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Protein

V-type proton ATPase subunit G 1

Gene

Atp6v1g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • ATPase activity Source: MGI
  • ATPase binding Source: MGI
  • hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 1
Short name:
V-ATPase subunit G 1
Alternative name(s):
V-ATPase 13 kDa subunit 1
Vacuolar proton pump subunit G 1
Gene namesi
Name:Atp6v1g1
Synonyms:Atp6g1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913540. Atp6v1g1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: MGI
  • intracellular Source: MGI
  • lysosomal membrane Source: MGI
  • plasma membrane Source: UniProtKB
  • vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 118117V-type proton ATPase subunit G 1PRO_0000192898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR51.
MaxQBiQ9CR51.
PaxDbiQ9CR51.
PRIDEiQ9CR51.

PTM databases

iPTMnetiQ9CR51.
PhosphoSiteiQ9CR51.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000039105.
CleanExiMM_ATP6V1G1.
ExpressionAtlasiQ9CR51. baseline and differential.
GenevisibleiQ9CR51. MM.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211359. 3 interactions.
IntActiQ9CR51. 2 interactions.
MINTiMINT-4139837.
STRINGi10090.ENSMUSP00000048770.

Structurei

3D structure databases

ProteinModelPortaliQ9CR51.
SMRiQ9CR51. Positions 3-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ9CR51.
KOiK02152.
OMAiQPEFHAN.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ9CR51.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ
60 70 80 90 100
REKEFKAKEA AALGSHGSCS SEVEKETREK MTVLQNYFEQ NRDEVLDNLL
110
AFVCDIRPEI HENYRING
Length:118
Mass (Da):13,724
Last modified:January 23, 2007 - v3
Checksum:i1FC54025CFCFD951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010131 mRNA. Translation: BAB26720.1.
AK003563 mRNA. Translation: BAB22859.1.
AK007596 mRNA. Translation: BAB25127.1.
BC003429 mRNA. Translation: AAH03429.1.
CCDSiCCDS18260.1.
RefSeqiNP_077135.1. NM_024173.2.
UniGeneiMm.371615.

Genome annotation databases

EnsembliENSMUST00000035301; ENSMUSP00000048770; ENSMUSG00000039105.
GeneIDi66290.
KEGGimmu:66290.
UCSCiuc008tgq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010131 mRNA. Translation: BAB26720.1.
AK003563 mRNA. Translation: BAB22859.1.
AK007596 mRNA. Translation: BAB25127.1.
BC003429 mRNA. Translation: AAH03429.1.
CCDSiCCDS18260.1.
RefSeqiNP_077135.1. NM_024173.2.
UniGeneiMm.371615.

3D structure databases

ProteinModelPortaliQ9CR51.
SMRiQ9CR51. Positions 3-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211359. 3 interactions.
IntActiQ9CR51. 2 interactions.
MINTiMINT-4139837.
STRINGi10090.ENSMUSP00000048770.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiQ9CR51.
PhosphoSiteiQ9CR51.

Proteomic databases

EPDiQ9CR51.
MaxQBiQ9CR51.
PaxDbiQ9CR51.
PRIDEiQ9CR51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035301; ENSMUSP00000048770; ENSMUSG00000039105.
GeneIDi66290.
KEGGimmu:66290.
UCSCiuc008tgq.2. mouse.

Organism-specific databases

CTDi9550.
MGIiMGI:1913540. Atp6v1g1.

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ9CR51.
KOiK02152.
OMAiQPEFHAN.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ9CR51.
TreeFamiTF313777.

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

PROiQ9CR51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039105.
CleanExiMM_ATP6V1G1.
ExpressionAtlasiQ9CR51. baseline and differential.
GenevisibleiQ9CR51. MM.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATG1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.