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Q9CU19

- Q9CU19_MOUSE

UniProt

Q9CU19 - Q9CU19_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Acvrl1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. activin receptor activity, type I Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. receptor signaling protein serine/threonine kinase activity Source: Ensembl
    5. transforming growth factor beta receptor activity, type I Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. blood vessel morphogenesis Source: MGI
    3. BMP signaling pathway Source: MGI
    4. cellular response to BMP stimulus Source: Ensembl
    5. endothelial tube morphogenesis Source: Ensembl
    6. in utero embryonic development Source: MGI
    7. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    8. negative regulation of cell growth Source: Ensembl
    9. negative regulation of cell proliferation Source: Ensembl
    10. negative regulation of DNA biosynthetic process Source: Ensembl
    11. negative regulation of focal adhesion assembly Source: Ensembl
    12. positive regulation of angiogenesis Source: MGI
    13. positive regulation of BMP signaling pathway Source: Ensembl
    14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. protein heterooligomerization Source: Ensembl
    17. regulation of blood pressure Source: Ensembl
    18. transforming growth factor beta receptor signaling pathway Source: MGI
    19. wound healing, spreading of epidermal cells Source: Ensembl

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Acvrl1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1338946. Acvrl1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl
    4. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CU19.
    BgeeiQ9CU19.
    GenevestigatoriQ9CU19.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000114027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CU19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG054502.
    InParanoidiQ9CU19.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9CU19-1 [UniParc]FASTAAdd to Basket

    « Hide

    LGRPTEFLNH HCCYRSFCNH NVSLMLEATQ TPSEEPEVDA HLPLILGPVL    50
    ALPVLVALGA LGLWRVRRRQ EKQRDLHSDL GESSLILKAS EQADSMLGDF 100
    LDSDCTTGSG SGLPFLVQRT VARQVALVEC VGKGRYGEVW RGSWHGESVA 150
    VKIFSSRDEQ SWFRETEIYN TVLLRHDNIL GFIASDMTS 189
    Length:189
    Mass (Da):21,067
    Last modified:March 1, 2003 - v2
    Checksum:i7A05664B911B7EDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei189 – 1891Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018754 mRNA. Translation: BAB31388.2.
    UniGeneiMm.279542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018754 mRNA. Translation: BAB31388.2 .
    UniGenei Mm.279542.

    3D structure databases

    ProteinModelPortali Q9CU19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000114027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1338946. Acvrl1.

    Phylogenomic databases

    HOVERGENi HBG054502.
    InParanoidi Q9CU19.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CU19.
    Bgeei Q9CU19.
    Genevestigatori Q9CU19.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ9CU19_MOUSE
    AccessioniPrimary (citable) accession number: Q9CU19
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)