Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ecto-ADP-ribosyltransferase 4

Gene

Art4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei185 – 1851NADBy similarity
Binding sitei219 – 2191NADBy similarity
Active sitei230 – 2301By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 4
Short name:
ARTC4
Mono(ADP-ribosyl)transferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
CD_antigen: CD297
Gene namesi
Name:Art4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202710. Art4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 269246ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 28617HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 30014CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 264241Ecto-ADP-ribosyltransferase 4PRO_0000416110Add
BLAST
Propeptidei265 – 30036Removed in mature formSequence AnalysisPRO_0000416111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 259By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 210By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Lipidationi264 – 2641GPI-anchor amidated alanineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ9CRA0.

PTM databases

PhosphoSiteiQ9CRA0.

Expressioni

Gene expression databases

BgeeiQ9CRA0.
GenevestigatoriQ9CRA0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032341.

Structurei

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0. Positions 34-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiHSFHFKY.
OrthoDBiEOG7D85WV.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PANTHERiPTHR10339. PTHR10339. 1 hit.
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE
60 70 80 90 100
QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV
110 120 130 140 150
AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR
160 170 180 190 200
KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG
210 220 230 240 250
NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS
260 270 280 290 300
AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF
Length:300
Mass (Da):33,080
Last modified:June 1, 2001 - v1
Checksum:i0BB0B42D6AAC3406
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in CAD31119 (PubMed:12070318).Curated
Sequence conflicti39 – 391D → N in CAD31119 (PubMed:12070318).Curated
Sequence conflicti81 – 811L → R in CAD31119 (PubMed:12070318).Curated
Sequence conflicti174 – 1741G → E in CAD31119 (PubMed:12070318).Curated
Sequence conflicti195 – 1951E → G in CAA69608 (PubMed:12070318).Curated
Sequence conflicti277 – 2771G → V in CAD31119 (PubMed:12070318).Curated
Sequence conflicti292 – 2921A → E in CAD31119 (PubMed:12070318).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0. Positions 34-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032341.

PTM databases

PhosphoSiteiQ9CRA0.

Proteomic databases

PRIDEiQ9CRA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Organism-specific databases

CTDi420.
MGIiMGI:1202710. Art4.

Phylogenomic databases

GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiHSFHFKY.
OrthoDBiEOG7D85WV.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Miscellaneous databases

NextBioi363109.
PROiQ9CRA0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CRA0.
GenevestigatoriQ9CRA0.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PANTHERiPTHR10339. PTHR10339. 1 hit.
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
    Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
    Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiNAR4_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA0
Secondary accession number(s): Q80VB5, Q80W56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.