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Protein

Receptor protein serine/threonine kinase

Gene

Acvrl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. activin binding Source: MGI
  2. activin receptor activity, type I Source: MGI
  3. ATP binding Source: MGI
  4. protein kinase binding Source: MGI
  5. protein serine/threonine kinase activity Source: MGI
  6. receptor signaling protein serine/threonine kinase activity Source: Ensembl
  7. SMAD binding Source: MGI
  8. transforming growth factor beta-activated receptor activity Source: MGI
  9. transforming growth factor beta binding Source: MGI
  10. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. blood circulation Source: MGI
  3. blood vessel morphogenesis Source: MGI
  4. BMP signaling pathway Source: MGI
  5. cellular response to BMP stimulus Source: MGI
  6. cellular response to transforming growth factor beta stimulus Source: MGI
  7. endothelial tube morphogenesis Source: MGI
  8. in utero embryonic development Source: MGI
  9. lymphatic endothelial cell differentiation Source: MGI
  10. negative regulation of blood vessel endothelial cell migration Source: MGI
  11. negative regulation of cell adhesion Source: MGI
  12. negative regulation of cell growth Source: MGI
  13. negative regulation of cell migration Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of DNA biosynthetic process Source: MGI
  16. negative regulation of endothelial cell migration Source: MGI
  17. negative regulation of focal adhesion assembly Source: MGI
  18. positive regulation of angiogenesis Source: MGI
  19. positive regulation of BMP signaling pathway Source: MGI
  20. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  21. positive regulation of transcription, DNA-templated Source: MGI
  22. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  23. protein heterooligomerization Source: Ensembl
  24. protein phosphorylation Source: MGI
  25. regulation of blood pressure Source: MGI
  26. regulation of transcription, DNA-templated Source: MGI
  27. signal transduction Source: MGI
  28. transforming growth factor beta receptor signaling pathway Source: MGI
  29. wound healing, spreading of epidermal cells Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Acvrl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338946. Acvrl1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. dendrite Source: Ensembl
  3. integral component of plasma membrane Source: MGI
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ9CU19.
ExpressionAtlasiQ9CU19. baseline and differential.
GenevestigatoriQ9CU19.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114027.

Structurei

3D structure databases

ProteinModelPortaliQ9CU19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CU19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LGRPTEFLNH HCCYRSFCNH NVSLMLEATQ TPSEEPEVDA HLPLILGPVL
60 70 80 90 100
ALPVLVALGA LGLWRVRRRQ EKQRDLHSDL GESSLILKAS EQADSMLGDF
110 120 130 140 150
LDSDCTTGSG SGLPFLVQRT VARQVALVEC VGKGRYGEVW RGSWHGESVA
160 170 180
VKIFSSRDEQ SWFRETEIYN TVLLRHDNIL GFIASDMTS
Length:189
Mass (Da):21,067
Last modified:February 28, 2003 - v2
Checksum:i7A05664B911B7EDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei189 – 1891Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018754 mRNA. Translation: BAB31388.2.
UniGeneiMm.279542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018754 mRNA. Translation: BAB31388.2.
UniGeneiMm.279542.

3D structure databases

ProteinModelPortaliQ9CU19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114027.

Chemistry

BindingDBiQ9CU19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1338946. Acvrl1.

Phylogenomic databases

HOVERGENiHBG054502.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ9CU19.
ExpressionAtlasiQ9CU19. baseline and differential.
GenevestigatoriQ9CU19.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9CU19_MOUSE
AccessioniPrimary (citable) accession number: Q9CU19
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2001
Last sequence update: February 28, 2003
Last modified: February 3, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.