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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

Ndufb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:Ndufb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914166 Ndufb7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001188122 – 137NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Disulfide bondi59 ↔ 90PROSITE-ProRule annotation
Disulfide bondi69 ↔ 80PROSITE-ProRule annotation
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CR61
MaxQBiQ9CR61
PaxDbiQ9CR61
PeptideAtlasiQ9CR61
PRIDEiQ9CR61

PTM databases

iPTMnetiQ9CR61
PhosphoSitePlusiQ9CR61

Expressioni

Gene expression databases

BgeeiENSMUSG00000033938
GenevisibleiQ9CR61 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi2118081 interactor.
CORUMiQ9CR61
IntActiQ9CR61 3 interactors.
MINTiQ9CR61
STRINGi10090.ENSMUSP00000037341

Structurei

3D structure databases

ProteinModelPortaliQ9CR61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 98CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 69Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi80 – 90Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3468 Eukaryota
ENOG411230N LUCA
GeneTreeiENSGT00390000018759
HOGENOMiHOG000199343
HOVERGENiHBG001948
InParanoidiQ9CR61
KOiK03963
OMAiVMRMKEY
OrthoDBiEOG091G10SJ
PhylomeDBiQ9CR61
TreeFamiTF315152

Family and domain databases

InterProiView protein in InterPro
IPR008698 NADH_UbQ_OxRdtase_B18_su
PANTHERiPTHR20900 PTHR20900, 1 hit
PfamiView protein in Pfam
PF05676 NDUF_B7, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLTRRYL WDASVEPDPE KIPSFPPDLG FPERKERVMV ATQQEMMDAQ
60 70 80 90 100
LTLQQRDYCA HYLIRLLKCK RDSFPNFLAC KHEQHDWDYC EHLDYVKRMK
110 120 130
EFERERRLLQ RKKRRALKEA RVAQGQGEGE VGPEVAL
Length:137
Mass (Da):16,331
Last modified:January 23, 2007 - v3
Checksum:i1B83033240133FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003300 mRNA Translation: BAB22701.1
AK002678 mRNA Translation: BAB22280.1
BC034787 mRNA Translation: AAH34787.1
CCDSiCCDS22455.1
RefSeqiNP_080119.1, NM_025843.3
UniGeneiMm.29683

Genome annotation databases

EnsembliENSMUST00000036996; ENSMUSP00000037341; ENSMUSG00000033938
GeneIDi66916
KEGGimmu:66916
UCSCiuc009mkk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUB7_MOUSE
AccessioniPrimary (citable) accession number: Q9CR61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome