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Protein
Submitted name:

Putative uncharacterized protein

Gene

Ryr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-induced calcium release activity Source: MGI
  2. calcium-release channel activity Source: MGI
  3. calmodulin binding Source: MGI
  4. enzyme binding Source: MGI
  5. identical protein binding Source: MGI
  6. organic cyclic compound binding Source: MGI
  7. protein kinase A catalytic subunit binding Source: MGI
  8. protein kinase A regulatory subunit binding Source: MGI
  9. ryanodine-sensitive calcium-release channel activity Source: MGI
  10. suramin binding Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. calcium ion transmembrane transport Source: MGI
  3. calcium ion transport Source: MGI
  4. calcium ion transport into cytosol Source: MGI
  5. calcium-mediated signaling using intracellular calcium source Source: MGI
  6. canonical Wnt signaling pathway Source: MGI
  7. cardiac muscle contraction Source: MGI
  8. cardiac muscle hypertrophy Source: MGI
  9. cellular response to caffeine Source: MGI
  10. cytosolic calcium ion transport Source: MGI
  11. detection of calcium ion Source: MGI
  12. establishment of protein localization to endoplasmic reticulum Source: MGI
  13. left ventricular cardiac muscle tissue morphogenesis Source: MGI
  14. positive regulation of calcium-transporting ATPase activity Source: MGI
  15. positive regulation of heart rate Source: MGI
  16. positive regulation of sequestering of calcium ion Source: MGI
  17. positive regulation of the force of heart contraction Source: MGI
  18. regulation of cardiac muscle contraction Source: MGI
  19. regulation of heart rate Source: MGI
  20. release of sequestered calcium ion into cytosol Source: MGI
  21. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
  22. response to caffeine Source: MGI
  23. response to muscle stretch Source: MGI
  24. response to redox state Source: MGI
  25. type B pancreatic cell apoptotic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Ryr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:99685. Ryr2.

Subcellular locationi

GO - Cellular componenti

  1. calcium channel complex Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of membrane Source: MGI
  4. membrane Source: MGI
  5. protein complex Source: MGI
  6. sarcoplasmic reticulum Source: MGI
  7. sarcoplasmic reticulum membrane Source: MGI
  8. smooth endoplasmic reticulum Source: MGI
  9. Z disc Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9CTT8.
ExpressionAtlasiQ9CTT8. baseline and differential.
GenevestigatoriQ9CTT8.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG083019.

Family and domain databases

InterProiIPR014821. Ins145_P3_rcpt.
IPR016093. MIR_motif.
IPR013333. Ryan_recept.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
[Graphical view]
PRINTSiPR00795. RYANODINER.
PROSITEiPS50919. MIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9CTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE
60 70 80 90 100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GKFMMKTAQG
110 120 130 140 150
GGHRTLLYGH AILLRHSYSG MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA
160
CWWTIHPASK QRS
Length:163
Mass (Da):18,013
Last modified:October 11, 2005 - v3
Checksum:i254B5014B85538BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei163 – 1631Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020368 mRNA. Translation: BAB32083.3.
UniGeneiMm.239871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020368 mRNA. Translation: BAB32083.3.
UniGeneiMm.239871.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:99685. Ryr2.

Phylogenomic databases

HOVERGENiHBG083019.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ9CTT8.
ExpressionAtlasiQ9CTT8. baseline and differential.
GenevestigatoriQ9CTT8.

Family and domain databases

InterProiIPR014821. Ins145_P3_rcpt.
IPR016093. MIR_motif.
IPR013333. Ryan_recept.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
[Graphical view]
PRINTSiPR00795. RYANODINER.
PROSITEiPS50919. MIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: DiencephalonImported.

Entry informationi

Entry nameiQ9CTT8_MOUSE
AccessioniPrimary (citable) accession number: Q9CTT8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.