Q9CS84 (NRX1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexin-1-alpha

Alternative name(s):
Neurexin I-alpha

Gene names

Name:	Nrxn1
Synonyms:	Kiaa0578

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Subunit structure	The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1 By similarity. Interacts with SYT13 and SYTL1. Ref.7 Ref.8
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains.
Sequence caution	The sequence BAC41433.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adult behavior Inferred from mutant phenotype. Source: BHF-UCL cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW gephyrin clustering Inferred from direct assay. Source: BHF-UCL learning Inferred from mutant phenotype. Source: BHF-UCL neuroligin clustering Inferred from direct assay. Source: BHF-UCL neuromuscular process controlling balance Inferred from mutant phenotype. Source: BHF-UCL neurotransmitter secretion Traceable author statement. Source: MGI positive regulation of excitatory postsynaptic membrane potential Inferred from mutant phenotype. Source: BHF-UCL positive regulation of synapse maturation Inferred from direct assay. Source: MGI positive regulation of synaptic transmission, glutamatergic Inferred from mutant phenotype. Source: BHF-UCL postsynaptic density protein 95 clustering Inferred from direct assay. Source: BHF-UCL postsynaptic membrane assembly Inferred from direct assay. Source: BHF-UCL prepulse inhibition Inferred from mutant phenotype. Source: BHF-UCL regulation of grooming behavior Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	cell surface Inferred from direct assay. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Traceable author statement. Source: MGI plasma membrane Inferred by curator. Source: BHF-UCL presynaptic membrane Inferred from direct assay. Source: MGI
Molecular function	acetylcholine receptor binding Inferred from direct assay. Source: MGI cell adhesion molecule binding Inferred from physical interaction. Source: BHF-UCL metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW neuroligin family protein binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1a (identifier: Q9CS84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2a (identifier: Q9CS84-2)

Also known as: Alpha-2B;

The sequence of this isoform differs from the canonical sequence as follows:
     387-393: Missing.

Isoform 3a (identifier: Q9CS84-3)

Also known as: Alpha-2C;

The sequence of this isoform differs from the canonical sequence as follows:
     379-393: Missing.

Isoform 4a (identifier: Q9CS84-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     379-393: Missing.
     1410-1412: Missing.

Note: No experimental confirmation available.

Isoform 1b (identifier: P0DI97-1)

The sequence of this isoform can be found in the external entry P0DI97.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Potential

Chain

31 – 1514

1484

Neurexin-1-alpha

PRO_0000043164

Regions

Topological domain

31 – 1438

1408

Extracellular Potential

Transmembrane

1439 – 1459

21

Helical; Potential

Topological domain

1460 – 1514

55

Cytoplasmic Potential

Domain

31 – 217

187

Laminin G-like 1

Domain

219 – 256

38

EGF-like 1

Domain

283 – 480

198

Laminin G-like 2

Domain

487 – 679

193

Laminin G-like 3

Domain

683 – 720

38

EGF-like 2

Domain

725 – 898

174

Laminin G-like 4

Domain

912 – 1087

176

Laminin G-like 5

Domain

1090 – 1127

38

EGF-like 3

Domain

1133 – 1331

199

Laminin G-like 6

Compositional bias

13 – 21

9

Poly-Leu

Compositional bias

1361 – 1364

4

Poly-Thr

Compositional bias

1446 – 1449

4

Poly-Ala

Sites

Metal binding

329

1

Calcium By similarity

Metal binding

346

1

Calcium; via carbonyl oxygen By similarity

Metal binding

414

1

Calcium; via carbonyl oxygen By similarity

Amino acid modifications

Glycosylation

125

1

N-linked (GlcNAc...) Potential

Glycosylation

190

1

N-linked (GlcNAc...) Potential

Glycosylation

797

1

N-linked (GlcNAc...) Potential

Glycosylation

1230

1

N-linked (GlcNAc...) Potential

Disulfide bond

228 ↔ 243

By similarity

Disulfide bond

245 ↔ 255

By similarity

Disulfide bond

444 ↔ 480

By similarity

Disulfide bond

650 ↔ 679

By similarity

Disulfide bond

687 ↔ 698

By similarity

Disulfide bond

692 ↔ 707

By similarity

Disulfide bond

709 ↔ 719

By similarity

Disulfide bond

1059 ↔ 1087

By similarity

Disulfide bond

1094 ↔ 1105

By similarity

Disulfide bond

1099 ↔ 1114

By similarity

Disulfide bond

1116 ↔ 1126

By similarity

Natural variations

Alternative sequence

1 – 320

320

Missing in isoform 4a.

VSP_016400

Alternative sequence

379 – 393

15

Missing in isoform 3a and isoform 4a.

VSP_003485

Alternative sequence

387 – 393

7

Missing in isoform 2a.

VSP_003484

Alternative sequence

1410 – 1412

3

Missing in isoform 4a.

VSP_016401

Secondary structure

1

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1514

Helix Strand Turn

Details...

Beta strand

1133 – 1135

3

Beta strand

1142 – 1145

4

Beta strand

1154 – 1161

8

Beta strand

1168 – 1177

10

Beta strand

1184 – 1189

6

Beta strand

1197 – 1199

3

Beta strand

1222 – 1226

5

Beta strand

1231 – 1235

5

Beta strand

1241 – 1243

3

Beta strand

1286 – 1291

6

Helix

1314 – 1319

6

Beta strand

1325 – 1327

3

Beta strand

1331 – 1333

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1a [UniParc]. Last modified December 6, 2005. Version 3. Checksum: 412281FE441F0EFC	FASTA	1,514	166,169
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVNKL HCSVTISVDG ILTTTGYTQE DYTMLGSDDF 430 440 450 460 470 480 FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDVRLELS RLAKQGDPKM KIHGVVAFKC 490 500 510 520 530 540 ENVATLDPIT FETPESFISL PKWNAKKTGS ISFDFRTTEP NGLILFSHGK PRHQKDAKHP 550 560 570 580 590 600 QMIKVDFFAI EMLDGHLYLL LDMGSGTIKI KALQKKVNDG EWYHVDFQRD GRSGTISVNT 610 620 630 640 650 660 LRTPYTAPGE SEILDLDDEL YLGGLPENKA GLVFPTEVWT ALLNYGYVGC IRDLFIDGQS 670 680 690 700 710 720 KDIRQMAEIQ STAGVKPSCS KETAKPCLSN PCKNNGMCRD GWNRYVCDCS GTGYLGRSCE 730 740 750 760 770 780 REATVLSYDG SMFMKIQLPV VMHTEAEDVS LRFRSQRAYG ILMATTSRDS ADTLRLELDA 790 800 810 820 830 840 GRVKLTVNLD CIRINCNSSK GPETLFAGYN LNDNEWHTVR VVRRGKSLKL TVDDQQAMTG 850 860 870 880 890 900 QMAGDHTRLE FHNIETGIIT ERRYLSSVPS NFIGHLQSLT FNGMAYIDLC KNGDIDYCEL 910 920 930 940 950 960 NARFGFRNII ADPVTFKTKS SYVALATLQA YTSMHLFFQF KTTSLDGLIL YNSGDGNDFI 970 980 990 1000 1010 1020 VVELVKGYLH YVFDLGNGAN LIKGSSNKPL NDNQWHNVMI SRDTSNLHTV KIDTKITTQI 1030 1040 1050 1060 1070 1080 TAGARNLDLK SDLYIGGVAK ETYKSLPKLV HAKEGFQGCL ASVDLNGRLP DLISDALFCN 1090 1100 1110 1120 1130 1140 GQIERGCEGP STTCQEDSCS NQGVCLQQWD GFSCDCSMTS FSGPLCNDPG TTYIFSKGGG 1150 1160 1170 1180 1190 1200 QITYKWPPND RPSTRADRLA IGFSTVQKEA VLVRVDSSSG LGDYLELHIH QGKIGVKFNV 1210 1220 1230 1240 1250 1260 GTDDIAIEES NAIINDGKYH VVRFTRSGGN ATLQVDSWPV IERYPAGNND NERLAIARQR 1270 1280 1290 1300 1310 1320 IPYRLGRVVD EWLLDKGRQL TIFNSQATII IGGKEQGQPF QGQLSGLYYN GLKVLNMAAE 1330 1340 1350 1360 1370 1380 NDANIAIVGN VRLVGEVPSS MTTESTATAM QSEMSTSIME TTTTLATSTA RRGKPPTKEP 1390 1400 1410 1420 1430 1440 ISQTTDDILV ASAECPSDDE DIDPCEPSSG GLANPTRVGG REPYPGSAEV IRESSSTTGM 1450 1460 1470 1480 1490 1500 VVGIVAAAAL CILILLYAMY KYRNRDEGSY HVDESRNYIS NSAQSNGAVV KEKQPSSAKS 1510 ANKNKKNKDK EYYV
	Isoform 2a (Alpha-2B) [UniParc]. Checksum: B3372630D1BD0606	FASTA	1,507	165,387
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 430 440 450 460 470 480 STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 490 500 510 520 530 540 PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 550 560 570 580 590 600 FAIEMLDGHL YLLLDMGSGT IKIKALQKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 610 620 630 640 650 660 PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 670 680 690 700 710 720 EIQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 730 740 750 760 770 780 YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 790 800 810 820 830 840 NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 850 860 870 880 890 900 RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 910 920 930 940 950 960 NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 970 980 990 1000 1010 1020 YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 1030 1040 1050 1060 1070 1080 DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 1090 1100 1110 1120 1130 1140 EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 1150 1160 1170 1180 1190 1200 PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 1210 1220 1230 1240 1250 1260 EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG NNDNERLAIA RQRIPYRLGR 1270 1280 1290 1300 1310 1320 VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG QPFQGQLSGL YYNGLKVLNM AAENDANIAI 1330 1340 1350 1360 1370 1380 VGNVRLVGEV PSSMTTESTA TAMQSEMSTS IMETTTTLAT STARRGKPPT KEPISQTTDD 1390 1400 1410 1420 1430 1440 ILVASAECPS DDEDIDPCEP SSGGLANPTR VGGREPYPGS AEVIRESSST TGMVVGIVAA 1450 1460 1470 1480 1490 1500 AALCILILLY AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSANKNKKN KDKEYYV
	Isoform 3a (Alpha-2C) [UniParc]. Checksum: 5574E00C647EAD9E	FASTA	1,499	164,596
