Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER membrane protein complex subunit 2

Gene

Emc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:Emc2
Synonyms:Kiaa0103, Ttc35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913986. Emc2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • ER membrane protein complex Source: UniProtKB
  • mitochondrion Source: MGI
  • nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000106354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei255 – 2551N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CRD2.
PaxDbiQ9CRD2.
PRIDEiQ9CRD2.

PTM databases

PhosphoSiteiQ9CRD2.

Expressioni

Gene expression databases

BgeeiQ9CRD2.
CleanExiMM_TTC35.
ExpressionAtlasiQ9CRD2. baseline and differential.
GenevisibleiQ9CRD2. MM.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).By similarity

Protein-protein interaction databases

BioGridi211681. 1 interaction.
IntActiQ9CRD2. 1 interaction.
STRINGi10090.ENSMUSP00000022962.

Structurei

3D structure databases

ProteinModelPortaliQ9CRD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati192 – 22534TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the EMC2 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG236229.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ9CRD2.
OMAiVWEYLCL.
OrthoDBiEOG7QK0C9.
PhylomeDBiQ9CRD2.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 2 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKTVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK
260 270 280 290
KDNIKYASWA ANQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,935
Last modified:June 1, 2001 - v1
Checksum:i009366B7A3B5BCEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015968 mRNA. Translation: BAB30057.1.
AK014989 mRNA. Translation: BAB29657.1.
BC004716 mRNA. Translation: AAH04716.1.
AF332065 mRNA. Translation: AAK56094.1.
CCDSiCCDS27453.1.
RefSeqiNP_080012.1. NM_025736.2.
UniGeneiMm.244512.

Genome annotation databases

EnsembliENSMUST00000022962; ENSMUSP00000022962; ENSMUSG00000022337.
GeneIDi66736.
KEGGimmu:66736.
UCSCiuc007vpm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015968 mRNA. Translation: BAB30057.1.
AK014989 mRNA. Translation: BAB29657.1.
BC004716 mRNA. Translation: AAH04716.1.
AF332065 mRNA. Translation: AAK56094.1.
CCDSiCCDS27453.1.
RefSeqiNP_080012.1. NM_025736.2.
UniGeneiMm.244512.

3D structure databases

ProteinModelPortaliQ9CRD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211681. 1 interaction.
IntActiQ9CRD2. 1 interaction.
STRINGi10090.ENSMUSP00000022962.

PTM databases

PhosphoSiteiQ9CRD2.

Proteomic databases

MaxQBiQ9CRD2.
PaxDbiQ9CRD2.
PRIDEiQ9CRD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022962; ENSMUSP00000022962; ENSMUSG00000022337.
GeneIDi66736.
KEGGimmu:66736.
UCSCiuc007vpm.1. mouse.

Organism-specific databases

CTDi9694.
MGIiMGI:1913986. Emc2.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG236229.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ9CRD2.
OMAiVWEYLCL.
OrthoDBiEOG7QK0C9.
PhylomeDBiQ9CRD2.
TreeFamiTF312997.

Miscellaneous databases

NextBioi322511.
PROiQ9CRD2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CRD2.
CleanExiMM_TTC35.
ExpressionAtlasiQ9CRD2. baseline and differential.
GenevisibleiQ9CRD2. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 2 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-297.
    Strain: ISS.
  4. "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane."
    Dreger M., Bengtsson L., Schoeneberg T., Otto H., Hucho F.
    Proc. Natl. Acad. Sci. U.S.A. 98:11943-11948(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiEMC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CRD2
Secondary accession number(s): Q925K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.