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Q9CR42 (ANKR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene names
Name:Ankrd1
Synonyms:Carp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Ref.1

Subunit structure

Interacts with TTN/titin and YBX1 By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in heart, cardiac muscle. Ref.1

Developmental stage

Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts. Ref.1 Ref.5

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
   Cellular componentNucleus
   DomainANK repeat
Coiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from direct assay PubMed 17239933. Source: UniProtKB

cellular response to hypoxia

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from direct assay PubMed 17239933. Source: UniProtKB

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

negative regulation of DNA biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron projection development

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein secretion

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.1. Source: MGI

response to muscle stretch

Inferred from electronic annotation. Source: Ensembl

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

   Cellular_componentI band

Inferred from direct assay PubMed 11309420. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 17239933. Source: UniProtKB

cytosol

Inferred from electronic annotation. Source: Ensembl

myofibril

Inferred from direct assay PubMed 18310072. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 9382869. Source: MGI

transcription factor complex

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 14741210. Source: MGI

titin binding

Inferred from physical interaction PubMed 18310072. Source: UniProtKB

transcription corepressor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Ankyrin repeat domain-containing protein 1
PRO_0000240480

Regions

Repeat152 – 18130ANK 1
Repeat185 – 21430ANK 2
Repeat218 – 24730ANK 3
Repeat251 – 28030ANK 4
Repeat284 – 31532ANK 5
Coiled coil53 – 8937 Potential

Experimental info

Sequence conflict481L → F in BAE27549. Ref.2
Sequence conflict139 – 1402FL → LV in AAC03533. Ref.1
Sequence conflict139 – 1402FL → LV in AAB97080. Ref.4
Sequence conflict2991T → N in BAE27316. Ref.2
Sequence conflict3061L → P in AAC03533. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9CR42 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 26A3C4062CF0E7D0

FASTA31936,004
        10         20         30         40         50         60 
MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA NSVKQGEEQR 

        70         80         90        100        110        120 
KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK KTKVPVVKEP EPEIMTEPVD 

       130        140        150        160        170        180 
VPRFLKAALE NKLPVVEKFL SDKNSPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE 

       190        200        210        220        230        240 
FRDMLESTAI HWACRGGNAD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA 

       250        260        270        280        290        300 
CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK 

       310 
AIFDSLKENA YKNSRIATF 

« Hide

References

« Hide 'large scale' references
[1]"CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway."
Zou Y., Evans S., Chen J., Kuo H.-C., Harvey R.P., Chien K.R.
Development 124:793-804(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
Tissue: Heart.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]Schoenfeld J.R., Lowe D.G., Zou Y., Chen J.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 103-176.
[5]"A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes."
Jeyaseelan R., Poizat C., Baker R.K., Abdishoo S., Isterabadi L.B., Lyons G.E., Kedes L.
J. Biol. Chem. 272:22800-22808(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSCCDS29771.1.
RefSeqNP_038496.2. NM_013468.3.
UniGeneMm.10279.

3D structure databases

ProteinModelPortalQ9CR42.
SMRQ9CR42. Positions 98-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid223553. 2 interactions.
IntActQ9CR42. 2 interactions.
MINTMINT-7990347.
STRING10090.ENSMUSP00000025718.

PTM databases

PhosphoSiteQ9CR42.

Proteomic databases

PRIDEQ9CR42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneID107765.
KEGGmmu:107765.
UCSCuc008hhh.1. mouse.

Organism-specific databases

CTD27063.
MGIMGI:1097717. Ankrd1.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00750000117296.
HOGENOMHOG000236321.
HOVERGENHBG071561.
InParanoidQ9CR42.
OMAEGDTPMH.
OrthoDBEOG7FJH17.
PhylomeDBQ9CR42.
TreeFamTF331650.

Gene expression databases

BgeeQ9CR42.
CleanExMM_ANKRD1.
GenevestigatorQ9CR42.

Family and domain databases

Gene3D1.25.40.20. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio359408.
PROQ9CR42.
SOURCESearch...

Entry information

Entry nameANKR1_MOUSE
AccessionPrimary (citable) accession number: Q9CR42
Secondary accession number(s): O55014 expand/collapse secondary AC list , Q3UIF7, Q3UJ39, Q792Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot