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Q9CR56

- KBRS2_MOUSE

UniProt

Q9CR56 - KBRS2_MOUSE

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Protein

NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene

Nkiras2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi120 – 1234GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-interacting Ras-like protein 2
Alternative name(s):
I-kappa-B-interacting Ras-like protein 2
Short name:
Kappa B-Ras protein 2
Short name:
KappaB-Ras2
Gene namesi
Name:Nkiras2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919216. Nkiras2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191NF-kappa-B inhibitor-interacting Ras-like protein 2PRO_0000225680Add
BLAST

Proteomic databases

MaxQBiQ9CR56.
PaxDbiQ9CR56.
PRIDEiQ9CR56.

PTM databases

PhosphoSiteiQ9CR56.

Expressioni

Gene expression databases

BgeeiQ9CR56.
CleanExiMM_NKIRAS2.
ExpressionAtlasiQ9CR56. baseline and differential.
GenevestigatoriQ9CR56.

Interactioni

Subunit structurei

Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CR56.
SMRiQ9CR56. Positions 6-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 191191Small GTPase-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Domaini

In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG302793.
GeneTreeiENSGT00390000006495.
HOGENOMiHOG000230991.
HOVERGENiHBG105089.
InParanoidiQ9CR56.
KOiK17197.
OMAiIEPFVYL.
OrthoDBiEOG70KGQS.
PhylomeDBiQ9CR56.
TreeFamiTF314483.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD
60 70 80 90 100
RGVREQVRFY DTRGLRDGAE LPKHCFSCTD GYVLVYSTDS RESFQRVELL
110 120 130 140 150
KKEIDKSKDK KEVTIVVLGN KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS
160 170 180 190
VADRRSLLEP FIYLASKMTQ PQSKSAFPLS RKNKGSGSLD G
Length:191
Mass (Da):21,494
Last modified:June 1, 2001 - v1
Checksum:i1E429230C348C823
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571V → E in BAC35078. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010371 mRNA. Translation: BAB26889.1.
AK015918 mRNA. Translation: BAB30030.1.
AK052645 mRNA. Translation: BAC35078.1.
AK083475 mRNA. Translation: BAC38929.1.
AK149696 mRNA. Translation: BAE29033.1.
AK169878 mRNA. Translation: BAE41430.1.
BC013469 mRNA. Translation: AAH13469.1.
BC024398 mRNA. Translation: AAH24398.1.
CCDSiCCDS25429.1.
RefSeqiNP_082300.1. NM_028024.2.
UniGeneiMm.274734.
Mm.485819.

Genome annotation databases

EnsembliENSMUST00000017981; ENSMUSP00000017981; ENSMUSG00000017837.
ENSMUST00000051947; ENSMUSP00000059559; ENSMUSG00000017837.
ENSMUST00000107376; ENSMUSP00000102999; ENSMUSG00000017837.
GeneIDi71966.
KEGGimmu:71966.
UCSCiuc007llt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010371 mRNA. Translation: BAB26889.1 .
AK015918 mRNA. Translation: BAB30030.1 .
AK052645 mRNA. Translation: BAC35078.1 .
AK083475 mRNA. Translation: BAC38929.1 .
AK149696 mRNA. Translation: BAE29033.1 .
AK169878 mRNA. Translation: BAE41430.1 .
BC013469 mRNA. Translation: AAH13469.1 .
BC024398 mRNA. Translation: AAH24398.1 .
CCDSi CCDS25429.1.
RefSeqi NP_082300.1. NM_028024.2.
UniGenei Mm.274734.
Mm.485819.

3D structure databases

ProteinModelPortali Q9CR56.
SMRi Q9CR56. Positions 6-155.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CR56.

Proteomic databases

MaxQBi Q9CR56.
PaxDbi Q9CR56.
PRIDEi Q9CR56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017981 ; ENSMUSP00000017981 ; ENSMUSG00000017837 .
ENSMUST00000051947 ; ENSMUSP00000059559 ; ENSMUSG00000017837 .
ENSMUST00000107376 ; ENSMUSP00000102999 ; ENSMUSG00000017837 .
GeneIDi 71966.
KEGGi mmu:71966.
UCSCi uc007llt.1. mouse.

Organism-specific databases

CTDi 28511.
MGIi MGI:1919216. Nkiras2.

Phylogenomic databases

eggNOGi NOG302793.
GeneTreei ENSGT00390000006495.
HOGENOMi HOG000230991.
HOVERGENi HBG105089.
InParanoidi Q9CR56.
KOi K17197.
OMAi IEPFVYL.
OrthoDBi EOG70KGQS.
PhylomeDBi Q9CR56.
TreeFami TF314483.

Miscellaneous databases

ChiTaRSi NKIRAS2. mouse.
NextBioi 335068.
PROi Q9CR56.
SOURCEi Search...

Gene expression databases

Bgeei Q9CR56.
CleanExi MM_NKIRAS2.
ExpressionAtlasi Q9CR56. baseline and differential.
Genevestigatori Q9CR56.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Kidney and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Colon and Mammary tumor.

Entry informationi

Entry nameiKBRS2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR56
Secondary accession number(s): Q8BWG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3