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Q9CRR2 (Q9CRR2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Adrb1 MGI 87937
OrganismMus musculus (Mouse) EMBL BAB31185.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length405 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS002233
Membrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS002233
   Molecular functionG-protein coupled receptor RuleBase RU000688 SAAS SAAS002233
Receptor
Transducer
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 8693001. Source: MGI

adrenergic receptor signaling pathway

Inferred from direct assay PubMed 7738011PubMed 9305915. Source: GOC

brown fat cell differentiation

Inferred from genetic interaction PubMed 12387862. Source: MGI

diet induced thermogenesis

Inferred from genetic interaction PubMed 12161655. Source: MGI

fear response

Inferred from mutant phenotype PubMed 15066288. Source: MGI

heat generation

Inferred from genetic interaction PubMed 12161655. Source: MGI

negative regulation of multicellular organism growth

Inferred from genetic interaction PubMed 12387862. Source: MGI

positive regulation of heart rate by epinephrine-norepinephrine

Inferred from mutant phenotype PubMed 10358009PubMed 8693001. Source: MGI

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Inferred from direct assay PubMed 7761854. Source: MGI

response to cold

Inferred from genetic interaction PubMed 12161655PubMed 12387862. Source: MGI

vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 10358009PubMed 11641423. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from mutant phenotype PubMed 8693001. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta1-adrenergic receptor activity

Inferred from direct assay PubMed 7738011PubMed 9305915. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAB31185.1

Sequences

Sequence LengthMass (Da)Tools
Q9CRR2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4F0F3FBB956EF2F4

FASTA40544,742
        10         20         30         40         50         60 
GLQLALIVLL IVVGNVLVIV AIAKTPRLQT LTNLFIMSLA SADLVMGLLV VPFGATIVVW 

        70         80         90        100        110        120 
GRWEYGSFFC ELWTSVDVLC VTASIETLCV IALDRYLAIT SPFRYQSLLT RARARALVCT 

       130        140        150        160        170        180 
VWAISALVSF LPILMHWWRA ESDEARRCYN DPKCCDFVTN RAYAIASSVV SFYVPLCIMA 

       190        200        210        220        230        240 
FVYLRVFREA QKQVKKIDSC ERRFLGGPAR PPSPEPSPSP GPPRPADSLA NGRSSKRRPS 

       250        260        270        280        290        300 
RLVALREQKA LKTLGIIMGV FTLCWLPFFL ANVVKAFHRD LVPDRLFVFF NWLGYANSAF 

       310        320        330        340        350        360 
NPIIYCRSPD FRKAFQRLLC CARRAACRRR AAHGDRPRAS GCLARAGPPP SPGAPSDDDD 

       370        380        390        400 
DDAGTTPPAR LLEPWTGCNG GTTTVDSDSS LDEPGRQGFS SESKV 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB31185.1.
Tissue: Lung EMBL BAB31185.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK018378 mRNA. Translation: BAB31185.1.
UniGeneMm.46797.

3D structure databases

ProteinModelPortalQ9CRR2.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:87937. Adrb1.

Phylogenomic databases

HOVERGENHBG106962.
InParanoidQ9CRR2.

Gene expression databases

GenevestigatorQ9CRR2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248. PTHR24248. 1 hit.
PTHR24248:SF3. PTHR24248:SF3. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ9CRR2_MOUSE
AccessionPrimary (citable) accession number: Q9CRR2
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)