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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

Slc25a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:21448454).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.29.2.11 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915113 Slc25a11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 42Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 101Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 240Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906262 – 314Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei57N6-succinyllysineCombined sources1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei102PhosphotyrosineCombined sources1
Modified residuei256N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CR62
MaxQBiQ9CR62
PaxDbiQ9CR62
PRIDEiQ9CR62

PTM databases

CarbonylDBiQ9CR62
iPTMnetiQ9CR62
PhosphoSitePlusiQ9CR62
SwissPalmiQ9CR62

Expressioni

Gene expression databases

BgeeiENSMUSG00000014606
ExpressionAtlasiQ9CR62 baseline and differential
GenevisibleiQ9CR62 MM

Interactioni

Protein-protein interaction databases

BioGridi212490, 4 interactors
IntActiQ9CR62, 11 interactors
MINTiQ9CR62
STRINGi10090.ENSMUSP00000014750

Structurei

3D structure databases

ProteinModelPortaliQ9CR62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 108Solcar 1Add BLAST86
Repeati117 – 208Solcar 2Add BLAST92
Repeati217 – 306Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165139
HOVERGENiHBG009528
InParanoidiQ9CR62
KOiK15104
OMAiGFTPYYF
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9CR62
TreeFamiTF354262

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASPGAG RMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKTEGLKGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKALIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALVR IAREEGVPTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIVKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLLKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,155
Last modified:January 23, 2007 - v3
Checksum:i1B19A5DB093941A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009824 mRNA Translation: BAB26524.1
AK009487 mRNA Translation: BAB26319.1
BC003455 mRNA Translation: AAH03455.1
BC019631 mRNA Translation: AAH19631.1
CCDSiCCDS24958.1
RefSeqiNP_077173.1, NM_024211.3
UniGeneiMm.296082
Mm.466994

Genome annotation databases

EnsembliENSMUST00000014750; ENSMUSP00000014750; ENSMUSG00000014606
GeneIDi67863
KEGGimmu:67863
UCSCiuc007jvr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiM2OM_MOUSE
AccessioniPrimary (citable) accession number: Q9CR62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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