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Q9CUB6 (OTUD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 1

EC=3.4.19.12
Gene names
Name:Otud1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Domain

The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin By similarity.

Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops) By similarity.

Sequence similarities

Contains 1 OTU domain.

Contains 1 UIM (ubiquitin-interacting motif) repeat.

Sequence caution

The sequence BAB30530.1 differs from that shown. Reason: Frameshift at position 62.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454OTU domain-containing protein 1
PRO_0000271019

Regions

Domain282 – 411130OTU
Repeat430 – 44920UIM
Region287 – 2937Cys-loop By similarity
Region342 – 35211His-loop By similarity
Region399 – 4046Variable-loop By similarity
Compositional bias20 – 8869Ala-rich

Sites

Active site2901 By similarity
Active site2931Nucleophile By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CUB6 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: BAF1702C35D1EF89

FASTA45448,823
        10         20         30         40         50         60 
MQLYSSVCTH YPAGTPGPTA AAPPATAAAA FKVSLQSASP AAAAPEPDTG ERPPAAATEP 

        70         80         90        100        110        120 
REAAAAAAMP AFSACFERSG SAAAPPGACS KPPLPPHFTS TAHIAVRALG AERLLLPPPS 

       130        140        150        160        170        180 
APSPPRRGSS AWLLEELLRP DEPAAPNAVR DAPDRNFRLS EHRQALAASQ HRAPAPAPVG 

       190        200        210        220        230        240 
PEPGAGPGSG PWGEERRAER SSRGWDRASG RSDASGSDAL RRQDPEAEAH PVPAPARSSG 

       250        260        270        280        290        300 
EPAQNGEGEA VGTSRADPRD EKLALYLAEV ERQDKYLRQR NKYRFHIIPD GNCLYRAVSK 

       310        320        330        340        350        360 
TVYGDQSLHR ELREQTVHYI ADHLDHFSPL IEGDVGEFII AAAQDGAWAG YPELLAMGQM 

       370        380        390        400        410        420 
LNVNIHLTTG GRLESPTVST MIHYLGPEDS LRPSIWLSWL SNGHYDAVFD HSYPNPEYDN 

       430        440        450 
WCKQTQIQKK RDEELAKSMA ISLSKMYIEQ NACS 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-454.
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928877 Genomic DNA. Translation: CAM25812.1.
AK016972 mRNA. Translation: BAB30530.1. Frameshift.
RefSeqNP_081991.1. NM_027715.1.
UniGeneMm.83981.

3D structure databases

ProteinModelPortalQ9CUB6.
SMRQ9CUB6. Positions 261-410.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC85.004.

PTM databases

PhosphoSiteQ9CUB6.

Proteomic databases

PRIDEQ9CUB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052168; ENSMUSP00000100617; ENSMUSG00000043415.
GeneID71198.
KEGGmmu:71198.
UCSCuc008imj.2. mouse.

Organism-specific databases

CTD220213.
MGIMGI:1918448. Otud1.

Phylogenomic databases

eggNOGNOG327202.
GeneTreeENSGT00510000049635.
HOGENOMHOG000115304.
HOVERGENHBG080487.
InParanoidQ9CUB6.
KOK13716.
OMANFRLSEH.
OrthoDBEOG7TBC35.
PhylomeDBQ9CUB6.
TreeFamTF338508.

Gene expression databases

BgeeQ9CUB6.
GenevestigatorQ9CUB6.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio333266.
PROQ9CUB6.
SOURCESearch...

Entry information

Entry nameOTUD1_MOUSE
AccessionPrimary (citable) accession number: Q9CUB6
Secondary accession number(s): A2ATK4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot