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Protein

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi329Calcium 1By similarity1
Metal bindingi346Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi414Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi772Calcium 2By similarity1
Metal bindingi789Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi848Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi1183Calcium 31
Metal bindingi1200Calcium 3; via carbonyl oxygen1
Metal bindingi1282Calcium 3; via carbonyl oxygen1
Metal bindingi1284Calcium 31

GO - Molecular functioni

  • acetylcholine receptor binding Source: MGI
  • calcium channel regulator activity Source: MGI
  • calcium ion binding Source: BHF-UCL
  • cell adhesion molecule binding Source: BHF-UCL
  • neuroligin family protein binding Source: BHF-UCL

GO - Biological processi

  • adult behavior Source: BHF-UCL
  • cell adhesion Source: UniProtKB-KW
  • chemical synaptic transmission Source: MGI
  • gephyrin clustering involved in postsynaptic density assembly Source: BHF-UCL
  • learning Source: BHF-UCL
  • neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCL
  • neuromuscular process controlling balance Source: BHF-UCL
  • neurotransmitter secretion Source: MGI
  • positive regulation of excitatory postsynaptic potential Source: BHF-UCL
  • positive regulation of synapse assembly Source: MGI
  • positive regulation of synapse maturation Source: MGI
  • positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  • postsynaptic density protein 95 clustering Source: BHF-UCL
  • postsynaptic membrane assembly Source: BHF-UCL
  • prepulse inhibition Source: BHF-UCL
  • regulation of grooming behavior Source: BHF-UCL
  • regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • social behavior Source: MGI
  • synapse assembly Source: MGI
  • vesicle docking involved in exocytosis Source: MGI
  • vocalization behavior Source: MGI
  • vocal learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1
Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha
Gene namesi
Name:Nrxn1
Synonyms:Kiaa0578
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Cell junctionsynapse 1 Publication

  • Note: Localized on the pre-synaptic membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 1438ExtracellularSequence analysisAdd BLAST1408
Transmembranei1439 – 1459HelicalSequence analysisAdd BLAST21
Topological domaini1460 – 1514CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • endoplasmic reticulum Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: BHF-UCL
  • nuclear membrane Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • presynaptic membrane Source: BHF-UCL
  • protein complex Source: MGI
  • vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

No visible phenotype, but mice display subtle behavorial deficits. Females show deficits in nest building and taking care of pups. Mice lacking the alpha-type isoforms of NRXN1, NRXN2 and NRXN3 are born at the expected Mendelian rate, but die during the first day after birth, probably due to neurological defects in the brainstem that impair normal breathing. These mice express normal levels of the beta-type isoforms of NRXN1, NRXN2 and NRXN3. Mice show reduced density of synapses in the brainstem, especially a reduction in the numbers of GABA-releasing synapses. Their brains display a reduced frequency of spontaneous neurotransmitter release, and decreased neurotransmitter release in response to an action potential. Likewise, the activity of voltage-gated calcium channels is strongly decreased. A small proportion (5-10%) of mice lacking the alpha-type isoforms of both NRXN1 and NRXN2 survive to adulthood; these mice do not show any gross anatomical defects in their brains or changes in the distribution of synaptic proteins, but they have fewer synapses in the neocortex and show defects in neurotransmitter release at neuromuscular junctions.7 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004316431 – 1514Neurexin-1Add BLAST1484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi228 ↔ 243By similarity
Disulfide bondi245 ↔ 255By similarity
Disulfide bondi444 ↔ 480By similarity
Disulfide bondi650 ↔ 679By similarity
Disulfide bondi687 ↔ 698By similarity
Disulfide bondi692 ↔ 707By similarity
Disulfide bondi709 ↔ 719By similarity
Glycosylationi797N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1059 ↔ 1087By similarity
Disulfide bondi1094 ↔ 1105By similarity
Disulfide bondi1099 ↔ 1114By similarity
Disulfide bondi1116 ↔ 1126By similarity
Glycosylationi1230N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CS84.
PeptideAtlasiQ9CS84.
PRIDEiQ9CS84.

PTM databases

iPTMnetiQ9CS84.
PhosphoSitePlusiQ9CS84.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024109.
CleanExiMM_NRXN1.
ExpressionAtlasiQ9CS84. baseline and differential.
GenevisibleiQ9CS84. MM.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3 (By similarity). Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom. Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 (By similarity). Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2, NLGN3 and NLGN4L; these interactions are calcium-dependent. Interacts with SYT13 and SYTL1. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRTO145222EBI-399696,EBI-728180From a different organism.

GO - Molecular functioni

  • acetylcholine receptor binding Source: MGI
  • cell adhesion molecule binding Source: BHF-UCL
  • neuroligin family protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi201851. 1 interactor.
IntActiQ9CS84. 6 interactors.
MINTiMINT-7989270.
STRINGi10090.ENSMUSP00000125407.

Structurei

Secondary structure

11514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1132 – 1145Combined sources14
Beta strandi1154 – 1164Combined sources11
Beta strandi1168 – 1181Combined sources14
Beta strandi1184 – 1190Combined sources7
Beta strandi1193 – 1202Combined sources10
Beta strandi1205 – 1208Combined sources4
Beta strandi1216 – 1218Combined sources3
Beta strandi1220 – 1227Combined sources8
Beta strandi1230 – 1235Combined sources6
Beta strandi1241 – 1243Combined sources3
Beta strandi1265 – 1277Combined sources13
Beta strandi1286 – 1292Combined sources7
Helixi1294 – 1296Combined sources3
Beta strandi1302 – 1309Combined sources8
Helixi1314 – 1319Combined sources6
Beta strandi1325 – 1333Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BODX-ray1.70A1132-1334[»]
3MW2X-ray2.69A/B1132-1334[»]
ProteinModelPortaliQ9CS84.
SMRiQ9CS84.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CS84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 217Laminin G-like 1PROSITE-ProRule annotationAdd BLAST187
Domaini219 – 256EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini283 – 480Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini487 – 679Laminin G-like 3PROSITE-ProRule annotationAdd BLAST193
Domaini683 – 720EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini725 – 898Laminin G-like 4PROSITE-ProRule annotationAdd BLAST174
Domaini912 – 1087Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1090 – 1127EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1133 – 1331Laminin G-like 6PROSITE-ProRule annotationAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 21Poly-Leu9
Compositional biasi1361 – 1364Poly-Thr4
Compositional biasi1446 – 1449Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ9CS84.
KOiK07377.
OMAiQPNSAKS.
OrthoDBiEOG091G00KC.
PhylomeDBiQ9CS84.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1a (identifier: Q9CS84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP
310 320 330 340 350
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA
360 370 380 390 400
FEALVEPVNG KFNDNAWHDV KVTRNLRQHS GIGHAMVNKL HCSVTISVDG
410 420 430 440 450
ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY
460 470 480 490 500
KNNDVRLELS RLAKQGDPKM KIHGVVAFKC ENVATLDPIT FETPESFISL
510 520 530 540 550
PKWNAKKTGS ISFDFRTTEP NGLILFSHGK PRHQKDAKHP QMIKVDFFAI
560 570 580 590 600
EMLDGHLYLL LDMGSGTIKI KALQKKVNDG EWYHVDFQRD GRSGTISVNT
610 620 630 640 650
LRTPYTAPGE SEILDLDDEL YLGGLPENKA GLVFPTEVWT ALLNYGYVGC
660 670 680 690 700
IRDLFIDGQS KDIRQMAEIQ STAGVKPSCS KETAKPCLSN PCKNNGMCRD
710 720 730 740 750
GWNRYVCDCS GTGYLGRSCE REATVLSYDG SMFMKIQLPV VMHTEAEDVS
760 770 780 790 800
LRFRSQRAYG ILMATTSRDS ADTLRLELDA GRVKLTVNLD CIRINCNSSK
810 820 830 840 850
GPETLFAGYN LNDNEWHTVR VVRRGKSLKL TVDDQQAMTG QMAGDHTRLE
860 870 880 890 900
FHNIETGIIT ERRYLSSVPS NFIGHLQSLT FNGMAYIDLC KNGDIDYCEL
910 920 930 940 950
NARFGFRNII ADPVTFKTKS SYVALATLQA YTSMHLFFQF KTTSLDGLIL
960 970 980 990 1000
YNSGDGNDFI VVELVKGYLH YVFDLGNGAN LIKGSSNKPL NDNQWHNVMI
1010 1020 1030 1040 1050
SRDTSNLHTV KIDTKITTQI TAGARNLDLK SDLYIGGVAK ETYKSLPKLV
1060 1070 1080 1090 1100
HAKEGFQGCL ASVDLNGRLP DLISDALFCN GQIERGCEGP STTCQEDSCS
1110 1120 1130 1140 1150
NQGVCLQQWD GFSCDCSMTS FSGPLCNDPG TTYIFSKGGG QITYKWPPND
1160 1170 1180 1190 1200
RPSTRADRLA IGFSTVQKEA VLVRVDSSSG LGDYLELHIH QGKIGVKFNV
1210 1220 1230 1240 1250
GTDDIAIEES NAIINDGKYH VVRFTRSGGN ATLQVDSWPV IERYPAGNND
1260 1270 1280 1290 1300
NERLAIARQR IPYRLGRVVD EWLLDKGRQL TIFNSQATII IGGKEQGQPF
1310 1320 1330 1340 1350
QGQLSGLYYN GLKVLNMAAE NDANIAIVGN VRLVGEVPSS MTTESTATAM
1360 1370 1380 1390 1400
QSEMSTSIME TTTTLATSTA RRGKPPTKEP ISQTTDDILV ASAECPSDDE
1410 1420 1430 1440 1450
DIDPCEPSSG GLANPTRVGG REPYPGSAEV IRESSSTTGM VVGIVAAAAL
1460 1470 1480 1490 1500
CILILLYAMY KYRNRDEGSY HVDESRNYIS NSAQSNGAVV KEKQPSSAKS
1510
ANKNKKNKDK EYYV
Length:1,514
Mass (Da):166,169
Last modified:December 6, 2005 - v3
Checksum:i412281FE441F0EFC
GO
Isoform 2a (identifier: Q9CS84-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     387-393: Missing.

Show »
Length:1,507
Mass (Da):165,387
Checksum:iB3372630D1BD0606
GO
Isoform 3a (identifier: Q9CS84-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     379-393: Missing.

Show »
Length:1,499
Mass (Da):164,596
Checksum:i5574E00C647EAD9E
GO
Isoform 4a (identifier: Q9CS84-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     379-393: Missing.
     1410-1412: Missing.

Note: No experimental confirmation available.
Show »
Length:1,496
Mass (Da):164,369
Checksum:i7927795160A5DFA2
GO
Isoform 1b (identifier: P0DI97-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DI97.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:468
Mass (Da):50,223
GO
Isoform 5a (identifier: Q9CS84-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-393: Missing.
     1247-1276: Missing.

Show »
Length:1,477
Mass (Da):161,824
Checksum:i31E076AB249810B5
GO
Isoform 6 (identifier: Q9CS84-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1372: Missing.
     1373-1381: GKPPTKEPI → MDMRWHCEN
     1410-1412: Missing.

Note: Produced by alternative promoter usage and alternative splicing.1 Publication
Show »
Length:139
Mass (Da):15,289
Checksum:iD5FCC748C08D696F
GO

Sequence cautioni

The sequence AAH47146 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC41433 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0582031 – 1372Missing in isoform 6. 1 PublicationAdd BLAST1372
Alternative sequenceiVSP_003485379 – 393Missing in isoform 3a and isoform 4a. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_003484387 – 393Missing in isoform 2a and isoform 5a. 2 Publications7
Alternative sequenceiVSP_0439461247 – 1276Missing in isoform 5a. CuratedAdd BLAST30
Alternative sequenceiVSP_0582041373 – 1381GKPPTKEPI → MDMRWHCEN in isoform 6. 1 Publication9
Alternative sequenceiVSP_0164011410 – 1412Missing in isoform 4a and isoform 6. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093249 mRNA. Translation: BAC41433.2. Different initiation.
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
BC047146 mRNA. Translation: AAH47146.1. Sequence problems.
AF387674 Genomic DNA. Translation: AAK70469.1.
AF387674 Genomic DNA. Translation: AAK70470.1.
AF387674 Genomic DNA. Translation: AAK70471.1.
AK017578 mRNA. Translation: BAB30815.1.
AJ006802 mRNA. Translation: CAA07257.1.
CCDSiCCDS57113.1. [Q9CS84-2]
RefSeqiNP_064648.3. NM_020252.3. [Q9CS84-2]
NP_796258.2. NM_177284.2.
XP_006523874.1. XM_006523811.3. [Q9CS84-3]
XP_006523875.1. XM_006523812.3. [Q9CS84-4]
XP_006523879.1. XM_006523816.3. [Q9CS84-5]
XP_017172806.1. XM_017317317.1. [Q9CS84-6]
UniGeneiMm.478418.
Mm.491332.

