Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9CR73 (PNRC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline-rich nuclear receptor coactivator 2
Gene names
Name:Pnrc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure By similarity. Ref.6

Subunit structure

Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR By similarity.

Subcellular location

Nucleus By similarity. CytoplasmP-body By similarity.

Tissue specificity

Strong expression is detected in lung, spleen, ovary, thymus, and colon. Ref.5

Domain

The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif By similarity.

Disruption phenotype

Mice are lean, resistant to high fat diet-induced obesity but without the induction of insulin resistance and have a higher metabolic rate than wild-type mice. Ref.6

Sequence similarities

Belongs to the PNRC family. PNRC2 subfamily.

Sequence caution

The sequence CAM15897.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Proline-rich nuclear receptor coactivator 2
PRO_0000058486

Regions

Motif100 – 1067SH3-binding

Experimental info

Sequence conflict981K → Q in BAB31186. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9CR73 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 17321057158B36B3

FASTA14015,401
        10         20         30         40         50         60 
MGGGERYNIP DPQSRNASKN QEQQNRQKSK DQNSSQTKIA HKKKERGHGY NPAAAAWQAM 

        70         80         90        100        110        120 
QNGGKTKSLS NNSNWNAGLS SPSLLFKSQA SQNYAGAKFS EPPSPSVLPK PPSHWVHVSL 

       130        140 
NPSDKETMTF QLKTLLKVQV 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Head, Lung and Small intestine.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[5]"Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1."
Zhou D., Masri S., Ye J.J., Chen S.
Gene 361:89-100(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity."
Zhou D., Shen R., Ye J.J., Li Y., Tsark W., Isbell D., Tso P., Chen S.
J. Biol. Chem. 283:541-553(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK011192 mRNA. Translation: BAB27457.1.
AK012073 mRNA. Translation: BAB28010.1.
AK013163 mRNA. Translation: BAB28686.1.
AK018384 mRNA. Translation: BAB31186.1.
AK075816 mRNA. Translation: BAC35983.1.
AK077403 mRNA. Translation: BAC36786.1.
AL672076 Genomic DNA. Translation: CAM15896.1.
AL672076 Genomic DNA. Translation: CAM15897.1. Sequence problems.
CH466552 Genomic DNA. Translation: EDL29966.1.
BC006598 mRNA. Translation: AAH06598.1.
CCDSCCDS18792.1.
RefSeqNP_080659.1. NM_026383.3.
XP_006539101.1. XM_006539038.1.
XP_006539102.1. XM_006539039.1.
UniGeneMm.29159.

3D structure databases

ProteinModelPortalQ9CR73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000030436.

PTM databases

PhosphoSiteQ9CR73.

Proteomic databases

PRIDEQ9CR73.

Protocols and materials databases

DNASU52830.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030436; ENSMUSP00000030436; ENSMUSG00000028675.
GeneID52830.
KEGGmmu:52830.
UCSCuc008vhf.2. mouse.

Organism-specific databases

CTD55629.
MGIMGI:106512. Pnrc2.

Phylogenomic databases

eggNOGNOG45103.
GeneTreeENSGT00530000063881.
HOGENOMHOG000115593.
HOVERGENHBG053627.
InParanoidB1AV48.
OMAERYNIPD.
OrthoDBEOG71VSVM.
PhylomeDBQ9CR73.

Gene expression databases

BgeeQ9CR73.
CleanExMM_PNRC2.
GenevestigatorQ9CR73.

Family and domain databases

InterProIPR026780. PNRC1/2.
IPR026781. PNRC2.
[Graphical view]
PANTHERPTHR15405. PTHR15405. 1 hit.
PTHR15405:SF5. PTHR15405:SF5. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPNRC2. mouse.
NextBio309599.
PROQ9CR73.
SOURCESearch...

Entry information

Entry namePNRC2_MOUSE
AccessionPrimary (citable) accession number: Q9CR73
Secondary accession number(s): B1AV48, B1AV49, Q9CXC6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot