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Q9CTT8 (Q9CTT8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Ryr2 MGI 99685
OrganismMus musculus (Mouse) EMBL BAB32083.3
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length163 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 17360443. Source: MGI

calcium ion transmembrane transport

Inferred from mutant phenotype PubMed 21673970. Source: MGI

calcium ion transport

Inferred from direct assay PubMed 14593104. Source: MGI

calcium-mediated signaling using intracellular calcium source

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from direct assay PubMed 17360443. Source: MGI

cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 17431507. Source: MGI

cellular response to caffeine

Inferred from direct assay PubMed 12089338. Source: MGI

cytosolic calcium ion transport

Inferred from mutant phenotype PubMed 17431507. Source: MGI

detection of calcium ion

Inferred from electronic annotation. Source: Ensembl

establishment of protein localization to endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

left ventricular cardiac muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 17431507. Source: MGI

positive regulation of calcium-transporting ATPase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from mutant phenotype PubMed 12089338PubMed 17431507. Source: MGI

positive regulation of sequestering of calcium ion

Inferred from electronic annotation. Source: Ensembl

regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Inferred from mutant phenotype PubMed 12089338. Source: MGI

response to caffeine

Inferred from direct assay PubMed 14593104. Source: MGI

response to redox state

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentZ disc

Inferred from direct assay PubMed 16204356PubMed 19383796. Source: MGI

calcium channel complex

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred by curator PubMed 14593104. Source: MGI

membrane

Inferred from direct assay PubMed 17431507. Source: MGI

protein complex

Inferred from sequence orthology PubMed 18468998. Source: MGI

sarcoplasmic reticulum

Inferred from direct assay PubMed 21788490. Source: MGI

sarcoplasmic reticulum membrane

Inferred from direct assay PubMed 14592808PubMed 16481613. Source: MGI

   Molecular_functionbinding

Inferred from physical interaction PubMed 17431507. Source: MGI

calcium-induced calcium release activity

Inferred from electronic annotation. Source: Ensembl

calmodulin binding

Inferred from direct assay PubMed 17431507. Source: MGI

ryanodine-sensitive calcium-release channel activity

Inferred from direct assay PubMed 14593104PubMed 17431507. Source: MGI

suramin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1631 EMBL BAB32083.3

Sequences

Sequence LengthMass (Da)Tools
Q9CTT8 [UniParc].

Last modified October 11, 2005. Version 3.
Checksum: 254B5014B85538BC

FASTA16318,013
        10         20         30         40         50         60 
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE STSNSKNVPP 

        70         80         90        100        110        120 
DLSICTFVLE QSLSVRALQE MLANTVEKSE GKFMMKTAQG GGHRTLLYGH AILLRHSYSG 

       130        140        150        160 
MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA CWWTIHPASK QRS 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB32083.3.
Tissue: Diencephalon EMBL BAB32083.3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK020368 mRNA. Translation: BAB32083.3.
UniGeneMm.239871.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:99685. Ryr2.

Phylogenomic databases

HOVERGENHBG083019.
InParanoidQ9CTT8.

Gene expression databases

ArrayExpressQ9CTT8.
BgeeQ9CTT8.
GenevestigatorQ9CTT8.

Family and domain databases

InterProIPR014821. Ins145_P3_rcpt.
IPR016093. MIR_motif.
IPR013333. Ryan_recept.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERPTHR13715. PTHR13715. 1 hit.
PfamPF08709. Ins145_P3_rec. 1 hit.
[Graphical view]
PRINTSPR00795. RYANODINER.
PROSITEPS50919. MIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ9CTT8_MOUSE
AccessionPrimary (citable) accession number: Q9CTT8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)