SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CRD2

- EMC2_MOUSE

UniProt

Q9CRD2 - EMC2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
ER membrane protein complex subunit 2
Gene
Emc2, Kiaa0103, Ttc35
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:Emc2
Synonyms:Kiaa0103, Ttc35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913986. Emc2.

Subcellular locationi

Nucleus. Cytoplasm By similarity 1 Publication

GO - Cellular componenti

  1. ER membrane protein complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. mitochondrion Source: MGI
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 297296ER membrane protein complex subunit 2
PRO_0000106354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei255 – 2551N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CRD2.
PaxDbiQ9CRD2.
PRIDEiQ9CRD2.

PTM databases

PhosphoSiteiQ9CRD2.

Expressioni

Gene expression databases

BgeeiQ9CRD2.
CleanExiMM_TTC35.
GenevestigatoriQ9CRD2.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC) By similarity.

Protein-protein interaction databases

BioGridi211681. 1 interaction.
IntActiQ9CRD2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9CRD2.
SMRiQ9CRD2. Positions 121-220, 267-295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034TPR 1
Add
BLAST
Repeati155 – 18834TPR 2
Add
BLAST
Repeati192 – 22534TPR 3
Add
BLAST

Sequence similaritiesi

Belongs to the EMC2 family.
Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG236229.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ9CRD2.
OMAiQGKNLEA.
OrthoDBiEOG7QK0C9.
PhylomeDBiQ9CRD2.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 2 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRD2-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD    50
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM 100
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKTVEA IRELNEYLEQ 150
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY 200
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK 250
KDNIKYASWA ANQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS 297
Length:297
Mass (Da):34,935
Last modified:June 1, 2001 - v1
Checksum:i009366B7A3B5BCEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK015968 mRNA. Translation: BAB30057.1.
AK014989 mRNA. Translation: BAB29657.1.
BC004716 mRNA. Translation: AAH04716.1.
AF332065 mRNA. Translation: AAK56094.1.
CCDSiCCDS27453.1.
RefSeqiNP_080012.1. NM_025736.2.
UniGeneiMm.244512.

Genome annotation databases

EnsembliENSMUST00000022962; ENSMUSP00000022962; ENSMUSG00000022337.
GeneIDi66736.
KEGGimmu:66736.
UCSCiuc007vpm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK015968 mRNA. Translation: BAB30057.1 .
AK014989 mRNA. Translation: BAB29657.1 .
BC004716 mRNA. Translation: AAH04716.1 .
AF332065 mRNA. Translation: AAK56094.1 .
CCDSi CCDS27453.1.
RefSeqi NP_080012.1. NM_025736.2.
UniGenei Mm.244512.

3D structure databases

ProteinModelPortali Q9CRD2.
SMRi Q9CRD2. Positions 121-220, 267-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211681. 1 interaction.
IntActi Q9CRD2. 1 interaction.

PTM databases

PhosphoSitei Q9CRD2.

Proteomic databases

MaxQBi Q9CRD2.
PaxDbi Q9CRD2.
PRIDEi Q9CRD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022962 ; ENSMUSP00000022962 ; ENSMUSG00000022337 .
GeneIDi 66736.
KEGGi mmu:66736.
UCSCi uc007vpm.1. mouse.

Organism-specific databases

CTDi 9694.
MGIi MGI:1913986. Emc2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG236229.
GeneTreei ENSGT00390000011922.
HOGENOMi HOG000007547.
HOVERGENi HBG055231.
InParanoidi Q9CRD2.
OMAi QGKNLEA.
OrthoDBi EOG7QK0C9.
PhylomeDBi Q9CRD2.
TreeFami TF312997.

Miscellaneous databases

NextBioi 322511.
PROi Q9CRD2.
SOURCEi Search...

Gene expression databases

Bgeei Q9CRD2.
CleanExi MM_TTC35.
Genevestigatori Q9CRD2.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF07719. TPR_2. 2 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-297.
    Strain: ISS.
  4. "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane."
    Dreger M., Bengtsson L., Schoeneberg T., Otto H., Hucho F.
    Proc. Natl. Acad. Sci. U.S.A. 98:11943-11948(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiEMC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CRD2
Secondary accession number(s): Q925K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi