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Q9CRA0

- NAR4_MOUSE

UniProt

Q9CRA0 - NAR4_MOUSE

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Protein

Ecto-ADP-ribosyltransferase 4

Gene

Art4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei185 – 1851NADBy similarity
Binding sitei219 – 2191NADBy similarity
Active sitei230 – 2301By similarity

GO - Molecular functioni

  1. NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein ADP-ribosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 4
Short name:
ARTC4
Mono(ADP-ribosyl)transferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
CD_antigen: CD297
Gene namesi
Name:Art4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1202710. Art4.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 264241Ecto-ADP-ribosyltransferase 4PRO_0000416110Add
BLAST
Propeptidei265 – 30036Removed in mature formSequence AnalysisPRO_0000416111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 259By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 210By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Lipidationi264 – 2641GPI-anchor amidated alanineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ9CRA0.

PTM databases

PhosphoSiteiQ9CRA0.

Expressioni

Gene expression databases

BgeeiQ9CRA0.
GenevestigatoriQ9CRA0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032341.

Structurei

3D structure databases

ProteinModelPortaliQ9CRA0.
SMRiQ9CRA0. Positions 34-259.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 269246ExtracellularSequence AnalysisAdd
BLAST
Topological domaini287 – 30014CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei270 – 28617HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ9CRA0.
KOiK06717.
OMAiHSFHFKY.
OrthoDBiEOG7D85WV.
PhylomeDBiQ9CRA0.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PANTHERiPTHR10339. PTHR10339. 1 hit.
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CRA0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALWLPGGQL TLLLLLWVQQ TPAGSTEAPL KVDVDLTPDS FDDQYQGCSE
60 70 80 90 100
QMVEELNQGD YFIKEVDTHK YYSRAWQKAH LTWLNQAKAL PESMTPVHAV
110 120 130 140 150
AIVVFTLNLN VSSDLAKAMA RAAGSPGQYS QSFHFKYLHY YLTSAIQLLR
160 170 180 190 200
KDSSTKNGSL CYKVYHGMKD VSIGANVGST IRFGQFLSAS LLKEETRVSG
210 220 230 240 250
NQTLFTIFTC LGASVQDFSL RKEVLIPPYE LFEVVSKSGS PKGDLINLRS
260 270 280 290 300
AGNMSTYNCQ LLKACSKKCA PAPVVIGCLF LVTVVISSKS RAQRNLLAPF
Length:300
Mass (Da):33,080
Last modified:June 1, 2001 - v1
Checksum:i0BB0B42D6AAC3406
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in CAD31119. (PubMed:12070318)Curated
Sequence conflicti39 – 391D → N in CAD31119. (PubMed:12070318)Curated
Sequence conflicti81 – 811L → R in CAD31119. (PubMed:12070318)Curated
Sequence conflicti174 – 1741G → E in CAD31119. (PubMed:12070318)Curated
Sequence conflicti195 – 1951E → G in CAA69608. (PubMed:12070318)Curated
Sequence conflicti277 – 2771G → V in CAD31119. (PubMed:12070318)Curated
Sequence conflicti292 – 2921A → E in CAD31119. (PubMed:12070318)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1.
Y08300 Genomic DNA. Translation: CAA69608.1.
AK004744 mRNA. Translation: BAB23525.1.
AK019467 mRNA. Translation: BAB31738.1.
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1.
CCDSiCCDS20658.1.
RefSeqiNP_080915.1. NM_026639.2.
UniGeneiMm.31840.

Genome annotation databases

EnsembliENSMUST00000032341; ENSMUSP00000032341; ENSMUSG00000030217.
GeneIDi109978.
KEGGimmu:109978.
UCSCiuc009emk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ486881 Genomic DNA. Translation: CAD31119.1 .
Y08300 Genomic DNA. Translation: CAA69608.1 .
AK004744 mRNA. Translation: BAB23525.1 .
AK019467 mRNA. Translation: BAB31738.1 .
AC122804 Genomic DNA. No translation available.
BC046306 mRNA. Translation: AAH46306.1 .
CCDSi CCDS20658.1.
RefSeqi NP_080915.1. NM_026639.2.
UniGenei Mm.31840.

3D structure databases

ProteinModelPortali Q9CRA0.
SMRi Q9CRA0. Positions 34-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032341.

PTM databases

PhosphoSitei Q9CRA0.

Proteomic databases

PRIDEi Q9CRA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032341 ; ENSMUSP00000032341 ; ENSMUSG00000030217 .
GeneIDi 109978.
KEGGi mmu:109978.
UCSCi uc009emk.1. mouse.

Organism-specific databases

CTDi 420.
MGIi MGI:1202710. Art4.

Phylogenomic databases

GeneTreei ENSGT00530000062975.
HOGENOMi HOG000273888.
HOVERGENi HBG004464.
InParanoidi Q9CRA0.
KOi K06717.
OMAi HSFHFKY.
OrthoDBi EOG7D85WV.
PhylomeDBi Q9CRA0.
TreeFami TF335356.

Miscellaneous databases

NextBioi 363109.
PROi Q9CRA0.
SOURCEi Search...

Gene expression databases

Bgeei Q9CRA0.
Genevestigatori Q9CRA0.

Family and domain databases

InterProi IPR000768. ART.
[Graphical view ]
PANTHERi PTHR10339. PTHR10339. 1 hit.
Pfami PF01129. ART. 1 hit.
[Graphical view ]
PRINTSi PR00970. RIBTRNSFRASE.
PROSITEi PS01291. ART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
    Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
    Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiNAR4_MOUSE
AccessioniPrimary (citable) accession number: Q9CRA0
Secondary accession number(s): Q80VB5, Q80W56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3