Q9CS84 (NRX1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexin-1

Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha

Gene names

Name:	Nrxn1
Synonyms:	Kiaa0578

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.18
Subunit structure	The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3 By similarity. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom. Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 By similarity. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2, NLGN3 and NLGN4L; these interactions are calcium-dependent. Interacts with SYT13 and SYTL1. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4. Ref.8 Ref.9 Ref.10 Ref.16 Ref.18 Ref.19 Ref.20
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell junction › synapse. Note: Localized on the pre-synaptic membrane By similarity. Ref.18
Post-translational modification	N-glycosylated By similarity. O-glycosylated By similarity.
Disruption phenotype	No visible phenotype, but mice display subtle behavorial deficits. Females show deficits in nest building and taking care of pups. Mice lacking the alpha-type isoforms of NRXN1, NRXN2 and NRXN3 are born at the expected Mendelian rate, but die during the first day after birth, probably due to neurological defects in the brainstem that impair normal breathing. These mice express normal levels of the beta-type isoforms of NRXN1, NRXN2 and NRXN3. Mice show reduced density of synapses in the brainstem, especially a reduction in the numbers of GABA-releasing synapses. Their brains display a reduced frequency of spontaneous neurotransmitter release, and decreased neurotransmitter release in response to an action potential. Likewise, the activity of voltage-gated calcium channels is strongly decreased. A small proportion (5-10%) of mice lacking the alpha-type isoforms of both NRXN1 and NRXN2 survive to adulthood; these mice do not show any gross anatomical defects in their brains or changes in the distribution of synaptic proteins, but they have fewer synapses in the neocortex and show defects in neurotransmitter release at neuromuscular junctions. Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17
Sequence similarities	Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains.
Sequence caution	The sequence BAC41433.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult behavior Inferred from mutant phenotype Ref.17. Source: BHF-UCL cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW gephyrin clustering Inferred from direct assay PubMed 21424692. Source: BHF-UCL learning Inferred from mutant phenotype Ref.17. Source: BHF-UCL neuroligin clustering Inferred from direct assay PubMed 21424692. Source: BHF-UCL neuromuscular process controlling balance Inferred from mutant phenotype Ref.17. Source: BHF-UCL neurotransmitter secretion Inferred from genetic interaction Ref.11. Source: MGI positive regulation of excitatory postsynaptic membrane potential Inferred from mutant phenotype Ref.17. Source: BHF-UCL positive regulation of synapse assembly Inferred from genetic interaction PubMed 21356198. Source: MGI positive regulation of synapse maturation Inferred from direct assay PubMed 19567877. Source: MGI positive regulation of synaptic transmission, glutamatergic Inferred from mutant phenotype Ref.17. Source: BHF-UCL postsynaptic density protein 95 clustering Inferred from direct assay PubMed 21424692. Source: BHF-UCL postsynaptic membrane assembly Inferred from direct assay PubMed 21424692. Source: BHF-UCL prepulse inhibition Inferred from mutant phenotype Ref.17. Source: BHF-UCL regulation of grooming behavior Inferred from mutant phenotype Ref.17. Source: BHF-UCL social behavior Inferred from electronic annotation. Source: Compara vocalization behavior Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from direct assay PubMed 21424692. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred by curator PubMed 21424692. Source: BHF-UCL presynaptic membrane Inferred from direct assay Ref.11. Source: MGI
Molecular_function	acetylcholine receptor binding Inferred from direct assay PubMed 19567877. Source: MGI calcium channel regulator activity Inferred from genetic interaction Ref.11. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1a (identifier: Q9CS84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2a (identifier: Q9CS84-2)

Also known as: Alpha-2B;

The sequence of this isoform differs from the canonical sequence as follows:
     387-393: Missing.

Isoform 3a (identifier: Q9CS84-3)

Also known as: Alpha-2C;

The sequence of this isoform differs from the canonical sequence as follows:
     379-393: Missing.

