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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

Slc25a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-70263. Gluconeogenesis.
R-MMU-70326. Glucose metabolism.

Protein family/group databases

TCDBi2.A.29.2.11. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915113. Slc25a11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 42Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 101Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 240Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906262 – 314Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei57N6-succinyllysineCombined sources1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei102PhosphotyrosineCombined sources1
Modified residuei256N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CR62.
MaxQBiQ9CR62.
PaxDbiQ9CR62.
PRIDEiQ9CR62.

PTM databases

iPTMnetiQ9CR62.
PhosphoSitePlusiQ9CR62.
SwissPalmiQ9CR62.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014606.
ExpressionAtlasiQ9CR62. baseline and differential.
GenevisibleiQ9CR62. MM.

Interactioni

Protein-protein interaction databases

BioGridi212490. 3 interactors.
IntActiQ9CR62. 11 interactors.
MINTiMINT-1851446.
STRINGi10090.ENSMUSP00000014750.

Structurei

3D structure databases

ProteinModelPortaliQ9CR62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 108Solcar 1Add BLAST86
Repeati117 – 208Solcar 2Add BLAST92
Repeati217 – 306Solcar 3Add BLAST90

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9CR62.
KOiK15104.
OMAiSDNIFCH.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9CR62.
TreeFamiTF354262.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASPGAG RMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKTEGLKGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKALIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALVR IAREEGVPTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIVKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLLKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,155
Last modified:January 23, 2007 - v3
Checksum:i1B19A5DB093941A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009824 mRNA. Translation: BAB26524.1.
AK009487 mRNA. Translation: BAB26319.1.
BC003455 mRNA. Translation: AAH03455.1.
BC019631 mRNA. Translation: AAH19631.1.
CCDSiCCDS24958.1.
RefSeqiNP_077173.1. NM_024211.3.
UniGeneiMm.296082.
Mm.466994.

Genome annotation databases

EnsembliENSMUST00000014750; ENSMUSP00000014750; ENSMUSG00000014606.
GeneIDi67863.
KEGGimmu:67863.
UCSCiuc007jvr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009824 mRNA. Translation: BAB26524.1.
AK009487 mRNA. Translation: BAB26319.1.
BC003455 mRNA. Translation: AAH03455.1.
BC019631 mRNA. Translation: AAH19631.1.
CCDSiCCDS24958.1.
RefSeqiNP_077173.1. NM_024211.3.
UniGeneiMm.296082.
Mm.466994.

3D structure databases

ProteinModelPortaliQ9CR62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212490. 3 interactors.
IntActiQ9CR62. 11 interactors.
MINTiMINT-1851446.
STRINGi10090.ENSMUSP00000014750.

Protein family/group databases

TCDBi2.A.29.2.11. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9CR62.
PhosphoSitePlusiQ9CR62.
SwissPalmiQ9CR62.

Proteomic databases

EPDiQ9CR62.
MaxQBiQ9CR62.
PaxDbiQ9CR62.
PRIDEiQ9CR62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014750; ENSMUSP00000014750; ENSMUSG00000014606.
GeneIDi67863.
KEGGimmu:67863.
UCSCiuc007jvr.2. mouse.

Organism-specific databases

CTDi8402.
MGIiMGI:1915113. Slc25a11.

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9CR62.
KOiK15104.
OMAiSDNIFCH.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9CR62.
TreeFamiTF354262.

Enzyme and pathway databases

ReactomeiR-MMU-70263. Gluconeogenesis.
R-MMU-70326. Glucose metabolism.

Miscellaneous databases

ChiTaRSiSlc25a11. mouse.
PROiQ9CR62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014606.
ExpressionAtlasiQ9CR62. baseline and differential.
GenevisibleiQ9CR62. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM2OM_MOUSE
AccessioniPrimary (citable) accession number: Q9CR62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.