAHT.
OrthoDBiEOG091G0TF1.
PhylomeDBiQ9CV28.
TreeFamiTF323996.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR025257. DUF4205.
IPR011992. EF-hand-dom_pair.
[Graphical view]
PfamiPF13898. DUF4205. 1 hit.
[Graphical view]
SMARTiSM01174. DUF4205. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CV28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVTKELLE LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP
60 70 80 90 100
CAVIAPVQAF LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDIVESAYDS
110 120 130 140 150
SGSYCLVSWL RGRTPEEAAR ISGSPAQSSC QVEHSSALAV EELGFERFHA
160 170 180 190 200
LIQKRSFRTV SELKDAVLDQ YSMWGNKFGV LLFLYSVLLT KGIENIKNSI
210 220 230 240 250
EDANEPLIDP VYGHGSQSLI NLLLTGHAVS NVWDGDRECS GMQLLGIHEQ
260 270 280 290 300
AAVGFLTLME ALRYCKVGSY LKSPKFPIWI VGSETHLTVF FAKDMALVAP
310 320 330 340 350
EAPSEQARRV FQTYDPEDNG FIADSLLEDV MKALDLVSDP EYINLMKNKL
360 370 380 390 400
DPEGLGIILL GPFLQEFFPD QGSSGPESFT VYHYNGLKQS NYNEKVMYVE
410 420 430 440
GTAVVMGFED PMLQTDDTPI KRCLQTKWPY IELLWTTDRC PSLN
Length:444
Mass (Da):49,612
Last modified:March 1, 2003 - v2
Checksum:i02D382FAEB3D6167
GO
Isoform 2 (identifier: Q9CV28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-444: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):37,789
Checksum:i68ACB4EBA251BF04
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031041342 – 444Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002900 mRNA. Translation: BAB22443.1.
AK009891 mRNA. Translation: BAB26566.2.
AK143250 mRNA. Translation: BAE25325.1.
AL772342, AL845533 Genomic DNA. Translation: CAM13409.1.
AL845533, AL772342 Genomic DNA. Translation: CAM18188.1.
BC027202 mRNA. Translation: AAH27202.1.
CCDSiCCDS15690.1. [Q9CV28-1]
RefSeqiNP_077147.2. NM_024185.4. [Q9CV28-1]
UniGeneiMm.34059.

Genome annotation databases

EnsembliENSMUST00000028105; ENSMUSP00000028105; ENSMUSG00000026767. [Q9CV28-1]
GeneIDi66960.
KEGGimmu:66960.
UCSCiuc008ijn.1. mouse. [Q9CV28-1]
uc008ijs.1. mouse. [Q9CV28-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002900 mRNA. Translation: BAB22443.1.
AK009891 mRNA. Translation: BAB26566.2.
AK143250 mRNA. Translation: BAE25325.1.
AL772342, AL845533 Genomic DNA. Translation: CAM13409.1.
AL845533, AL772342 Genomic DNA. Translation: CAM18188.1.
BC027202 mRNA. Translation: AAH27202.1.
CCDSiCCDS15690.1. [Q9CV28-1]
RefSeqiNP_077147.2. NM_024185.4. [Q9CV28-1]
UniGeneiMm.34059.

3D structure databases

ProteinModelPortaliQ9CV28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028105.

PTM databases

iPTMnetiQ9CV28.
PhosphoSitePlusiQ9CV28.

Proteomic databases

EPDiQ9CV28.
PaxDbiQ9CV28.
PeptideAtlasiQ9CV28.
PRIDEiQ9CV28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028105; ENSMUSP00000028105; ENSMUSG00000026767. [Q9CV28-1]
GeneIDi66960.
KEGGimmu:66960.
UCSCiuc008ijn.1. mouse. [Q9CV28-1]
uc008ijs.1. mouse. [Q9CV28-2]

Organism-specific databases

CTDi80013.
MGIiMGI:1914210. Fam188a.

Phylogenomic databases

eggNOGiKOG2871. Eukaryota.
ENOG410XSGV. LUCA.
GeneTreeiENSGT00530000063283.
HOGENOMiHOG000031396.
HOVERGENiHBG061682.
InParanoidiQ9CV28.
OMAiYGQLAHT.
OrthoDBiEOG091G0TF1.
PhylomeDBiQ9CV28.
TreeFamiTF323996.

Miscellaneous databases

ChiTaRSiFam188a. mouse.
PROiQ9CV28.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026767.
CleanExiMM_2310047O13RIK.
ExpressionAtlasiQ9CV28. baseline and differential.
GenevisibleiQ9CV28. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR025257. DUF4205.
IPR011992. EF-hand-dom_pair.
[Graphical view]
PfamiPF13898. DUF4205. 1 hit.
[Graphical view]
SMARTiSM01174. DUF4205. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF188A_MOUSE
AccessioniPrimary (citable) accession number: Q9CV28
Secondary accession number(s): Q3UPS0, Q9DCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.