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Q9CUB6

- OTUD1_MOUSE

UniProt

Q9CUB6 - OTUD1_MOUSE

Protein

OTU domain-containing protein 1

Gene

Otud1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901By similarity
    Active sitei293 – 2931NucleophileBy similarity
    Active sitei404 – 4041By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K63-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC85.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 1 (EC:3.4.19.12)
    Gene namesi
    Name:Otud1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1918448. Otud1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454OTU domain-containing protein 1PRO_0000271019Add
    BLAST

    Proteomic databases

    PRIDEiQ9CUB6.

    PTM databases

    PhosphoSiteiQ9CUB6.

    Expressioni

    Gene expression databases

    BgeeiQ9CUB6.
    GenevestigatoriQ9CUB6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CUB6.
    SMRiQ9CUB6. Positions 261-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 411130OTUPROSITE-ProRule annotationAdd
    BLAST
    Repeati430 – 44920UIMAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni287 – 2937Cys-loopBy similarity
    Regioni342 – 35211His-loopBy similarityAdd
    BLAST
    Regioni399 – 4046Variable-loopBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 8869Ala-richAdd
    BLAST

    Domaini

    The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin.By similarity
    Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).By similarity

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327202.
    GeneTreeiENSGT00510000049635.
    HOGENOMiHOG000115304.
    HOVERGENiHBG080487.
    InParanoidiQ9CUB6.
    KOiK13716.
    OMAiNFRLSEH.
    OrthoDBiEOG7TBC35.
    PhylomeDBiQ9CUB6.
    TreeFamiTF338508.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CUB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLYSSVCTH YPAGTPGPTA AAPPATAAAA FKVSLQSASP AAAAPEPDTG    50
    ERPPAAATEP REAAAAAAMP AFSACFERSG SAAAPPGACS KPPLPPHFTS 100
    TAHIAVRALG AERLLLPPPS APSPPRRGSS AWLLEELLRP DEPAAPNAVR 150
    DAPDRNFRLS EHRQALAASQ HRAPAPAPVG PEPGAGPGSG PWGEERRAER 200
    SSRGWDRASG RSDASGSDAL RRQDPEAEAH PVPAPARSSG EPAQNGEGEA 250
    VGTSRADPRD EKLALYLAEV ERQDKYLRQR NKYRFHIIPD GNCLYRAVSK 300
    TVYGDQSLHR ELREQTVHYI ADHLDHFSPL IEGDVGEFII AAAQDGAWAG 350
    YPELLAMGQM LNVNIHLTTG GRLESPTVST MIHYLGPEDS LRPSIWLSWL 400
    SNGHYDAVFD HSYPNPEYDN WCKQTQIQKK RDEELAKSMA ISLSKMYIEQ 450
    NACS 454
    Length:454
    Mass (Da):48,823
    Last modified:January 9, 2007 - v2
    Checksum:iBAF1702C35D1EF89
    GO

    Sequence cautioni

    The sequence BAB30530.1 differs from that shown. Reason: Frameshift at position 62.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928877 Genomic DNA. Translation: CAM25812.1.
    AK016972 mRNA. Translation: BAB30530.1. Frameshift.
    CCDSiCCDS50508.1.
    RefSeqiNP_081991.1. NM_027715.1.
    UniGeneiMm.83981.

    Genome annotation databases

    EnsembliENSMUST00000052168; ENSMUSP00000100617; ENSMUSG00000043415.
    GeneIDi71198.
    KEGGimmu:71198.
    UCSCiuc008imj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928877 Genomic DNA. Translation: CAM25812.1 .
    AK016972 mRNA. Translation: BAB30530.1 . Frameshift.
    CCDSi CCDS50508.1.
    RefSeqi NP_081991.1. NM_027715.1.
    UniGenei Mm.83981.

    3D structure databases

    ProteinModelPortali Q9CUB6.
    SMRi Q9CUB6. Positions 261-410.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C85.004.

    PTM databases

    PhosphoSitei Q9CUB6.

    Proteomic databases

    PRIDEi Q9CUB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052168 ; ENSMUSP00000100617 ; ENSMUSG00000043415 .
    GeneIDi 71198.
    KEGGi mmu:71198.
    UCSCi uc008imj.2. mouse.

    Organism-specific databases

    CTDi 220213.
    MGIi MGI:1918448. Otud1.

    Phylogenomic databases

    eggNOGi NOG327202.
    GeneTreei ENSGT00510000049635.
    HOGENOMi HOG000115304.
    HOVERGENi HBG080487.
    InParanoidi Q9CUB6.
    KOi K13716.
    OMAi NFRLSEH.
    OrthoDBi EOG7TBC35.
    PhylomeDBi Q9CUB6.
    TreeFami TF338508.

    Miscellaneous databases

    NextBioi 333266.
    PROi Q9CUB6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CUB6.
    Genevestigatori Q9CUB6.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-454.
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiOTUD1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CUB6
    Secondary accession number(s): A2ATK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3