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Q9CU96

- Q9CU96_MOUSE

UniProt

Q9CU96 - Q9CU96_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Pdgfa

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. platelet-derived growth factor receptor binding Source: RefGenome

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. angiogenesis Source: MGI
    3. blood coagulation Source: RefGenome
    4. cell projection assembly Source: MGI
    5. hair follicle development Source: MGI
    6. lung alveolus development Source: MGI
    7. organ morphogenesis Source: MGI
    8. platelet-derived growth factor receptor signaling pathway Source: RefGenome
    9. positive regulation of cell division Source: UniProtKB-KW
    10. positive regulation of cell migration Source: RefGenome
    11. positive regulation of cell proliferation Source: MGI
    12. positive regulation of ERK1 and ERK2 cascade Source: RefGenome
    13. positive regulation of MAP kinase activity Source: RefGenome
    14. positive regulation of mesenchymal cell proliferation Source: MGI
    15. positive regulation of phosphatidylinositol 3-kinase signaling Source: RefGenome
    16. positive regulation of protein autophosphorylation Source: RefGenome
    17. regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling Source: MGI
    18. regulation of peptidyl-tyrosine phosphorylation Source: MGI
    19. skin development Source: MGI

    Keywords - Molecular functioni

    Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:PdgfaImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97527. Pdgfa.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro
    2. microvillus Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ9CU96.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000038870.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CU96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG053546.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9CU96-1 [UniParc]FASTAAdd to Basket

    « Hide

    NVPIRRKRSI EEAIPAVCKT RTVIYEIPRS QVDPTSANFL IWPPCVEVKR    50
    CTGCCNTSSV KCQPSRVHHR SVKVAKVEYV RKKPKLKEVQ VRLEEHLECA 100
    CATSNLNPDH REEETDVR 118
    Length:118
    Mass (Da):13,551
    Last modified:June 1, 2001 - v1
    Checksum:i00B514B7C6E050D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017169 mRNA. Translation: BAB30622.1.
    UniGeneiMm.2675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017169 mRNA. Translation: BAB30622.1 .
    UniGenei Mm.2675.

    3D structure databases

    ProteinModelPortali Q9CU96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000038870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97527. Pdgfa.

    Phylogenomic databases

    HOVERGENi HBG053546.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9CU96.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.

    Entry informationi

    Entry nameiQ9CU96_MOUSE
    AccessioniPrimary (citable) accession number: Q9CU96
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)