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Protein

FGFR1 oncogene partner 2 homolog

Gene

Fgfr1op2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in wound healing pathway.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

  • wound healing Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FGFR1 oncogene partner 2 homolog
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914779. Fgfr1op2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990421 – 253FGFR1 oncogene partner 2 homologAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CRA9.
PRIDEiQ9CRA9.

PTM databases

iPTMnetiQ9CRA9.
PhosphoSitePlusiQ9CRA9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040242.
CleanExiMM_FGFR1OP2.
ExpressionAtlasiQ9CRA9. baseline and differential.
GenevisibleiQ9CRA9. MM.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107292.

Structurei

3D structure databases

ProteinModelPortaliQ9CRA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 104Sequence analysisAdd BLAST100
Coiled coili160 – 223Sequence analysisAdd BLAST64

Sequence similaritiesi

Belongs to the SIKE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHR3. Eukaryota.
ENOG410XS48. LUCA.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ9CRA9.
OMAiHGCKEQE.
OrthoDBiEOG091G0M4E.
PhylomeDBiQ9CRA9.
TreeFamiTF324337.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 2 hits.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CRA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALSKRV EAMKQYQEEI
60 70 80 90 100
QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI
110 120 130 140 150
MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNS CEGFFLDASR
160 170 180 190 200
HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE
210 220 230 240 250
QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL

RKS
Length:253
Mass (Da):29,374
Last modified:June 1, 2001 - v1
Checksum:i07A077BAB5071119
GO
Isoform 2 (identifier: Q9CRA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-170: Missing.

Show »
Length:215
Mass (Da):24,950
Checksum:i4709C59555880914
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108M → V in BAE35385 (PubMed:16141072).Curated1
Sequence conflicti211N → D in BAE41127 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027541133 – 170Missing in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004662 mRNA. Translation: BAB23452.1.
AK005320 mRNA. Translation: BAB23951.1.
AK008983 mRNA. Translation: BAB26006.1.
AK151318 mRNA. Translation: BAE30299.1.
AK152617 mRNA. Translation: BAE31360.1.
AK153137 mRNA. Translation: BAE31749.1.
AK159805 mRNA. Translation: BAE35385.1.
AK169380 mRNA. Translation: BAE41127.1.
AK169383 mRNA. Translation: BAE41130.1.
BC028876 mRNA. Translation: AAH28876.1.
CCDSiCCDS39711.1. [Q9CRA9-1]
RefSeqiNP_080494.1. NM_026218.2. [Q9CRA9-1]
XP_006507157.1. XM_006507094.2. [Q9CRA9-2]
UniGeneiMm.333499.

Genome annotation databases

EnsembliENSMUST00000067404; ENSMUSP00000098352; ENSMUSG00000040242. [Q9CRA9-2]
ENSMUST00000111663; ENSMUSP00000107292; ENSMUSG00000040242. [Q9CRA9-1]
GeneIDi67529.
KEGGimmu:67529.
UCSCiuc009esc.1. mouse. [Q9CRA9-1]
uc009esd.1. mouse. [Q9CRA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004662 mRNA. Translation: BAB23452.1.
AK005320 mRNA. Translation: BAB23951.1.
AK008983 mRNA. Translation: BAB26006.1.
AK151318 mRNA. Translation: BAE30299.1.
AK152617 mRNA. Translation: BAE31360.1.
AK153137 mRNA. Translation: BAE31749.1.
AK159805 mRNA. Translation: BAE35385.1.
AK169380 mRNA. Translation: BAE41127.1.
AK169383 mRNA. Translation: BAE41130.1.
BC028876 mRNA. Translation: AAH28876.1.
CCDSiCCDS39711.1. [Q9CRA9-1]
RefSeqiNP_080494.1. NM_026218.2. [Q9CRA9-1]
XP_006507157.1. XM_006507094.2. [Q9CRA9-2]
UniGeneiMm.333499.

3D structure databases

ProteinModelPortaliQ9CRA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107292.

PTM databases

iPTMnetiQ9CRA9.
PhosphoSitePlusiQ9CRA9.

Proteomic databases

PaxDbiQ9CRA9.
PRIDEiQ9CRA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067404; ENSMUSP00000098352; ENSMUSG00000040242. [Q9CRA9-2]
ENSMUST00000111663; ENSMUSP00000107292; ENSMUSG00000040242. [Q9CRA9-1]
GeneIDi67529.
KEGGimmu:67529.
UCSCiuc009esc.1. mouse. [Q9CRA9-1]
uc009esd.1. mouse. [Q9CRA9-2]

Organism-specific databases

CTDi26127.
MGIiMGI:1914779. Fgfr1op2.

Phylogenomic databases

eggNOGiENOG410IHR3. Eukaryota.
ENOG410XS48. LUCA.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ9CRA9.
OMAiHGCKEQE.
OrthoDBiEOG091G0M4E.
PhylomeDBiQ9CRA9.
TreeFamiTF324337.

Miscellaneous databases

PROiQ9CRA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040242.
CleanExiMM_FGFR1OP2.
ExpressionAtlasiQ9CRA9. baseline and differential.
GenevisibleiQ9CRA9. MM.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 2 hits.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGOP2_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA9
Secondary accession number(s): Q3TEX1, Q3TW81, Q9D7R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.