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Protein

NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene

Nkiras2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1810476 RIP-mediated NFkB activation via ZBP1
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-interacting Ras-like protein 2
Alternative name(s):
I-kappa-B-interacting Ras-like protein 2
Short name:
Kappa B-Ras protein 2
Short name:
KappaB-Ras2
Gene namesi
Name:Nkiras2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919216 Nkiras2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256801 – 191NF-kappa-B inhibitor-interacting Ras-like protein 2Add BLAST191

Proteomic databases

EPDiQ9CR56
MaxQBiQ9CR56
PaxDbiQ9CR56
PeptideAtlasiQ9CR56
PRIDEiQ9CR56

PTM databases

iPTMnetiQ9CR56
PhosphoSitePlusiQ9CR56

Expressioni

Gene expression databases

BgeeiENSMUSG00000017837
CleanExiMM_NKIRAS2
ExpressionAtlasiQ9CR56 baseline and differential
GenevisibleiQ9CR56 MM

Interactioni

Subunit structurei

Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CR56
SMRiQ9CR56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 191Small GTPase-likeAdd BLAST191

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Domaini

In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3883 Eukaryota
ENOG4110VES LUCA
GeneTreeiENSGT00390000006495
HOGENOMiHOG000230991
HOVERGENiHBG105089
InParanoidiQ9CR56
KOiK17197
OMAiPLSRNKN
OrthoDBiEOG091G0IH8
PhylomeDBiQ9CR56
TreeFamiTF314483

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD
60 70 80 90 100
RGVREQVRFY DTRGLRDGAE LPKHCFSCTD GYVLVYSTDS RESFQRVELL
110 120 130 140 150
KKEIDKSKDK KEVTIVVLGN KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS
160 170 180 190
VADRRSLLEP FIYLASKMTQ PQSKSAFPLS RKNKGSGSLD G
Length:191
Mass (Da):21,494
Last modified:June 1, 2001 - v1
Checksum:i1E429230C348C823
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → E in BAC35078 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010371 mRNA Translation: BAB26889.1
AK015918 mRNA Translation: BAB30030.1
AK052645 mRNA Translation: BAC35078.1
AK083475 mRNA Translation: BAC38929.1
AK149696 mRNA Translation: BAE29033.1
AK169878 mRNA Translation: BAE41430.1
BC013469 mRNA Translation: AAH13469.1
BC024398 mRNA Translation: AAH24398.1
CCDSiCCDS25429.1
RefSeqiNP_082300.1, NM_028024.2
XP_017170264.1, XM_017314775.1
XP_017170265.1, XM_017314776.1
UniGeneiMm.274734
Mm.485819

Genome annotation databases

EnsembliENSMUST00000017981; ENSMUSP00000017981; ENSMUSG00000017837
ENSMUST00000051947; ENSMUSP00000059559; ENSMUSG00000017837
ENSMUST00000107376; ENSMUSP00000102999; ENSMUSG00000017837
GeneIDi71966
KEGGimmu:71966
UCSCiuc007llt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKBRS2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR56
Secondary accession number(s): Q8BWG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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