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Protein

rRNA-processing protein FCF1 homolog

Gene

Fcf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein FCF1 homolog
Gene namesi
Name:Fcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920986. Fcf1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899211 – 198rRNA-processing protein FCF1 homologAdd BLAST198

Proteomic databases

EPDiQ9CTH6.
MaxQBiQ9CTH6.
PaxDbiQ9CTH6.
PRIDEiQ9CTH6.

PTM databases

PhosphoSitePlusiQ9CTH6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021243.
ExpressionAtlasiQ9CTH6. baseline and differential.
GenevisibleiQ9CTH6. MM.

Interactioni

Protein-protein interaction databases

BioGridi216221. 1 interactor.
STRINGi10090.ENSMUSP00000021669.

Structurei

3D structure databases

ProteinModelPortaliQ9CTH6.
SMRiQ9CTH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 166PINcAdd BLAST100

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3165. Eukaryota.
COG1412. LUCA.
GeneTreeiENSGT00550000074979.
HOGENOMiHOG000183747.
HOVERGENiHBG051022.
InParanoidiQ9CTH6.
KOiK14566.
OMAiRLMKPTD.
OrthoDBiEOG091G0KRZ.
PhylomeDBiQ9CTH6.
TreeFamiTF314992.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiView protein in InterPro
IPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
IPR029060. PIN_domain-like.
PfamiView protein in Pfam
PF04900. Fcf1. 1 hit.
SMARTiView protein in SMART
SM00670. PINc. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CTH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQKKTRKY ATMKRMLSLR DERLKEKDRL KPKKKEKKDP SALKEREVPQ
60 70 80 90 100
HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP
110 120 130 140 150
CITDCVMAEI EKLGQKFRVA LRIAKDPRFD RLPCTHKGTY ADDCLVQRVT
160 170 180 190
QHKCYIVATV DRDLKRRIRK IPGVPIMYLS NHRYNIERMP DDYGAPRF
Length:198
Mass (Da):23,341
Last modified:September 9, 2003 - v2
Checksum:iFBEC2ABABC12C109
GO

Sequence cautioni

The sequence AAH33045 differs from that shown. Reason: Erroneous termination at position 165. Translated as Lys.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033045 mRNA. Translation: AAH33045.1. Different termination.
BC094619 mRNA. No translation available.
AK003561 mRNA. Translation: BAB22857.1.
CCDSiCCDS49113.1.
RefSeqiNP_082908.2. NM_028632.2.
UniGeneiMm.341848.

Genome annotation databases

EnsembliENSMUST00000021669; ENSMUSP00000021669; ENSMUSG00000021243.
GeneIDi73736.
KEGGimmu:73736.
UCSCiuc007ogc.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFCF1_MOUSE
AccessioniPrimary (citable) accession number: Q9CTH6
Secondary accession number(s): Q505C6, Q8K261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: June 7, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families