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Q9CRA7

- ATP5S_MOUSE

UniProt

Q9CRA7 - ATP5S_MOUSE

Protein

ATP synthase subunit s, mitochondrial

Gene

Atp5s

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi93 – 931MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP biosynthetic process Source: UniProtKB-KW
    2. proton transport Source: UniProtKB-KW

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit s, mitochondrial
    Alternative name(s):
    ATP synthase-coupling factor B
    Mitochondrial ATP synthase regulatory component factor B
    Gene namesi
    Name:Atp5s
    Synonyms:Atpw
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1915305. Atp5s.

    Subcellular locationi

    Mitochondrion By similarity. Mitochondrion inner membrane By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI
    3. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW

    Keywords - Cellular componenti

    CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionBy similarityAdd
    BLAST
    Chaini26 – 200175ATP synthase subunit s, mitochondrialPRO_0000002539Add
    BLAST

    Proteomic databases

    MaxQBiQ9CRA7.
    PaxDbiQ9CRA7.
    PRIDEiQ9CRA7.

    PTM databases

    PhosphoSiteiQ9CRA7.

    Expressioni

    Gene expression databases

    BgeeiQ9CRA7.
    GenevestigatoriQ9CRA7.

    Interactioni

    Subunit structurei

    Homotetramer. Associates with ATP synthase By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CRA7.
    SMRiQ9CRA7. Positions 26-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati62 – 8726LRR 1Add
    BLAST
    Repeati88 – 11629LRR 2Add
    BLAST
    Repeati117 – 14125LRR 3Add
    BLAST
    Repeati142 – 17332LRR 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6161N-terminal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATP synthase subunit s family.Curated
    Contains 4 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiNOG307162.
    GeneTreeiENSGT00530000063680.
    HOGENOMiHOG000230741.
    HOVERGENiHBG050615.
    InParanoidiQ9CRA7.
    KOiK07554.
    OMAiRHFWGWL.
    OrthoDBiEOG7GJ6FJ.
    PhylomeDBiQ9CRA7.
    TreeFamiTF315274.

    Family and domain databases

    InterProiIPR026063. ATP_synthase_s.
    [Graphical view]
    PANTHERiPTHR13382. PTHR13382. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CRA7-1 [UniParc]FASTAAdd to Basket

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    MMMFGKISRQ LCSLKKIPWS CDSRYFWEWL NTVFNKVDYE RLRDVGPDRA    50
    ASEWLLRCGA KVRYCGHQKW LHDYNTLPGS SIDRYKIQAI DATDSCIMDI 100
    GLDHMVGLEH VEKITLCKCH YIEDNCLQRL SQLENLRKSL LELEIIACGN 150
    VTDNGVIALR HFRNLKYLFL SDLPGVKDKE YLAQVFKTAL PSLELKLNLK 200
    Length:200
    Mass (Da):23,275
    Last modified:June 1, 2001 - v1
    Checksum:i0878BD50B281AA2F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561V → I in AAH27442. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003725 mRNA. Translation: BAB22960.1.
    AK009141 mRNA. No translation available.
    BC027442 mRNA. Translation: AAH27442.1.
    CCDSiCCDS25954.1.
    RefSeqiNP_080812.1. NM_026536.1.
    XP_006516245.1. XM_006516182.1.
    UniGeneiMm.27844.

    Genome annotation databases

    EnsembliENSMUST00000021372; ENSMUSP00000021372; ENSMUSG00000054894.
    GeneIDi68055.
    KEGGimmu:68055.
    UCSCiuc007nsr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003725 mRNA. Translation: BAB22960.1 .
    AK009141 mRNA. No translation available.
    BC027442 mRNA. Translation: AAH27442.1 .
    CCDSi CCDS25954.1.
    RefSeqi NP_080812.1. NM_026536.1.
    XP_006516245.1. XM_006516182.1.
    UniGenei Mm.27844.

    3D structure databases

    ProteinModelPortali Q9CRA7.
    SMRi Q9CRA7. Positions 26-200.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CRA7.

    Proteomic databases

    MaxQBi Q9CRA7.
    PaxDbi Q9CRA7.
    PRIDEi Q9CRA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021372 ; ENSMUSP00000021372 ; ENSMUSG00000054894 .
    GeneIDi 68055.
    KEGGi mmu:68055.
    UCSCi uc007nsr.1. mouse.

    Organism-specific databases

    CTDi 27109.
    MGIi MGI:1915305. Atp5s.

    Phylogenomic databases

    eggNOGi NOG307162.
    GeneTreei ENSGT00530000063680.
    HOGENOMi HOG000230741.
    HOVERGENi HBG050615.
    InParanoidi Q9CRA7.
    KOi K07554.
    OMAi RHFWGWL.
    OrthoDBi EOG7GJ6FJ.
    PhylomeDBi Q9CRA7.
    TreeFami TF315274.

    Miscellaneous databases

    NextBioi 326332.
    PROi Q9CRA7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CRA7.
    Genevestigatori Q9CRA7.

    Family and domain databases

    InterProi IPR026063. ATP_synthase_s.
    [Graphical view ]
    PANTHERi PTHR13382. PTHR13382. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiATP5S_MOUSE
    AccessioniPrimary (citable) accession number: Q9CRA7
    Secondary accession number(s): Q8R2M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3