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Protein

MICOS complex subunit Mic19

Gene

Chchd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic19
Alternative name(s):
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
Gene namesi
Name:Chchd3
Synonyms:Mic19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913325. Chchd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001291642 – 227MICOS complex subunit Mic19Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei29PhosphoserineCombined sources1
Modified residuei49PhosphotyrosineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1
Disulfide bondi183 ↔ 214PROSITE-ProRule annotation
Disulfide bondi193 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CRB9.
MaxQBiQ9CRB9.
PaxDbiQ9CRB9.
PeptideAtlasiQ9CRB9.
PRIDEiQ9CRB9.
TopDownProteomicsiQ9CRB9.

PTM databases

iPTMnetiQ9CRB9.
PhosphoSitePlusiQ9CRB9.
SwissPalmiQ9CRB9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053768.
ExpressionAtlasiQ9CRB9. baseline and differential.
GenevisibleiQ9CRB9. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form.By similarity1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi211197. 3 interactors.
IntActiQ9CRB9. 6 interactors.
MINTiMINT-4125142.
STRINGi10090.ENSMUSP00000070149.

Structurei

3D structure databases

ProteinModelPortaliQ9CRB9.
SMRiQ9CRB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 222CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 193Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi204 – 214Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ9CRB9.
KOiK17563.
OMAiQYMRCVN.
OrthoDBiEOG091G173O.
PhylomeDBiQ9CRB9.
TreeFamiTF326279.

Family and domain databases

InterProiView protein in InterPro
IPR007964. MIC19/MIC25.
PfamiView protein in Pfam
PF05300. DUF737. 2 hits.
PROSITEiView protein in PROSITE
PS51808. CHCH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTASTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS
60 70 80 90 100
SVYGASVSDE DLKRRVAEEL ALEQAKKESE HQRRLKQARD LERERAAANE
110 120 130 140 150
QLTRAVLRER ISSEEERMKA KHLARQLEEK DRVMRKQDAF YKEQLARLEE
160 170 180 190 200
RSSEFYKVTT EEYQKAAEEV EAKFKRYEYH PVCADLQTKI LQCYRQNTQQ
210 220
TLSCSALASQ YMHCVNHAKQ SMLEKGG
Length:227
Mass (Da):26,335
Last modified:June 1, 2001 - v1
Checksum:i055B1AF5A6DB808E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002263 mRNA. Translation: BAB21974.1.
AK003519 mRNA. Translation: BAB22832.1.
BC021941 mRNA. Translation: AAH21941.1.
CCDSiCCDS19986.1.
RefSeqiNP_079612.1. NM_025336.1.
UniGeneiMm.21501.

Genome annotation databases

EnsembliENSMUST00000066379; ENSMUSP00000070149; ENSMUSG00000053768.
GeneIDi66075.
KEGGimmu:66075.
UCSCiuc009bgo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMIC19_MOUSE
AccessioniPrimary (citable) accession number: Q9CRB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families