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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

Ndufb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:Ndufb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914166. Ndufb7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial intermembrane space Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001188122 – 137NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Disulfide bondi59 ↔ 90PROSITE-ProRule annotation
Disulfide bondi69 ↔ 80PROSITE-ProRule annotation
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CR61.
MaxQBiQ9CR61.
PaxDbiQ9CR61.
PeptideAtlasiQ9CR61.
PRIDEiQ9CR61.

PTM databases

iPTMnetiQ9CR61.
PhosphoSitePlusiQ9CR61.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033938.
GenevisibleiQ9CR61. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211808. 1 interactor.
IntActiQ9CR61. 3 interactors.
MINTiMINT-4103071.
STRINGi10090.ENSMUSP00000037341.

Structurei

3D structure databases

ProteinModelPortaliQ9CR61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 98CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 69Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi80 – 90Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ9CR61.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
PhylomeDBiQ9CR61.
TreeFamiTF315152.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLTRRYL WDASVEPDPE KIPSFPPDLG FPERKERVMV ATQQEMMDAQ
60 70 80 90 100
LTLQQRDYCA HYLIRLLKCK RDSFPNFLAC KHEQHDWDYC EHLDYVKRMK
110 120 130
EFERERRLLQ RKKRRALKEA RVAQGQGEGE VGPEVAL
Length:137
Mass (Da):16,331
Last modified:January 23, 2007 - v3
Checksum:i1B83033240133FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003300 mRNA. Translation: BAB22701.1.
AK002678 mRNA. Translation: BAB22280.1.
BC034787 mRNA. Translation: AAH34787.1.
CCDSiCCDS22455.1.
RefSeqiNP_080119.1. NM_025843.3.
UniGeneiMm.29683.

Genome annotation databases

EnsembliENSMUST00000036996; ENSMUSP00000037341; ENSMUSG00000033938.
GeneIDi66916.
KEGGimmu:66916.
UCSCiuc009mkk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003300 mRNA. Translation: BAB22701.1.
AK002678 mRNA. Translation: BAB22280.1.
BC034787 mRNA. Translation: AAH34787.1.
CCDSiCCDS22455.1.
RefSeqiNP_080119.1. NM_025843.3.
UniGeneiMm.29683.

3D structure databases

ProteinModelPortaliQ9CR61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211808. 1 interactor.
IntActiQ9CR61. 3 interactors.
MINTiMINT-4103071.
STRINGi10090.ENSMUSP00000037341.

PTM databases

iPTMnetiQ9CR61.
PhosphoSitePlusiQ9CR61.

Proteomic databases

EPDiQ9CR61.
MaxQBiQ9CR61.
PaxDbiQ9CR61.
PeptideAtlasiQ9CR61.
PRIDEiQ9CR61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036996; ENSMUSP00000037341; ENSMUSG00000033938.
GeneIDi66916.
KEGGimmu:66916.
UCSCiuc009mkk.1. mouse.

Organism-specific databases

CTDi4713.
MGIiMGI:1914166. Ndufb7.

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ9CR61.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
PhylomeDBiQ9CR61.
TreeFamiTF315152.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CR61.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033938.
GenevisibleiQ9CR61. MM.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB7_MOUSE
AccessioniPrimary (citable) accession number: Q9CR61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.