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Protein

Transmembrane protein 33

Gene

Tmem33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
Gene namesi
Name:Tmem33
Synonyms:Db83
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915128 Tmem33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31LumenalCuratedAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 100CytoplasmicCuratedAdd BLAST48
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 155LumenalCuratedAdd BLAST34
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 247CytoplasmicCuratedAdd BLAST71

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209002 – 247Transmembrane protein 33Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR67
MaxQBiQ9CR67
PaxDbiQ9CR67
PeptideAtlasiQ9CR67
PRIDEiQ9CR67
TopDownProteomicsiQ9CR67

PTM databases

iPTMnetiQ9CR67
PhosphoSitePlusiQ9CR67
SwissPalmiQ9CR67

Expressioni

Gene expression databases

BgeeiENSMUSG00000037720
CleanExiMM_TMEM33
ExpressionAtlasiQ9CR67 baseline and differential
GenevisibleiQ9CR67 MM

Interactioni

Subunit structurei

Interacts with EIF2AK3. Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1.By similarity

Protein-protein interaction databases

BioGridi212504, 2 interactors
IntActiQ9CR67, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9CR67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4002 Eukaryota
ENOG4111BM3 LUCA
GeneTreeiENSGT00390000011368
HOGENOMiHOG000007460
HOVERGENiHBG054225
InParanoidiQ9CR67
KOiK20724
OMAiIMKPSCP
OrthoDBiEOG091G0IX8
PhylomeDBiQ9CR67
TreeFamiTF314068

Family and domain databases

InterProiView protein in InterPro
IPR005344 TMEM33/Pom33
PfamiView protein in Pfam
PF03661 UPF0121, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDAKGSNSLP LLRSFLDKLS
160 170 180 190 200
TNQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRNLFNE LRIVVEHIIM KPSCPLFVRR LCLQSIAFIS RLAPTVA
Length:247
Mass (Da):28,031
Last modified:June 1, 2001 - v1
Checksum:i1813EF1C109ACC05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → T in BAB24078 (PubMed:16141072).Curated1
Sequence conflicti246Missing in BAB30671 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005493 mRNA Translation: BAB24078.1
AK007607 mRNA Translation: BAB25131.1
AK007750 mRNA Translation: BAB25233.1
AK017281 mRNA Translation: BAB30671.1
AK032555 mRNA Translation: BAC27922.1
AK153441 mRNA Translation: BAE31997.1
AK165369 mRNA Translation: BAE38149.1
BC005562 mRNA Translation: AAH05562.1
BC016570 mRNA Translation: AAH16570.1
BC023966 mRNA Translation: AAH23966.1
CCDSiCCDS19317.1
RefSeqiNP_001272381.1, NM_001285452.1
NP_083251.2, NM_028975.4
NP_084384.1, NM_030108.2
UniGeneiMm.23217

Genome annotation databases

EnsembliENSMUST00000037918; ENSMUSP00000042852; ENSMUSG00000037720
ENSMUST00000161369; ENSMUSP00000124390; ENSMUSG00000037720
GeneIDi67878
KEGGimmu:67878
UCSCiuc008xpp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTMM33_MOUSE
AccessioniPrimary (citable) accession number: Q9CR67
Secondary accession number(s): Q544Q3, Q9D3M3, Q9DAV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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