Isoform 4a (identifier: Q9CS84-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     379-393: Missing.
     1410-1412: Missing.

Note: No experimental confirmation available.

Isoform 1b (identifier: P0DI97-1)

The sequence of this isoform can be found in the external entry P0DI97.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 5a (identifier: Q9CS84-5)

The sequence of this isoform differs from the canonical sequence as follows:
     387-393: Missing.
     1247-1276: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Potential

Chain

31 – 1514

1484

Neurexin-1

PRO_0000043164

Regions

Topological domain

31 – 1438

1408

Extracellular Potential

Transmembrane

1439 – 1459

21

Helical; Potential

Topological domain

1460 – 1514

55

Cytoplasmic Potential

Domain

31 – 217

187

Laminin G-like 1

Domain

219 – 256

38

EGF-like 1

Domain

283 – 480

198

Laminin G-like 2

Domain

487 – 679

193

Laminin G-like 3

Domain

683 – 720

38

EGF-like 2

Domain

725 – 898

174

Laminin G-like 4

Domain

912 – 1087

176

Laminin G-like 5

Domain

1090 – 1127

38

EGF-like 3

Domain

1133 – 1331

199

Laminin G-like 6

Compositional bias

13 – 21

9

Poly-Leu

Compositional bias

1361 – 1364

4

Poly-Thr

Compositional bias

1446 – 1449

4

Poly-Ala

Sites

Metal binding

329

1

Calcium 1 By similarity

Metal binding

346

1

Calcium 1; via carbonyl oxygen By similarity

Metal binding

414

1

Calcium 1; via carbonyl oxygen By similarity

Metal binding

772

1

Calcium 2 By similarity

Metal binding

789

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

848

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

1183

1

Calcium 3

Metal binding

1200

1

Calcium 3; via carbonyl oxygen

Metal binding

1282

1

Calcium 3; via carbonyl oxygen

Metal binding

1284

1

Calcium 3

Amino acid modifications

Glycosylation

125

1

N-linked (GlcNAc...) Potential

Glycosylation

190

1

N-linked (GlcNAc...) Potential

Glycosylation

797

1

N-linked (GlcNAc...) Potential

Glycosylation

1230

1

N-linked (GlcNAc...) Potential

Disulfide bond

228 ↔ 243

By similarity

Disulfide bond

245 ↔ 255

By similarity

Disulfide bond

444 ↔ 480

By similarity

Disulfide bond

650 ↔ 679

By similarity

Disulfide bond

687 ↔ 698

By similarity

Disulfide bond

692 ↔ 707

By similarity

Disulfide bond

709 ↔ 719

By similarity

Disulfide bond

1059 ↔ 1087

By similarity

Disulfide bond

1094 ↔ 1105

By similarity

Disulfide bond

1099 ↔ 1114

By similarity

Disulfide bond

1116 ↔ 1126

By similarity

Natural variations

Alternative sequence

1 – 320

320

Missing in isoform 4a.

VSP_016400

Alternative sequence

379 – 393

15

Missing in isoform 3a and isoform 4a.

VSP_003485

Alternative sequence

387 – 393

7

Missing in isoform 2a and isoform 5a.

VSP_003484

Alternative sequence

1247 – 1276

30

Missing in isoform 5a.

VSP_043946

Alternative sequence

1410 – 1412

3

Missing in isoform 4a.

VSP_016401

Secondary structure

1

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1514

Helix Strand Turn

Details...

