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Q9CRA0

- NAR4_MOUSE

UniProt

Q9CRA0 - NAR4_MOUSE

Protein

Ecto-ADP-ribosyltransferase 4

Gene

Art4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei185 – 1851NADBy similarity
    Binding sitei219 – 2191NADBy similarity
    Active sitei230 – 2301By similarity

    GO - Molecular functioni

    1. NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein ADP-ribosylation Source: InterPro

    Keywords - Molecular functioni

    Blood group antigen, Glycosyltransferase, Transferase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
    Alternative name(s):
    ADP-ribosyltransferase C2 and C3 toxin-like 4
    Short name:
    ARTC4
    Mono(ADP-ribosyl)transferase 4
    NAD(P)(+)--arginine ADP-ribosyltransferase 4
    CD_antigen: CD297
    Gene namesi
    Name:Art4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1202710. Art4.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 264241Ecto-ADP-ribosyltransferase 4PRO_0000416110Add
    BLAST
    Propeptidei265 – 30036Removed in mature formSequence AnalysisPRO_0000416111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 259By similarity
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 210By similarity
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Lipidationi264 – 2641GPI-anchor amidated alanineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ9CRA0.

    PTM databases

    PhosphoSiteiQ9CRA0.

    Expressioni

    Gene expression databases

    BgeeiQ9CRA0.
    GenevestigatoriQ9CRA0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032341.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CRA0.
    SMRiQ9CRA0. Positions 34-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 269246ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 30014CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei270 – 28617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00530000062975.
    HOGENOMiHOG000273888.
    HOVERGENiHBG004464.
    InParanoidiQ9CRA0.
    KOiK06717.
    OMAiHSFHFKY.
    OrthoDBiEOG7D85WV.
    PhylomeDBiQ9CRA0.
    TreeFamiTF335356.

    Family and domain databases

    InterProiIPR000768. ART.
    [Graphical view]
    PANTHERiPTHR10339. PTHR10339. 1 hit.
    PfamiPF01129. ART. 1 hit.
    [Graphical view]
    PRINTSiPR00970. RIBTRNSFRASE.
    PROSITEiPS01291. ART. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CRA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE    50
    QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV 100
    AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR 150
    KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG 200
    NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS 250
    AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF 300
    Length:300
    Mass (Da):33,080
    Last modified:June 1, 2001 - v1
    Checksum:i0BB0B42D6AAC3406
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261T → A in CAD31119. (PubMed:12070318)Curated
    Sequence conflicti39 – 391D → N in CAD31119. (PubMed:12070318)Curated
    Sequence conflicti81 – 811L → R in CAD31119. (PubMed:12070318)Curated
    Sequence conflicti174 – 1741G → E in CAD31119. (PubMed:12070318)Curated
    Sequence conflicti195 – 1951E → G in CAA69608. (PubMed:12070318)Curated
    Sequence conflicti277 – 2771G → V in CAD31119. (PubMed:12070318)Curated
    Sequence conflicti292 – 2921A → E in CAD31119. (PubMed:12070318)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ486881 Genomic DNA. Translation: CAD31119.1.
    Y08300 Genomic DNA. Translation: CAA69608.1.
    AK004744 mRNA. Translation: BAB23525.1.
    AK019467 mRNA. Translation: BAB31738.1.
    AC122804 Genomic DNA. No translation available.
    BC046306 mRNA. Translation: AAH46306.1.
    CCDSiCCDS20658.1.
    RefSeqiNP_080915.1. NM_026639.2.
    UniGeneiMm.31840.

    Genome annotation databases

    EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
    GeneIDi109978.
    KEGGimmu:109978.
    UCSCiuc009emk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ486881 Genomic DNA. Translation: CAD31119.1 .
    Y08300 Genomic DNA. Translation: CAA69608.1 .
    AK004744 mRNA. Translation: BAB23525.1 .
    AK019467 mRNA. Translation: BAB31738.1 .
    AC122804 Genomic DNA. No translation available.
    BC046306 mRNA. Translation: AAH46306.1 .
    CCDSi CCDS20658.1.
    RefSeqi NP_080915.1. NM_026639.2.
    UniGenei Mm.31840.

    3D structure databases

    ProteinModelPortali Q9CRA0.
    SMRi Q9CRA0. Positions 34-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032341.

    PTM databases

    PhosphoSitei Q9CRA0.

    Proteomic databases

    PRIDEi Q9CRA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032341 ; ENSMUSP00000032341 ; ENSMUSG00000030217 .
    GeneIDi 109978.
    KEGGi mmu:109978.
    UCSCi uc009emk.1. mouse.

    Organism-specific databases

    CTDi 420.
    MGIi MGI:1202710. Art4.

    Phylogenomic databases

    GeneTreei ENSGT00530000062975.
    HOGENOMi HOG000273888.
    HOVERGENi HBG004464.
    InParanoidi Q9CRA0.
    KOi K06717.
    OMAi HSFHFKY.
    OrthoDBi EOG7D85WV.
    PhylomeDBi Q9CRA0.
    TreeFami TF335356.

    Miscellaneous databases

    NextBioi 363109.
    PROi Q9CRA0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CRA0.
    Genevestigatori Q9CRA0.

    Family and domain databases

    InterProi IPR000768. ART.
    [Graphical view ]
    PANTHERi PTHR10339. PTHR10339. 1 hit.
    Pfami PF01129. ART. 1 hit.
    [Graphical view ]
    PRINTSi PR00970. RIBTRNSFRASE.
    PROSITEi PS01291. ART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
      Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
      Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiNAR4_MOUSE
    AccessioniPrimary (citable) accession number: Q9CRA0
    Secondary accession number(s): Q80VB5, Q80W56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3