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Q9CU19

- Q9CU19_MOUSE

UniProt

Q9CU19 - Q9CU19_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Acvrl1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. activin receptor activity, type I Source: Ensembl
  3. protein binding Source: MGI
  4. receptor signaling protein serine/threonine kinase activity Source: Ensembl
  5. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. angiogenesis Source: MGI
  3. blood vessel morphogenesis Source: MGI
  4. cellular response to BMP stimulus Source: Ensembl
  5. endothelial tube morphogenesis Source: Ensembl
  6. in utero embryonic development Source: MGI
  7. negative regulation of DNA biosynthetic process Source: Ensembl
  8. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  9. negative regulation of cell growth Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. negative regulation of focal adhesion assembly Source: Ensembl
  12. positive regulation of BMP signaling pathway Source: Ensembl
  13. positive regulation of angiogenesis Source: MGI
  14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. protein heterooligomerization Source: Ensembl
  17. regulation of blood pressure Source: Ensembl
  18. transforming growth factor beta receptor signaling pathway Source: MGI
  19. wound healing, spreading of epidermal cells Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotations, Serine/threonine-protein kinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Acvrl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338946. Acvrl1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ9CU19.
BgeeiQ9CU19.
GenevestigatoriQ9CU19.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114027.

Structurei

3D structure databases

ProteinModelPortaliQ9CU19.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG054502.
InParanoidiQ9CU19.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CU19-1 [UniParc]FASTAAdd to Basket

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LGRPTEFLNH HCCYRSFCNH NVSLMLEATQ TPSEEPEVDA HLPLILGPVL    50
ALPVLVALGA LGLWRVRRRQ EKQRDLHSDL GESSLILKAS EQADSMLGDF 100
LDSDCTTGSG SGLPFLVQRT VARQVALVEC VGKGRYGEVW RGSWHGESVA 150
VKIFSSRDEQ SWFRETEIYN TVLLRHDNIL GFIASDMTS 189
Length:189
Mass (Da):21,067
Last modified:March 1, 2003 - v2
Checksum:i7A05664B911B7EDF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei189 – 1891Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018754 mRNA. Translation: BAB31388.2.
UniGeneiMm.279542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018754 mRNA. Translation: BAB31388.2 .
UniGenei Mm.279542.

3D structure databases

ProteinModelPortali Q9CU19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000114027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1338946. Acvrl1.

Phylogenomic databases

HOVERGENi HBG054502.
InParanoidi Q9CU19.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CU19.
Bgeei Q9CU19.
Genevestigatori Q9CU19.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9CU19_MOUSE
AccessioniPrimary (citable) accession number: Q9CU19
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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