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Protein

Tumor necrosis factor receptor superfamily member 12A

Gene

Tnfrsf12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.By similarity

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell adhesion Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • regulation of angiogenesis Source: UniProtKB
  • regulation of wound healing Source: MGI
  • substrate-dependent cell migration, cell attachment to substrate Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis, Apoptosis, Cell adhesion, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 12A
Alternative name(s):
Fibroblast growth factor-inducible immediate-early response protein 14
Short name:
FGF-inducible 14
Fibroblast growth factor-regulated protein 2
Tweak-receptor
Short name:
TweakR
CD_antigen: CD266
Gene namesi
Name:Tnfrsf12a
Synonyms:Fgfrp2, Fn14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1351484. Tnfrsf12a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 8053ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Topological domaini102 – 12928CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • ruffle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 129102Tumor necrosis factor receptor superfamily member 12APRO_0000034612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 49By similarity
Disulfide bondi52 ↔ 67By similarity
Disulfide bondi55 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9CR75.
PaxDbiQ9CR75.
PRIDEiQ9CR75.

PTM databases

iPTMnetiQ9CR75.
PhosphoSiteiQ9CR75.

Expressioni

Tissue specificityi

Highly expressed in fetal heart, intestine, kidney, liver, lung and skin, and in adult heart and ovary. Intermediate expression in adult kidney, lung and skin.

Inductioni

By FGF-1.

Gene expression databases

BgeeiQ9CR75.
ExpressionAtlasiQ9CR75. baseline and differential.
GenevisibleiQ9CR75. MM.

Interactioni

Subunit structurei

Associates with TRAF1 and TRAF2, and probably also with TRAF3.By similarity

Protein-protein interaction databases

BioGridi205159. 4 interactions.
STRINGi10090.ENSMUSP00000024698.

Structurei

3D structure databases

ProteinModelPortaliQ9CR75.
SMRiQ9CR75. Positions 28-80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6732TNFR-Cys; atypicalAdd
BLAST

Sequence similaritiesi

Contains 1 TNFR-Cys repeat.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHX. Eukaryota.
ENOG41116AK. LUCA.
GeneTreeiENSGT00390000001948.
HOGENOMiHOG000154660.
HOVERGENiHBG031553.
InParanoidiQ9CR75.
KOiK05149.
OMAiMDCASCP.
PhylomeDBiQ9CR75.
TreeFamiTF337901.

Family and domain databases

InterProiIPR022316. TNFR_12.
[Graphical view]
PfamiPF12191. stn_TNFRSF12A. 1 hit.
[Graphical view]
PRINTSiPR01962. TNFACTORR12.
ProDomiPD336131. TNFR_12. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAWPRSLP QILVLGFGLV LMRAAAGEQA PGTSPCSSGS SWSADLDKCM
60 70 80 90 100
DCASCPARPH SDFCLGCAAA PPAHFRLLWP ILGGALSLVL VLALVSSFLV
110 120
WRRCRRREKF TTPIEETGGE GCPGVALIQ
Length:129
Mass (Da):13,641
Last modified:June 1, 2001 - v1
Checksum:i1665C68B4D9A9253
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42SA → PG in AAF07882 (PubMed:10551889).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156164 mRNA. Translation: AAF07882.1.
AK005382 mRNA. Translation: BAB23989.1.
AK005530 mRNA. Translation: BAB24101.1.
AK160136 mRNA. Translation: BAE35650.1.
BC025860 mRNA. Translation: AAH25860.1.
CCDSiCCDS28456.1.
RefSeqiNP_001155218.1. NM_001161746.1.
NP_038777.2. NM_013749.2.
UniGeneiMm.28518.

Genome annotation databases

EnsembliENSMUST00000024698; ENSMUSP00000024698; ENSMUSG00000023905.
GeneIDi27279.
KEGGimmu:27279.
UCSCiuc008asv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156164 mRNA. Translation: AAF07882.1.
AK005382 mRNA. Translation: BAB23989.1.
AK005530 mRNA. Translation: BAB24101.1.
AK160136 mRNA. Translation: BAE35650.1.
BC025860 mRNA. Translation: AAH25860.1.
CCDSiCCDS28456.1.
RefSeqiNP_001155218.1. NM_001161746.1.
NP_038777.2. NM_013749.2.
UniGeneiMm.28518.

3D structure databases

ProteinModelPortaliQ9CR75.
SMRiQ9CR75. Positions 28-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205159. 4 interactions.
STRINGi10090.ENSMUSP00000024698.

PTM databases

iPTMnetiQ9CR75.
PhosphoSiteiQ9CR75.

Proteomic databases

MaxQBiQ9CR75.
PaxDbiQ9CR75.
PRIDEiQ9CR75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024698; ENSMUSP00000024698; ENSMUSG00000023905.
GeneIDi27279.
KEGGimmu:27279.
UCSCiuc008asv.2. mouse.

Organism-specific databases

CTDi51330.
MGIiMGI:1351484. Tnfrsf12a.

Phylogenomic databases

eggNOGiENOG410IYHX. Eukaryota.
ENOG41116AK. LUCA.
GeneTreeiENSGT00390000001948.
HOGENOMiHOG000154660.
HOVERGENiHBG031553.
InParanoidiQ9CR75.
KOiK05149.
OMAiMDCASCP.
PhylomeDBiQ9CR75.
TreeFamiTF337901.

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Miscellaneous databases

PROiQ9CR75.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR75.
ExpressionAtlasiQ9CR75. baseline and differential.
GenevisibleiQ9CR75. MM.

Family and domain databases

InterProiIPR022316. TNFR_12.
[Graphical view]
PfamiPF12191. stn_TNFRSF12A. 1 hit.
[Graphical view]
PRINTSiPR01962. TNFACTORR12.
ProDomiPD336131. TNFR_12. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration."
    Meighan-Mantha R.L., Hsu D.K.W., Guo Y., Brown S.A.N., Feng S.-L.Y., Peifley K.A., Alberts G.F., Copeland N.G., Gilbert D.J., Jenkins N.A., Richards C.M., Winkles J.A.
    J. Biol. Chem. 274:33166-33176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Fibroblast.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTNR12_MOUSE
AccessioniPrimary (citable) accession number: Q9CR75
Secondary accession number(s): Q3TVG8, Q9QZW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.