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Q9CRD2

- EMC2_MOUSE

UniProt

Q9CRD2 - EMC2_MOUSE

Protein

ER membrane protein complex subunit 2

Gene

Emc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER membrane protein complex subunit 2
    Alternative name(s):
    Tetratricopeptide repeat protein 35
    Short name:
    TPR repeat protein 35
    Gene namesi
    Name:Emc2
    Synonyms:Kiaa0103, Ttc35
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913986. Emc2.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. ER membrane protein complex Source: UniProtKB
    4. mitochondrion Source: MGI
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000106354Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei255 – 2551N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CRD2.
    PaxDbiQ9CRD2.
    PRIDEiQ9CRD2.

    PTM databases

    PhosphoSiteiQ9CRD2.

    Expressioni

    Gene expression databases

    BgeeiQ9CRD2.
    CleanExiMM_TTC35.
    GenevestigatoriQ9CRD2.

    Interactioni

    Subunit structurei

    Component of the ER membrane protein complex (EMC).By similarity

    Protein-protein interaction databases

    BioGridi211681. 1 interaction.
    IntActiQ9CRD2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CRD2.
    SMRiQ9CRD2. Positions 121-220, 267-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati87 – 12034TPR 1Add
    BLAST
    Repeati155 – 18834TPR 2Add
    BLAST
    Repeati192 – 22534TPR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the EMC2 family.Curated
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG236229.
    GeneTreeiENSGT00390000011922.
    HOGENOMiHOG000007547.
    HOVERGENiHBG055231.
    InParanoidiQ9CRD2.
    OMAiQGKNLEA.
    OrthoDBiEOG7QK0C9.
    PhylomeDBiQ9CRD2.
    TreeFamiTF312997.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF07719. TPR_2. 2 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CRD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD    50
    DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM 100
    ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKTVEA IRELNEYLEQ 150
    FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY 200
    TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK 250
    KDNIKYASWA ANQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS 297
    Length:297
    Mass (Da):34,935
    Last modified:June 1, 2001 - v1
    Checksum:i009366B7A3B5BCEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015968 mRNA. Translation: BAB30057.1.
    AK014989 mRNA. Translation: BAB29657.1.
    BC004716 mRNA. Translation: AAH04716.1.
    AF332065 mRNA. Translation: AAK56094.1.
    CCDSiCCDS27453.1.
    RefSeqiNP_080012.1. NM_025736.2.
    UniGeneiMm.244512.

    Genome annotation databases

    EnsembliENSMUST00000022962; ENSMUSP00000022962; ENSMUSG00000022337.
    GeneIDi66736.
    KEGGimmu:66736.
    UCSCiuc007vpm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015968 mRNA. Translation: BAB30057.1 .
    AK014989 mRNA. Translation: BAB29657.1 .
    BC004716 mRNA. Translation: AAH04716.1 .
    AF332065 mRNA. Translation: AAK56094.1 .
    CCDSi CCDS27453.1.
    RefSeqi NP_080012.1. NM_025736.2.
    UniGenei Mm.244512.

    3D structure databases

    ProteinModelPortali Q9CRD2.
    SMRi Q9CRD2. Positions 121-220, 267-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211681. 1 interaction.
    IntActi Q9CRD2. 1 interaction.

    PTM databases

    PhosphoSitei Q9CRD2.

    Proteomic databases

    MaxQBi Q9CRD2.
    PaxDbi Q9CRD2.
    PRIDEi Q9CRD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022962 ; ENSMUSP00000022962 ; ENSMUSG00000022337 .
    GeneIDi 66736.
    KEGGi mmu:66736.
    UCSCi uc007vpm.1. mouse.

    Organism-specific databases

    CTDi 9694.
    MGIi MGI:1913986. Emc2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG236229.
    GeneTreei ENSGT00390000011922.
    HOGENOMi HOG000007547.
    HOVERGENi HBG055231.
    InParanoidi Q9CRD2.
    OMAi QGKNLEA.
    OrthoDBi EOG7QK0C9.
    PhylomeDBi Q9CRD2.
    TreeFami TF312997.

    Miscellaneous databases

    NextBioi 322511.
    PROi Q9CRD2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CRD2.
    CleanExi MM_TTC35.
    Genevestigatori Q9CRD2.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF07719. TPR_2. 2 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-297.
      Strain: ISS.
    4. "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane."
      Dreger M., Bengtsson L., Schoeneberg T., Otto H., Hucho F.
      Proc. Natl. Acad. Sci. U.S.A. 98:11943-11948(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiEMC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CRD2
    Secondary accession number(s): Q925K1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3