Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CR73

- PNRC2_MOUSE

UniProt

Q9CR73 - PNRC2_MOUSE

Protein

Proline-rich nuclear receptor coactivator 2

Gene

Pnrc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure By similarity.By similarity

    GO - Biological processi

    1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Nonsense-mediated mRNA decay, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich nuclear receptor coactivator 2
    Gene namesi
    Name:Pnrc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:106512. Pnrc2.

    Subcellular locationi

    Nucleus By similarity. CytoplasmP-body By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are lean, resistant to high fat diet-induced obesity but without the induction of insulin resistance and have a higher metabolic rate than wild-type mice.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Proline-rich nuclear receptor coactivator 2PRO_0000058486Add
    BLAST

    Proteomic databases

    PRIDEiQ9CR73.

    PTM databases

    PhosphoSiteiQ9CR73.

    Expressioni

    Tissue specificityi

    Strong expression is detected in lung, spleen, ovary, thymus, and colon.1 Publication

    Gene expression databases

    BgeeiQ9CR73.
    CleanExiMM_PNRC2.
    GenevestigatoriQ9CR73.

    Interactioni

    Subunit structurei

    Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000030436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi100 – 1067SH3-binding

    Domaini

    The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.By similarity

    Sequence similaritiesi

    Belongs to the PNRC family. PNRC2 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG45103.
    GeneTreeiENSGT00530000063881.
    HOGENOMiHOG000115593.
    HOVERGENiHBG053627.
    InParanoidiB1AV48.
    OMAiERYNIPD.
    OrthoDBiEOG71VSVM.
    PhylomeDBiQ9CR73.

    Family and domain databases

    InterProiIPR026780. PNRC1/2.
    IPR026781. PNRC2.
    [Graphical view]
    PANTHERiPTHR15405. PTHR15405. 1 hit.
    PTHR15405:SF5. PTHR15405:SF5. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CR73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGGERYNIP DPQSRNASKN QEQQNRQKSK DQNSSQTKIA HKKKERGHGY    50
    NPAAAAWQAM QNGGKTKSLS NNSNWNAGLS SPSLLFKSQA SQNYAGAKFS 100
    EPPSPSVLPK PPSHWVHVSL NPSDKETMTF QLKTLLKVQV 140
    Length:140
    Mass (Da):15,401
    Last modified:June 1, 2001 - v1
    Checksum:i17321057158B36B3
    GO

    Sequence cautioni

    The sequence CAM15897.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 981K → Q in BAB31186. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011192 mRNA. Translation: BAB27457.1.
    AK012073 mRNA. Translation: BAB28010.1.
    AK013163 mRNA. Translation: BAB28686.1.
    AK018384 mRNA. Translation: BAB31186.1.
    AK075816 mRNA. Translation: BAC35983.1.
    AK077403 mRNA. Translation: BAC36786.1.
    AL672076 Genomic DNA. Translation: CAM15896.1.
    AL672076 Genomic DNA. Translation: CAM15897.1. Sequence problems.
    CH466552 Genomic DNA. Translation: EDL29966.1.
    BC006598 mRNA. Translation: AAH06598.1.
    CCDSiCCDS18792.1.
    RefSeqiNP_080659.1. NM_026383.3.
    XP_006539101.1. XM_006539038.1.
    XP_006539102.1. XM_006539039.1.
    UniGeneiMm.29159.

    Genome annotation databases

    EnsembliENSMUST00000030436; ENSMUSP00000030436; ENSMUSG00000028675.
    GeneIDi52830.
    KEGGimmu:52830.
    UCSCiuc008vhf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011192 mRNA. Translation: BAB27457.1 .
    AK012073 mRNA. Translation: BAB28010.1 .
    AK013163 mRNA. Translation: BAB28686.1 .
    AK018384 mRNA. Translation: BAB31186.1 .
    AK075816 mRNA. Translation: BAC35983.1 .
    AK077403 mRNA. Translation: BAC36786.1 .
    AL672076 Genomic DNA. Translation: CAM15896.1 .
    AL672076 Genomic DNA. Translation: CAM15897.1 . Sequence problems.
    CH466552 Genomic DNA. Translation: EDL29966.1 .
    BC006598 mRNA. Translation: AAH06598.1 .
    CCDSi CCDS18792.1.
    RefSeqi NP_080659.1. NM_026383.3.
    XP_006539101.1. XM_006539038.1.
    XP_006539102.1. XM_006539039.1.
    UniGenei Mm.29159.

    3D structure databases

    ProteinModelPortali Q9CR73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000030436.

    PTM databases

    PhosphoSitei Q9CR73.

    Proteomic databases

    PRIDEi Q9CR73.

    Protocols and materials databases

    DNASUi 52830.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030436 ; ENSMUSP00000030436 ; ENSMUSG00000028675 .
    GeneIDi 52830.
    KEGGi mmu:52830.
    UCSCi uc008vhf.2. mouse.

    Organism-specific databases

    CTDi 55629.
    MGIi MGI:106512. Pnrc2.

    Phylogenomic databases

    eggNOGi NOG45103.
    GeneTreei ENSGT00530000063881.
    HOGENOMi HOG000115593.
    HOVERGENi HBG053627.
    InParanoidi B1AV48.
    OMAi ERYNIPD.
    OrthoDBi EOG71VSVM.
    PhylomeDBi Q9CR73.

    Miscellaneous databases

    ChiTaRSi PNRC2. mouse.
    NextBioi 309599.
    PROi Q9CR73.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CR73.
    CleanExi MM_PNRC2.
    Genevestigatori Q9CR73.

    Family and domain databases

    InterProi IPR026780. PNRC1/2.
    IPR026781. PNRC2.
    [Graphical view ]
    PANTHERi PTHR15405. PTHR15405. 1 hit.
    PTHR15405:SF5. PTHR15405:SF5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Head, Lung and Small intestine.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1."
      Zhou D., Masri S., Ye J.J., Chen S.
      Gene 361:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity."
      Zhou D., Shen R., Ye J.J., Li Y., Tsark W., Isbell D., Tso P., Chen S.
      J. Biol. Chem. 283:541-553(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPNRC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR73
    Secondary accession number(s): B1AV48, B1AV49, Q9CXC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3