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Protein

Calcium-regulated heat stable protein 1

Gene

Carhsp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA and regulates the stability of target mRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of mRNA stability Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-regulated heat stable protein 1
Alternative name(s):
Calcium-regulated heat-stable protein of 24 kDa
Short name:
CRHSP-24
Gene namesi
Name:Carhsp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1196368. Carhsp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • extracellular exosome Source: MGI
  • P granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 148147Calcium-regulated heat stable protein 1PRO_0000100231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei31 – 311PhosphoserineCombined sources
Modified residuei33 – 331PhosphoserineCombined sources
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei46 – 461PhosphothreonineBy similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei147 – 1471PhosphoserineBy similarity

Post-translational modificationi

Can be phosphorylated by DYRK2 (in vitro). Dephosphorylated by calcineurin in a Ca2+ dependent manner (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CR86.
MaxQBiQ9CR86.
PaxDbiQ9CR86.
PRIDEiQ9CR86.

PTM databases

iPTMnetiQ9CR86.
PhosphoSiteiQ9CR86.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008393.
CleanExiMM_CARHSP1.
ExpressionAtlasiQ9CR86. baseline and differential.
GenevisibleiQ9CR86. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with STYX (By similarity).By similarity

Protein-protein interaction databases

BioGridi206625. 1 interaction.
IntActiQ9CR86. 2 interactions.
MINTiMINT-4090802.
STRINGi10090.ENSMUSP00000008537.

Structurei

3D structure databases

ProteinModelPortaliQ9CR86.
SMRiQ9CR86. Positions 44-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13068CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ9CR86.
OMAiCTIPPKN.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ9CR86.
TreeFamiTF324381.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEPPPPPL QPPTHQTSVG LLDTPRTRDR SPSPLRGNVV PSPLPTRRTR
60 70 80 90 100
TFSATVRASQ GPVYKGVCKC FCRSKGHGFI TPADGGPDIF LHISDVEGEY
110 120 130 140
VPVEGDEVTY KMCSIPPKNE KLQAVEVVIT HLAPGTKHET WSGHVISN
Length:148
Mass (Da):16,062
Last modified:June 1, 2001 - v1
Checksum:i117F3FE85D11BC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414101 mRNA. Translation: AAL07470.1.
AK004711 mRNA. Translation: BAB23495.1.
AK002853 mRNA. Translation: BAB22408.1.
AK003926 mRNA. Translation: BAB23077.1.
BC011225 mRNA. Translation: AAH11225.1.
CCDSiCCDS27942.1.
RefSeqiNP_080097.1. NM_025821.2.
XP_006522409.2. XM_006522346.2.
UniGeneiMm.142095.

Genome annotation databases

EnsembliENSMUST00000008537; ENSMUSP00000008537; ENSMUSG00000008393.
GeneIDi52502.
KEGGimmu:52502.
UCSCiuc007yct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414101 mRNA. Translation: AAL07470.1.
AK004711 mRNA. Translation: BAB23495.1.
AK002853 mRNA. Translation: BAB22408.1.
AK003926 mRNA. Translation: BAB23077.1.
BC011225 mRNA. Translation: AAH11225.1.
CCDSiCCDS27942.1.
RefSeqiNP_080097.1. NM_025821.2.
XP_006522409.2. XM_006522346.2.
UniGeneiMm.142095.

3D structure databases

ProteinModelPortaliQ9CR86.
SMRiQ9CR86. Positions 44-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206625. 1 interaction.
IntActiQ9CR86. 2 interactions.
MINTiMINT-4090802.
STRINGi10090.ENSMUSP00000008537.

PTM databases

iPTMnetiQ9CR86.
PhosphoSiteiQ9CR86.

Proteomic databases

EPDiQ9CR86.
MaxQBiQ9CR86.
PaxDbiQ9CR86.
PRIDEiQ9CR86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008537; ENSMUSP00000008537; ENSMUSG00000008393.
GeneIDi52502.
KEGGimmu:52502.
UCSCiuc007yct.1. mouse.

Organism-specific databases

CTDi23589.
MGIiMGI:1196368. Carhsp1.

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ9CR86.
OMAiCTIPPKN.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ9CR86.
TreeFamiTF324381.

Miscellaneous databases

ChiTaRSiCarhsp1. mouse.
PROiQ9CR86.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008393.
CleanExiMM_CARHSP1.
ExpressionAtlasiQ9CR86. baseline and differential.
GenevisibleiQ9CR86. MM.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHSP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.