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Q9CRA7

- ATP5S_MOUSE

UniProt

Q9CRA7 - ATP5S_MOUSE

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Protein

ATP synthase subunit s, mitochondrial

Gene

Atp5s

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Magnesium; via carbonyl oxygenBy similarity
Metal bindingi93 – 931MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_245290. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Mitochondrial ATP synthase regulatory component factor B
Gene namesi
Name:Atp5s
Synonyms:Atpw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1915305. Atp5s.

Subcellular locationi

Mitochondrion By similarity. Mitochondrion inner membrane By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 200175ATP synthase subunit s, mitochondrialPRO_0000002539Add
BLAST

Proteomic databases

MaxQBiQ9CRA7.
PaxDbiQ9CRA7.
PRIDEiQ9CRA7.

PTM databases

PhosphoSiteiQ9CRA7.

Expressioni

Gene expression databases

BgeeiQ9CRA7.
GenevestigatoriQ9CRA7.

Interactioni

Subunit structurei

Homotetramer. Associates with ATP synthase (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CRA7.
SMRiQ9CRA7. Positions 26-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 8726LRR 1Add
BLAST
Repeati88 – 11629LRR 2Add
BLAST
Repeati117 – 14125LRR 3Add
BLAST
Repeati142 – 17332LRR 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6161N-terminal domainAdd
BLAST

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiNOG307162.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiQ9CRA7.
KOiK07554.
OMAiRHFWGWL.
OrthoDBiEOG7GJ6FJ.
PhylomeDBiQ9CRA7.
TreeFamiTF315274.

Family and domain databases

InterProiIPR026063. ATP_synthase_s.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMMFGKISRQ LCSLKKIPWS CDSRYFWEWL NTVFNKVDYE RLRDVGPDRA
60 70 80 90 100
ASEWLLRCGA KVRYCGHQKW LHDYNTLPGS SIDRYKIQAI DATDSCIMDI
110 120 130 140 150
GLDHMVGLEH VEKITLCKCH YIEDNCLQRL SQLENLRKSL LELEIIACGN
160 170 180 190 200
VTDNGVIALR HFRNLKYLFL SDLPGVKDKE YLAQVFKTAL PSLELKLNLK
Length:200
Mass (Da):23,275
Last modified:June 1, 2001 - v1
Checksum:i0878BD50B281AA2F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561V → I in AAH27442. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003725 mRNA. Translation: BAB22960.1.
AK009141 mRNA. No translation available.
BC027442 mRNA. Translation: AAH27442.1.
CCDSiCCDS25954.1.
RefSeqiNP_080812.1. NM_026536.1.
XP_006516245.1. XM_006516182.1.
UniGeneiMm.27844.

Genome annotation databases

EnsembliENSMUST00000021372; ENSMUSP00000021372; ENSMUSG00000054894.
GeneIDi68055.
KEGGimmu:68055.
UCSCiuc007nsr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003725 mRNA. Translation: BAB22960.1 .
AK009141 mRNA. No translation available.
BC027442 mRNA. Translation: AAH27442.1 .
CCDSi CCDS25954.1.
RefSeqi NP_080812.1. NM_026536.1.
XP_006516245.1. XM_006516182.1.
UniGenei Mm.27844.

3D structure databases

ProteinModelPortali Q9CRA7.
SMRi Q9CRA7. Positions 26-200.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CRA7.

Proteomic databases

MaxQBi Q9CRA7.
PaxDbi Q9CRA7.
PRIDEi Q9CRA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021372 ; ENSMUSP00000021372 ; ENSMUSG00000054894 .
GeneIDi 68055.
KEGGi mmu:68055.
UCSCi uc007nsr.1. mouse.

Organism-specific databases

CTDi 27109.
MGIi MGI:1915305. Atp5s.

Phylogenomic databases

eggNOGi NOG307162.
GeneTreei ENSGT00530000063680.
HOGENOMi HOG000230741.
HOVERGENi HBG050615.
InParanoidi Q9CRA7.
KOi K07554.
OMAi RHFWGWL.
OrthoDBi EOG7GJ6FJ.
PhylomeDBi Q9CRA7.
TreeFami TF315274.

Enzyme and pathway databases

Reactomei REACT_245290. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

NextBioi 326332.
PROi Q9CRA7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CRA7.
Genevestigatori Q9CRA7.

Family and domain databases

InterProi IPR026063. ATP_synthase_s.
[Graphical view ]
PANTHERi PTHR13382. PTHR13382. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiATP5S_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA7
Secondary accession number(s): Q8R2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3