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Protein

52 kDa repressor of the inhibitor of the protein kinase

Gene

Thap12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8686THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
52 kDa repressor of the inhibitor of the protein kinase
Short name:
p52rIPK
Alternative name(s):
58 kDa interferon-induced protein kinase-interacting protein
Short name:
p58IPK-interacting protein
THAP domain-containing protein 0
THAP domain-containing protein 12By similarity
Gene namesi
Name:Thap12By similarity
Synonyms:PrkrirImported, Thap0
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920231. Prkrir.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 75875852 kDa repressor of the inhibitor of the protein kinasePRO_0000068635Add
BLAST

Proteomic databases

EPDiQ9CUX1.
MaxQBiQ9CUX1.
PaxDbiQ9CUX1.
PRIDEiQ9CUX1.

PTM databases

PhosphoSiteiQ9CUX1.

Expressioni

Gene expression databases

BgeeiQ9CUX1.
ExpressionAtlasiQ9CUX1. baseline and differential.
GenevisibleiQ9CUX1. MM.

Interactioni

Subunit structurei

Interacts with DNAJC3, probably sequestring it.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033009.

Structurei

3D structure databases

ProteinModelPortaliQ9CUX1.
SMRiQ9CUX1. Positions 1-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8686THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHFF. Eukaryota.
ENOG4110ZMY. LUCA.
GeneTreeiENSGT00530000063516.
HOGENOMiHOG000013127.
HOVERGENiHBG007908.
InParanoidiQ9CUX1.
OMAiFPNVNAF.
OrthoDBiEOG7JX34X.
PhylomeDBiQ9CUX1.
TreeFamiTF330114.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CUX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKIE ETSEQEQETN TNAQNPSAEA VNQQDANVLP
160 170 180 190 200
LTLEEKENKE YLKSLFEILV LMGKQNIPLD GHEADEVPEG LFAPDNFQAL
210 220 230 240 250
LECRINSGEE VLRKRFEATA VNTLFCSKTQ QRHMLEICES CIREETLREV
260 270 280 290 300
RDSHFFSIIT DDVVDIAGEE HLPVLVRFVD DAHNLREEFV GFLPYEADAE
310 320 330 340 350
ILAVKFHTTI TEKWGLNMEY CRGQAYIVSS GFSSKMKVVA SRLLEKYPQA
360 370 380 390 400
VYTLCSSCAL NAWLAKSVPV IGVSVALGTI EEVCSFFHRS PQLLLELDSV
410 420 430 440 450
ISVLFQNSEE RAKELKEICH SQWTGRHDAF EILVDLLQAL VLCLDGIINS
460 470 480 490 500
DTNVRWNNYI AGRAFVLCSA VTDFDFIVTI VVLKNVLSFT RAFGKNLQGQ
510 520 530 540 550
TSDVFFAASS LTAVLHSLNE VMENIEVYHE FWFEEATNLA TKLDIQMKLP
560 570 580 590 600
GKFRRAQQGN LESQLTSESY YKDTLSVPTV EHIIQELKDI FSEQHLKALK
610 620 630 640 650
CLSLVPSVMG QLKFNTSEEH HADMYRSDLP NPDTLSAELH CWRIKWKHRG
660 670 680 690 700
KDIELPSTIY EALHLPDIKF FPNVYALLKV LCILPVMKVE NERYENGRKR
710 720 730 740 750
LKAYLRNTLT DQRSSNLALL NINFDIKHDL DLMVDTYIKL YTNKSELPTI

NSETIENT
Length:758
Mass (Da):87,021
Last modified:January 16, 2004 - v2
Checksum:i0BEDA3FAF680CE1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049103 mRNA. Translation: AAH49103.1.
AK013663 mRNA. Translation: BAB28945.1.
CCDSiCCDS21474.1.
RefSeqiNP_082686.1. NM_028410.1.
XP_011240217.1. XM_011241915.1.
UniGeneiMm.4428.

Genome annotation databases

EnsembliENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753.
GeneIDi72981.
KEGGimmu:72981.
UCSCiuc009ikt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049103 mRNA. Translation: AAH49103.1.
AK013663 mRNA. Translation: BAB28945.1.
CCDSiCCDS21474.1.
RefSeqiNP_082686.1. NM_028410.1.
XP_011240217.1. XM_011241915.1.
UniGeneiMm.4428.

3D structure databases

ProteinModelPortaliQ9CUX1.
SMRiQ9CUX1. Positions 1-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033009.

PTM databases

PhosphoSiteiQ9CUX1.

Proteomic databases

EPDiQ9CUX1.
MaxQBiQ9CUX1.
PaxDbiQ9CUX1.
PRIDEiQ9CUX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753.
GeneIDi72981.
KEGGimmu:72981.
UCSCiuc009ikt.1. mouse.

Organism-specific databases

CTDi72981.
MGIiMGI:1920231. Prkrir.

Phylogenomic databases

eggNOGiENOG410IHFF. Eukaryota.
ENOG4110ZMY. LUCA.
GeneTreeiENSGT00530000063516.
HOGENOMiHOG000013127.
HOVERGENiHBG007908.
InParanoidiQ9CUX1.
OMAiFPNVNAF.
OrthoDBiEOG7JX34X.
PhylomeDBiQ9CUX1.
TreeFamiTF330114.

Miscellaneous databases

ChiTaRSiPrkrir. mouse.
NextBioi337269.
PROiQ9CUX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CUX1.
ExpressionAtlasiQ9CUX1. baseline and differential.
GenevisibleiQ9CUX1. MM.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-652.
    Strain: C57BL/6J.
    Tissue: Hippocampus.

Entry informationi

Entry nameiP52K_MOUSE
AccessioniPrimary (citable) accession number: Q9CUX1
Secondary accession number(s): Q80Y58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: January 16, 2004
Last modified: May 11, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.