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Protein
Submitted name:

Putative uncharacterized protein

Gene

Dnm2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. SH3 domain binding Source: MGI

GO - Biological processi

  1. negative regulation of membrane tubulation Source: MGI
  2. receptor internalization Source: MGI
  3. transferrin transport Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Dnm2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109547. Dnm2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. focal adhesion Source: MGI
  5. Golgi apparatus Source: MGI
  6. microtubule Source: MGI
  7. photoreceptor inner segment Source: MGI
  8. postsynaptic membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9CUM4.

Expressioni

Gene expression databases

GenevestigatoriQ9CUM4.

Structurei

3D structure databases

ProteinModelPortaliQ9CUM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dynamin family.UniRule annotation
Contains GED domain.SAAS annotation
Contains dynamin-type G (guanine nucleotide-binding) domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG107833.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CUM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NFVGRDFLPR GSGIVTRRPL ILQLIFSKTE YAEFLHCKSK KFTDFDEVRQ
60 70 80 90 100
EIEAETDRVT GTNKGISPVP INLRVYSPHV LNLTLIDLPG ITKVPVGDQP
110 120 130 140 150
PDIEYQIKDM ILQFISRESS LILAVTPANM DLANSDALKL AKEVDPQGLR
160 170 180 190 200
TIGVITKLDL MDEGTDARDD LENKLLPLRR GYIGVVNRSQ KDIEGKKDIR
210 220 230 240 250
AALAAERKFF LSHPAYRHMA DRMGTPHLQK TLNQQLTNHI RESLPTLRSK
260 270 280 290 300
LQSQLLSLEK EVEEYKNFRP DDPTRKTKAL LQMVQQFGVD FEKRIEGSGD
310 320 330 340 350
QVDTLELSGG ARINRIFHER FPFELVKMEF DEKDLRREIS YAIKNIHGVR
360 370 380 390 400
TGLFTPDMAF EAIVKKQLVK LKEPSLKCVD LVVSELATVI KKCAEKLSSY
410 420 430 440 450
PRLREETERI VTTYIREREG RTKDQILLLI DIEQSYINTN HEDFIGFANA
460 470 480 490
QQRSTQLNKK RAIPNQGEIL TSLTDQTMAY HMRRFAFLCL WQA
Length:493
Mass (Da):56,552
Last modified:June 1, 2001 - v1
Checksum:i7A359201900939AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015410 mRNA. Translation: BAB29835.1.
UniGeneiMm.433257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015410 mRNA. Translation: BAB29835.1.
UniGeneiMm.433257.

3D structure databases

ProteinModelPortaliQ9CUM4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9CUM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109547. Dnm2.

Phylogenomic databases

HOVERGENiHBG107833.

Miscellaneous databases

ChiTaRSiDnm2. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9CUM4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ9CUM4_MOUSE
AccessioniPrimary (citable) accession number: Q9CUM4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.