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Q9CTG6 (AT132_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cation-transporting ATPase 13A2
EC=3.6.3.-
Gene names
Name:Atp13a2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1169 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Lysosome By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11691169Probable cation-transporting ATPase 13A2
PRO_0000046424

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3422Helical; Potential
Topological domain35 – 4511Extracellular Potential
Transmembrane46 – 6621Helical; Potential
Topological domain67 – 225159Cytoplasmic Potential
Transmembrane226 – 24823Helical; Potential
Topological domain249 – 2513Extracellular Potential
Transmembrane252 – 27120Helical; Potential
Topological domain272 – 420149Cytoplasmic Potential
Transmembrane421 – 44020Helical; Potential
Topological domain441 – 45414Extracellular Potential
Transmembrane455 – 47521Helical; Potential
Topological domain476 – 921446Cytoplasmic Potential
Transmembrane922 – 94120Helical; Potential
Topological domain942 – 95211Extracellular Potential
Transmembrane953 – 97018Helical; Potential
Topological domain971 – 98616Cytoplasmic Potential
Transmembrane987 – 100721Helical; Potential
Topological domain1008 – 103528Extracellular Potential
Transmembrane1036 – 105520Helical; Potential
Topological domain1056 – 106813Cytoplasmic Potential
Transmembrane1069 – 108618Helical; Potential
Topological domain1087 – 110216Extracellular Potential
Transmembrane1103 – 112321Helical; Potential
Topological domain1124 – 116946Cytoplasmic Potential

Sites

Active site50814-aspartylphosphate intermediate By similarity
Metal binding8671Magnesium By similarity
Metal binding8711Magnesium By similarity

Experimental info

Sequence conflict1121V → L in AAH42661. Ref.2
Sequence conflict1861G → S in AAH42661. Ref.2
Sequence conflict4401I → V in AAH42661. Ref.2
Sequence conflict4851T → A in AAH42661. Ref.2
Sequence conflict5391C → R in AAH42661. Ref.2
Sequence conflict6951A → E in AAH42661. Ref.2
Sequence conflict8091S → F in AAH42661. Ref.2
Sequence conflict9431I → V in BAB22896. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9CTG6 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 35458FE5B45FEFBE

FASTA1,169126,443
        10         20         30         40         50         60 
MSADSSLLMG STPPSYGTLT TGTSIDPLSS SASSVRLSGY CGSPWRAIGY HAAVWMLAGI 

        70         80         90        100        110        120 
PWLLFRWKPL WGVRLRLKPC SLAHAETLVI EIKDKEGSSR QLFTVQVQTE AVVQGSLELP 

       130        140        150        160        170        180 
PQAQAEDGRS QAAVGVTPEG TWQDTSELHR QEEAKQVLRY YVLQGQRYVW METQQAFCQV 

       190        200        210        220        230        240 
SLLDHGRTCD DVHCSSSGLS LQDQATRKTI YGPNVISIPV KSYLQLLADE ALNPYYGFQA 

       250        260        270        280        290        300 
FSIALWLADH YYWYALCIFL ISAISICLAL YKTRKQSLTL RDMVKLSVRV QVCRPGGEEE 

       310        320        330        340        350        360 
WVDSSELVPG DCLVLPQEGG VMPCDAALVA GECVVNESSL TGESTPVLKT ALPEGPKPYC 

       370        380        390        400        410        420 
PETHRRHTLF CGTLILQARA YVGPRVLAVV TRTGFCTAKG GLVSSILHPR PISFKFYKHS 

       430        440        450        460        470        480 
MKFVAALSVL ALLGTVYSII ILYRNRVPVR EIVIRALDLV TVVVPPALPA AMTVCTLYAQ 

       490        500        510        520        530        540 
SRLRTQGIFC IHPLRINLGG KLRLVCFDKT GTLTEDGLDV MGVVPLKGQV LLPLVPEPCH 

       550        560        570        580        590        600 
LPLGPLLRAL ATCHALSQLH DTPVGDPMDL KMVESTGWVL EEGPAAGSAP GSQVLVVMRP 

       610        620        630        640        650        660 
PPGGPRQQEE PPVPVSVLCR FPFSSALQRM DVVVTWPGAT QPEAYVKGSP ELVASLCSPE 

       670        680        690        700        710        720 
TVPSDFSQVL QSYTAAGYRV VALAGKPLPI APSLAAAQQL TRDTVERELS LLGLLVMRNL 

       730        740        750        760        770        780 
LKPQTAPVIQ TLRKTGIRTV MVTGDNLQTA VTVARACGMV GAQEHLAVIH ATHPEQGQPA 

       790        800        810        820        830        840 
ALEFLPTESS AVMNGAKATG YPTVPEPQSC HLALSGSTFA VLRKHFPKLL PKVLVQATVF 

       850        860        870        880        890        900 
ARMAPEQKTE LVCELQRLQY CVGMCGDGAN DCGALKAADV GISLSQAEAS VVSPFTSSMA 

       910        920        930        940        950        960 
SIECVPTVIR EGRCSLDTSF SVFKYMALYS LTQFISVLIL YTINTNLGDL QFLAIDLVIT 

       970        980        990       1000       1010       1020 
TTVAVLMSRT GPALTLVRAR PPGALLSVPV LGSLLLQVAL VAGIQLGGYF LVIAQPWFVP 

      1030       1040       1050       1060       1070       1080 
LNRTVPAPDN LPNYENTVVF SLSGFQYLIL AAAVSKGAPF RQPLYTNVPF LVALALLGSV 

      1090       1100       1110       1120       1130       1140 
LVGLILVPGL LQGPLGLRNI VDSSFKLLLL GLVAFNFVGA FMLESVLDQC LPACLRWLRP 

      1150       1160 
KRASKKQFKR LQQELAEHPW PTLPVGSVR

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 582-1169.
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL645625 Genomic DNA. Translation: CAM16754.1.
BC042661 mRNA. Translation: AAH42661.1.
AK003623 mRNA. Translation: BAB22896.1.
IPIIPI00319385.
RefSeqNP_083373.2. NM_029097.2.
UniGeneMm.205625.

3D structure databases

ProteinModelPortalQ9CTG6.
SMRQ9CTG6. Positions 277-409, 851-911.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9CTG6.

Proteomic databases

PRIDEQ9CTG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037055; ENSMUSP00000039648; ENSMUSG00000036622.
GeneID74772.
KEGGmmu:74772.
NMPDRfig|10090.3.peg.10710.

Organism-specific databases

CTD23400.
MGIMGI:1922022. Atp13a2.

Phylogenomic databases

eggNOGroNOG13344.
GeneTreeENSGT00530000063001.
HOGENOMHBG735026.
HOVERGENHBG065757.
InParanoidQ9CTG6.
OrthoDBEOG4M0F0W.
PhylomeDBQ9CTG6.

Gene expression databases

ArrayExpressQ9CTG6.
BgeeQ9CTG6.
CleanExMM_ATP13A2.
GenevestigatorQ9CTG6.
GermOnlineENSMUSG00000036622. Mus musculus.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006544. ATPase_P-typ_unknown-pump-sp.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK13526.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio341604.
SOURCESearch...

Entry information

Entry nameAT132_MOUSE
AccessionPrimary (citable) accession number: Q9CTG6
Secondary accession number(s): A2AA78, Q8CG98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: December 14, 2011
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents