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Protein

Glycerophosphodiester phosphodiesterase domain-containing protein 1

Gene

Gdpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Divalent metal cationSequence analysis
Metal bindingi74 – 741Divalent metal cationSequence analysis
Metal bindingi87 – 871Divalent metal cationSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC:3.1.-.-)
Alternative name(s):
Glycerophosphodiester phosphodiesterase 4
Gene namesi
Name:Gdpd1
Synonyms:Gde4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913819. Gdpd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33ExtracellularSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 195171CytoplasmicSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 31498ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Glycerophosphodiester phosphodiesterase domain-containing protein 1PRO_0000251932Add
BLAST

Proteomic databases

MaxQBiQ9CRY7.
PaxDbiQ9CRY7.
PeptideAtlasiQ9CRY7.
PRIDEiQ9CRY7.

PTM databases

PhosphoSiteiQ9CRY7.

Expressioni

Gene expression databases

BgeeiQ9CRY7.
GenevisibleiQ9CRY7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020804.

Structurei

3D structure databases

ProteinModelPortaliQ9CRY7.
SMRiQ9CRY7. Positions 36-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 309270GP-PDEAdd
BLAST

Sequence similaritiesi

Contains 1 GP-PDE domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000046745.
HOGENOMiHOG000008170.
HOVERGENiHBG054611.
InParanoidiQ9CRY7.
OMAiQYRREHI.
OrthoDBiEOG77Q4X5.
PhylomeDBiQ9CRY7.
TreeFamiTF328545.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR004129. GlyceroP-diester-Pdiesterase.
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
[Graphical view]
PANTHERiPTHR23344. PTHR23344. 1 hit.
PfamiPF03009. GDPD. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS51704. GP_PDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CRY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAAFCLL STLGGYLVTS FLLLKYPALL HQRKKQRFLS RHISHRGGAG
60 70 80 90 100
ENLENTMAAF QHAVTIGTDM LELDCHITKD EQVVVSHDAN LKRSTGVNVN
110 120 130 140 150
VSDLKYCELP PYLCKLDVPF QRACKCEGKD TRIPLLKEVF EAFPETPINI
160 170 180 190 200
DIKVNNNVLI KKVSELVKQY KREHLTVWGN ANSEIVDKCY KENSDIPILF
210 220 230 240 250
SLQRVLLILG LFFTGLLPFV PIREQFFEIP MPSIILKLKE PHTISKGHKF
260 270 280 290 300
LIWLSDTLLM RKALFDHLTA RGIQVYVWVL NEEYEYKRAF DLGATGVMTD
310
YPTKLKDFLN NFSA
Length:314
Mass (Da):35,867
Last modified:June 1, 2001 - v1
Checksum:iAEDB140CB872A00C
GO

Sequence cautioni

The sequence BAB27650.1 differs from that shown. Reason: Frameshift at position 55. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091L → I in BAB27650 (PubMed:16141072).Curated
Sequence conflicti296 – 2961G → R in BAB30083 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011487 mRNA. Translation: BAB27650.1. Frameshift.
AK013864 mRNA. Translation: BAB29022.1.
AK016023 mRNA. Translation: BAB30083.1.
AK167812 mRNA. Translation: BAE39839.1.
AL713917 Genomic DNA. Translation: CAI25312.1.
BC016541 mRNA. Translation: AAH16541.1.
CCDSiCCDS25206.1.
RefSeqiNP_079914.1. NM_025638.2.
XP_006534007.1. XM_006533944.2.
UniGeneiMm.281887.
Mm.475327.
Mm.491118.

Genome annotation databases

EnsembliENSMUST00000020804; ENSMUSP00000020804; ENSMUSG00000061666.
GeneIDi66569.
KEGGimmu:66569.
UCSCiuc007kte.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011487 mRNA. Translation: BAB27650.1. Frameshift.
AK013864 mRNA. Translation: BAB29022.1.
AK016023 mRNA. Translation: BAB30083.1.
AK167812 mRNA. Translation: BAE39839.1.
AL713917 Genomic DNA. Translation: CAI25312.1.
BC016541 mRNA. Translation: AAH16541.1.
CCDSiCCDS25206.1.
RefSeqiNP_079914.1. NM_025638.2.
XP_006534007.1. XM_006533944.2.
UniGeneiMm.281887.
Mm.475327.
Mm.491118.

3D structure databases

ProteinModelPortaliQ9CRY7.
SMRiQ9CRY7. Positions 36-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020804.

PTM databases

PhosphoSiteiQ9CRY7.

Proteomic databases

MaxQBiQ9CRY7.
PaxDbiQ9CRY7.
PeptideAtlasiQ9CRY7.
PRIDEiQ9CRY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020804; ENSMUSP00000020804; ENSMUSG00000061666.
GeneIDi66569.
KEGGimmu:66569.
UCSCiuc007kte.2. mouse.

Organism-specific databases

CTDi284161.
MGIiMGI:1913819. Gdpd1.

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000046745.
HOGENOMiHOG000008170.
HOVERGENiHBG054611.
InParanoidiQ9CRY7.
OMAiQYRREHI.
OrthoDBiEOG77Q4X5.
PhylomeDBiQ9CRY7.
TreeFamiTF328545.

Enzyme and pathway databases

ReactomeiR-MMU-6814848. Glycerophospholipid catabolism.

Miscellaneous databases

ChiTaRSiGdpd1. mouse.
PROiQ9CRY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CRY7.
GenevisibleiQ9CRY7. MM.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR004129. GlyceroP-diester-Pdiesterase.
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
[Graphical view]
PANTHERiPTHR23344. PTHR23344. 1 hit.
PfamiPF03009. GDPD. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS51704. GP_PDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Embryo, Embryonic head and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGDPD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CRY7
Secondary accession number(s): Q9CT14, Q9D4X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.