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Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1097717. Ankrd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • I band Source: BHF-UCL
  • myofibril Source: UniProtKB
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404801 – 319Ankyrin repeat domain-containing protein 1Add BLAST319

Proteomic databases

PaxDbiQ9CR42.
PRIDEiQ9CR42.

PTM databases

iPTMnetiQ9CR42.
PhosphoSitePlusiQ9CR42.

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Developmental stagei

Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts.2 Publications

Gene expression databases

BgeeiENSMUSG00000024803.
CleanExiMM_ANKRD1.
GenevisibleiQ9CR42. MM.

Interactioni

Subunit structurei

Interacts with TTN/titin and YBX1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCLP193382EBI-8308696,EBI-346967From a different organism.
NclP094055EBI-8308696,EBI-641864

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223553. 2 interactors.
IntActiQ9CR42. 29 interactors.
MINTiMINT-7990347.
STRINGi10090.ENSMUSP00000025718.

Structurei

3D structure databases

ProteinModelPortaliQ9CR42.
SMRiQ9CR42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 181ANK 1Add BLAST30
Repeati185 – 214ANK 2Add BLAST30
Repeati218 – 247ANK 3Add BLAST30
Repeati251 – 280ANK 4Add BLAST30
Repeati284 – 315ANK 5Add BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 89Sequence analysisAdd BLAST37

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ9CR42.
OMAiKGDPNVC.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ9CR42.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA
60 70 80 90 100
NSVKQGEEQR KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK
110 120 130 140 150
KTKVPVVKEP EPEIMTEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD
160 170 180 190 200
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNAD
210 220 230 240 250
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK
310
AIFDSLKENA YKNSRIATF
Length:319
Mass (Da):36,004
Last modified:June 1, 2001 - v1
Checksum:i26A3C4062CF0E7D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48L → F in BAE27549 (PubMed:16141072).Curated1
Sequence conflicti139 – 140FL → LV in AAC03533 (PubMed:9043061).Curated2
Sequence conflicti139 – 140FL → LV in AAB97080 (Ref. 4) Curated2
Sequence conflicti299T → N in BAE27316 (PubMed:16141072).Curated1
Sequence conflicti306L → P in AAC03533 (PubMed:9043061).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSiCCDS29771.1.
RefSeqiNP_038496.2. NM_013468.3.
UniGeneiMm.10279.

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneIDi107765.
KEGGimmu:107765.
UCSCiuc008hhh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSiCCDS29771.1.
RefSeqiNP_038496.2. NM_013468.3.
UniGeneiMm.10279.

3D structure databases

ProteinModelPortaliQ9CR42.
SMRiQ9CR42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223553. 2 interactors.
IntActiQ9CR42. 29 interactors.
MINTiMINT-7990347.
STRINGi10090.ENSMUSP00000025718.

PTM databases

iPTMnetiQ9CR42.
PhosphoSitePlusiQ9CR42.

Proteomic databases

PaxDbiQ9CR42.
PRIDEiQ9CR42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneIDi107765.
KEGGimmu:107765.
UCSCiuc008hhh.1. mouse.

Organism-specific databases

CTDi27063.
MGIiMGI:1097717. Ankrd1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ9CR42.
OMAiKGDPNVC.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ9CR42.
TreeFamiTF331650.

Miscellaneous databases

PROiQ9CR42.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024803.
CleanExiMM_ANKRD1.
GenevisibleiQ9CR42. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR42
Secondary accession number(s): O55014
, Q3UIF7, Q3UJ39, Q792Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.