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Protein

Ecto-ADP-ribosyltransferase 4

Gene

Art4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei185NADBy similarity1
Binding sitei219NADBy similarity1
Active sitei230By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 4
Short name:
ARTC4
Mono(ADP-ribosyl)transferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
CD_antigen: CD297
Gene namesi
Name:Art4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202710. Art4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 269ExtracellularSequence analysisAdd BLAST246
Transmembranei270 – 286HelicalSequence analysisAdd BLAST17
Topological domaini287 – 300CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000041611024 – 264Ecto-ADP-ribosyltransferase 4Add BLAST241
PropeptideiPRO_0000416111265 – 300Removed in mature formSequence analysisAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 259By similarity
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi161 ↔ 210By similarity
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Lipidationi264GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9CRA0.
PaxDbiQ9CRA0.
PeptideAtlasiQ9CRA0.
PRIDEiQ9CRA0.

PTM databases

PhosphoSitePlusiQ9CRA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030217.
GenevisibleiQ9CRA0. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFER. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiPESMTPV.
OrthoDBiEOG091G0BSN.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE
60 70 80 90 100
QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV
110 120 130 140 150
AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR
160 170 180 190 200
KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG
210 220 230 240 250
NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS
260 270 280 290 300
AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF
Length:300
Mass (Da):33,080
Last modified:June 1, 2001 - v1
Checksum:i0BB0B42D6AAC3406
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → A in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti39D → N in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti81L → R in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti174G → E in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti195E → G in CAA69608 (PubMed:12070318).Curated1
Sequence conflicti277G → V in CAD31119 (PubMed:12070318).Curated1
Sequence conflicti292A → E in CAD31119 (PubMed:12070318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9CRA0.

Proteomic databases

MaxQBiQ9CRA0.
PaxDbiQ9CRA0.
PeptideAtlasiQ9CRA0.
PRIDEiQ9CRA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Organism-specific databases

CTDi420.
MGIiMGI:1202710. Art4.

Phylogenomic databases

eggNOGiENOG410IFER. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiPESMTPV.
OrthoDBiEOG091G0BSN.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Miscellaneous databases

PROiQ9CRA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030217.
GenevisibleiQ9CRA0. MM.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAR4_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA0
Secondary accession number(s): Q80VB5, Q80W56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.