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Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.1 Publication

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. histone deacetylase binding Source: MGI
  3. p53 binding Source: MGI
  4. RNA polymerase II transcription coactivator activity Source: MGI
  5. RNA polymerase II transcription factor binding Source: MGI
  6. R-SMAD binding Source: MGI
  7. titin binding Source: UniProtKB
  8. transcription corepressor activity Source: MGI

GO - Biological processi

  1. cardiac muscle tissue morphogenesis Source: MGI
  2. cellular response to drug Source: UniProtKB
  3. cellular response to hypoxia Source: Ensembl
  4. cellular response to interleukin-1 Source: MGI
  5. cellular response to lipopolysaccharide Source: UniProtKB
  6. cellular response to mechanical stimulus Source: MGI
  7. cellular response to organic cyclic compound Source: Ensembl
  8. cellular response to transforming growth factor beta stimulus Source: MGI
  9. cellular response to tumor necrosis factor Source: MGI
  10. muscle cell differentiation Source: GO_Central
  11. negative regulation of DNA biosynthetic process Source: MGI
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of apoptotic process Source: MGI
  14. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  15. positive regulation of neuron projection development Source: Ensembl
  16. positive regulation of protein secretion Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. regulation of transcription from RNA polymerase II promoter Source: MGI
  19. response to muscle stretch Source: MGI
  20. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1097717. Ankrd1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: MGI
  3. I band Source: BHF-UCL
  4. myofibril Source: UniProtKB
  5. nucleolus Source: MGI
  6. nucleus Source: MGI
  7. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Ankyrin repeat domain-containing protein 1PRO_0000240480Add
BLAST

Proteomic databases

PRIDEiQ9CR42.

PTM databases

PhosphoSiteiQ9CR42.

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Developmental stagei

Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts.2 Publications

Gene expression databases

BgeeiQ9CR42.
CleanExiMM_ANKRD1.
GenevestigatoriQ9CR42.

Interactioni

Subunit structurei

Interacts with TTN/titin and YBX1.By similarity

Protein-protein interaction databases

BioGridi223553. 2 interactions.
IntActiQ9CR42. 2 interactions.
MINTiMINT-7990347.
STRINGi10090.ENSMUSP00000025718.

Structurei

3D structure databases

ProteinModelPortaliQ9CR42.
SMRiQ9CR42. Positions 123-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati152 – 18130ANK 1Add
BLAST
Repeati185 – 21430ANK 2Add
BLAST
Repeati218 – 24730ANK 3Add
BLAST
Repeati251 – 28030ANK 4Add
BLAST
Repeati284 – 31532ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili53 – 8937Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117296.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ9CR42.
OMAiKGDPNVC.
OrthoDBiEOG7FJH17.
PhylomeDBiQ9CR42.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA
60 70 80 90 100
NSVKQGEEQR KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK
110 120 130 140 150
KTKVPVVKEP EPEIMTEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD
160 170 180 190 200
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNAD
210 220 230 240 250
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK
310
AIFDSLKENA YKNSRIATF
Length:319
Mass (Da):36,004
Last modified:June 1, 2001 - v1
Checksum:i26A3C4062CF0E7D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481L → F in BAE27549 (PubMed:16141072).Curated
Sequence conflicti139 – 1402FL → LV in AAC03533 (PubMed:9043061).Curated
Sequence conflicti139 – 1402FL → LV in AAB97080 (Ref. 4) Curated
Sequence conflicti299 – 2991T → N in BAE27316 (PubMed:16141072).Curated
Sequence conflicti306 – 3061L → P in AAC03533 (PubMed:9043061).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSiCCDS29771.1.
RefSeqiNP_038496.2. NM_013468.3.
UniGeneiMm.10279.

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneIDi107765.
KEGGimmu:107765.
UCSCiuc008hhh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSiCCDS29771.1.
RefSeqiNP_038496.2. NM_013468.3.
UniGeneiMm.10279.

3D structure databases

ProteinModelPortaliQ9CR42.
SMRiQ9CR42. Positions 123-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223553. 2 interactions.
IntActiQ9CR42. 2 interactions.
MINTiMINT-7990347.
STRINGi10090.ENSMUSP00000025718.

PTM databases

PhosphoSiteiQ9CR42.

Proteomic databases

PRIDEiQ9CR42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneIDi107765.
KEGGimmu:107765.
UCSCiuc008hhh.1. mouse.

Organism-specific databases

CTDi27063.
MGIiMGI:1097717. Ankrd1.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117296.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ9CR42.
OMAiKGDPNVC.
OrthoDBiEOG7FJH17.
PhylomeDBiQ9CR42.
TreeFamiTF331650.

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi359408.
PROiQ9CR42.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR42.
CleanExiMM_ANKRD1.
GenevestigatoriQ9CR42.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway."
    Zou Y., Evans S., Chen J., Kuo H.-C., Harvey R.P., Chien K.R.
    Development 124:793-804(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Schoenfeld J.R., Lowe D.G., Zou Y., Chen J.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 103-176.
  5. "A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes."
    Jeyaseelan R., Poizat C., Baker R.K., Abdishoo S., Isterabadi L.B., Lyons G.E., Kedes L.
    J. Biol. Chem. 272:22800-22808(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiANKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR42
Secondary accession number(s): O55014
, Q3UIF7, Q3UJ39, Q792Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.