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Protein

Transmembrane protein 186

Gene

Tmem186

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 186
Gene namesi
Name:Tmem186
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913940 Tmem186

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 91HelicalSequence analysisAdd BLAST23
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794401 – 216Transmembrane protein 186Add BLAST216

Proteomic databases

MaxQBiQ9CR76
PaxDbiQ9CR76
PRIDEiQ9CR76

PTM databases

iPTMnetiQ9CR76
PhosphoSitePlusiQ9CR76

Expressioni

Gene expression databases

BgeeiENSMUSG00000043140
CleanExiMM_TMEM186
ExpressionAtlasiQ9CR76 baseline and differential
GenevisibleiQ9CR76 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053862

Structurei

3D structure databases

ProteinModelPortaliQ9CR76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM186 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZSW Eukaryota
ENOG4111SG0 LUCA
GeneTreeiENSGT00390000000087
HOGENOMiHOG000059619
HOVERGENiHBG107416
InParanoidiQ9CR76
OMAiYRFDAIR
OrthoDBiEOG091G0YC4
PhylomeDBiQ9CR76
TreeFamiTF326623

Family and domain databases

InterProiView protein in InterPro
IPR026571 Tmem186
PANTHERiPTHR13603 PTHR13603, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLLRVVPR LQGPTAWRRP LQGLWCCSGQ GDSKRWVGSR SPHSREKSPG
60 70 80 90 100
TETETFHTIY RFRAIRAIGF LSRLKLAQTA VTVVALPPGF YCYSQGLMTL
110 120 130 140 150
SSLCLLGGVA SFALAMLCWM SHFFRRLVGI LYVNESGTLL RVAHLTFWGW
160 170 180 190 200
RQDTYCAVSD MIPLSESQER VQDVFVRIQQ YSGKQTFYLT LRYGRILDRE
210
RFAQVFGTLA TLKNSK
Length:216
Mass (Da):24,632
Last modified:July 5, 2004 - v2
Checksum:i3C60B8F1DE5963B3
GO

Sequence cautioni

The sequence BAC25393 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183G → D in BAC25393 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009236 mRNA Translation: BAB26157.2
AK013147 mRNA Translation: BAC25393.1 Frameshift.
AK014478 mRNA Translation: BAB29381.2
AK033686 mRNA Translation: BAC28430.1
AK088656 mRNA Translation: BAC40482.1
AK159727 mRNA Translation: BAE35321.1
AK159782 mRNA Translation: BAE35366.1
CCDSiCCDS27940.1
RefSeqiNP_079984.2, NM_025708.4
UniGeneiMm.10068
Mm.394528

Genome annotation databases

EnsembliENSMUST00000052505; ENSMUSP00000053862; ENSMUSG00000043140
GeneIDi66690
KEGGimmu:66690
UCSCiuc007ycq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTM186_MOUSE
AccessioniPrimary (citable) accession number: Q9CR76
Secondary accession number(s): Q8BHA7, Q8BHT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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