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Protein

Glycerophosphodiester phosphodiesterase domain-containing protein 1

Gene

Gdpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi72Divalent metal cationSequence analysis1
Metal bindingi74Divalent metal cationSequence analysis1
Metal bindingi87Divalent metal cationSequence analysis1

GO - Molecular functioni

  • lysophospholipase activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • phosphoric diester hydrolase activity Source: MGI

GO - Biological processi

  • glycerophospholipid catabolic process Source: Reactome
  • N-acylethanolamine metabolic process Source: MGI
  • phospholipid metabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC:3.1.-.-)
Alternative name(s):
Glycerophosphodiester phosphodiesterase 4
Gene namesi
Name:Gdpd1
Synonyms:Gde4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913819. Gdpd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3ExtracellularSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 195CytoplasmicSequence analysisAdd BLAST171
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 314ExtracellularSequence analysisAdd BLAST98

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002519321 – 314Glycerophosphodiester phosphodiesterase domain-containing protein 1Add BLAST314

Proteomic databases

MaxQBiQ9CRY7.
PaxDbiQ9CRY7.
PeptideAtlasiQ9CRY7.
PRIDEiQ9CRY7.

PTM databases

PhosphoSitePlusiQ9CRY7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061666.
GenevisibleiQ9CRY7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020804.

Structurei

3D structure databases

ProteinModelPortaliQ9CRY7.
SMRiQ9CRY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 309GP-PDEAdd BLAST270

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000046745.
HOGENOMiHOG000008170.
HOVERGENiHBG054611.
InParanoidiQ9CRY7.
OMAiRVCVGSF.
OrthoDBiEOG091G0G89.
PhylomeDBiQ9CRY7.
TreeFamiTF328545.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
PfamiView protein in Pfam
PF03009. GDPD. 1 hit.
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiView protein in PROSITE
PS51704. GP_PDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CRY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAAFCLL STLGGYLVTS FLLLKYPALL HQRKKQRFLS RHISHRGGAG
60 70 80 90 100
ENLENTMAAF QHAVTIGTDM LELDCHITKD EQVVVSHDAN LKRSTGVNVN
110 120 130 140 150
VSDLKYCELP PYLCKLDVPF QRACKCEGKD TRIPLLKEVF EAFPETPINI
160 170 180 190 200
DIKVNNNVLI KKVSELVKQY KREHLTVWGN ANSEIVDKCY KENSDIPILF
210 220 230 240 250
SLQRVLLILG LFFTGLLPFV PIREQFFEIP MPSIILKLKE PHTISKGHKF
260 270 280 290 300
LIWLSDTLLM RKALFDHLTA RGIQVYVWVL NEEYEYKRAF DLGATGVMTD
310
YPTKLKDFLN NFSA
Length:314
Mass (Da):35,867
Last modified:June 1, 2001 - v1
Checksum:iAEDB140CB872A00C
GO

Sequence cautioni

The sequence BAB27650 differs from that shown. Reason: Frameshift at position 55.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → I in BAB27650 (PubMed:16141072).Curated1
Sequence conflicti296G → R in BAB30083 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011487 mRNA. Translation: BAB27650.1. Frameshift.
AK013864 mRNA. Translation: BAB29022.1.
AK016023 mRNA. Translation: BAB30083.1.
AK167812 mRNA. Translation: BAE39839.1.
AL713917 Genomic DNA. Translation: CAI25312.1.
BC016541 mRNA. Translation: AAH16541.1.
CCDSiCCDS25206.1.
RefSeqiNP_079914.1. NM_025638.2.
UniGeneiMm.281887.
Mm.475327.
Mm.491118.

Genome annotation databases

EnsembliENSMUST00000020804; ENSMUSP00000020804; ENSMUSG00000061666.
GeneIDi66569.
KEGGimmu:66569.
UCSCiuc007kte.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGDPD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CRY7
Secondary accession number(s): Q9CT14, Q9D4X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families