Q9CS84 (NRX1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Neurexin-1-alpha Alternative name(s): Neurexin I-alpha | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 1514 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. |
| Subunit structure | The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1 By similarity. Interacts with SYT13 and SYTL1. Ref.7 Ref.8 |
| Subcellular location | Membrane; Single-pass type I membrane protein Potential. |
| Sequence similarities | Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains. |
| Sequence caution | The sequence BAC41433.2 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Alternative products
| This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist. | ||||||
| Isoform 1a (identifier: Q9CS84-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2a (identifier: Q9CS84-2) Also known as: Alpha-2B; The sequence of this isoform differs from the canonical sequence as follows: 387-393: Missing. | ||||||
| Isoform 3a (identifier: Q9CS84-3) Also known as: Alpha-2C; The sequence of this isoform differs from the canonical sequence as follows: 379-393: Missing. | ||||||
| Isoform 4a (identifier: Q9CS84-4) The sequence of this isoform differs from the canonical sequence as follows: 1-320: Missing. 379-393: Missing. 1410-1412: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 1b (identifier: P0DI97-1) The sequence of this isoform can be found in the external entry P0DI97. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||||||||||||||||||||||||||||
| Chain | 31 – 1514 | 1484 | Neurexin-1-alpha | PRO_0000043164 | |||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||
| Topological domain | 31 – 1438 | 1408 | Extracellular Potential | ||||||||||||||||||||||||||||||||
| Transmembrane | 1439 – 1459 | 21 | Helical; Potential | ||||||||||||||||||||||||||||||||
| Topological domain | 1460 – 1514 | 55 | Cytoplasmic Potential | ||||||||||||||||||||||||||||||||
| Domain | 31 – 217 | 187 | Laminin G-like 1 | ||||||||||||||||||||||||||||||||
| Domain | 219 – 256 | 38 | EGF-like 1 | ||||||||||||||||||||||||||||||||
| Domain | 283 – 480 | 198 | Laminin G-like 2 | ||||||||||||||||||||||||||||||||
| Domain | 487 – 679 | 193 | Laminin G-like 3 | ||||||||||||||||||||||||||||||||
| Domain | 683 – 720 | 38 | EGF-like 2 | ||||||||||||||||||||||||||||||||
| Domain | 725 – 898 | 174 | Laminin G-like 4 | ||||||||||||||||||||||||||||||||
| Domain | 912 – 1087 | 176 | Laminin G-like 5 | ||||||||||||||||||||||||||||||||
| Domain | 1090 – 1127 | 38 | EGF-like 3 | ||||||||||||||||||||||||||||||||
| Domain | 1133 – 1331 | 199 | Laminin G-like 6 | ||||||||||||||||||||||||||||||||
| Compositional bias | 13 – 21 | 9 | Poly-Leu | ||||||||||||||||||||||||||||||||
| Compositional bias | 1361 – 1364 | 4 | Poly-Thr | ||||||||||||||||||||||||||||||||
| Compositional bias | 1446 – 1449 | 4 | Poly-Ala | ||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||
| Metal binding | 329 | 1 | Calcium By similarity | ||||||||||||||||||||||||||||||||
| Metal binding | 346 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||||||||||||||||||||||||||
| Metal binding | 414 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||
| Glycosylation | 125 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||||||||
| Glycosylation | 190 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||||||||
| Glycosylation | 797 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||||||||
| Glycosylation | 1230 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||||||||
| Disulfide bond | 228 ↔ 243 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 245 ↔ 255 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 444 ↔ 480 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 650 ↔ 679 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 687 ↔ 698 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 692 ↔ 707 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 709 ↔ 719 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 1059 ↔ 1087 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 1094 ↔ 1105 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 1099 ↔ 1114 | By similarity | |||||||||||||||||||||||||||||||||
| Disulfide bond | 1116 ↔ 1126 | By similarity | |||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 320 | 320 | Missing in isoform 4a. | VSP_016400 | |||||||||||||||||||||||||||||||
| Alternative sequence | 379 – 393 | 15 | Missing in isoform 3a and isoform 4a. | VSP_003485 | |||||||||||||||||||||||||||||||
| Alternative sequence | 387 – 393 | 7 | Missing in isoform 2a. | VSP_003484 | |||||||||||||||||||||||||||||||
| Alternative sequence | 1410 – 1412 | 3 | Missing in isoform 4a. | VSP_016401 | |||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||
| Beta strand | 1133 – 1135 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 1142 – 1145 | 4 | |||||||||||||||||||||||||||||||||
| Beta strand | 1154 – 1161 | 8 | |||||||||||||||||||||||||||||||||
