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Protein

V-type proton ATPase subunit G 1

Gene

Atp6v1g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).By similarity

GO - Molecular functioni

  • ATPase activity Source: MGI
  • ATPase binding Source: MGI
  • proton-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 1
Short name:
V-ATPase subunit G 1
Alternative name(s):
V-ATPase 13 kDa subunit 1
Vacuolar proton pump subunit G 1
Gene namesi
Name:Atp6v1g1
Synonyms:Atp6g1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913540 Atp6v1g1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001928982 – 118V-type proton ATPase subunit G 1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR51
MaxQBiQ9CR51
PaxDbiQ9CR51
PRIDEiQ9CR51

PTM databases

iPTMnetiQ9CR51
PhosphoSitePlusiQ9CR51

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000039105
CleanExiMM_ATP6V1G1
ExpressionAtlasiQ9CR51 baseline and differential
GenevisibleiQ9CR51 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211359, 3 interactors
IntActiQ9CR51, 2 interactors
MINTiQ9CR51
STRINGi10090.ENSMUSP00000048770

Structurei

3D structure databases

ProteinModelPortaliQ9CR51
SMRiQ9CR51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiQ9CR51
KOiK02152
OMAiEFHANYR
OrthoDBiEOG091G0XIZ
PhylomeDBiQ9CR51
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ
60 70 80 90 100
REKEFKAKEA AALGSHGSCS SEVEKETREK MTVLQNYFEQ NRDEVLDNLL
110
AFVCDIRPEI HENYRING
Length:118
Mass (Da):13,724
Last modified:January 23, 2007 - v3
Checksum:i1FC54025CFCFD951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010131 mRNA Translation: BAB26720.1
AK003563 mRNA Translation: BAB22859.1
AK007596 mRNA Translation: BAB25127.1
BC003429 mRNA Translation: AAH03429.1
CCDSiCCDS18260.1
RefSeqiNP_077135.1, NM_024173.2
UniGeneiMm.371615

Genome annotation databases

EnsembliENSMUST00000035301; ENSMUSP00000048770; ENSMUSG00000039105
GeneIDi66290
KEGGimmu:66290
UCSCiuc008tgq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVATG1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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