Beta strand

1132 – 1145

14

Beta strand

1154 – 1164

11

Beta strand

1168 – 1181

14

Beta strand

1184 – 1190

7

Beta strand

1193 – 1202

10

Beta strand

1205 – 1208

4

Beta strand

1216 – 1218

3

Beta strand

1220 – 1227

8

Beta strand

1230 – 1235

6

Beta strand

1241 – 1243

3

Beta strand

1265 – 1277

13

Beta strand

1286 – 1292

7

Helix

1294 – 1296

3

Beta strand

1302 – 1309

8

Helix

1314 – 1319

6

Beta strand

1325 – 1333

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1a [UniParc]. Last modified December 6, 2005. Version 3. Checksum: 412281FE441F0EFC	FASTA	1,514	166,169
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVNKL HCSVTISVDG ILTTTGYTQE DYTMLGSDDF 430 440 450 460 470 480 FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDVRLELS RLAKQGDPKM KIHGVVAFKC 490 500 510 520 530 540 ENVATLDPIT FETPESFISL PKWNAKKTGS ISFDFRTTEP NGLILFSHGK PRHQKDAKHP 550 560 570 580 590 600 QMIKVDFFAI EMLDGHLYLL LDMGSGTIKI KALQKKVNDG EWYHVDFQRD GRSGTISVNT 610 620 630 640 650 660 LRTPYTAPGE SEILDLDDEL YLGGLPENKA GLVFPTEVWT ALLNYGYVGC IRDLFIDGQS 670 680 690 700 710 720 KDIRQMAEIQ STAGVKPSCS KETAKPCLSN PCKNNGMCRD GWNRYVCDCS GTGYLGRSCE 730 740 750 760 770 780 REATVLSYDG SMFMKIQLPV VMHTEAEDVS LRFRSQRAYG ILMATTSRDS ADTLRLELDA 790 800 810 820 830 840 GRVKLTVNLD CIRINCNSSK GPETLFAGYN LNDNEWHTVR VVRRGKSLKL TVDDQQAMTG 850 860 870 880 890 900 QMAGDHTRLE FHNIETGIIT ERRYLSSVPS NFIGHLQSLT FNGMAYIDLC KNGDIDYCEL 910 920 930 940 950 960 NARFGFRNII ADPVTFKTKS SYVALATLQA YTSMHLFFQF KTTSLDGLIL YNSGDGNDFI 970 980 990 1000 1010 1020 VVELVKGYLH YVFDLGNGAN LIKGSSNKPL NDNQWHNVMI SRDTSNLHTV KIDTKITTQI 1030 1040 1050 1060 1070 1080 TAGARNLDLK SDLYIGGVAK ETYKSLPKLV HAKEGFQGCL ASVDLNGRLP DLISDALFCN 1090 1100 1110 1120 1130 1140 GQIERGCEGP STTCQEDSCS NQGVCLQQWD GFSCDCSMTS FSGPLCNDPG TTYIFSKGGG 1150 1160 1170 1180 1190 1200 QITYKWPPND RPSTRADRLA IGFSTVQKEA VLVRVDSSSG LGDYLELHIH QGKIGVKFNV 1210 1220 1230 1240 1250 1260 GTDDIAIEES NAIINDGKYH VVRFTRSGGN ATLQVDSWPV IERYPAGNND NERLAIARQR 1270 1280 1290 1300 1310 1320 IPYRLGRVVD EWLLDKGRQL TIFNSQATII IGGKEQGQPF QGQLSGLYYN GLKVLNMAAE 1330 1340 1350 1360 1370 1380 NDANIAIVGN VRLVGEVPSS MTTESTATAM QSEMSTSIME TTTTLATSTA RRGKPPTKEP 1390 1400 1410 1420 1430 1440 ISQTTDDILV ASAECPSDDE DIDPCEPSSG GLANPTRVGG REPYPGSAEV IRESSSTTGM 1450 1460 1470 1480 1490 1500 VVGIVAAAAL CILILLYAMY KYRNRDEGSY HVDESRNYIS NSAQSNGAVV KEKQPSSAKS 1510 ANKNKKNKDK EYYV
	Isoform 2a (Alpha-2B) [UniParc]. Checksum: B3372630D1BD0606	FASTA	1,507	165,387
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 430 440 450 460 470 480 STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 490 500 510 520 530 540 PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 550 560 570 580 590 600 FAIEMLDGHL YLLLDMGSGT IKIKALQKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 610 620 630 640 650 660 PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 670 680 690 700 710 720 EIQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 730 740 750 760 770 780 YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 790 800 810 820 830 840 NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 850 860 870 880 890 900 RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 910 920 930 940 950 960 NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 970 980 990 1000 1010 1020 YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 1030 1040 1050 1060 1070 1080 DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 1090 1100 1110 1120 1130 1140 EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 1150 1160 1170 1180 1190 1200 PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 1210 1220 1230 1240 1250 1260 EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG NNDNERLAIA RQRIPYRLGR 1270 1280 1290 1300 1310 1320 VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG QPFQGQLSGL YYNGLKVLNM AAENDANIAI 1330 1340 1350 1360 1370 1380 VGNVRLVGEV PSSMTTESTA TAMQSEMSTS IMETTTTLAT STARRGKPPT KEPISQTTDD 1390 1400 1410 1420 1430 1440 ILVASAECPS DDEDIDPCEP SSGGLANPTR VGGREPYPGS AEVIRESSST TGMVVGIVAA 1450 1460 1470 1480 1490 1500 AALCILILLY AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSANKNKKN KDKEYYV
	Isoform 3a (Alpha-2C) [UniParc]. Checksum: 5574E00C647EAD9E	FASTA	1,499	164,596
