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Q9CR35

- CTRB1_MOUSE

UniProt

Q9CR35 - CTRB1_MOUSE

Protein

Chymotrypsinogen B

Gene

Ctrb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei213 – 2131Charge relay systemBy similarity

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW
    2. proteolysis Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.152.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsinogen B (EC:3.4.21.1)
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Ctrb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:88559. Ctrb1.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 263245Chymotrypsinogen BPRO_0000285874Add
    BLAST
    Chaini19 – 3113Chymotrypsin B chain ABy similarityPRO_0000285875Add
    BLAST
    Chaini34 – 164131Chymotrypsin B chain BBy similarityPRO_0000285876Add
    BLAST
    Chaini167 – 26397Chymotrypsin B chain CBy similarityPRO_0000285877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    MaxQBiQ9CR35.
    PaxDbiQ9CR35.
    PRIDEiQ9CR35.

    PTM databases

    PhosphoSiteiQ9CR35.

    Expressioni

    Gene expression databases

    BgeeiQ9CR35.
    CleanExiMM_CTRB1.
    GenevestigatoriQ9CR35.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR35.
    SMRiQ9CR35. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00730000110306.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ9CR35.
    KOiK01310.
    OMAiLATEARF.
    OrthoDBiEOG7MKW6Q.
    PhylomeDBiQ9CR35.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CR35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFLWLVSCF ALVGATFGCG VPAIQPVLTG LSRIVNGEDA IPGSWPWQVS    50
    LQDRTGFHFC GGSLISENWV VTAAHCGVKT TDVVVAGEFD QGSDEENVQV 100
    LKIAQVFKNP KFNSFTVRND ITLLKLATPA QFSETVSAVC LPTVDDDFPA 150
    GTLCATTGWG KTKYNALKTP DKLQQAALPI VSEAKCKESW GSKITDVMIC 200
    AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGFCST STPAVYARVT 250
    ALMPWVQEIL EAN 263
    Length:263
    Mass (Da):27,822
    Last modified:June 1, 2001 - v1
    Checksum:i28C4487AF1A26B27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631S → Y in BAB25112. (PubMed:16141072)Curated
    Sequence conflicti82 – 821D → N in BAB22539. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003060 mRNA. Translation: BAB22539.1.
    AK003079 mRNA. Translation: BAB22553.1.
    AK007566 mRNA. Translation: BAB25112.1.
    AK007765 mRNA. Translation: BAB25241.1.
    AK007815 mRNA. Translation: BAB25280.1.
    AK008644 mRNA. Translation: BAC25226.1.
    AK008729 mRNA. Translation: BAB25861.1.
    AK008888 mRNA. Translation: BAB25954.1.
    AK008927 mRNA. Translation: BAB25971.1.
    BC061083 mRNA. Translation: AAH61083.1.
    CCDSiCCDS22679.1.
    RefSeqiNP_079859.2. NM_025583.2.
    UniGeneiMm.34374.

    Genome annotation databases

    EnsembliENSMUST00000034435; ENSMUSP00000034435; ENSMUSG00000031957.
    GeneIDi66473.
    KEGGimmu:66473.
    UCSCiuc009nms.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003060 mRNA. Translation: BAB22539.1 .
    AK003079 mRNA. Translation: BAB22553.1 .
    AK007566 mRNA. Translation: BAB25112.1 .
    AK007765 mRNA. Translation: BAB25241.1 .
    AK007815 mRNA. Translation: BAB25280.1 .
    AK008644 mRNA. Translation: BAC25226.1 .
    AK008729 mRNA. Translation: BAB25861.1 .
    AK008888 mRNA. Translation: BAB25954.1 .
    AK008927 mRNA. Translation: BAB25971.1 .
    BC061083 mRNA. Translation: AAH61083.1 .
    CCDSi CCDS22679.1.
    RefSeqi NP_079859.2. NM_025583.2.
    UniGenei Mm.34374.

    3D structure databases

    ProteinModelPortali Q9CR35.
    SMRi Q9CR35. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.152.

    PTM databases

    PhosphoSitei Q9CR35.

    Proteomic databases

    MaxQBi Q9CR35.
    PaxDbi Q9CR35.
    PRIDEi Q9CR35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034435 ; ENSMUSP00000034435 ; ENSMUSG00000031957 .
    GeneIDi 66473.
    KEGGi mmu:66473.
    UCSCi uc009nms.2. mouse.

    Organism-specific databases

    CTDi 1504.
    MGIi MGI:88559. Ctrb1.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00730000110306.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q9CR35.
    KOi K01310.
    OMAi LATEARF.
    OrthoDBi EOG7MKW6Q.
    PhylomeDBi Q9CR35.
    TreeFami TF330455.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    ChiTaRSi CTRB1. mouse.
    NextBioi 321790.
    PROi Q9CR35.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CR35.
    CleanExi MM_CTRB1.
    Genevestigatori Q9CR35.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas, Spleen and Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCTRB1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR35
    Secondary accession number(s): Q9D8X8, Q9DC86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3