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Protein

Rho-related BTB domain-containing protein 3

Gene

Rhobtb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 3 (EC:3.6.1.-)
Gene namesi
Name:Rhobtb3
Synonyms:Kiaa0878
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920546. Rhobtb3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GOC
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Rho-related BTB domain-containing protein 3PRO_0000198965Add
BLAST

Proteomic databases

MaxQBiQ9CTN4.
PaxDbiQ9CTN4.
PRIDEiQ9CTN4.

PTM databases

iPTMnetiQ9CTN4.
PhosphoSiteiQ9CTN4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021589.
CleanExiMM_RHOBTB3.
ExpressionAtlasiQ9CTN4. baseline and differential.
GenevisibleiQ9CTN4. MM.

Interactioni

Subunit structurei

Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215902. 3 interactions.
STRINGi10090.ENSMUSP00000022078.

Structurei

3D structure databases

ProteinModelPortaliQ9CTN4.
SMRiQ9CTN4. Positions 414-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 356103BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 48768BTB 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 175175Rho-likeAdd
BLAST
Regioni420 – 611192Interaction with Rab9By similarityAdd
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000133048.
HOVERGENiHBG079130.
InParanoidiQ9CTN4.
KOiK07869.
OMAiDVVFYNP.
OrthoDBiEOG091G034E.
PhylomeDBiQ9CTN4.
TreeFamiTF323347.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027417. P-loop_NTPase.
IPR031260. RhoBTB3.
IPR011333. SKP1/BTB/POZ.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24072:SF139. PTHR24072:SF139. 1 hit.
PfamiPF00651. BTB. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CTN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV
60 70 80 90 100
ARPVFTEYQA SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY
110 120 130 140 150
NVNDKFSFHE VKDNYIPVIK RASNSVPVII AAVGTRQNEE LPCTCPLCTS
160 170 180 190 200
DRGSCVTTTE GIQLAKELGA TYLELHSLDD FYIGKYFGGV LEYFMIQALN
210 220 230 240 250
QKTSEKMKKR KMTSSFHGIR PPQLEQPEKM PVLKAEASHY HSDLNNLLLC
260 270 280 290 300
CQCVDVVFYH PEVTGVVEAH KIVLCSVSHV FMLLFNVKSP ADIQDSSIIR
310 320 330 340 350
TTQDLFAINR DAVLPGASQE APSNPPLPVI VKDALFCSCL SDILRFIYSG
360 370 380 390 400
AFQWEELEED VRRKLKDSGD VSDIIEKVKC ILKTPGKINC LRNCKTYQAR
410 420 430 440 450
KPLWFYNTSL KFFLNKPMLA DVVFEIQGAT VPAHRAILVA RCEVMAAMFN
460 470 480 490 500
GNYMEAKSVL IPVYGVSKET FLSFLEYLYT DSCCPAGIFQ AMCLLICAEM
510 520 530 540 550
YQVSRLQHIC ELFIITQLQS MPSRELASMN LDIVDLLKKA KFHHSDCLST
560 570 580 590 600
WLLHFIATNY LIFSQKPEFQ DLSVEERSFV EKHRWPSNMY LKQLAEYRKY
610
IHSRKCRCLV M
Length:611
Mass (Da):69,208
Last modified:October 13, 2009 - v3
Checksum:iF053962BD8CA1CDF
GO

Sequence cautioni

The sequence AAH05664 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC98044 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti588 – 5881N → H in BAB24689 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129234 mRNA. Translation: BAC98044.1. Different initiation.
AK020938 mRNA. No translation available.
AK006650 mRNA. Translation: BAB24689.1.
AK139158 mRNA. Translation: BAE23906.1.
CH466563 Genomic DNA. Translation: EDL37111.1.
BC005664 mRNA. Translation: AAH05664.1. Sequence problems.
BC050836 mRNA. Translation: AAH50836.1.
CCDSiCCDS26652.1.
RefSeqiNP_082769.1. NM_028493.2.
UniGeneiMm.276200.

Genome annotation databases

EnsembliENSMUST00000022078; ENSMUSP00000022078; ENSMUSG00000021589.
GeneIDi73296.
KEGGimmu:73296.
UCSCiuc007rfy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129234 mRNA. Translation: BAC98044.1. Different initiation.
AK020938 mRNA. No translation available.
AK006650 mRNA. Translation: BAB24689.1.
AK139158 mRNA. Translation: BAE23906.1.
CH466563 Genomic DNA. Translation: EDL37111.1.
BC005664 mRNA. Translation: AAH05664.1. Sequence problems.
BC050836 mRNA. Translation: AAH50836.1.
CCDSiCCDS26652.1.
RefSeqiNP_082769.1. NM_028493.2.
UniGeneiMm.276200.

3D structure databases

ProteinModelPortaliQ9CTN4.
SMRiQ9CTN4. Positions 414-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215902. 3 interactions.
STRINGi10090.ENSMUSP00000022078.

PTM databases

iPTMnetiQ9CTN4.
PhosphoSiteiQ9CTN4.

Proteomic databases

MaxQBiQ9CTN4.
PaxDbiQ9CTN4.
PRIDEiQ9CTN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022078; ENSMUSP00000022078; ENSMUSG00000021589.
GeneIDi73296.
KEGGimmu:73296.
UCSCiuc007rfy.1. mouse.

Organism-specific databases

CTDi22836.
MGIiMGI:1920546. Rhobtb3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000133048.
HOVERGENiHBG079130.
InParanoidiQ9CTN4.
KOiK07869.
OMAiDVVFYNP.
OrthoDBiEOG091G034E.
PhylomeDBiQ9CTN4.
TreeFamiTF323347.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ9CTN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021589.
CleanExiMM_RHOBTB3.
ExpressionAtlasiQ9CTN4. baseline and differential.
GenevisibleiQ9CTN4. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027417. P-loop_NTPase.
IPR031260. RhoBTB3.
IPR011333. SKP1/BTB/POZ.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24072:SF139. PTHR24072:SF139. 1 hit.
PfamiPF00651. BTB. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHBT3_MOUSE
AccessioniPrimary (citable) accession number: Q9CTN4
Secondary accession number(s): Q05DP2
, Q3UTS4, Q80X55, Q9CVT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.