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Q9CRA0

- NAR4_MOUSE

UniProt

Q9CRA0 - NAR4_MOUSE

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Protein

Ecto-ADP-ribosyltransferase 4

Gene
Art4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei185 – 1851NAD By similarity
Binding sitei219 – 2191NAD By similarity
Active sitei230 – 2301 By similarity

GO - Molecular functioni

  1. NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein ADP-ribosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 4
Short name:
ARTC4
Mono(ADP-ribosyl)transferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
CD_antigen: CD297
Gene namesi
Name:Art4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1202710. Art4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 269246Extracellular Reviewed predictionAdd
BLAST
Transmembranei270 – 28617Helical; Reviewed predictionAdd
BLAST
Topological domaini287 – 30014Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 264241Ecto-ADP-ribosyltransferase 4PRO_0000416110Add
BLAST
Propeptidei265 – 30036Removed in mature form Reviewed predictionPRO_0000416111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 259 By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 210 By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Lipidationi264 – 2641GPI-anchor amidated alanine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ9CRA0.

PTM databases

PhosphoSiteiQ9CRA0.

Expressioni

Gene expression databases

BgeeiQ9CRA0.
GenevestigatoriQ9CRA0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032341.

Structurei

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0. Positions 34-259.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiHSFHFKY.
OrthoDBiEOG7D85WV.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PANTHERiPTHR10339. PTHR10339. 1 hit.
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA0-1 [UniParc]FASTAAdd to Basket

« Hide

MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE    50
QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV 100
AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR 150
KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG 200
NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS 250
AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF 300
Length:300
Mass (Da):33,080
Last modified:June 1, 2001 - v1
Checksum:i0BB0B42D6AAC3406
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in CAD31119. 1 Publication
Sequence conflicti39 – 391D → N in CAD31119. 1 Publication
Sequence conflicti81 – 811L → R in CAD31119. 1 Publication
Sequence conflicti174 – 1741G → E in CAD31119. 1 Publication
Sequence conflicti195 – 1951E → G in CAA69608. 1 Publication
Sequence conflicti277 – 2771G → V in CAD31119. 1 Publication
Sequence conflicti292 – 2921A → E in CAD31119. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1 .
Y08300 Genomic DNA. Translation: CAA69608.1 .
AK004744 mRNA. Translation: BAB23525.1 .
AK019467 mRNA. Translation: BAB31738.1 .
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1 .
CCDSi CCDS20658.1.
RefSeqi NP_080915.1. NM_026639.2.
UniGenei Mm.31840.

3D structure databases

ProteinModelPortali Q9CRA0.
SMRi Q9CRA0. Positions 34-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032341.

PTM databases

PhosphoSitei Q9CRA0.

Proteomic databases

PRIDEi Q9CRA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032341 ; ENSMUSP00000032341 ; ENSMUSG00000030217 .
GeneIDi 109978.
KEGGi mmu:109978.
UCSCi uc009emk.1. mouse.

Organism-specific databases

CTDi 420.
MGIi MGI:1202710. Art4.

Phylogenomic databases

GeneTreei ENSGT00530000062975.
HOGENOMi HOG000273888.
HOVERGENi HBG004464.
InParanoidi Q9CRA0.
KOi K06717.
OMAi HSFHFKY.
OrthoDBi EOG7D85WV.
PhylomeDBi Q9CRA0.
TreeFami TF335356.

Miscellaneous databases

NextBioi 363109.
PROi Q9CRA0.
SOURCEi Search...

Gene expression databases

Bgeei Q9CRA0.
Genevestigatori Q9CRA0.

Family and domain databases

InterProi IPR000768. ART.
[Graphical view ]
PANTHERi PTHR10339. PTHR10339. 1 hit.
Pfami PF01129. ART. 1 hit.
[Graphical view ]
PRINTSi PR00970. RIBTRNSFRASE.
PROSITEi PS01291. ART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
    Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
    Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiNAR4_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA0
Secondary accession number(s): Q80VB5, Q80W56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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