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Q9CR73

- PNRC2_MOUSE

UniProt

Q9CR73 - PNRC2_MOUSE

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Protein
Proline-rich nuclear receptor coactivator 2
Gene
Pnrc2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure By similarity.1 Publication

GO - Biological processi

  1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Nonsense-mediated mRNA decay, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich nuclear receptor coactivator 2
Gene namesi
Name:Pnrc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:106512. Pnrc2.

Subcellular locationi

Nucleus By similarity. CytoplasmP-body By similarity

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are lean, resistant to high fat diet-induced obesity but without the induction of insulin resistance and have a higher metabolic rate than wild-type mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Proline-rich nuclear receptor coactivator 2
PRO_0000058486Add
BLAST

Proteomic databases

PRIDEiQ9CR73.

PTM databases

PhosphoSiteiQ9CR73.

Expressioni

Tissue specificityi

Strong expression is detected in lung, spleen, ovary, thymus, and colon.1 Publication

Gene expression databases

BgeeiQ9CR73.
CleanExiMM_PNRC2.
GenevestigatoriQ9CR73.

Interactioni

Subunit structurei

Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030436.

Structurei

3D structure databases

ProteinModelPortaliQ9CR73.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi100 – 1067SH3-binding

Domaini

The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif By similarity.

Sequence similaritiesi

Belongs to the PNRC family. PNRC2 subfamily.

Phylogenomic databases

eggNOGiNOG45103.
GeneTreeiENSGT00530000063881.
HOGENOMiHOG000115593.
HOVERGENiHBG053627.
InParanoidiB1AV48.
OMAiERYNIPD.
OrthoDBiEOG71VSVM.
PhylomeDBiQ9CR73.

Family and domain databases

InterProiIPR026780. PNRC1/2.
IPR026781. PNRC2.
[Graphical view]
PANTHERiPTHR15405. PTHR15405. 1 hit.
PTHR15405:SF5. PTHR15405:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CR73-1 [UniParc]FASTAAdd to Basket

« Hide

MGGGERYNIP DPQSRNASKN QEQQNRQKSK DQNSSQTKIA HKKKERGHGY    50
NPAAAAWQAM QNGGKTKSLS NNSNWNAGLS SPSLLFKSQA SQNYAGAKFS 100
EPPSPSVLPK PPSHWVHVSL NPSDKETMTF QLKTLLKVQV 140
Length:140
Mass (Da):15,401
Last modified:June 1, 2001 - v1
Checksum:i17321057158B36B3
GO

Sequence cautioni

The sequence CAM15897.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981K → Q in BAB31186. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011192 mRNA. Translation: BAB27457.1.
AK012073 mRNA. Translation: BAB28010.1.
AK013163 mRNA. Translation: BAB28686.1.
AK018384 mRNA. Translation: BAB31186.1.
AK075816 mRNA. Translation: BAC35983.1.
AK077403 mRNA. Translation: BAC36786.1.
AL672076 Genomic DNA. Translation: CAM15896.1.
AL672076 Genomic DNA. Translation: CAM15897.1. Sequence problems.
CH466552 Genomic DNA. Translation: EDL29966.1.
BC006598 mRNA. Translation: AAH06598.1.
CCDSiCCDS18792.1.
RefSeqiNP_080659.1. NM_026383.3.
XP_006539101.1. XM_006539038.1.
XP_006539102.1. XM_006539039.1.
UniGeneiMm.29159.

Genome annotation databases

EnsembliENSMUST00000030436; ENSMUSP00000030436; ENSMUSG00000028675.
GeneIDi52830.
KEGGimmu:52830.
UCSCiuc008vhf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011192 mRNA. Translation: BAB27457.1 .
AK012073 mRNA. Translation: BAB28010.1 .
AK013163 mRNA. Translation: BAB28686.1 .
AK018384 mRNA. Translation: BAB31186.1 .
AK075816 mRNA. Translation: BAC35983.1 .
AK077403 mRNA. Translation: BAC36786.1 .
AL672076 Genomic DNA. Translation: CAM15896.1 .
AL672076 Genomic DNA. Translation: CAM15897.1 . Sequence problems.
CH466552 Genomic DNA. Translation: EDL29966.1 .
BC006598 mRNA. Translation: AAH06598.1 .
CCDSi CCDS18792.1.
RefSeqi NP_080659.1. NM_026383.3.
XP_006539101.1. XM_006539038.1.
XP_006539102.1. XM_006539039.1.
UniGenei Mm.29159.

3D structure databases

ProteinModelPortali Q9CR73.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000030436.

PTM databases

PhosphoSitei Q9CR73.

Proteomic databases

PRIDEi Q9CR73.

Protocols and materials databases

DNASUi 52830.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030436 ; ENSMUSP00000030436 ; ENSMUSG00000028675 .
GeneIDi 52830.
KEGGi mmu:52830.
UCSCi uc008vhf.2. mouse.

Organism-specific databases

CTDi 55629.
MGIi MGI:106512. Pnrc2.

Phylogenomic databases

eggNOGi NOG45103.
GeneTreei ENSGT00530000063881.
HOGENOMi HOG000115593.
HOVERGENi HBG053627.
InParanoidi B1AV48.
OMAi ERYNIPD.
OrthoDBi EOG71VSVM.
PhylomeDBi Q9CR73.

Miscellaneous databases

ChiTaRSi PNRC2. mouse.
NextBioi 309599.
PROi Q9CR73.
SOURCEi Search...

Gene expression databases

Bgeei Q9CR73.
CleanExi MM_PNRC2.
Genevestigatori Q9CR73.

Family and domain databases

InterProi IPR026780. PNRC1/2.
IPR026781. PNRC2.
[Graphical view ]
PANTHERi PTHR15405. PTHR15405. 1 hit.
PTHR15405:SF5. PTHR15405:SF5. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Lung and Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1."
    Zhou D., Masri S., Ye J.J., Chen S.
    Gene 361:89-100(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity."
    Zhou D., Shen R., Ye J.J., Li Y., Tsark W., Isbell D., Tso P., Chen S.
    J. Biol. Chem. 283:541-553(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPNRC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR73
Secondary accession number(s): B1AV48, B1AV49, Q9CXC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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