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Protein

Cactin

Gene

Cactin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processImmunity, Innate immunity, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Cactin
Gene namesi
Name:Cactin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917562 Cactin

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316181 – 772CactinAdd BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineCombined sources1
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498PhosphoserineBy similarity1
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei573PhosphotyrosineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CS00
MaxQBiQ9CS00
PaxDbiQ9CS00
PRIDEiQ9CS00

PTM databases

iPTMnetiQ9CS00
PhosphoSitePlusiQ9CS00

Expressioni

Tissue specificityi

Expressed in cortex, hippocampus, cerebellum, heart, lung, kidney, liver, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000034889
CleanExiMM_2510012J08RIK
ExpressionAtlasiQ9CS00 baseline and differential
GenevisibleiQ9CS00 MM

Interactioni

Subunit structurei

Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi213980, 1 interactor
IntActiQ9CS00, 1 interactor
MINTiQ9CS00
STRINGi10090.ENSMUSP00000059533

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili157 – 207Sequence analysisAdd BLAST51
Coiled coili247 – 299Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 101Arg-richAdd BLAST100

Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2370 Eukaryota
ENOG410XPKF LUCA
GeneTreeiENSGT00390000000097
HOGENOMiHOG000184070
HOVERGENiHBG079755
InParanoidiQ9CS00
OMAiNQTHYDT
OrthoDBiEOG091G08BK
PhylomeDBiQ9CS00
TreeFamiTF300906

Family and domain databases

InterProiView protein in InterPro
IPR019134 Cactin_C
IPR018816 Cactin_central
PfamiView protein in Pfam
PF10312 Cactin_mid, 1 hit
PF09732 CactinC_cactus, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CS00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAGRQMGR DSRSRSRSVG RRGRKQRSRS RGRSRSRSRS RSRSRSRSRS
60 70 80 90 100
RSRSHGRSSR RRREHERRRE RKRRSRGRRS DSEGEQRQKS RRRSQSLRPP
110 120 130 140 150
RWHSQNQSSC SDSGEERAQG SWARKGHRRS WSPGSSASSL DSPRRSRSPG
160 170 180 190 200
TATLALSQQQ SLQERLRLRE ERKQQEELLK AFETPEEKRA RRLAKKEAKE
210 220 230 240 250
RKKREKMGWG EEYMGYTNTD NPFGDNNLLG TFIWNKALEK KGISHLEEKE
260 270 280 290 300
LKERNKRIQE DNRLELQKVK QLRLEREREK AMREQELELL QREKEAEHFK
310 320 330 340 350
TWEEQEDSFH LRQAKLRSKI RIRDGRAKPI DLLAKYISAE DDDLAVEMHE
360 370 380 390 400
PYTFLNGLTV ADMEDLLEDI QVYMELEQGK NVDFWRDMTT ITEDEIAKLR
410 420 430 440 450
KLEASGKGPG ERREGVNASV SSDVQSVFKG KTYNQLQVIF QGIEGKIRAG
460 470 480 490 500
GPNLDMGYWE SLLQQLRAHM ARARLRERHQ DVLRQKLFKL KQEQGVESEP
510 520 530 540 550
LFPILKSEPS AAHSPEPEER PPSPGTSVDP VEPVEPEEAT APGEAEGEAE
560 570 580 590 600
GEAVLMEEDL IQQSLADYDA GRYSPRLLTA HELPLDAHVL EPHEDLQRLQ
610 620 630 640 650
LSRQQLQATG DASESAEDIF FRRAREGMGQ DEAQFSVEMP LGGRAYLWAD
660 670 680 690 700
KYRPRKPRFF NRVHTGFEWN KYNQTHYDFD NPPPKIVQGY KFNIFYPDLI
710 720 730 740 750
RKRATPEYFL EACADNRDFA ILRFHAGPPY EDIAFKIVSR EWEYSHRHGF
760 770
RCQFANGIFQ LWFHFKRYRY RR
Length:772
Mass (Da):90,661
Last modified:April 4, 2006 - v2
Checksum:i4A4C6DF15D077D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155937 Genomic DNA No translation available.
AK010963 mRNA Translation: BAB27295.1
CCDSiCCDS35995.1
RefSeqiNP_081657.1, NM_027381.2
UniGeneiMm.87628

Genome annotation databases

EnsembliENSMUST00000050867; ENSMUSP00000059533; ENSMUSG00000034889
GeneIDi70312
KEGGimmu:70312
UCSCiuc007ghf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCATIN_MOUSE
AccessioniPrimary (citable) accession number: Q9CS00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 28, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health