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Q9CR62

- M2OM_MOUSE

UniProt

Q9CR62 - M2OM_MOUSE

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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene
Slc25a11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism By similarity.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.2.11. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:Slc25a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1915113. Slc25a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4219Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei83 – 10119Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei119 – 14022Helical; Name=3; Reviewed predictionAdd
BLAST
Transmembranei183 – 20220Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei222 – 24019Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei281 – 30020Helical; Name=6; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 314313Mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000090626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei57 – 571N6-succinyllysine1 Publication
Modified residuei73 – 731N6-acetyllysine By similarity
Modified residuei102 – 1021Phosphotyrosine1 Publication
Modified residuei256 – 2561N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CR62.
PaxDbiQ9CR62.
PRIDEiQ9CR62.

PTM databases

PhosphoSiteiQ9CR62.

Expressioni

Gene expression databases

ArrayExpressiQ9CR62.
BgeeiQ9CR62.
GenevestigatoriQ9CR62.

Interactioni

Protein-protein interaction databases

BioGridi212490. 3 interactions.
IntActiQ9CR62. 5 interactions.
MINTiMINT-1851446.

Structurei

3D structure databases

ProteinModelPortaliQ9CR62.
SMRiQ9CR62. Positions 22-306.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 10886Solcar 1Add
BLAST
Repeati117 – 20892Solcar 2Add
BLAST
Repeati217 – 30690Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00750000117384.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9CR62.
KOiK15104.
OMAiFRISKHE.
OrthoDBiEOG793B7Z.
PhylomeDBiQ9CR62.
TreeFamiTF354262.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR62-1 [UniParc]FASTAAdd to Basket

« Hide

MAATASPGAG RMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ    50
LSGEGAKTRE YKTSFHALTS ILKTEGLKGI YTGLSAGLLR QATYTTTRLG 100
IYTVLFERLT GADGTPPGFL LKALIGMTAG ATGAFVGTPA EVALIRMTAD 150
GRLPADQRRG YKNVFNALVR IAREEGVPTL WRGCIPTMAR AVVVNAAQLA 200
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIVKTRIQNM 250
RMIDGKPEYK NGLDVLLKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 300
EQMNKAYKRL FLSG 314
Length:314
Mass (Da):34,155
Last modified:January 23, 2007 - v3
Checksum:i1B19A5DB093941A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009824 mRNA. Translation: BAB26524.1.
AK009487 mRNA. Translation: BAB26319.1.
BC003455 mRNA. Translation: AAH03455.1.
BC019631 mRNA. Translation: AAH19631.1.
CCDSiCCDS24958.1.
RefSeqiNP_077173.1. NM_024211.3.
UniGeneiMm.296082.
Mm.466994.

Genome annotation databases

EnsembliENSMUST00000014750; ENSMUSP00000014750; ENSMUSG00000014606.
GeneIDi67863.
KEGGimmu:67863.
UCSCiuc007jvr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009824 mRNA. Translation: BAB26524.1 .
AK009487 mRNA. Translation: BAB26319.1 .
BC003455 mRNA. Translation: AAH03455.1 .
BC019631 mRNA. Translation: AAH19631.1 .
CCDSi CCDS24958.1.
RefSeqi NP_077173.1. NM_024211.3.
UniGenei Mm.296082.
Mm.466994.

3D structure databases

ProteinModelPortali Q9CR62.
SMRi Q9CR62. Positions 22-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212490. 3 interactions.
IntActi Q9CR62. 5 interactions.
MINTi MINT-1851446.

Protein family/group databases

TCDBi 2.A.29.2.11. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q9CR62.

Proteomic databases

MaxQBi Q9CR62.
PaxDbi Q9CR62.
PRIDEi Q9CR62.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014750 ; ENSMUSP00000014750 ; ENSMUSG00000014606 .
GeneIDi 67863.
KEGGi mmu:67863.
UCSCi uc007jvr.2. mouse.

Organism-specific databases

CTDi 8402.
MGIi MGI:1915113. Slc25a11.

Phylogenomic databases

eggNOGi NOG300113.
GeneTreei ENSGT00750000117384.
HOGENOMi HOG000165139.
HOVERGENi HBG009528.
InParanoidi Q9CR62.
KOi K15104.
OMAi FRISKHE.
OrthoDBi EOG793B7Z.
PhylomeDBi Q9CR62.
TreeFami TF354262.

Miscellaneous databases

ChiTaRSi SLC25A11. mouse.
NextBioi 325753.
PROi Q9CR62.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CR62.
Bgeei Q9CR62.
Genevestigatori Q9CR62.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 79-90; 99-146; 163-170; 174-182; 191-206 AND 289-205, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-57, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiM2OM_MOUSE
AccessioniPrimary (citable) accession number: Q9CR62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi