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Protein

Probable cation-transporting ATPase 13A2

Gene

Atp13a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating intracellular cation homeostasis and neuronal integrity.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5084-aspartylphosphate intermediateBy similarity1
Metal bindingi867MagnesiumBy similarity1
Metal bindingi871MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • autophagosome organization Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular iron ion homeostasis Source: MGI
  • cellular response to manganese ion Source: MGI
  • cellular response to oxidative stress Source: ParkinsonsUK-UCL
  • cellular zinc ion homeostasis Source: MGI
  • peptidyl-aspartic acid autophosphorylation Source: MGI
  • polyamine import Source: MGI
  • positive regulation of exosomal secretion Source: ParkinsonsUK-UCL
  • positive regulation of protein secretion Source: MGI
  • regulation of autophagosome size Source: MGI
  • regulation of endopeptidase activity Source: MGI
  • regulation of glucosylceramidase activity Source: ParkinsonsUK-UCL
  • regulation of intracellular protein transport Source: ParkinsonsUK-UCL
  • regulation of lysosomal protein catabolic process Source: ParkinsonsUK-UCL
  • regulation of macroautophagy Source: MGI
  • regulation of mitochondrion organization Source: ParkinsonsUK-UCL
  • zinc ion homeostasis Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A2 (EC:3.6.3.-)
Gene namesi
Name:Atp13a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1922022. Atp13a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 34HelicalSequence analysisAdd BLAST22
Topological domaini35 – 45ExtracellularSequence analysisAdd BLAST11
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 225CytoplasmicSequence analysisAdd BLAST159
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23
Topological domaini249 – 251ExtracellularSequence analysis3
Transmembranei252 – 271HelicalSequence analysisAdd BLAST20
Topological domaini272 – 420CytoplasmicSequence analysisAdd BLAST149
Transmembranei421 – 440HelicalSequence analysisAdd BLAST20
Topological domaini441 – 454ExtracellularSequence analysisAdd BLAST14
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 921CytoplasmicSequence analysisAdd BLAST446
Transmembranei922 – 941HelicalSequence analysisAdd BLAST20
Topological domaini942 – 952ExtracellularSequence analysisAdd BLAST11
Transmembranei953 – 970HelicalSequence analysisAdd BLAST18
Topological domaini971 – 986CytoplasmicSequence analysisAdd BLAST16
Transmembranei987 – 1007HelicalSequence analysisAdd BLAST21
Topological domaini1008 – 1035ExtracellularSequence analysisAdd BLAST28
Transmembranei1036 – 1055HelicalSequence analysisAdd BLAST20
Topological domaini1056 – 1068CytoplasmicSequence analysisAdd BLAST13
Transmembranei1069 – 1086HelicalSequence analysisAdd BLAST18
Topological domaini1087 – 1102ExtracellularSequence analysisAdd BLAST16
Transmembranei1103 – 1123HelicalSequence analysisAdd BLAST21
Topological domaini1124 – 1169CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464241 – 1169Probable cation-transporting ATPase 13A2Add BLAST1169

Proteomic databases

MaxQBiQ9CTG6.
PaxDbiQ9CTG6.
PRIDEiQ9CTG6.

PTM databases

iPTMnetiQ9CTG6.
PhosphoSitePlusiQ9CTG6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036622.
CleanExiMM_ATP13A2.
ExpressionAtlasiQ9CTG6. baseline and differential.
GenevisibleiQ9CTG6. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998039.
STRINGi10090.ENSMUSP00000039648.

Structurei

3D structure databases

ProteinModelPortaliQ9CTG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ9CTG6.
KOiK13526.
OMAiPPLWEPQ.
OrthoDBiEOG091G01IL.
TreeFamiTF300331.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CTG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADSSLLMG STPPSYGTLT TGTSIDPLSS SASSVRLSGY CGSPWRAIGY
60 70 80 90 100
HAAVWMLAGI PWLLFRWKPL WGVRLRLKPC SLAHAETLVI EIKDKEGSSR
110 120 130 140 150
QLFTVQVQTE AVVQGSLELP PQAQAEDGRS QAAVGVTPEG TWQDTSELHR
160 170 180 190 200
QEEAKQVLRY YVLQGQRYVW METQQAFCQV SLLDHGRTCD DVHCSSSGLS
210 220 230 240 250
LQDQATRKTI YGPNVISIPV KSYLQLLADE ALNPYYGFQA FSIALWLADH
260 270 280 290 300
YYWYALCIFL ISAISICLAL YKTRKQSLTL RDMVKLSVRV QVCRPGGEEE
310 320 330 340 350
WVDSSELVPG DCLVLPQEGG VMPCDAALVA GECVVNESSL TGESTPVLKT
360 370 380 390 400
ALPEGPKPYC PETHRRHTLF CGTLILQARA YVGPRVLAVV TRTGFCTAKG
410 420 430 440 450
GLVSSILHPR PISFKFYKHS MKFVAALSVL ALLGTVYSII ILYRNRVPVR
460 470 480 490 500
EIVIRALDLV TVVVPPALPA AMTVCTLYAQ SRLRTQGIFC IHPLRINLGG
510 520 530 540 550
KLRLVCFDKT GTLTEDGLDV MGVVPLKGQV LLPLVPEPCH LPLGPLLRAL
560 570 580 590 600
ATCHALSQLH DTPVGDPMDL KMVESTGWVL EEGPAAGSAP GSQVLVVMRP
610 620 630 640 650
PPGGPRQQEE PPVPVSVLCR FPFSSALQRM DVVVTWPGAT QPEAYVKGSP
660 670 680 690 700
ELVASLCSPE TVPSDFSQVL QSYTAAGYRV VALAGKPLPI APSLAAAQQL
710 720 730 740 750
TRDTVERELS LLGLLVMRNL LKPQTAPVIQ TLRKTGIRTV MVTGDNLQTA
760 770 780 790 800
VTVARACGMV GAQEHLAVIH ATHPEQGQPA ALEFLPTESS AVMNGAKATG
810 820 830 840 850
YPTVPEPQSC HLALSGSTFA VLRKHFPKLL PKVLVQATVF ARMAPEQKTE
860 870 880 890 900
LVCELQRLQY CVGMCGDGAN DCGALKAADV GISLSQAEAS VVSPFTSSMA
910 920 930 940 950
SIECVPTVIR EGRCSLDTSF SVFKYMALYS LTQFISVLIL YTINTNLGDL
960 970 980 990 1000
QFLAIDLVIT TTVAVLMSRT GPALTLVRAR PPGALLSVPV LGSLLLQVAL
1010 1020 1030 1040 1050
VAGIQLGGYF LVIAQPWFVP LNRTVPAPDN LPNYENTVVF SLSGFQYLIL
1060 1070 1080 1090 1100
AAAVSKGAPF RQPLYTNVPF LVALALLGSV LVGLILVPGL LQGPLGLRNI
1110 1120 1130 1140 1150
VDSSFKLLLL GLVAFNFVGA FMLESVLDQC LPACLRWLRP KRASKKQFKR
1160
LQQELAEHPW PTLPVGSVR
Length:1,169
Mass (Da):126,443
Last modified:July 27, 2011 - v3
Checksum:i35458FE5B45FEFBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112V → L in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti186G → S in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti440I → V in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti485T → A in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti539C → R in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti695A → E in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti809S → F in AAH42661 (PubMed:15489334).Curated1
Sequence conflicti943I → V in BAB22896 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645625 Genomic DNA. Translation: CAM16754.1.
BC042661 mRNA. Translation: AAH42661.1.
AK003623 mRNA. Translation: BAB22896.1.
CCDSiCCDS18859.1.
RefSeqiNP_083373.2. NM_029097.2.
UniGeneiMm.205625.

Genome annotation databases

EnsembliENSMUST00000037055; ENSMUSP00000039648; ENSMUSG00000036622.
GeneIDi74772.
KEGGimmu:74772.
UCSCiuc008vnn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645625 Genomic DNA. Translation: CAM16754.1.
BC042661 mRNA. Translation: AAH42661.1.
AK003623 mRNA. Translation: BAB22896.1.
CCDSiCCDS18859.1.
RefSeqiNP_083373.2. NM_029097.2.
UniGeneiMm.205625.

3D structure databases

ProteinModelPortaliQ9CTG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998039.
STRINGi10090.ENSMUSP00000039648.

PTM databases

iPTMnetiQ9CTG6.
PhosphoSitePlusiQ9CTG6.

Proteomic databases

MaxQBiQ9CTG6.
PaxDbiQ9CTG6.
PRIDEiQ9CTG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037055; ENSMUSP00000039648; ENSMUSG00000036622.
GeneIDi74772.
KEGGimmu:74772.
UCSCiuc008vnn.2. mouse.

Organism-specific databases

CTDi23400.
MGIiMGI:1922022. Atp13a2.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ9CTG6.
KOiK13526.
OMAiPPLWEPQ.
OrthoDBiEOG091G01IL.
TreeFamiTF300331.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp13a2. mouse.
PROiQ9CTG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036622.
CleanExiMM_ATP13A2.
ExpressionAtlasiQ9CTG6. baseline and differential.
GenevisibleiQ9CTG6. MM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT132_MOUSE
AccessioniPrimary (citable) accession number: Q9CTG6
Secondary accession number(s): A2AA78, Q8CG98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.