Q9CRR2 (Q9CRR2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAB31185.1

Gene names

Name:

Adrb1 MGI 87937

Organism

Mus musculus (Mouse) EMBL BAB31185.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	405 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Cell membrane SAAS SAAS002233 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS002233
Molecular function	G-protein coupled receptor RuleBase RU000688 SAAS SAAS002233 Receptor Transducer
Gene Ontology (GO)
Biological_process	adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 8693001. Source: MGI brown fat cell differentiation Inferred from genetic interaction PubMed 12387862. Source: MGI diet induced thermogenesis Inferred from genetic interaction PubMed 12161655. Source: MGI fear response Inferred from mutant phenotype PubMed 15066288. Source: MGI heat generation Inferred from genetic interaction PubMed 12161655. Source: MGI negative regulation of multicellular organism growth Inferred from genetic interaction PubMed 12387862. Source: MGI positive regulation of heart rate by epinephrine-norepinephrine Inferred from mutant phenotype PubMed 10358009PubMed 8693001. Source: MGI positive regulation of the force of heart contraction by epinephrine-norepinephrine Inferred from direct assay PubMed 7761854. Source: MGI response to cold Inferred from genetic interaction PubMed 12161655PubMed 12387862. Source: MGI vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure Inferred from mutant phenotype PubMed 10358009PubMed 11641423. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from mutant phenotype PubMed 8693001. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta1-adrenergic receptor activity Inferred from direct assay PubMed 7738011PubMed 9305915. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAB31185.1

Sequences

	Sequence		Length	Mass (Da)
	Q9CRR2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4F0F3FBB956EF2F4	FASTA	405	44,742
	10 20 30 40 50 60 GLQLALIVLL IVVGNVLVIV AIAKTPRLQT LTNLFIMSLA SADLVMGLLV VPFGATIVVW 70 80 90 100 110 120 GRWEYGSFFC ELWTSVDVLC VTASIETLCV IALDRYLAIT SPFRYQSLLT RARARALVCT 130 140 150 160 170 180 VWAISALVSF LPILMHWWRA ESDEARRCYN DPKCCDFVTN RAYAIASSVV SFYVPLCIMA 190 200 210 220 230 240 FVYLRVFREA QKQVKKIDSC ERRFLGGPAR PPSPEPSPSP GPPRPADSLA NGRSSKRRPS 250 260 270 280 290 300 RLVALREQKA LKTLGIIMGV FTLCWLPFFL ANVVKAFHRD LVPDRLFVFF NWLGYANSAF 310 320 330 340 350 360 NPIIYCRSPD FRKAFQRLLC CARRAACRRR AAHGDRPRAS GCLARAGPPP SPGAPSDDDD 370 380 390 400 DDAGTTPPAR LLEPWTGCNG GTTTVDSDSS LDEPGRQGFS SESKV

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[4]	Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB31185.1. Tissue: Lung EMBL BAB31185.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK018378 mRNA. Translation: BAB31185.1.
IPI	IPI00119827.
UniGene	Mm.46797.
3D structure databases
ProteinModelPortal	Q9CRR2.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:87937. Adrb1.
Phylogenomic databases
HOVERGEN	HBG106962.
InParanoid	Q9CRR2.
Gene expression databases
Genevestigator	Q9CRR2.
Family and domain databases
InterPro	IPR000507. Adrgc_rcpt_B1. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00561. ADRENRGCB1AR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q9CRR2_MOUSE

Accession

Primary (citable) accession number: Q9CRR2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)