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Protein

Partitioning defective 3 homolog B

Gene

Pard3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 3 homolog B
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog
PAR3-beta
Partitioning defective 3-like protein
Short name:
PAR3-L protein
Gene namesi
Name:Pard3b
Synonyms:Als2cr19, Par3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919301. Pard3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12031203Partitioning defective 3 homolog BPRO_0000185073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei346 – 3461PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei368 – 3681PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineCombined sources
Modified residuei710 – 7101PhosphoserineCombined sources
Modified residuei728 – 7281PhosphoserineCombined sources
Modified residuei730 – 7301PhosphoserineCombined sources
Modified residuei746 – 7461PhosphoserineCombined sources
Modified residuei749 – 7491PhosphoserineCombined sources
Modified residuei801 – 8011PhosphoserineBy similarity
Modified residuei810 – 8101PhosphothreonineCombined sources
Modified residuei1088 – 10881PhosphoserineCombined sources
Modified residuei1182 – 11821PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CSB4.
PaxDbiQ9CSB4.
PRIDEiQ9CSB4.

PTM databases

iPTMnetiQ9CSB4.
PhosphoSiteiQ9CSB4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052062.
ExpressionAtlasiQ9CSB4. baseline and differential.
GenevisibleiQ9CSB4. MM.

Interactioni

Subunit structurei

Interacts with PARD6B. Interacts with INSC/inscuteable (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60855N.
STRINGi10090.ENSMUSP00000074837.

Structurei

Secondary structure

1
1203
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi482 – 4843Combined sources
Beta strandi493 – 5008Combined sources
Beta strandi502 – 5043Combined sources
Turni505 – 5073Combined sources
Beta strandi512 – 5187Combined sources
Turni519 – 5224Combined sources
Beta strandi523 – 5319Combined sources
Beta strandi534 – 5374Combined sources
Helixi539 – 5424Combined sources
Beta strandi549 – 5535Combined sources
Beta strandi556 – 5583Combined sources
Helixi563 – 58018Combined sources
Beta strandi583 – 5908Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG6NMR-A478-591[»]
ProteinModelPortaliQ9CSB4.
SMRiQ9CSB4. Positions 2-82, 204-290, 376-591.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CSB4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 28989PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini383 – 46886PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 58590PDZ 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1109 – 116254Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PAR3 family.Curated
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITA1. Eukaryota.
ENOG410ZRQX. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.
InParanoidiQ9CSB4.
OMAiAMLRFGK.
OrthoDBiEOG091G04AU.
PhylomeDBiQ9CSB4.
TreeFamiTF323729.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CSB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVTVCFGRT GIVVPCKDGQ LRVRELTQQA LQRYLKTRDQ DPGYWVKIHH
60 70 80 90 100
LEYTDGGILD PDDVLADVVE DKDKLIAVFD EQEPLQKTES PGGNPADRQS
110 120 130 140 150
PDAFETEVAA QLAAFKPVGG EIVVTPSALK LGTPLLVRRS SDPAPGPHAD
160 170 180 190 200
AQPSTASLSG QSLKPVVLDS TQNVENKEAM NGEQAGLLSL HRPKDELSDM
210 220 230 240 250
TRAVEISGEG DPLGIHVVPF FSSLSGRILG LFIRGIEENS RCKQEGLFQE
260 270 280 290 300
NECIVKINNV ELLDKTFAQA QDVFRQAMKS PSVILHVLLP QNREQYEKSV
310 320 330 340 350
IGPLNIFGNN DGASRTKAAP PARGKPGLKA VHLTRASSPE GEEPASPQQS
360 370 380 390 400
KSPRVPRLGR KPSSPSLSPL MGFGSKKNAK KIKIDLKKGP EGLGFTVVTR
410 420 430 440 450
DSSIHGPGPI FVKNILPKGA AVKDGRLQSG DRILEVNGRD VTGRTQEELV
460 470 480 490 500
AMLRSTKQGE TVSLVIARQE GSFLPRELKG EPDCYALSLE SSEQLTLEIP
510 520 530 540 550
LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK DGRLRMNDQL
560 570 580 590 600
IAVNGETLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPLEELS
610 620 630 640 650
ECGALSRPGF ENCQEALSTS RRNDSSILYP FGTYSPQDKR KDLLLPSDGW
660 670 680 690 700
AENEVPPSPP PHPALEWGLE DFSHSSGVDS TGYFPDQHVN FRTVTPVRQP
710 720 730 740 750
ELINLKASKS MDLVPDEGKV QSLADRRSDS PGKDFGPTLG LKKSSSLESL
760 770 780 790 800
QTAVAEVRKN DLPFHRPRPH MVRGRGCNES FRAAIDKSYD GPEEADADGL
810 820 830 840 850
SDKSSRSGHT ALNCESAPQG NPELDNVENK AKNIKKTKEK EKKKGKGKLK
860 870 880 890 900
VKEKKLKEEH EDAERKMKRK GFGAMLRFGK KKDDKVGKAE QKGAQKSGHP
910 920 930 940 950
EEEELERMKE ERERIGAKHQ ELREKQARGL VDYATAVTGP VHDMDDDEMD
960 970 980 990 1000
PNYARVNHFR EPCASANVFR SPSPLRAGPL AYPRDGRPLS PDHLEGLYAK
1010 1020 1030 1040 1050
VNKPYHPPAL ADSGRPMAGT TDRIQKLRKE YYQARREGFL LYEDENTRAR
1060 1070 1080 1090 1100
PSDHDLRWVS GKGPDGSTHN LRFEGMERQY ASLPRGGSAD PVDYLTASPR
1110 1120 1130 1140 1150
GRYNDRELPY YPGPHPVHAP RGSYPRPPDL RATDLRYPQY YPPPPAHQHK
1160 1170 1180 1190 1200
GPFRQDVPPS PPQHQRVPVY QEMGRAGPRG SSPDQYPYRN QDPRQKNPMT

AAV
Length:1,203
Mass (Da):132,780
Last modified:December 12, 2006 - v2
Checksum:i7A9D63ED45BD3109
GO
Isoform 2 (identifier: Q9CSB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-213: DSTQNVENKE...VEISGEGDPL → RTLIGNSSSG...TENKIKTFKD

Note: Sequence incomplete. No experimental confirmation available.
Show »
Length:1,203
Mass (Da):133,086
Checksum:iAE3A8004B99D4CAB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei169 – 21345DSTQN…EGDPL → RTLIGNSSSGEFSALFWLLW ALHSCAWINTHSKHITENKI KTFKD in isoform 2. 1 PublicationVSP_022017Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645727
, AL662815, AL645669, AL645544, AL662920 Genomic DNA. Translation: CAI24504.1.
AL645669
, AL662920, AL662815, AL645727, AL645544 Genomic DNA. Translation: CAI24824.1.
AL645544
, AL645669, AL645727, AL662815, AL662920 Genomic DNA. Translation: CAI25199.1.
AL662815
, AL645544, AL645669, AL645727, AL662920 Genomic DNA. Translation: CAI25349.1.
AL662920
, AL645544, AL645669, AL645727, AL662815 Genomic DNA. Translation: CAI26112.1.
AK013352 mRNA. Translation: BAB28805.1.
CCDSiCCDS48276.1. [Q9CSB4-1]
RefSeqiNP_001074519.2. NM_001081050.2. [Q9CSB4-1]
UniGeneiMm.35153.
Mm.441881.

Genome annotation databases

EnsembliENSMUST00000075374; ENSMUSP00000074837; ENSMUSG00000052062. [Q9CSB4-1]
GeneIDi72823.
KEGGimmu:72823.
UCSCiuc007bfe.2. mouse. [Q9CSB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645727
, AL662815, AL645669, AL645544, AL662920 Genomic DNA. Translation: CAI24504.1.
AL645669
, AL662920, AL662815, AL645727, AL645544 Genomic DNA. Translation: CAI24824.1.
AL645544
, AL645669, AL645727, AL662815, AL662920 Genomic DNA. Translation: CAI25199.1.
AL662815
, AL645544, AL645669, AL645727, AL662920 Genomic DNA. Translation: CAI25349.1.
AL662920
, AL645544, AL645669, AL645727, AL662815 Genomic DNA. Translation: CAI26112.1.
AK013352 mRNA. Translation: BAB28805.1.
CCDSiCCDS48276.1. [Q9CSB4-1]
RefSeqiNP_001074519.2. NM_001081050.2. [Q9CSB4-1]
UniGeneiMm.35153.
Mm.441881.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG6NMR-A478-591[»]
ProteinModelPortaliQ9CSB4.
SMRiQ9CSB4. Positions 2-82, 204-290, 376-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60855N.
STRINGi10090.ENSMUSP00000074837.

PTM databases

iPTMnetiQ9CSB4.
PhosphoSiteiQ9CSB4.

Proteomic databases

MaxQBiQ9CSB4.
PaxDbiQ9CSB4.
PRIDEiQ9CSB4.

Protocols and materials databases

DNASUi72823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075374; ENSMUSP00000074837; ENSMUSG00000052062. [Q9CSB4-1]
GeneIDi72823.
KEGGimmu:72823.
UCSCiuc007bfe.2. mouse. [Q9CSB4-1]

Organism-specific databases

CTDi117583.
MGIiMGI:1919301. Pard3b.

Phylogenomic databases

eggNOGiENOG410ITA1. Eukaryota.
ENOG410ZRQX. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.
InParanoidiQ9CSB4.
OMAiAMLRFGK.
OrthoDBiEOG091G04AU.
PhylomeDBiQ9CSB4.
TreeFamiTF323729.

Miscellaneous databases

ChiTaRSiPard3b. mouse.
EvolutionaryTraceiQ9CSB4.
PROiQ9CSB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052062.
ExpressionAtlasiQ9CSB4. baseline and differential.
GenevisibleiQ9CSB4. MM.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR3L_MOUSE
AccessioniPrimary (citable) accession number: Q9CSB4
Secondary accession number(s): Q5SV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.