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Protein

Transmembrane protein 186

Gene

Tmem186

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 186
Gene namesi
Name:Tmem186
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913940. Tmem186.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 91HelicalSequence analysisAdd BLAST23
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794401 – 216Transmembrane protein 186Add BLAST216

Proteomic databases

MaxQBiQ9CR76.
PaxDbiQ9CR76.
PRIDEiQ9CR76.

PTM databases

iPTMnetiQ9CR76.
PhosphoSitePlusiQ9CR76.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043140.
CleanExiMM_TMEM186.
ExpressionAtlasiQ9CR76. baseline and differential.
GenevisibleiQ9CR76. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053862.

Structurei

3D structure databases

ProteinModelPortaliQ9CR76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM186 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZSW. Eukaryota.
ENOG4111SG0. LUCA.
GeneTreeiENSGT00390000000087.
HOGENOMiHOG000059619.
HOVERGENiHBG107416.
InParanoidiQ9CR76.
OMAiYRFDAIR.
OrthoDBiEOG091G0YC4.
PhylomeDBiQ9CR76.
TreeFamiTF326623.

Family and domain databases

InterProiView protein in InterPro
IPR026571. Tmem186.
PANTHERiPTHR13603. PTHR13603. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLLRVVPR LQGPTAWRRP LQGLWCCSGQ GDSKRWVGSR SPHSREKSPG
60 70 80 90 100
TETETFHTIY RFRAIRAIGF LSRLKLAQTA VTVVALPPGF YCYSQGLMTL
110 120 130 140 150
SSLCLLGGVA SFALAMLCWM SHFFRRLVGI LYVNESGTLL RVAHLTFWGW
160 170 180 190 200
RQDTYCAVSD MIPLSESQER VQDVFVRIQQ YSGKQTFYLT LRYGRILDRE
210
RFAQVFGTLA TLKNSK
Length:216
Mass (Da):24,632
Last modified:July 5, 2004 - v2
Checksum:i3C60B8F1DE5963B3
GO

Sequence cautioni

The sequence BAC25393 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183G → D in BAC25393 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009236 mRNA. Translation: BAB26157.2.
AK013147 mRNA. Translation: BAC25393.1. Frameshift.
AK014478 mRNA. Translation: BAB29381.2.
AK033686 mRNA. Translation: BAC28430.1.
AK088656 mRNA. Translation: BAC40482.1.
AK159727 mRNA. Translation: BAE35321.1.
AK159782 mRNA. Translation: BAE35366.1.
CCDSiCCDS27940.1.
RefSeqiNP_079984.2. NM_025708.4.
UniGeneiMm.10068.
Mm.394528.

Genome annotation databases

EnsembliENSMUST00000052505; ENSMUSP00000053862; ENSMUSG00000043140.
GeneIDi66690.
KEGGimmu:66690.
UCSCiuc007ycq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTM186_MOUSE
AccessioniPrimary (citable) accession number: Q9CR76
Secondary accession number(s): Q8BHA7, Q8BHT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families