SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CR42

- ANKR1_MOUSE

UniProt

Q9CR42 - ANKR1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ankyrin repeat domain-containing protein 1
Gene
Ankrd1, Carp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.1 Publication

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. RNA polymerase II transcription coactivator activity Source: Ensembl
  3. protein binding Source: MGI
  4. titin binding Source: UniProtKB
  5. transcription corepressor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cardiac muscle tissue morphogenesis Source: Ensembl
  2. cellular response to drug Source: UniProtKB
  3. cellular response to hypoxia Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to lipopolysaccharide Source: UniProtKB
  6. cellular response to mechanical stimulus Source: Ensembl
  7. cellular response to organic cyclic compound Source: Ensembl
  8. cellular response to transforming growth factor beta stimulus Source: Ensembl
  9. cellular response to tumor necrosis factor Source: Ensembl
  10. negative regulation of DNA biosynthetic process Source: Ensembl
  11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  13. positive regulation of apoptotic process Source: Ensembl
  14. positive regulation of neuron projection development Source: Ensembl
  15. positive regulation of protein secretion Source: Ensembl
  16. regulation of transcription from RNA polymerase II promoter Source: MGI
  17. response to muscle stretch Source: Ensembl
  18. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1097717. Ankrd1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. I band Source: BHF-UCL
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Ensembl
  4. myofibril Source: UniProtKB
  5. nucleus Source: MGI
  6. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Ankyrin repeat domain-containing protein 1
PRO_0000240480Add
BLAST

Proteomic databases

PRIDEiQ9CR42.

PTM databases

PhosphoSiteiQ9CR42.

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Developmental stagei

Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts.2 Publications

Gene expression databases

BgeeiQ9CR42.
CleanExiMM_ANKRD1.
GenevestigatoriQ9CR42.

Interactioni

Subunit structurei

Interacts with TTN/titin and YBX1 By similarity.

Protein-protein interaction databases

BioGridi223553. 2 interactions.
IntActiQ9CR42. 2 interactions.
MINTiMINT-7990347.
STRINGi10090.ENSMUSP00000025718.

Structurei

3D structure databases

ProteinModelPortaliQ9CR42.
SMRiQ9CR42. Positions 98-312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati152 – 18130ANK 1
Add
BLAST
Repeati185 – 21430ANK 2
Add
BLAST
Repeati218 – 24730ANK 3
Add
BLAST
Repeati251 – 28030ANK 4
Add
BLAST
Repeati284 – 31532ANK 5
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili53 – 8937 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117296.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ9CR42.
OMAiEGDTPMH.
OrthoDBiEOG7FJH17.
PhylomeDBiQ9CR42.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR42-1 [UniParc]FASTAAdd to Basket

« Hide

MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA    50
NSVKQGEEQR KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK 100
KTKVPVVKEP EPEIMTEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD 150
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNAD 200
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR 250
EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK 300
AIFDSLKENA YKNSRIATF 319
Length:319
Mass (Da):36,004
Last modified:June 1, 2001 - v1
Checksum:i26A3C4062CF0E7D0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481L → F in BAE27549. 1 Publication
Sequence conflicti139 – 1402FL → LV in AAC03533. 1 Publication
Sequence conflicti139 – 1402FL → LV in AAB97080. 1 Publication
Sequence conflicti299 – 2991T → N in BAE27316. 1 Publication
Sequence conflicti306 – 3061L → P in AAC03533. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041847 mRNA. Translation: AAC03533.1.
AK009655 mRNA. Translation: BAB26419.1.
AK009959 mRNA. Translation: BAB26611.1.
AK145944 mRNA. Translation: BAE26773.1.
AK146471 mRNA. Translation: BAE27197.1.
AK146627 mRNA. Translation: BAE27316.1.
AK146940 mRNA. Translation: BAE27549.1.
BC037138 mRNA. Translation: AAH37138.1.
AF041849 mRNA. Translation: AAB97080.1.
CCDSiCCDS29771.1.
RefSeqiNP_038496.2. NM_013468.3.
UniGeneiMm.10279.

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803.
GeneIDi107765.
KEGGimmu:107765.
UCSCiuc008hhh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041847 mRNA. Translation: AAC03533.1 .
AK009655 mRNA. Translation: BAB26419.1 .
AK009959 mRNA. Translation: BAB26611.1 .
AK145944 mRNA. Translation: BAE26773.1 .
AK146471 mRNA. Translation: BAE27197.1 .
AK146627 mRNA. Translation: BAE27316.1 .
AK146940 mRNA. Translation: BAE27549.1 .
BC037138 mRNA. Translation: AAH37138.1 .
AF041849 mRNA. Translation: AAB97080.1 .
CCDSi CCDS29771.1.
RefSeqi NP_038496.2. NM_013468.3.
UniGenei Mm.10279.

3D structure databases

ProteinModelPortali Q9CR42.
SMRi Q9CR42. Positions 98-312.
ModBasei Search...

Protein-protein interaction databases

BioGridi 223553. 2 interactions.
IntActi Q9CR42. 2 interactions.
MINTi MINT-7990347.
STRINGi 10090.ENSMUSP00000025718.

PTM databases

PhosphoSitei Q9CR42.

Proteomic databases

PRIDEi Q9CR42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025718 ; ENSMUSP00000025718 ; ENSMUSG00000024803 .
GeneIDi 107765.
KEGGi mmu:107765.
UCSCi uc008hhh.1. mouse.

Organism-specific databases

CTDi 27063.
MGIi MGI:1097717. Ankrd1.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00750000117296.
HOGENOMi HOG000236321.
HOVERGENi HBG071561.
InParanoidi Q9CR42.
OMAi EGDTPMH.
OrthoDBi EOG7FJH17.
PhylomeDBi Q9CR42.
TreeFami TF331650.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 359408.
PROi Q9CR42.
SOURCEi Search...

Gene expression databases

Bgeei Q9CR42.
CleanExi MM_ANKRD1.
Genevestigatori Q9CR42.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway."
    Zou Y., Evans S., Chen J., Kuo H.-C., Harvey R.P., Chien K.R.
    Development 124:793-804(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Schoenfeld J.R., Lowe D.G., Zou Y., Chen J.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 103-176.
  5. "A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes."
    Jeyaseelan R., Poizat C., Baker R.K., Abdishoo S., Isterabadi L.B., Lyons G.E., Kedes L.
    J. Biol. Chem. 272:22800-22808(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiANKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR42
Secondary accession number(s): O55014
, Q3UIF7, Q3UJ39, Q792Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi