Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 33

Gene

Tmem33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
Gene namesi
Name:Tmem33
Synonyms:Db83
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915128. Tmem33.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Melanosome By similarity
  • Nucleus envelope By similarity

  • Note: Co-localizes with RTN4 at the ER sheets.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3130LumenalCuratedAdd
BLAST
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Topological domaini53 – 10048CytoplasmicCuratedAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 15534LumenalCuratedAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 24771CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 247246Transmembrane protein 33PRO_0000220900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR67.
MaxQBiQ9CR67.
PaxDbiQ9CR67.
PRIDEiQ9CR67.
TopDownProteomicsiQ9CR67.

PTM databases

iPTMnetiQ9CR67.
PhosphoSiteiQ9CR67.
SwissPalmiQ9CR67.

Expressioni

Gene expression databases

BgeeiQ9CR67.
CleanExiMM_TMEM33.
ExpressionAtlasiQ9CR67. baseline and differential.
GenevisibleiQ9CR67. MM.

Interactioni

Subunit structurei

Interacts with EIF2AK3. Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1.By similarity

Protein-protein interaction databases

BioGridi212504. 1 interaction.
IntActiQ9CR67. 1 interaction.
MINTiMINT-1843567.
STRINGi10090.ENSMUSP00000042852.

Structurei

3D structure databases

ProteinModelPortaliQ9CR67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
GeneTreeiENSGT00390000011368.
HOGENOMiHOG000007460.
HOVERGENiHBG054225.
InParanoidiQ9CR67.
OMAiIMKPSCP.
OrthoDBiEOG78SQJW.
PhylomeDBiQ9CR67.
TreeFamiTF314068.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDAKGSNSLP LLRSFLDKLS
160 170 180 190 200
TNQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRNLFNE LRIVVEHIIM KPSCPLFVRR LCLQSIAFIS RLAPTVA
Length:247
Mass (Da):28,031
Last modified:June 1, 2001 - v1
Checksum:i1813EF1C109ACC05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → T in BAB24078 (PubMed:16141072).Curated
Sequence conflicti246 – 2461Missing in BAB30671 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005493 mRNA. Translation: BAB24078.1.
AK007607 mRNA. Translation: BAB25131.1.
AK007750 mRNA. Translation: BAB25233.1.
AK017281 mRNA. Translation: BAB30671.1.
AK032555 mRNA. Translation: BAC27922.1.
AK153441 mRNA. Translation: BAE31997.1.
AK165369 mRNA. Translation: BAE38149.1.
BC005562 mRNA. Translation: AAH05562.1.
BC016570 mRNA. Translation: AAH16570.1.
BC023966 mRNA. Translation: AAH23966.1.
CCDSiCCDS19317.1.
RefSeqiNP_001272381.1. NM_001285452.1.
NP_083251.2. NM_028975.4.
NP_084384.1. NM_030108.2.
UniGeneiMm.23217.

Genome annotation databases

EnsembliENSMUST00000037918; ENSMUSP00000042852; ENSMUSG00000037720.
ENSMUST00000161369; ENSMUSP00000124390; ENSMUSG00000037720.
GeneIDi67878.
KEGGimmu:67878.
UCSCiuc008xpp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005493 mRNA. Translation: BAB24078.1.
AK007607 mRNA. Translation: BAB25131.1.
AK007750 mRNA. Translation: BAB25233.1.
AK017281 mRNA. Translation: BAB30671.1.
AK032555 mRNA. Translation: BAC27922.1.
AK153441 mRNA. Translation: BAE31997.1.
AK165369 mRNA. Translation: BAE38149.1.
BC005562 mRNA. Translation: AAH05562.1.
BC016570 mRNA. Translation: AAH16570.1.
BC023966 mRNA. Translation: AAH23966.1.
CCDSiCCDS19317.1.
RefSeqiNP_001272381.1. NM_001285452.1.
NP_083251.2. NM_028975.4.
NP_084384.1. NM_030108.2.
UniGeneiMm.23217.

3D structure databases

ProteinModelPortaliQ9CR67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212504. 1 interaction.
IntActiQ9CR67. 1 interaction.
MINTiMINT-1843567.
STRINGi10090.ENSMUSP00000042852.

PTM databases

iPTMnetiQ9CR67.
PhosphoSiteiQ9CR67.
SwissPalmiQ9CR67.

Proteomic databases

EPDiQ9CR67.
MaxQBiQ9CR67.
PaxDbiQ9CR67.
PRIDEiQ9CR67.
TopDownProteomicsiQ9CR67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037918; ENSMUSP00000042852; ENSMUSG00000037720.
ENSMUST00000161369; ENSMUSP00000124390; ENSMUSG00000037720.
GeneIDi67878.
KEGGimmu:67878.
UCSCiuc008xpp.2. mouse.

Organism-specific databases

CTDi55161.
MGIiMGI:1915128. Tmem33.

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
GeneTreeiENSGT00390000011368.
HOGENOMiHOG000007460.
HOVERGENiHBG054225.
InParanoidiQ9CR67.
OMAiIMKPSCP.
OrthoDBiEOG78SQJW.
PhylomeDBiQ9CR67.
TreeFamiTF314068.

Miscellaneous databases

PROiQ9CR67.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR67.
CleanExiMM_TMEM33.
ExpressionAtlasiQ9CR67. baseline and differential.
GenevisibleiQ9CR67. MM.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Brain, Head, Pancreas, Placenta and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTMM33_MOUSE
AccessioniPrimary (citable) accession number: Q9CR67
Secondary accession number(s): Q544Q3, Q9D3M3, Q9DAV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.