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Protein
Submitted name:

Putative uncharacterized protein

Gene

Pdgfa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • angiogenesis Source: MGI
  • bone development Source: MGI
  • cell projection assembly Source: MGI
  • digestive tract development Source: MGI
  • hair follicle development Source: MGI
  • lung alveolus development Source: MGI
  • negative chemotaxis Source: MGI
  • negative regulation of phosphatidylinositol biosynthetic process Source: MGI
  • negative regulation of platelet activation Source: MGI
  • organ morphogenesis Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell migration Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of DNA replication Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of MAP kinase activity Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein autophosphorylation Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling Source: MGI
  • regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • regulation of smooth muscle cell migration Source: MGI
  • response to wounding Source: MGI
  • skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:PdgfaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97527. Pdgfa.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • extracellular space Source: MGI
  • membrane Source: InterPro
  • microvillus Source: MGI
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075463.

Structurei

3D structure databases

ProteinModelPortaliQ9CU96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG053546.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CU96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NVPIRRKRSI EEAIPAVCKT RTVIYEIPRS QVDPTSANFL IWPPCVEVKR
60 70 80 90 100
CTGCCNTSSV KCQPSRVHHR SVKVAKVEYV RKKPKLKEVQ VRLEEHLECA
110
CATSNLNPDH REEETDVR
Length:118
Mass (Da):13,551
Last modified:June 1, 2001 - v1
Checksum:i00B514B7C6E050D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017169 mRNA. Translation: BAB30622.1.
UniGeneiMm.2675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017169 mRNA. Translation: BAB30622.1.
UniGeneiMm.2675.

3D structure databases

ProteinModelPortaliQ9CU96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97527. Pdgfa.

Phylogenomic databases

HOVERGENiHBG053546.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Ovary and uterusImported.

Entry informationi

Entry nameiQ9CU96_MOUSE
AccessioniPrimary (citable) accession number: Q9CU96
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.