Reviewed,
UniProtKB/Swiss-Prot Q9CR68 (UCRI_MOUSE)
Last modified
November 3, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Cytochrome b-c1 complex subunit Rieske, mitochondrial EC=1.10.2.2 Alternative name(s): Ubiquinol-cytochrome c reductase iron-sulfur subunit Rieske iron-sulfur protein Short name=RISP Complex III subunit 5 Cleaved into the following chain: 1- Recommended name: Cytochrome b-c1 complex subunit 11 Alternative name(s): Ubiquinol-cytochrome c reductase 8 kDa protein Complex III subunit IX | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 274 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex By similarity. |
| Catalytic activity | QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+. |
| Cofactor | Binds 1 2Fe-2S cluster per subunit By similarity. |
| Subunit structure | The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity. |
| Subcellular location | |
| Miscellaneous | The Rieske protein is a high potential 2Fe-2S protein. |
| Sequence similarities | Contains 1 Rieske domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 78 | 78 | Cytochrome b-c1 complex subunit 11 By similarity | PRO_0000307244 | |||||||
| Transit peptide | 1 – 78 | 78 | Mitochondrion By similarity | ||||||||
| Chain | 79 – 274 | 196 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | PRO_0000030667 | |||||||
Regions | |||||||||||
| Domain | 187 – 272 | 86 | Rieske | ||||||||
Sites | |||||||||||
| Metal binding | 217 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 219 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
| Metal binding | 236 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 239 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 222 ↔ 238 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| AK003966 mRNA. Translation: BAB23097.1. AK012180 mRNA. Translation: BAB28081.1. AK014470 mRNA. Translation: BAB29374.1. AK153139 mRNA. Translation: BAE31751.1. AK152391 mRNA. Translation: BAE31179.1. AL611944 Genomic DNA. Translation: CAI24872.1. BC019934 mRNA. Translation: AAH19934.1. | |
| IPI | IPI00133240. |
| RefSeq | NP_079986.1. |
| UniGene | Mm.181933 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RIE based on UniProtKB P13272. |
| SMR | Q9CR68. Positions 1-57, 79-274. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9CR68. |
PTM databases | |
| PhosphoSite | Q9CR68. |
Proteomic databases | |
| PRIDE | Q9CR68. |
Genome annotation databases | |
| Ensembl | ENSMUST00000042834; ENSMUSP00000045284; ENSMUSG00000038462; Mus musculus. [Genome view] |
| GeneID | 66694. |
| KEGG | mmu:66694. |
| NMPDR | fig|10090.3.peg.27643. |
| UCSC | uc007pyv.1. mouse. |
Organism-specific databases | |
| CTD | 66694. |
| MGI | MGI:1913944. Uqcrfs1. |
Phylogenomic databases | |
| HOGENOM | Q9CR68. |
| HOVERGEN | Q9CR68. |
| OMA | DYRRAEV. |
Enzyme and pathway databases | |
| BRENDA | 1.10.2.2. 244. |
Gene expression databases | |
| ArrayExpress | Q9CR68. |
| Bgee | Q9CR68. |
| Genevestigator | Q9CR68. |
| GermOnline | ENSMUSG00000038462. Mus musculus. |
Family and domain databases | |
| InterPro | IPR017941. Rieske_2Fe-2S. IPR014349. Rieske_Fe-S_prot. IPR005805. Rieske_Fe-S_prot_C. IPR015248. Ubiqinol_cyt_c_Rdtase_N. IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su. IPR004192. Ubiquinol_cyt_Rdtase_TM. [Graphical view] |
| Gene3D | G3DSA:2.102.10.10. Rieske_reg. 1 hit. |
| PANTHER | PTHR10134. Rieske. 1 hit. |
| Pfam | PF00355. Rieske. 1 hit. PF09165. Ubiq-Cytc-red_N. 1 hit. PF02921. UCR_TM. 1 hit. [Graphical view] |
| PRINTS | PR00162. RIESKE. |
| TIGRFAMs | TIGR01416. Rieske_proteo. 1 hit. |
| PROSITE | PS51296. RIESKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 322393. |
| SOURCE | Search... |
Entry information
| Entry name | UCRI_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9CR68 Secondary accession number(s): Q5SVV1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