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 430 440 450 460 470 480 PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE 490 500 510 520 530 540 SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG 550 560 570 580 590 600 HLYLLLDMGS GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 610 620 630 640 650 660 LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV 670 680 690 700 710 720 KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 730 740 750 760 770 780 IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN 790 800 810 820 830 840 CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE 850 860 870 880 890 900 TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 910 920 930 940 950 960 FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL 970 980 990 1000 1010 1020 GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 1030 1040 1050 1060 1070 1080 GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ 1090 1100 1110 1120 1130 1140 EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR 1150 1160 1170 1180 1190 1200 ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 1210 1220 1230 1240 1250 1260 DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD 1270 1280 1290 1300 1310 1320 KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 1330 1340 1350 1360 1370 1380 EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC 1390 1400 1410 1420 1430 1440 PSDDEDIDPC EPSSGGLANP TRVGGREPYP GSAEVIRESS STTGMVVGIV AAAALCILIL 1450 1460 1470 1480 1490 LYAMYKYRNR DEGSYHVDES RNYISNSAQS NGAVVKEKQP SSAKSANKNK KNKDKEYYV
	Isoform 4a [UniParc]. Checksum: 9AA6E9F48CF994CE	FASTA	1,176	129,340
	10 20 30 40 50 60 MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV KVTRNLRQVT 70 80 90 100 110 120 ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV 130 140 150 160 170 180 RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF 190 200 210 220 230 240 RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALQK 250 260 270 280 290 300 KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP 310 320 330 340 350 360 TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV KPSCSKETAK PCLSNPCKNN 370 380 390 400 410 420 GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS 430 440 450 460 470 480 QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE 490 500 510 520 530 540 WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH 550 560 570 580 590 600 LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH 610 620 630 640 650 660 LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS SNKPLNDNQW 670 680 690 700 710 720 HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG 730 740 750 760 770 780 FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD 790 800 810 820 830 840 CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV 850 860 870 880 890 900 DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV 910 920 930 940 950 960 DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS QATIIIGGKE 970 980 990 1000 1010 1020 QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS 1030 1040 1050 1060 1070 1080 TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRV 1090 1100 1110 1120 1130 1140 GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY 1150 1160 1170 ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV
	Isoform 1b [UniParc]. See P0DI97.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed: 12465718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A). Tissue: Brain.
[2]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4A). Tissue: Eye.
[4]	"Sequencing of the neurexin genes." Graveley B.R., Philipps D.L. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 298-437 (ISOFORMS 1A; 2A AND 3A/4A). Strain: CD-1. Tissue: Brain.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1514 (ISOFORMS 1A/2A/3A). Strain: C57BL/6J. Tissue: Embryo.
[6]	"Differential seizure-induced and developmental changes of neurexin expression." Gorecki D.C., Szklarczyk A., Lukasiuk K., Kaczmarek L., Simons J.P. Mol. Cell. Neurosci. 13:218-227(1999) [PubMed: 10408888] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1463-1505 (ISOFORMS 1A/2A/3A/4A). Strain: C57BL/10. Tissue: Brain.
[7]	"Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins." Fukuda M., Mikoshiba K. Biochem. Biophys. Res. Commun. 281:1226-1233(2001) [PubMed: 11243866] [Abstract] Cited for: INTERACTION WITH SYTL1.
[8]	"Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)." Fukuda M., Mikoshiba K. Biochem. J. 354:249-257(2001) [PubMed: 11171101] [Abstract] Cited for: INTERACTION WITH SYT13.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB093249 mRNA. Translation: BAC41433.2. Different initiation.
BC047146 mRNA. Translation: AAH47146.1.
AF387674 Genomic DNA. Translation: AAK70469.1.
AF387674 Genomic DNA. Translation: AAK70470.1.
AF387674 Genomic DNA. Translation: AAK70471.1.
AK017578 mRNA. Translation: BAB30815.1.
AJ006802 mRNA. Translation: CAA07257.1.

IPI

IPI00230050.
IPI00230051.
IPI00468539.
IPI00970455.

RefSeq

NP_064648.3. NM_020252.3.
NP_796258.2. NM_177284.2.

UniGene

Mm.312068.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BOD	X-ray	1.70	A	1132-1334	[»]
3MW2	X-ray	2.69	A/B	1132-1334	[»]

ProteinModelPortal

Q9CS84.

SMR

Q9CS84. Positions 221-258, 279-475, 489-906, 911-1335.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9CS84. 5 interactions.

STRING

Q9CS84.

PTM databases

PhosphoSite

Q9CS84.

Proteomic databases

PRIDE

Q9CS84.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000160844; ENSMUSP00000125407; ENSMUSG00000024109.
ENSMUST00000161402; ENSMUSP00000124116; ENSMUSG00000024109.

GeneID

18189.

KEGG

mmu:18189.

UCSC

uc008dvz.2. mouse.
uc008dwa.2. mouse.
uc012ayq.1. mouse.

Organism-specific databases

CTD

9378.

MGI

MGI:1096391. Nrxn1.

Rouge

Search...

Phylogenomic databases

eggNOG

roNOG14987.

GeneTree

ENSGT00560000076996.

HOGENOM

HBG358378.

HOVERGEN

HBG052670.

InParanoid

Q9CS84.

OMA

MGDQGKS.

OrthoDB

EOG41G339.

Gene expression databases

ArrayExpress

Q9CS84.

Bgee

Q9CS84.

CleanEx

MM_NRXN1.

Genevestigator

Q9CS84.

GermOnline

ENSMUSG00000024109. Mus musculus.

Family and domain databases

InterPro

IPR008985. ConA-like_lec_gl.
IPR013320. ConA-like_subgrp.
IPR006210. EGF-like.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000742. EGF_3.
IPR001791. Laminin_G.
IPR012680. Laminin_G_2.
IPR003585. Neurexin-like.
[Graphical view]

Gene3D

G3DSA:2.60.120.200. ConA_like_subgrp. 6 hits.

KO

K07377.

Pfam

PF02210. Laminin_G_2. 6 hits.
[Graphical view]

SMART

SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 6 hits.

PROSITE

PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. False negative.
PS01186. EGF_2. False negative.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

293528.

SOURCE

Search...

Entry information

Entry name

NRX1A_MOUSE

Accession

Primary (citable) accession number: Q9CS84
Secondary accession number(s): O88722, Q80Y87, Q8CHE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	December 6, 2005
Last modified:	November 16, 2011
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program