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 430 440 450 460 470 480 PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE 490 500 510 520 530 540 SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG 550 560 570 580 590 600 HLYLLLDMGS GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 610 620 630 640 650 660 LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV 670 680 690 700 710 720 KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 730 740 750 760 770 780 IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN 790 800 810 820 830 840 CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE 850 860 870 880 890 900 TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 910 920 930 940 950 960 FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL 970 980 990 1000 1010 1020 GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 1030 1040 1050 1060 1070 1080 GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ 1090 1100 1110 1120 1130 1140 EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR 1150 1160 1170 1180 1190 1200 ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 1210 1220 1230 1240 1250 1260 DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD 1270 1280 1290 1300 1310 1320 KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 1330 1340 1350 1360 1370 1380 EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC 1390 1400 1410 1420 1430 1440 PSDDEDIDPC EPSSGGLANP TRVGGREPYP GSAEVIRESS STTGMVVGIV AAAALCILIL 1450 1460 1470 1480 1490 LYAMYKYRNR DEGSYHVDES RNYISNSAQS NGAVVKEKQP SSAKSANKNK KNKDKEYYV
	Isoform 4a [UniParc]. Checksum: 9AA6E9F48CF994CE	FASTA	1,176	129,340
	10 20 30 40 50 60 MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV KVTRNLRQVT 70 80 90 100 110 120 ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV 130 140 150 160 170 180 RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF 190 200 210 220 230 240 RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALQK 250 260 270 280 290 300 KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP 310 320 330 340 350 360 TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV KPSCSKETAK PCLSNPCKNN 370 380 390 400 410 420 GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS 430 440 450 460 470 480 QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE 490 500 510 520 530 540 WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH 550 560 570 580 590 600 LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH 610 620 630 640 650 660 LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS SNKPLNDNQW 670 680 690 700 710 720 HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG 730 740 750 760 770 780 FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD 790 800 810 820 830 840 CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV 850 860 870 880 890 900 DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV 910 920 930 940 950 960 DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS QATIIIGGKE 970 980 990 1000 1010 1020 QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS 1030 1040 1050 1060 1070 1080 TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRV 1090 1100 1110 1120 1130 1140 GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY 1150 1160 1170 ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV
	Isoform 1b [UniParc]. See P0DI97.		–	–
	Isoform 5a [UniParc]. Checksum: 31E076AB249810B5	FASTA	1,477	161,824
	10 20 30 40 50 60 MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 430 440 450 460 470 480 STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 490 500 510 520 530 540 PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 550 560 570 580 590 600 FAIEMLDGHL YLLLDMGSGT IKIKALQKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 610 620 630 640 650 660 PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 670 680 690 700 710 720 EIQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 730 740 750 760 770 780 YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 790 800 810 820 830 840 NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 850 860 870 880 890 900 RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 910 920 930 940 950 960 NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 970 980 990 1000 1010 1020 YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 1030 1040 1050 1060 1070 1080 DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 1090 1100 1110 1120 1130 1140 EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 1150 1160 1170 1180 1190 1200 PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 1210 1220 1230 1240 1250 1260 EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG RQLTIFNSQA TIIIGGKEQG 1270 1280 1290 1300 1310 1320 QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA TAMQSEMSTS 1330 1340 1350 1360 1370 1380 IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP SSGGLANPTR 1390 1400 1410 1420 1430 1440 VGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE GSYHVDESRN 1450 1460 1470 YISNSAQSNG AVVKEKQPSS AKSANKNKKN KDKEYYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A). Tissue: Brain.
