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Protein

Kidney mitochondrial carrier protein 1

Gene

Slc25a30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.24.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Kidney mitochondrial carrier protein 1
Alternative name(s):
Solute carrier family 25 member 30
Gene namesi
Name:Slc25a30
Synonyms:Kmcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914804. Slc25a30.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2618Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei71 – 8919Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei106 – 12419Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei264 – 28320Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 291290Kidney mitochondrial carrier protein 1PRO_0000288918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR58.
MaxQBiQ9CR58.
PaxDbiQ9CR58.
PRIDEiQ9CR58.

PTM databases

PhosphoSiteiQ9CR58.

Expressioni

Tissue specificityi

Present in kidney (at protein level). Expressed predominantly within the kidney cortex in the proximal and distal tubules and at lower levels in the testis and white adipose tissue.1 Publication

Inductioni

Up-regulated during fasting and in the regenerative phase following renal tubular injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000022003.
CleanExiMM_SLC25A30.
GenevisibleiQ9CR58. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022580.

Structurei

3D structure databases

ProteinModelPortaliQ9CR58.
SMRiQ9CR58. Positions 9-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 9690Solcar 1Add
BLAST
Repeati104 – 18986Solcar 2Add
BLAST
Repeati198 – 28992Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9CR58.
KOiK15106.
OMAiMNIYQQE.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9CR58.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DANFREIRYR
60 70 80 90 100
GMLHALMRIG REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLAVER
110 120 130 140 150
PEDETLLVNV VCGILSGVIS SAIANPTDVL KIRMQAQNSA VQGGMIDSFM
160 170 180 190 200
SIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL PVYDITKKHL ILSGLMGDTV
210 220 230 240 250
ATHFLSSFTC GLVGALASNP VDVVRTRMMN QRALRDGRCA GYKGTLDCLL
260 270 280 290
QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF LTYEQLKKLD L
Length:291
Mass (Da):32,282
Last modified:June 1, 2001 - v1
Checksum:i1CD3138F9FF27B99
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171I → M in BAE30385 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015679 mRNA. Translation: BAB29928.1.
AK017035 mRNA. Translation: BAB30563.1.
AK151334 mRNA. Translation: BAE30312.1.
AK151420 mRNA. Translation: BAE30385.1.
AK159122 mRNA. Translation: BAE34837.1.
AK159732 mRNA. Translation: BAE35326.1.
CCDSiCCDS27281.1.
RefSeqiNP_080508.1. NM_026232.3.
UniGeneiMm.46067.

Genome annotation databases

EnsembliENSMUST00000022580; ENSMUSP00000022580; ENSMUSG00000022003.
GeneIDi67554.
KEGGimmu:67554.
UCSCiuc007uqx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015679 mRNA. Translation: BAB29928.1.
AK017035 mRNA. Translation: BAB30563.1.
AK151334 mRNA. Translation: BAE30312.1.
AK151420 mRNA. Translation: BAE30385.1.
AK159122 mRNA. Translation: BAE34837.1.
AK159732 mRNA. Translation: BAE35326.1.
CCDSiCCDS27281.1.
RefSeqiNP_080508.1. NM_026232.3.
UniGeneiMm.46067.

3D structure databases

ProteinModelPortaliQ9CR58.
SMRiQ9CR58. Positions 9-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022580.

Protein family/group databases

TCDBi2.A.29.24.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ9CR58.

Proteomic databases

EPDiQ9CR58.
MaxQBiQ9CR58.
PaxDbiQ9CR58.
PRIDEiQ9CR58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022580; ENSMUSP00000022580; ENSMUSG00000022003.
GeneIDi67554.
KEGGimmu:67554.
UCSCiuc007uqx.1. mouse.

Organism-specific databases

CTDi253512.
MGIiMGI:1914804. Slc25a30.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9CR58.
KOiK15106.
OMAiMNIYQQE.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9CR58.
TreeFamiTF323211.

Miscellaneous databases

PROiQ9CR58.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022003.
CleanExiMM_SLC25A30.
GenevisibleiQ9CR58. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKMCP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR58
Secondary accession number(s): Q3UAD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.