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Q9CTH6 (FCF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
rRNA-processing protein FCF1 homolog
Gene names
Name:Fcf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the UTP23/FCF1 family. FCF1 subfamily.

Contains 1 PINc domain.

Sequence caution

The sequence AAH33045.1 differs from that shown. Reason: Erroneous termination at position 165. Translated as Lys.

Ontologies

Keywords
   Biological processRibosome biogenesis
rRNA processing
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

small-subunit processome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198rRNA-processing protein FCF1 homolog
PRO_0000089921

Regions

Domain67 – 166100PINc

Sequences

Sequence LengthMass (Da)Tools
Q9CTH6 [UniParc].

Last modified September 9, 2003. Version 2.
Checksum: FBEC2ABABC12C109

FASTA19823,341
        10         20         30         40         50         60 
MGKQKKTRKY ATMKRMLSLR DERLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN 

        70         80         90        100        110        120 
TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKFRVA 

       130        140        150        160        170        180 
LRIAKDPRFD RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYLS 

       190 
NHRYNIERMP DDYGAPRF 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-198.
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC033045 mRNA. Translation: AAH33045.1. Different termination.
BC094619 mRNA. No translation available.
AK003561 mRNA. Translation: BAB22857.1.
RefSeqNP_082908.2. NM_028632.2.
UniGeneMm.341848.

3D structure databases

ProteinModelPortalQ9CTH6.
SMRQ9CTH6. Positions 55-180.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9CTH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021669; ENSMUSP00000021669; ENSMUSG00000021243.
GeneID73736.
KEGGmmu:73736.
UCSCuc007ogc.2. mouse.

Organism-specific databases

CTD51077.
MGIMGI:1920986. Fcf1.

Phylogenomic databases

eggNOGCOG1412.
GeneTreeENSGT00550000074979.
HOGENOMHOG000183747.
HOVERGENHBG051022.
InParanoidQ9CTH6.
KOK14566.
OMAKLGHRYR.
OrthoDBEOG7WQ7TQ.
PhylomeDBQ9CTH6.
TreeFamTF314992.

Gene expression databases

BgeeQ9CTH6.
GenevestigatorQ9CTH6.

Family and domain databases

InterProIPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
[Graphical view]
PfamPF04900. Fcf1. 1 hit.
[Graphical view]
SMARTSM00670. PINc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio338939.
PROQ9CTH6.
SOURCESearch...

Entry information

Entry nameFCF1_MOUSE
AccessionPrimary (citable) accession number: Q9CTH6
Secondary accession number(s): Q505C6, Q8K261
Entry history
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot