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Q9CRA7 (ATP5S_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Mitochondrial ATP synthase regulatory component factor B
Gene names
Name:Atp5s
Synonyms:Atpw
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

Subunit structure

Homotetramer. Associates with ATP synthase By similarity.

Subcellular location

Mitochondrion By similarity. Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the ATP synthase subunit s family.

Contains 4 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion By similarity
Chain26 – 200175ATP synthase subunit s, mitochondrial
PRO_0000002539

Regions

Repeat62 – 8726LRR 1
Repeat88 – 11629LRR 2
Repeat117 – 14125LRR 3
Repeat142 – 17332LRR 4
Region1 – 6161N-terminal domain

Sites

Metal binding591Magnesium; via carbonyl oxygen By similarity
Metal binding931Magnesium By similarity

Experimental info

Sequence conflict1561V → I in AAH27442. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CRA7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0878BD50B281AA2F

FASTA20023,275
        10         20         30         40         50         60 
MMMFGKISRQ LCSLKKIPWS CDSRYFWEWL NTVFNKVDYE RLRDVGPDRA ASEWLLRCGA 

        70         80         90        100        110        120 
KVRYCGHQKW LHDYNTLPGS SIDRYKIQAI DATDSCIMDI GLDHMVGLEH VEKITLCKCH 

       130        140        150        160        170        180 
YIEDNCLQRL SQLENLRKSL LELEIIACGN VTDNGVIALR HFRNLKYLFL SDLPGVKDKE 

       190        200 
YLAQVFKTAL PSLELKLNLK 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Tongue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK003725 mRNA. Translation: BAB22960.1.
AK009141 mRNA. No translation available.
BC027442 mRNA. Translation: AAH27442.1.
RefSeqNP_080812.1. NM_026536.1.
XP_006516245.1. XM_006516182.1.
UniGeneMm.27844.

3D structure databases

ProteinModelPortalQ9CRA7.
SMRQ9CRA7. Positions 26-200.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CRA7.

Proteomic databases

PaxDbQ9CRA7.
PRIDEQ9CRA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021372; ENSMUSP00000021372; ENSMUSG00000054894.
GeneID68055.
KEGGmmu:68055.
UCSCuc007nsr.1. mouse.

Organism-specific databases

CTD27109.
MGIMGI:1915305. Atp5s.

Phylogenomic databases

eggNOGNOG307162.
GeneTreeENSGT00530000063680.
HOGENOMHOG000230741.
HOVERGENHBG050615.
InParanoidQ9CRA7.
KOK07554.
OMATESCIMY.
OrthoDBEOG7GJ6FJ.
PhylomeDBQ9CRA7.
TreeFamTF315274.

Gene expression databases

BgeeQ9CRA7.
GenevestigatorQ9CRA7.

Family and domain databases

InterProIPR026063. ATP_synthase_s.
[Graphical view]
PANTHERPTHR13382. PTHR13382. 1 hit.
ProtoNetSearch...

Other

NextBio326332.
PROQ9CRA7.
SOURCESearch...

Entry information

Entry nameATP5S_MOUSE
AccessionPrimary (citable) accession number: Q9CRA7
Secondary accession number(s): Q8R2M3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot