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Protein

OTU domain-containing protein 1

Gene

Otud1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901By similarity
Active sitei293 – 2931NucleophileBy similarity
Active sitei404 – 4041By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.004.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 1 (EC:3.4.19.12)
Gene namesi
Name:Otud1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918448. Otud1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454OTU domain-containing protein 1PRO_0000271019Add
BLAST

Proteomic databases

PRIDEiQ9CUB6.

PTM databases

PhosphoSiteiQ9CUB6.

Expressioni

Gene expression databases

BgeeiQ9CUB6.
GenevisibleiQ9CUB6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100617.

Structurei

3D structure databases

ProteinModelPortaliQ9CUB6.
SMRiQ9CUB6. Positions 261-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 411130OTUPROSITE-ProRule annotationAdd
BLAST
Domaini430 – 44920UIMCuratedAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni287 – 2937Cys-loopBy similarity
Regioni342 – 35211His-loopBy similarityAdd
BLAST
Regioni399 – 4046Variable-loopBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 8869Ala-richAdd
BLAST

Domaini

The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin.By similarity
Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).By similarity

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327202.
GeneTreeiENSGT00510000049635.
HOGENOMiHOG000115304.
HOVERGENiHBG080487.
InParanoidiQ9CUB6.
KOiK13716.
OMAiPHYTSTA.
OrthoDBiEOG7TBC35.
PhylomeDBiQ9CUB6.
TreeFamiTF338508.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CUB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYSSVCTH YPAGTPGPTA AAPPATAAAA FKVSLQSASP AAAAPEPDTG
60 70 80 90 100
ERPPAAATEP REAAAAAAMP AFSACFERSG SAAAPPGACS KPPLPPHFTS
110 120 130 140 150
TAHIAVRALG AERLLLPPPS APSPPRRGSS AWLLEELLRP DEPAAPNAVR
160 170 180 190 200
DAPDRNFRLS EHRQALAASQ HRAPAPAPVG PEPGAGPGSG PWGEERRAER
210 220 230 240 250
SSRGWDRASG RSDASGSDAL RRQDPEAEAH PVPAPARSSG EPAQNGEGEA
260 270 280 290 300
VGTSRADPRD EKLALYLAEV ERQDKYLRQR NKYRFHIIPD GNCLYRAVSK
310 320 330 340 350
TVYGDQSLHR ELREQTVHYI ADHLDHFSPL IEGDVGEFII AAAQDGAWAG
360 370 380 390 400
YPELLAMGQM LNVNIHLTTG GRLESPTVST MIHYLGPEDS LRPSIWLSWL
410 420 430 440 450
SNGHYDAVFD HSYPNPEYDN WCKQTQIQKK RDEELAKSMA ISLSKMYIEQ

NACS
Length:454
Mass (Da):48,823
Last modified:January 9, 2007 - v2
Checksum:iBAF1702C35D1EF89
GO

Sequence cautioni

The sequence BAB30530.1 differs from that shown. Reason: Frameshift at position 62. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928877 Genomic DNA. Translation: CAM25812.1.
AK016972 mRNA. Translation: BAB30530.1. Frameshift.
CCDSiCCDS50508.1.
RefSeqiNP_081991.1. NM_027715.1.
UniGeneiMm.83981.

Genome annotation databases

EnsembliENSMUST00000052168; ENSMUSP00000100617; ENSMUSG00000043415.
GeneIDi71198.
KEGGimmu:71198.
UCSCiuc008imj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928877 Genomic DNA. Translation: CAM25812.1.
AK016972 mRNA. Translation: BAB30530.1. Frameshift.
CCDSiCCDS50508.1.
RefSeqiNP_081991.1. NM_027715.1.
UniGeneiMm.83981.

3D structure databases

ProteinModelPortaliQ9CUB6.
SMRiQ9CUB6. Positions 261-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100617.

Protein family/group databases

MEROPSiC85.004.

PTM databases

PhosphoSiteiQ9CUB6.

Proteomic databases

PRIDEiQ9CUB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052168; ENSMUSP00000100617; ENSMUSG00000043415.
GeneIDi71198.
KEGGimmu:71198.
UCSCiuc008imj.2. mouse.

Organism-specific databases

CTDi220213.
MGIiMGI:1918448. Otud1.

Phylogenomic databases

eggNOGiNOG327202.
GeneTreeiENSGT00510000049635.
HOGENOMiHOG000115304.
HOVERGENiHBG080487.
InParanoidiQ9CUB6.
KOiK13716.
OMAiPHYTSTA.
OrthoDBiEOG7TBC35.
PhylomeDBiQ9CUB6.
TreeFamiTF338508.

Miscellaneous databases

NextBioi333266.
PROiQ9CUB6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CUB6.
GenevisibleiQ9CUB6. MM.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-454.
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiOTUD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CUB6
Secondary accession number(s): A2ATK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.