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Protein

Ecto-ADP-ribosyltransferase 4

Gene

Art4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei185NADBy similarity1
Binding sitei219NADBy similarity1
Active sitei230By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen, Glycosyltransferase, Transferase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 4
Short name:
ARTC4
Mono(ADP-ribosyl)transferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
CD_antigen: CD297
Gene namesi
Name:Art4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202710 Art4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 269ExtracellularSequence analysisAdd BLAST246
Transmembranei270 – 286HelicalSequence analysisAdd BLAST17
Topological domaini287 – 300CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000041611024 – 264Ecto-ADP-ribosyltransferase 4Add BLAST241
PropeptideiPRO_0000416111265 – 300Removed in mature formSequence analysisAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 259By similarity
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 210By similarity
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi264GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9CRA0
PaxDbiQ9CRA0
PeptideAtlasiQ9CRA0
PRIDEiQ9CRA0

PTM databases

PhosphoSitePlusiQ9CRA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030217
GenevisibleiQ9CRA0 MM

Structurei

3D structure databases

ProteinModelPortaliQ9CRA0
SMRiQ9CRA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFER Eukaryota
ENOG4111WZG LUCA
GeneTreeiENSGT00530000062975
HOGENOMiHOG000273888
HOVERGENiHBG004464
InParanoidiQ9CRA0
KOiK06717
OMAiHFKYLHY
OrthoDBiEOG091G0BSN
PhylomeDBiQ9CRA0
TreeFamiTF335356

Family and domain databases

InterProiView protein in InterPro
IPR000768 ART
PfamiView protein in Pfam
PF01129 ART, 1 hit
PRINTSiPR00970 RIBTRNSFRASE
PROSITEiView protein in PROSITE
PS01291 ART, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE
60 70 80 90 100
QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV
110 120 130 140 150
AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR
160 170 180 190 200
KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG
210 220 230 240 250
NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS
260 270 280 290 300
AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF
Length:300
Mass (Da):33,080
Last modified:June 1, 2001 - v1
Checksum:i0BB0B42D6AAC3406
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → A in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti39D → N in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti81L → R in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti174G → E in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti195E → G in CAA69608 (PubMed:12070318).Curated1
Sequence conflicti277G → V in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti292A → E in CAD31119 (PubMed:12070318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ486881 Genomic DNA Translation: CAD31119.1
Y08300 Genomic DNA Translation: CAA69608.1
AK004744 mRNA Translation: BAB23525.1
AK019467 mRNA Translation: BAB31738.1
AC122804 Genomic DNA No translation available.
BC046306 mRNA Translation: AAH46306.1
CCDSiCCDS20658.1
RefSeqiNP_080915.1, NM_026639.2
UniGeneiMm.31840

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217
GeneIDi109978
KEGGimmu:109978
UCSCiuc009emk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNAR4_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA0
Secondary accession number(s): Q80VB5, Q80W56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health