[2]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4A). Tissue: Eye.
[5]	"Sequencing of the neurexin genes." Graveley B.R., Philipps D.L. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 298-437 (ISOFORMS 1A; 2A AND 3A/4A). Strain: CD-1. Tissue: Brain.
[6]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1514 (ISOFORMS 1A/2A/3A). Strain: C57BL/6J. Tissue: Embryo.
[7]	"Differential seizure-induced and developmental changes of neurexin expression." Gorecki D.C., Szklarczyk A., Lukasiuk K., Kaczmarek L., Simons J.P. Mol. Cell. Neurosci. 13:218-227(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1463-1505 (ISOFORMS 1A/2A/3A/4A). Strain: C57BL/10. Tissue: Brain.
[8]	"Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action." Geppert M., Khvotchev M., Krasnoperov V., Goda Y., Missler M., Hammer R.E., Ichtchenko K., Petrenko A.G., Sudhof T.C. J. Biol. Chem. 273:1705-1710(1998) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION, CALCIUM-DEPENDENT INTERACTION WITH ALPHA-LATROTOXIN.
[9]	"Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins." Fukuda M., Mikoshiba K. Biochem. Biophys. Res. Commun. 281:1226-1233(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SYTL1.
[10]	"Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)." Fukuda M., Mikoshiba K. Biochem. J. 354:249-257(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SYT13.
[11]	"Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis." Missler M., Zhang W., Rohlmann A., Kattenstroth G., Hammer R.E., Gottmann K., Sudhof T.C. Nature 423:939-948(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION IN NEUROTRANSMITTER RELEASE.
[12]	"Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins." Kattenstroth G., Tantalaki E., Sudhof T.C., Gottmann K., Missler M. Proc. Natl. Acad. Sci. U.S.A. 101:2607-2612(2004) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[13]	"Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules." Dudanova I., Sedej S., Ahmad M., Masius H., Sargsyan V., Zhang W., Riedel D., Angenstein F., Schild D., Rupnik M., Missler M. J. Neurosci. 26:10599-10613(2006) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[14]	"alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction." Sons M.S., Busche N., Strenzke N., Moser T., Ernsberger U., Mooren F.C., Zhang W., Ahmad M., Steffens H., Schomburg E.D., Plomp J.J., Missler M. Neuroscience 138:433-446(2006) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[15]	"Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation." Dudanova I., Tabuchi K., Rohlmann A., Sudhof T.C., Missler M. J. Comp. Neurol. 502:261-274(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[16]	"Unusually rapid evolution of neuroligin-4 in mice." Bolliger M.F., Pei J., Maxeiner S., Boucard A.A., Grishin N.V., Sudhof T.C. Proc. Natl. Acad. Sci. U.S.A. 105:6421-6426(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NLGN4L.
[17]	"Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments." Etherton M.R., Blaiss C.A., Powell C.M., Sudhof T.C. Proc. Natl. Acad. Sci. U.S.A. 106:17998-18003(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[18]	"Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions." Matsuda K., Yuzaki M. Eur. J. Neurosci. 33:1447-1461(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CBLN1; CBLN2 AND CBLN4.
[19]	"Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4." Koehnke J., Jin X., Trbovic N., Katsamba P.S., Brasch J., Ahlsen G., Scheiffele P., Honig B., Palmer A.G. III, Shapiro L. Structure 16:410-421(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1132-1334 (ISOFORM 5A) IN COMPLEX WITH CALCIUM, SUBUNIT, INTERACTION WITH NLGN1 AND NLGN2, ALTERNATIVE SPLICING.
[20]	"Splice form dependence of beta-neurexin/neuroligin binding interactions." Koehnke J., Katsamba P.S., Ahlsen G., Bahna F., Vendome J., Honig B., Shapiro L., Jin X. Neuron 67:61-74(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 1132-1334, INTERACTION WITH NLGN1; NLGN2 AND NLGN3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB093249 mRNA. Translation: BAC41433.2. Different initiation.
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
BC047146 mRNA. Translation: AAH47146.1.
AF387674 Genomic DNA. Translation: AAK70469.1.
AF387674 Genomic DNA. Translation: AAK70470.1.
AF387674 Genomic DNA. Translation: AAK70471.1.
AK017578 mRNA. Translation: BAB30815.1.
AJ006802 mRNA. Translation: CAA07257.1.

IPI

IPI00230050.
IPI00230051.
IPI00468539.
IPI00970455.

RefSeq

NP_064648.3. NM_020252.3.
NP_796258.2. NM_177284.2.

UniGene

Mm.312068.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BOD	X-ray	1.70	A	1132-1334	[»]
3MW2	X-ray	2.69	A/B	1132-1334	[»]

ProteinModelPortal

Q9CS84.

SMR

Q9CS84. Positions 56-1335.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9CS84. 5 interactions.

PTM databases

PhosphoSite

Q9CS84.

Proteomic databases

PaxDb

Q9CS84.

PRIDE

Q9CS84.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000054059; ENSMUSP00000057294; ENSMUSG00000024109.
ENSMUST00000160844; ENSMUSP00000125407; ENSMUSG00000024109.
ENSMUST00000161402; ENSMUSP00000124116; ENSMUSG00000024109.
ENSMUST00000174331; ENSMUSP00000133491; ENSMUSG00000024109.

GeneID

18189.

KEGG

mmu:18189.

UCSC

uc008dvz.2. mouse.
uc008dwa.2. mouse.
uc012ayq.1. mouse.

Organism-specific databases

CTD

9378.

MGI

MGI:1096391. Nrxn1.

Rouge

Search...

Phylogenomic databases

eggNOG

NOG302266.

GeneTree

ENSGT00560000076996.

HOGENOM

HOG000230481.

HOVERGEN

HBG052670.

InParanoid

Q9CS84.

KO

K07377.

OMA

NAYACEC.

OrthoDB

EOG41G339.

Gene expression databases

ArrayExpress

Q9CS84.

Bgee

Q9CS84.

CleanEx

MM_NRXN1.

Genevestigator

Q9CS84.

GermOnline

ENSMUSG00000024109. Mus musculus.

Family and domain databases

Gene3D

2.60.120.200. 6 hits.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027158. NRXN1-alpha.
[Graphical view]

PANTHER

PTHR10127:SF309. PTHR10127:SF309. 1 hit.

Pfam

PF02210. Laminin_G_2. 6 hits.
[Graphical view]

SMART

SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 6 hits.

PROSITE

PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. False negative.
PS01186. EGF_2. False negative.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NRXN1. mouse.

EvolutionaryTrace

Q9CS84.

NextBio

293528.

SOURCE

Search...

Entry information

Entry name

NRX1A_MOUSE

Accession

Primary (citable) accession number: Q9CS84
Secondary accession number(s): G3UWZ9 , O88722, Q80Y87, Q8CHE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program