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Protein

Exportin-T

Gene

Xpot

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
tRNA exportin
Gene namesi
Name:Xpot
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920442. Xpot.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Exportin-TPRO_0000204717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei635 – 6351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CRT8.
MaxQBiQ9CRT8.
PaxDbiQ9CRT8.
PeptideAtlasiQ9CRT8.
PRIDEiQ9CRT8.

PTM databases

iPTMnetiQ9CRT8.
PhosphoSiteiQ9CRT8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034667.
GenevisibleiQ9CRT8. MM.

Interactioni

Subunit structurei

Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CRT8. 5 interactions.
MINTiMINT-1770319.
STRINGi10090.ENSMUSP00000043488.

Structurei

3D structure databases

ProteinModelPortaliQ9CRT8.
SMRiQ9CRT8. Positions 8-962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG2021. Eukaryota.
ENOG410XZDZ. LUCA.
GeneTreeiENSGT00390000007890.
HOGENOMiHOG000007104.
HOVERGENiHBG094163.
InParanoidiQ9CRT8.
OMAiMRYDETS.
OrthoDBiEOG091G04A1.
PhylomeDBiQ9CRT8.
TreeFamiTF314001.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9CRT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQKTYSDD
60 70 80 90 100
HVKFFCFQVL EHQVKYKYSE LSTAQQQLIR ETLLSWLQAQ MQNPQPEKTF
110 120 130 140 150
IRNKAAQVFA LLFVTEYLTK WPKFFFDILS VVDLNPRGVD LYLRILMAID
160 170 180 190 200
SELVDRDVVH TSEASGLENT LIKDTMREQC IPNLVESWYQ ILHNYQYTNS
210 220 230 240 250
EVLCQCLEVV GAYVSWIDLS LIANDRFINM LLGHMSVEVL REEACDCLFE
260 270 280 290 300
IVNKGMDPVD KMKLVESLCQ VLQTAGFFSI DQEEDLDFVA RFSKLVNGMG
310 320 330 340 350
QSLIVSWTKL IKNGAVKNAQ EALEAIETKV PLMLQLLVHE DDDISSNIIG
360 370 380 390 400
FCYDYLHILK QLPVLSDQQK ANVEAIMLAV MKKLTYDEEY NFENEGEDEA
410 420 430 440 450
MFVEYRKQLK LLLDRLAQVS PELVLASVRR VFSATLQNWQ TTRFMEVEVA
460 470 480 490 500
VRLLYMLAEA LPVSHGAHFS GDVSKASALQ DMMRTLVTSG VSSYQHTSVT
510 520 530 540 550
LEFFETVVRY EKFFTVEPQH IPCVLMAFLD HRGLWHSSAK VRSRTAYLFS
560 570 580 590 600
RFVKSLNKQM NPYIEEILNR IQDLLALSPP ENGYQSLLSS DDQLFIYETA
610 620 630 640 650
GALIVNSEYP AENKQALMKD LLTPLMERFK VLLEKLMMAQ DEERQASLAD
660 670 680 690 700
SLNHAVGFAS RTSKAFSNKQ TVKQCGCSQV YLDCLQTFLP ALSCPLQKDV
710 720 730 740 750
LRSGVRTFLH RMIICLEEEV LPFIPSASEH MLKDCEAKDL QEFIPLINQI
760 770 780 790 800
TAKFKMQVSP FLQQMFMPLL HAIFEVLLRP AEDNDQSAAL EKQMLRRSYF
810 820 830 840 850
AFLQTVTGSG MSEVIANQGA ENVEQVLVTI IQGAVDYPDP IAQKTCFIIL
860 870 880 890 900
SKLVELWGGK DGPVGFADFV YKHIVPACFL APLKQTFDLA DAQTVLALSE
910 920 930 940 950
CAVTLKTIHL KRGPECVQYL QQEYLPSLQV APEIIQEFCQ ALQQPDAKVF
960
KNYLKVFFQR AKP
Length:963
Mass (Da):109,734
Last modified:January 9, 2007 - v3
Checksum:iEE600F41FBF3A9C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti726 – 7261S → T in BAB29220 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124992 Genomic DNA. No translation available.
BC094337 mRNA. Translation: AAH94337.1.
AK014235 mRNA. Translation: BAB29220.1.
UniGeneiMm.25042.

Genome annotation databases

EnsembliENSMUST00000039810; ENSMUSP00000043488; ENSMUSG00000034667.
UCSCiuc007hfv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124992 Genomic DNA. No translation available.
BC094337 mRNA. Translation: AAH94337.1.
AK014235 mRNA. Translation: BAB29220.1.
UniGeneiMm.25042.

3D structure databases

ProteinModelPortaliQ9CRT8.
SMRiQ9CRT8. Positions 8-962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CRT8. 5 interactions.
MINTiMINT-1770319.
STRINGi10090.ENSMUSP00000043488.

PTM databases

iPTMnetiQ9CRT8.
PhosphoSiteiQ9CRT8.

Proteomic databases

EPDiQ9CRT8.
MaxQBiQ9CRT8.
PaxDbiQ9CRT8.
PeptideAtlasiQ9CRT8.
PRIDEiQ9CRT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039810; ENSMUSP00000043488; ENSMUSG00000034667.
UCSCiuc007hfv.1. mouse.

Organism-specific databases

MGIiMGI:1920442. Xpot.

Phylogenomic databases

eggNOGiKOG2021. Eukaryota.
ENOG410XZDZ. LUCA.
GeneTreeiENSGT00390000007890.
HOGENOMiHOG000007104.
HOVERGENiHBG094163.
InParanoidiQ9CRT8.
OMAiMRYDETS.
OrthoDBiEOG091G04A1.
PhylomeDBiQ9CRT8.
TreeFamiTF314001.

Miscellaneous databases

PROiQ9CRT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034667.
GenevisibleiQ9CRT8. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiXPOT_MOUSE
AccessioniPrimary (citable) accession number: Q9CRT8
Secondary accession number(s): Q52KI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.