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Q9CR56

- KBRS2_MOUSE

UniProt

Q9CR56 - KBRS2_MOUSE

Protein

NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene

Nkiras2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi120 – 1234GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Alternative name(s):
    I-kappa-B-interacting Ras-like protein 2
    Short name:
    Kappa B-Ras protein 2
    Short name:
    KappaB-Ras2
    Gene namesi
    Name:Nkiras2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919216. Nkiras2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191NF-kappa-B inhibitor-interacting Ras-like protein 2PRO_0000225680Add
    BLAST

    Proteomic databases

    MaxQBiQ9CR56.
    PaxDbiQ9CR56.
    PRIDEiQ9CR56.

    PTM databases

    PhosphoSiteiQ9CR56.

    Expressioni

    Gene expression databases

    BgeeiQ9CR56.
    CleanExiMM_NKIRAS2.
    GenevestigatoriQ9CR56.

    Interactioni

    Subunit structurei

    Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR56.
    SMRiQ9CR56. Positions 6-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 191191Small GTPase-likeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector region

    Domaini

    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG302793.
    GeneTreeiENSGT00390000006495.
    HOGENOMiHOG000230991.
    HOVERGENiHBG105089.
    InParanoidiQ9CR56.
    KOiK17197.
    OMAiIEPFVYL.
    OrthoDBiEOG70KGQS.
    PhylomeDBiQ9CR56.
    TreeFamiTF314483.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CR56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD    50
    RGVREQVRFY DTRGLRDGAE LPKHCFSCTD GYVLVYSTDS RESFQRVELL 100
    KKEIDKSKDK KEVTIVVLGN KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS 150
    VADRRSLLEP FIYLASKMTQ PQSKSAFPLS RKNKGSGSLD G 191
    Length:191
    Mass (Da):21,494
    Last modified:June 1, 2001 - v1
    Checksum:i1E429230C348C823
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571V → E in BAC35078. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010371 mRNA. Translation: BAB26889.1.
    AK015918 mRNA. Translation: BAB30030.1.
    AK052645 mRNA. Translation: BAC35078.1.
    AK083475 mRNA. Translation: BAC38929.1.
    AK149696 mRNA. Translation: BAE29033.1.
    AK169878 mRNA. Translation: BAE41430.1.
    BC013469 mRNA. Translation: AAH13469.1.
    BC024398 mRNA. Translation: AAH24398.1.
    CCDSiCCDS25429.1.
    RefSeqiNP_082300.1. NM_028024.2.
    UniGeneiMm.274734.
    Mm.485819.

    Genome annotation databases

    EnsembliENSMUST00000017981; ENSMUSP00000017981; ENSMUSG00000017837.
    ENSMUST00000051947; ENSMUSP00000059559; ENSMUSG00000017837.
    ENSMUST00000107376; ENSMUSP00000102999; ENSMUSG00000017837.
    GeneIDi71966.
    KEGGimmu:71966.
    UCSCiuc007llt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010371 mRNA. Translation: BAB26889.1 .
    AK015918 mRNA. Translation: BAB30030.1 .
    AK052645 mRNA. Translation: BAC35078.1 .
    AK083475 mRNA. Translation: BAC38929.1 .
    AK149696 mRNA. Translation: BAE29033.1 .
    AK169878 mRNA. Translation: BAE41430.1 .
    BC013469 mRNA. Translation: AAH13469.1 .
    BC024398 mRNA. Translation: AAH24398.1 .
    CCDSi CCDS25429.1.
    RefSeqi NP_082300.1. NM_028024.2.
    UniGenei Mm.274734.
    Mm.485819.

    3D structure databases

    ProteinModelPortali Q9CR56.
    SMRi Q9CR56. Positions 6-155.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CR56.

    Proteomic databases

    MaxQBi Q9CR56.
    PaxDbi Q9CR56.
    PRIDEi Q9CR56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017981 ; ENSMUSP00000017981 ; ENSMUSG00000017837 .
    ENSMUST00000051947 ; ENSMUSP00000059559 ; ENSMUSG00000017837 .
    ENSMUST00000107376 ; ENSMUSP00000102999 ; ENSMUSG00000017837 .
    GeneIDi 71966.
    KEGGi mmu:71966.
    UCSCi uc007llt.1. mouse.

    Organism-specific databases

    CTDi 28511.
    MGIi MGI:1919216. Nkiras2.

    Phylogenomic databases

    eggNOGi NOG302793.
    GeneTreei ENSGT00390000006495.
    HOGENOMi HOG000230991.
    HOVERGENi HBG105089.
    InParanoidi Q9CR56.
    KOi K17197.
    OMAi IEPFVYL.
    OrthoDBi EOG70KGQS.
    PhylomeDBi Q9CR56.
    TreeFami TF314483.

    Miscellaneous databases

    ChiTaRSi NKIRAS2. mouse.
    NextBioi 335068.
    PROi Q9CR56.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CR56.
    CleanExi MM_NKIRAS2.
    Genevestigatori Q9CR56.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Kidney and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N and FVB/N-3.
      Tissue: Colon and Mammary tumor.

    Entry informationi

    Entry nameiKBRS2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR56
    Secondary accession number(s): Q8BWG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3