Genome annotation databases

EnsembliENSMUST00000054059; ENSMUSP00000057294; ENSMUSG00000024109. [Q9CS84-3]
ENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109. [Q9CS84-4]
ENSMUST00000160844; ENSMUSP00000125407; ENSMUSG00000024109. [Q9CS84-2]
ENSMUST00000161402; ENSMUSP00000124116; ENSMUSG00000024109. [Q9CS84-1]
ENSMUST00000174331; ENSMUSP00000133491; ENSMUSG00000024109. [Q9CS84-5]
ENSMUST00000197268; ENSMUSP00000142815; ENSMUSG00000024109. [Q9CS84-6]
GeneIDi18189.
KEGGimmu:18189.
UCSCiuc008dvz.2. mouse. [Q9CS84-2]
uc008dwa.2. mouse. [Q9CS84-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093249 mRNA. Translation: BAC41433.2. Different initiation.
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
BC047146 mRNA. Translation: AAH47146.1. Sequence problems.
AF387674 Genomic DNA. Translation: AAK70469.1.
AF387674 Genomic DNA. Translation: AAK70470.1.
AF387674 Genomic DNA. Translation: AAK70471.1.
AK017578 mRNA. Translation: BAB30815.1.
AJ006802 mRNA. Translation: CAA07257.1.
CCDSiCCDS57113.1. [Q9CS84-2]
RefSeqiNP_064648.3. NM_020252.3. [Q9CS84-2]
NP_796258.2. NM_177284.2.
XP_006523874.1. XM_006523811.3. [Q9CS84-3]
XP_006523875.1. XM_006523812.3. [Q9CS84-4]
XP_006523879.1. XM_006523816.3. [Q9CS84-5]
XP_017172806.1. XM_017317317.1. [Q9CS84-6]
UniGeneiMm.478418.
Mm.491332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BODX-ray1.70A1132-1334[»]
3MW2X-ray2.69A/B1132-1334[»]
ProteinModelPortaliQ9CS84.
SMRiQ9CS84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201851. 1 interactor.
IntActiQ9CS84. 6 interactors.
MINTiMINT-7989270.
STRINGi10090.ENSMUSP00000125407.

PTM databases

iPTMnetiQ9CS84.
PhosphoSitePlusiQ9CS84.

Proteomic databases

PaxDbiQ9CS84.
PeptideAtlasiQ9CS84.
PRIDEiQ9CS84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054059; ENSMUSP00000057294; ENSMUSG00000024109. [Q9CS84-3]
ENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109. [Q9CS84-4]
ENSMUST00000160844; ENSMUSP00000125407; ENSMUSG00000024109. [Q9CS84-2]
ENSMUST00000161402; ENSMUSP00000124116; ENSMUSG00000024109. [Q9CS84-1]
ENSMUST00000174331; ENSMUSP00000133491; ENSMUSG00000024109. [Q9CS84-5]
ENSMUST00000197268; ENSMUSP00000142815; ENSMUSG00000024109. [Q9CS84-6]
GeneIDi18189.
KEGGimmu:18189.
UCSCiuc008dvz.2. mouse. [Q9CS84-2]
uc008dwa.2. mouse. [Q9CS84-4]

Organism-specific databases

CTDi9378.
MGIiMGI:1096391. Nrxn1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ9CS84.
KOiK07377.
OMAiQPNSAKS.
OrthoDBiEOG091G00KC.
PhylomeDBiQ9CS84.

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiNrxn1. mouse.
EvolutionaryTraceiQ9CS84.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024109.
CleanExiMM_NRXN1.
ExpressionAtlasiQ9CS84. baseline and differential.
GenevisibleiQ9CS84. MM.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1A_MOUSE
AccessioniPrimary (citable) accession number: Q9CS84
Secondary accession number(s): G3UWZ9
, O88722, Q80Y87, Q8CHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.