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Q9CR30

- JOS2_MOUSE

UniProt

Q9CR30 - JOS2_MOUSE

Protein

Josephin-2

Gene

Josd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei24 – 241NucleophilePROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. omega peptidase activity Source: InterPro
    2. ubiquitin-specific protease activity Source: Ensembl

    GO - Biological processi

    1. protein deubiquitination Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC86.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Josephin-2 (EC:3.4.19.12)
    Alternative name(s):
    Josephin domain-containing protein 2
    Gene namesi
    Name:Josd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1913374. Josd2.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Josephin-2PRO_0000053844Add
    BLAST

    Proteomic databases

    PaxDbiQ9CR30.
    PRIDEiQ9CR30.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CR30.
    BgeeiQ9CR30.
    CleanExiMM_JOSD2.
    GenevestigatoriQ9CR30.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR30.
    SMRiQ9CR30. Positions 13-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 188178JosephinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Josephin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG321724.
    GeneTreeiENSGT00390000009228.
    HOGENOMiHOG000005731.
    HOVERGENiHBG039523.
    InParanoidiQ9CR30.
    KOiK15235.
    OMAiAVWWDRR.
    OrthoDBiEOG75B871.
    PhylomeDBiQ9CR30.
    TreeFamiTF313660.

    Family and domain databases

    InterProiIPR006155. Josephin.
    [Graphical view]
    PfamiPF02099. Josephin. 1 hit.
    [Graphical view]
    PRINTSiPR01233. JOSEPHIN.
    PROSITEiPS50957. JOSEPHIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CR30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQAPEARPS PPSVYHERQR LELCAVHALN NVLQEQLFSQ EAADEICKRL    50
    APDSRLNPHR SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ 100
    VLGLILNLPS PVSLGLLSLP LRRRHWVALR QVDGIYYNLD SKLRAPEALG 150
    DEDGVRTFLA AALAQGLCEV LLVVTKEVEE AGCWLNTS 188
    Length:188
    Mass (Da):20,776
    Last modified:June 1, 2001 - v1
    Checksum:i2B2DE4BB1E9243F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003525 mRNA. Translation: BAB22837.1.
    AK002872 mRNA. Translation: BAB22420.1.
    CCDSiCCDS21208.1.
    RefSeqiNP_001191999.1. NM_001205070.1.
    NP_001192000.1. NM_001205071.1.
    NP_001192001.1. NM_001205072.1.
    NP_001192002.1. NM_001205073.1.
    NP_079644.1. NM_025368.4.
    XP_006541136.1. XM_006541073.1.
    XP_006541137.1. XM_006541074.1.
    UniGeneiMm.358691.

    Genome annotation databases

    EnsembliENSMUST00000035844; ENSMUSP00000048415; ENSMUSG00000038695.
    ENSMUST00000117324; ENSMUSP00000113313; ENSMUSG00000038695.
    ENSMUST00000118493; ENSMUSP00000113226; ENSMUSG00000038695.
    ENSMUST00000118628; ENSMUSP00000113172; ENSMUSG00000038695.
    ENSMUST00000120852; ENSMUSP00000114105; ENSMUSG00000038695.
    GeneIDi66124.
    KEGGimmu:66124.
    UCSCiuc009gpl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003525 mRNA. Translation: BAB22837.1 .
    AK002872 mRNA. Translation: BAB22420.1 .
    CCDSi CCDS21208.1.
    RefSeqi NP_001191999.1. NM_001205070.1.
    NP_001192000.1. NM_001205071.1.
    NP_001192001.1. NM_001205072.1.
    NP_001192002.1. NM_001205073.1.
    NP_079644.1. NM_025368.4.
    XP_006541136.1. XM_006541073.1.
    XP_006541137.1. XM_006541074.1.
    UniGenei Mm.358691.

    3D structure databases

    ProteinModelPortali Q9CR30.
    SMRi Q9CR30. Positions 13-165.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C86.005.

    Proteomic databases

    PaxDbi Q9CR30.
    PRIDEi Q9CR30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035844 ; ENSMUSP00000048415 ; ENSMUSG00000038695 .
    ENSMUST00000117324 ; ENSMUSP00000113313 ; ENSMUSG00000038695 .
    ENSMUST00000118493 ; ENSMUSP00000113226 ; ENSMUSG00000038695 .
    ENSMUST00000118628 ; ENSMUSP00000113172 ; ENSMUSG00000038695 .
    ENSMUST00000120852 ; ENSMUSP00000114105 ; ENSMUSG00000038695 .
    GeneIDi 66124.
    KEGGi mmu:66124.
    UCSCi uc009gpl.2. mouse.

    Organism-specific databases

    CTDi 126119.
    MGIi MGI:1913374. Josd2.

    Phylogenomic databases

    eggNOGi NOG321724.
    GeneTreei ENSGT00390000009228.
    HOGENOMi HOG000005731.
    HOVERGENi HBG039523.
    InParanoidi Q9CR30.
    KOi K15235.
    OMAi AVWWDRR.
    OrthoDBi EOG75B871.
    PhylomeDBi Q9CR30.
    TreeFami TF313660.

    Miscellaneous databases

    NextBioi 320702.
    PROi Q9CR30.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CR30.
    Bgeei Q9CR30.
    CleanExi MM_JOSD2.
    Genevestigatori Q9CR30.

    Family and domain databases

    InterProi IPR006155. Josephin.
    [Graphical view ]
    Pfami PF02099. Josephin. 1 hit.
    [Graphical view ]
    PRINTSi PR01233. JOSEPHIN.
    PROSITEi PS50957. JOSEPHIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    2. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
      Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
      Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiJOS2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3