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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

Ndufb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:Ndufb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914166. Ndufb7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial intermembrane space Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 137136NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7PRO_0000118812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Disulfide bondi59 ↔ 90Sequence analysis
Disulfide bondi69 ↔ 80Sequence analysis
Modified residuei73 – 731PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CR61.
MaxQBiQ9CR61.
PaxDbiQ9CR61.
PRIDEiQ9CR61.

PTM databases

PhosphoSiteiQ9CR61.

Expressioni

Gene expression databases

BgeeiQ9CR61.
GenevisibleiQ9CR61. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211808. 1 interaction.
IntActiQ9CR61. 3 interactions.
MINTiMINT-4103071.
STRINGi10090.ENSMUSP00000037341.

Structurei

3D structure databases

ProteinModelPortaliQ9CR61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 6911C-X9-C motif 1Add
BLAST
Motifi80 – 9011C-X9-C motif 2Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ9CR61.
KOiK03963.
OMAiIAYQACR.
OrthoDBiEOG7ZSHW5.
PhylomeDBiQ9CR61.
TreeFamiTF315152.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLTRRYL WDASVEPDPE KIPSFPPDLG FPERKERVMV ATQQEMMDAQ
60 70 80 90 100
LTLQQRDYCA HYLIRLLKCK RDSFPNFLAC KHEQHDWDYC EHLDYVKRMK
110 120 130
EFERERRLLQ RKKRRALKEA RVAQGQGEGE VGPEVAL
Length:137
Mass (Da):16,331
Last modified:January 23, 2007 - v3
Checksum:i1B83033240133FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003300 mRNA. Translation: BAB22701.1.
AK002678 mRNA. Translation: BAB22280.1.
BC034787 mRNA. Translation: AAH34787.1.
CCDSiCCDS22455.1.
RefSeqiNP_080119.1. NM_025843.3.
UniGeneiMm.29683.

Genome annotation databases

EnsembliENSMUST00000036996; ENSMUSP00000037341; ENSMUSG00000033938.
GeneIDi66916.
KEGGimmu:66916.
UCSCiuc009mkk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003300 mRNA. Translation: BAB22701.1.
AK002678 mRNA. Translation: BAB22280.1.
BC034787 mRNA. Translation: AAH34787.1.
CCDSiCCDS22455.1.
RefSeqiNP_080119.1. NM_025843.3.
UniGeneiMm.29683.

3D structure databases

ProteinModelPortaliQ9CR61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211808. 1 interaction.
IntActiQ9CR61. 3 interactions.
MINTiMINT-4103071.
STRINGi10090.ENSMUSP00000037341.

PTM databases

PhosphoSiteiQ9CR61.

Proteomic databases

EPDiQ9CR61.
MaxQBiQ9CR61.
PaxDbiQ9CR61.
PRIDEiQ9CR61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036996; ENSMUSP00000037341; ENSMUSG00000033938.
GeneIDi66916.
KEGGimmu:66916.
UCSCiuc009mkk.1. mouse.

Organism-specific databases

CTDi4713.
MGIiMGI:1914166. Ndufb7.

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ9CR61.
KOiK03963.
OMAiIAYQACR.
OrthoDBiEOG7ZSHW5.
PhylomeDBiQ9CR61.
TreeFamiTF315152.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

NextBioi323013.
PROiQ9CR61.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR61.
GenevisibleiQ9CR61. MM.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-35; 38-65; 72-97 AND 122-137, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUB7_MOUSE
AccessioniPrimary (citable) accession number: Q9CR61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.