| Beta strand | 1168 – 1177 | 10 | |||||||||||||||||||||||||||||||||
| Beta strand | 1184 – 1189 | 6 | |||||||||||||||||||||||||||||||||
| Beta strand | 1197 – 1199 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 1222 – 1226 | 5 | |||||||||||||||||||||||||||||||||
| Beta strand | 1231 – 1235 | 5 | |||||||||||||||||||||||||||||||||
| Beta strand | 1241 – 1243 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 1286 – 1291 | 6 | |||||||||||||||||||||||||||||||||
| Helix | 1314 – 1319 | 6 | |||||||||||||||||||||||||||||||||
| Beta strand | 1325 – 1327 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 1331 – 1333 | 3 | |||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed: 12465718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A). Tissue: Brain. |
| [2] | Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4A). Tissue: Eye. |
| [4] | "Sequencing of the neurexin genes." Graveley B.R., Philipps D.L. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 298-437 (ISOFORMS 1A; 2A AND 3A/4A). Strain: CD-1. Tissue: Brain. |
| [5] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1514 (ISOFORMS 1A/2A/3A). Strain: C57BL/6J. Tissue: Embryo. |
| [6] | "Differential seizure-induced and developmental changes of neurexin expression." Gorecki D.C., Szklarczyk A., Lukasiuk K., Kaczmarek L., Simons J.P. Mol. Cell. Neurosci. 13:218-227(1999) [PubMed: 10408888] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1463-1505 (ISOFORMS 1A/2A/3A/4A). Strain: C57BL/10. Tissue: Brain. |
| [7] | "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins." Fukuda M., Mikoshiba K. Biochem. Biophys. Res. Commun. 281:1226-1233(2001) [PubMed: 11243866] [Abstract] Cited for: INTERACTION WITH SYTL1. |
| [8] | "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)." Fukuda M., Mikoshiba K. Biochem. J. 354:249-257(2001) [PubMed: 11171101] [Abstract] Cited for: INTERACTION WITH SYT13. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB093249 mRNA. Translation: BAC41433.2. Different initiation. BC047146 mRNA. Translation: AAH47146.1. AF387674 Genomic DNA. Translation: AAK70469.1. AF387674 Genomic DNA. Translation: AAK70470.1. AF387674 Genomic DNA. Translation: AAK70471.1. AK017578 mRNA. Translation: BAB30815.1. AJ006802 mRNA. Translation: CAA07257.1. | ||||||||||||||||||
| IPI | IPI00230050. IPI00230051. IPI00468539. IPI00970455. | ||||||||||||||||||
| RefSeq | NP_064648.3. NM_020252.3. NP_796258.2. NM_177284.2. | ||||||||||||||||||
| UniGene | Mm.312068. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q9CS84. | ||||||||||||||||||
| SMR | Q9CS84. Positions 221-258, 279-475, 489-906, 911-1335. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | Q9CS84. 5 interactions. | ||||||||||||||||||
| STRING | Q9CS84. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q9CS84. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q9CS84. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSMUST00000160844; ENSMUSP00000125407; ENSMUSG00000024109. ENSMUST00000161402; ENSMUSP00000124116; ENSMUSG00000024109. | ||||||||||||||||||
| GeneID | 18189. | ||||||||||||||||||
| KEGG | mmu:18189. | ||||||||||||||||||
| UCSC | uc008dvz.2. mouse. uc008dwa.2. mouse. uc012ayq.1. mouse. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 9378. | ||||||||||||||||||
| MGI | MGI:1096391. Nrxn1. | ||||||||||||||||||
| Rouge | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | roNOG14987. | ||||||||||||||||||
| GeneTree | ENSGT00560000076996. | ||||||||||||||||||
| HOGENOM | HBG358378. | ||||||||||||||||||
| HOVERGEN | HBG052670. | ||||||||||||||||||
| InParanoid | Q9CS84. | ||||||||||||||||||
| OMA | MGDQGKS. | ||||||||||||||||||
| OrthoDB | EOG41G339. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q9CS84. | ||||||||||||||||||
| Bgee | Q9CS84. | ||||||||||||||||||
| CleanEx | MM_NRXN1. | ||||||||||||||||||
| Genevestigator | Q9CS84. | ||||||||||||||||||
| GermOnline | ENSMUSG00000024109. Mus musculus. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. IPR006210. EGF-like. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR001791. Laminin_G. IPR012680. Laminin_G_2. IPR003585. Neurexin-like. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.60.120.200. ConA_like_subgrp. 6 hits. | ||||||||||||||||||
| KO | K07377. | ||||||||||||||||||
| Pfam | PF02210. Laminin_G_2. 6 hits. [Graphical view] | ||||||||||||||||||
| SMART | SM00294. 4.1m. 1 hit. SM00181. EGF. 3 hits. SM00282. LamG. 6 hits. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF49899. ConA_like_lec_gl. 6 hits. | ||||||||||||||||||
| PROSITE | PS00010. ASX_HYDROXYL. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. 3 hits. PS50025. LAM_G_DOMAIN. 6 hits. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 293528. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | NRX1A_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9CS84 Secondary accession number(s): O88722, Q80Y87, Q8CHE6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with