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Q9CTH6

- FCF1_MOUSE

UniProt

Q9CTH6 - FCF1_MOUSE

Protein

rRNA-processing protein FCF1 homolog

Gene

Fcf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (09 Sep 2003)
      Previous versions | rss
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    Functioni

    Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Gene namesi
    Name:Fcf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1920986. Fcf1.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell
    2. small-subunit processome Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198rRNA-processing protein FCF1 homologPRO_0000089921Add
    BLAST

    Proteomic databases

    PRIDEiQ9CTH6.

    Expressioni

    Gene expression databases

    BgeeiQ9CTH6.
    GenevestigatoriQ9CTH6.

    Interactioni

    Protein-protein interaction databases

    BioGridi216221. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CTH6.
    SMRiQ9CTH6. Positions 55-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 166100PINcAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated
    Contains 1 PINc domain.Curated

    Phylogenomic databases

    eggNOGiCOG1412.
    GeneTreeiENSGT00550000074979.
    HOGENOMiHOG000183747.
    HOVERGENiHBG051022.
    InParanoidiQ9CTH6.
    KOiK14566.
    OMAiNFSIQKK.
    OrthoDBiEOG7WQ7TQ.
    PhylomeDBiQ9CTH6.
    TreeFamiTF314992.

    Family and domain databases

    Gene3Di3.40.50.1010. 1 hit.
    InterProiIPR006984. Fcf1/Utp23.
    IPR002716. PIN_dom.
    IPR029060. PIN_domain-like.
    [Graphical view]
    PfamiPF04900. Fcf1. 1 hit.
    [Graphical view]
    SMARTiSM00670. PINc. 1 hit.
    [Graphical view]
    SUPFAMiSSF88723. SSF88723. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CTH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQKKTRKY ATMKRMLSLR DERLKEKDRL KPKKKEKKDP SALKEREVPQ    50
    HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP 100
    CITDCVMAEI EKLGQKFRVA LRIAKDPRFD RLPCTHKGTY ADDCLVQRVT 150
    QHKCYIVATV DRDLKRRIRK IPGVPIMYLS NHRYNIERMP DDYGAPRF 198
    Length:198
    Mass (Da):23,341
    Last modified:September 9, 2003 - v2
    Checksum:iFBEC2ABABC12C109
    GO

    Sequence cautioni

    The sequence AAH33045.1 differs from that shown. Reason: Erroneous termination at position 165. Translated as Lys.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC033045 mRNA. Translation: AAH33045.1. Different termination.
    BC094619 mRNA. No translation available.
    AK003561 mRNA. Translation: BAB22857.1.
    CCDSiCCDS49113.1.
    RefSeqiNP_082908.2. NM_028632.2.
    UniGeneiMm.341848.

    Genome annotation databases

    EnsembliENSMUST00000021669; ENSMUSP00000021669; ENSMUSG00000021243.
    GeneIDi73736.
    KEGGimmu:73736.
    UCSCiuc007ogc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC033045 mRNA. Translation: AAH33045.1 . Different termination.
    BC094619 mRNA. No translation available.
    AK003561 mRNA. Translation: BAB22857.1 .
    CCDSi CCDS49113.1.
    RefSeqi NP_082908.2. NM_028632.2.
    UniGenei Mm.341848.

    3D structure databases

    ProteinModelPortali Q9CTH6.
    SMRi Q9CTH6. Positions 55-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216221. 1 interaction.

    Proteomic databases

    PRIDEi Q9CTH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021669 ; ENSMUSP00000021669 ; ENSMUSG00000021243 .
    GeneIDi 73736.
    KEGGi mmu:73736.
    UCSCi uc007ogc.2. mouse.

    Organism-specific databases

    CTDi 51077.
    MGIi MGI:1920986. Fcf1.

    Phylogenomic databases

    eggNOGi COG1412.
    GeneTreei ENSGT00550000074979.
    HOGENOMi HOG000183747.
    HOVERGENi HBG051022.
    InParanoidi Q9CTH6.
    KOi K14566.
    OMAi NFSIQKK.
    OrthoDBi EOG7WQ7TQ.
    PhylomeDBi Q9CTH6.
    TreeFami TF314992.

    Miscellaneous databases

    NextBioi 338939.
    PROi Q9CTH6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CTH6.
    Genevestigatori Q9CTH6.

    Family and domain databases

    Gene3Di 3.40.50.1010. 1 hit.
    InterProi IPR006984. Fcf1/Utp23.
    IPR002716. PIN_dom.
    IPR029060. PIN_domain-like.
    [Graphical view ]
    Pfami PF04900. Fcf1. 1 hit.
    [Graphical view ]
    SMARTi SM00670. PINc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88723. SSF88723. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-198.
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiFCF1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CTH6
    Secondary accession number(s): Q505C6, Q8K261
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 9, 2003
    Last sequence update: September 9, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3