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Protein

MICOS complex subunit Mic19

Gene

Chchd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic19
Alternative name(s):
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
Gene namesi
Name:Chchd3
Synonyms:Mic19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913325. Chchd3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • MICOS complex Source: MGI
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 227226MICOS complex subunit Mic19PRO_0000129164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei29 – 291PhosphoserineCombined sources
Modified residuei49 – 491PhosphotyrosineBy similarity
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CRB9.
MaxQBiQ9CRB9.
PaxDbiQ9CRB9.
PeptideAtlasiQ9CRB9.
PRIDEiQ9CRB9.
TopDownProteomicsiQ9CRB9.

PTM databases

iPTMnetiQ9CRB9.
PhosphoSiteiQ9CRB9.
SwissPalmiQ9CRB9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053768.
ExpressionAtlasiQ9CRB9. baseline and differential.
GenevisibleiQ9CRB9. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). Found in a complex with IMMT/MIC60 and SAMM50 termed mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form.By similarity1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein complex scaffold Source: UniProtKB

Protein-protein interaction databases

BioGridi211197. 3 interactions.
IntActiQ9CRB9. 6 interactions.
MINTiMINT-4125142.
STRINGi10090.ENSMUSP00000070149.

Structurei

3D structure databases

ProteinModelPortaliQ9CRB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 21742CHCHAdd
BLAST

Sequence similaritiesi

Contains 1 CHCH domain.Curated

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ9CRB9.
KOiK17563.
OMAiQYMRCVN.
OrthoDBiEOG091G173O.
PhylomeDBiQ9CRB9.
TreeFamiTF326279.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTASTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS
60 70 80 90 100
SVYGASVSDE DLKRRVAEEL ALEQAKKESE HQRRLKQARD LERERAAANE
110 120 130 140 150
QLTRAVLRER ISSEEERMKA KHLARQLEEK DRVMRKQDAF YKEQLARLEE
160 170 180 190 200
RSSEFYKVTT EEYQKAAEEV EAKFKRYEYH PVCADLQTKI LQCYRQNTQQ
210 220
TLSCSALASQ YMHCVNHAKQ SMLEKGG
Length:227
Mass (Da):26,335
Last modified:June 1, 2001 - v1
Checksum:i055B1AF5A6DB808E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002263 mRNA. Translation: BAB21974.1.
AK003519 mRNA. Translation: BAB22832.1.
BC021941 mRNA. Translation: AAH21941.1.
CCDSiCCDS19986.1.
RefSeqiNP_079612.1. NM_025336.1.
UniGeneiMm.21501.

Genome annotation databases

EnsembliENSMUST00000066379; ENSMUSP00000070149; ENSMUSG00000053768.
GeneIDi66075.
KEGGimmu:66075.
UCSCiuc009bgo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002263 mRNA. Translation: BAB21974.1.
AK003519 mRNA. Translation: BAB22832.1.
BC021941 mRNA. Translation: AAH21941.1.
CCDSiCCDS19986.1.
RefSeqiNP_079612.1. NM_025336.1.
UniGeneiMm.21501.

3D structure databases

ProteinModelPortaliQ9CRB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211197. 3 interactions.
IntActiQ9CRB9. 6 interactions.
MINTiMINT-4125142.
STRINGi10090.ENSMUSP00000070149.

PTM databases

iPTMnetiQ9CRB9.
PhosphoSiteiQ9CRB9.
SwissPalmiQ9CRB9.

Proteomic databases

EPDiQ9CRB9.
MaxQBiQ9CRB9.
PaxDbiQ9CRB9.
PeptideAtlasiQ9CRB9.
PRIDEiQ9CRB9.
TopDownProteomicsiQ9CRB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066379; ENSMUSP00000070149; ENSMUSG00000053768.
GeneIDi66075.
KEGGimmu:66075.
UCSCiuc009bgo.1. mouse.

Organism-specific databases

CTDi54927.
MGIiMGI:1913325. Chchd3.

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ9CRB9.
KOiK17563.
OMAiQYMRCVN.
OrthoDBiEOG091G173O.
PhylomeDBiQ9CRB9.
TreeFamiTF326279.

Miscellaneous databases

ChiTaRSiChchd3. mouse.
PROiQ9CRB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053768.
ExpressionAtlasiQ9CRB9. baseline and differential.
GenevisibleiQ9CRB9. MM.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIC19_MOUSE
AccessioniPrimary (citable) accession number: Q9CRB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.