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Q9CR42

- ANKR1_MOUSE

UniProt

Q9CR42 - ANKR1_MOUSE

Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. protein binding Source: MGI
    3. RNA polymerase II transcription coactivator activity Source: Ensembl
    4. titin binding Source: UniProtKB
    5. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. cardiac muscle tissue morphogenesis Source: Ensembl
    2. cellular response to drug Source: UniProtKB
    3. cellular response to hypoxia Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to lipopolysaccharide Source: UniProtKB
    6. cellular response to mechanical stimulus Source: Ensembl
    7. cellular response to organic cyclic compound Source: Ensembl
    8. cellular response to transforming growth factor beta stimulus Source: Ensembl
    9. cellular response to tumor necrosis factor Source: Ensembl
    10. negative regulation of DNA biosynthetic process Source: Ensembl
    11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. positive regulation of apoptotic process Source: Ensembl
    13. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    14. positive regulation of neuron projection development Source: Ensembl
    15. positive regulation of protein secretion Source: Ensembl
    16. regulation of transcription from RNA polymerase II promoter Source: MGI
    17. response to muscle stretch Source: Ensembl
    18. skeletal muscle cell differentiation Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 1
    Alternative name(s):
    Cardiac ankyrin repeat protein
    Gene namesi
    Name:Ankrd1
    Synonyms:Carp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1097717. Ankrd1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Ensembl
    3. I band Source: BHF-UCL
    4. myofibril Source: UniProtKB
    5. nucleus Source: MGI
    6. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Ankyrin repeat domain-containing protein 1PRO_0000240480Add
    BLAST

    Proteomic databases

    PRIDEiQ9CR42.

    PTM databases

    PhosphoSiteiQ9CR42.

    Expressioni

    Tissue specificityi

    Expressed in heart, cardiac muscle.1 Publication

    Developmental stagei

    Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts.2 Publications

    Gene expression databases

    BgeeiQ9CR42.
    CleanExiMM_ANKRD1.
    GenevestigatoriQ9CR42.

    Interactioni

    Subunit structurei

    Interacts with TTN/titin and YBX1.By similarity

    Protein-protein interaction databases

    BioGridi223553. 2 interactions.
    IntActiQ9CR42. 2 interactions.
    MINTiMINT-7990347.
    STRINGi10090.ENSMUSP00000025718.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR42.
    SMRiQ9CR42. Positions 98-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati152 – 18130ANK 1Add
    BLAST
    Repeati185 – 21430ANK 2Add
    BLAST
    Repeati218 – 24730ANK 3Add
    BLAST
    Repeati251 – 28030ANK 4Add
    BLAST
    Repeati284 – 31532ANK 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili53 – 8937Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00750000117296.
    HOGENOMiHOG000236321.
    HOVERGENiHBG071561.
    InParanoidiQ9CR42.
    OMAiEGDTPMH.
    OrthoDBiEOG7FJH17.
    PhylomeDBiQ9CR42.
    TreeFamiTF331650.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CR42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA    50
    NSVKQGEEQR KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK 100
    KTKVPVVKEP EPEIMTEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD 150
    EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNAD 200
    VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR 250
    EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK 300
    AIFDSLKENA YKNSRIATF 319
    Length:319
    Mass (Da):36,004
    Last modified:June 1, 2001 - v1
    Checksum:i26A3C4062CF0E7D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481L → F in BAE27549. (PubMed:16141072)Curated
    Sequence conflicti139 – 1402FL → LV in AAC03533. (PubMed:9043061)Curated
    Sequence conflicti139 – 1402FL → LV in AAB97080. 1 PublicationCurated
    Sequence conflicti299 – 2991T → N in BAE27316. (PubMed:16141072)Curated
    Sequence conflicti306 – 3061L → P in AAC03533. (PubMed:9043061)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041847 mRNA. Translation: AAC03533.1.
    AK009655 mRNA. Translation: BAB26419.1.
    AK009959 mRNA. Translation: BAB26611.1.
    AK145944 mRNA. Translation: BAE26773.1.
    AK146471 mRNA. Translation: BAE27197.1.
    AK146627 mRNA. Translation: BAE27316.1.
    AK146940 mRNA. Translation: BAE27549.1.
    BC037138 mRNA. Translation: AAH37138.1.
    AF041849 mRNA. Translation: AAB97080.1.
    CCDSiCCDS29771.1.
    RefSeqiNP_038496.2. NM_013468.3.
    UniGeneiMm.10279.

    Genome annotation databases

    EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
    GeneIDi107765.
    KEGGimmu:107765.
    UCSCiuc008hhh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041847 mRNA. Translation: AAC03533.1 .
    AK009655 mRNA. Translation: BAB26419.1 .
    AK009959 mRNA. Translation: BAB26611.1 .
    AK145944 mRNA. Translation: BAE26773.1 .
    AK146471 mRNA. Translation: BAE27197.1 .
    AK146627 mRNA. Translation: BAE27316.1 .
    AK146940 mRNA. Translation: BAE27549.1 .
    BC037138 mRNA. Translation: AAH37138.1 .
    AF041849 mRNA. Translation: AAB97080.1 .
    CCDSi CCDS29771.1.
    RefSeqi NP_038496.2. NM_013468.3.
    UniGenei Mm.10279.

    3D structure databases

    ProteinModelPortali Q9CR42.
    SMRi Q9CR42. Positions 98-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223553. 2 interactions.
    IntActi Q9CR42. 2 interactions.
    MINTi MINT-7990347.
    STRINGi 10090.ENSMUSP00000025718.

    PTM databases

    PhosphoSitei Q9CR42.

    Proteomic databases

    PRIDEi Q9CR42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025718 ; ENSMUSP00000025718 ; ENSMUSG00000024803 .
    GeneIDi 107765.
    KEGGi mmu:107765.
    UCSCi uc008hhh.1. mouse.

    Organism-specific databases

    CTDi 27063.
    MGIi MGI:1097717. Ankrd1.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00750000117296.
    HOGENOMi HOG000236321.
    HOVERGENi HBG071561.
    InParanoidi Q9CR42.
    OMAi EGDTPMH.
    OrthoDBi EOG7FJH17.
    PhylomeDBi Q9CR42.
    TreeFami TF331650.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 359408.
    PROi Q9CR42.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CR42.
    CleanExi MM_ANKRD1.
    Genevestigatori Q9CR42.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway."
      Zou Y., Evans S., Chen J., Kuo H.-C., Harvey R.P., Chien K.R.
      Development 124:793-804(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
      Tissue: Heart.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. Schoenfeld J.R., Lowe D.G., Zou Y., Chen J.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 103-176.
    5. "A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes."
      Jeyaseelan R., Poizat C., Baker R.K., Abdishoo S., Isterabadi L.B., Lyons G.E., Kedes L.
      J. Biol. Chem. 272:22800-22808(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiANKR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR42
    Secondary accession number(s): O55014
    , Q3UIF7, Q3UJ39, Q792Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3