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Q9CR30

- JOS2_MOUSE

UniProt

Q9CR30 - JOS2_MOUSE

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Protein

Josephin-2

Gene

Josd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241NucleophilePROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: Ensembl

GO - Biological processi

  1. protein deubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC86.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Josephin-2 (EC:3.4.19.12)
Alternative name(s):
Josephin domain-containing protein 2
Gene namesi
Name:Josd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1913374. Josd2.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Josephin-2PRO_0000053844Add
BLAST

Proteomic databases

PaxDbiQ9CR30.
PRIDEiQ9CR30.

Expressioni

Gene expression databases

BgeeiQ9CR30.
CleanExiMM_JOSD2.
ExpressionAtlasiQ9CR30. baseline and differential.
GenevestigatoriQ9CR30.

Structurei

3D structure databases

ProteinModelPortaliQ9CR30.
SMRiQ9CR30. Positions 13-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 188178JosephinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG321724.
GeneTreeiENSGT00390000009228.
HOGENOMiHOG000005731.
HOVERGENiHBG039523.
InParanoidiQ9CR30.
KOiK15235.
OMAiAVWWDRR.
OrthoDBiEOG75B871.
PhylomeDBiQ9CR30.
TreeFamiTF313660.

Family and domain databases

InterProiIPR006155. Josephin.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR30 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAPEARPS PPSVYHERQR LELCAVHALN NVLQEQLFSQ EAADEICKRL
60 70 80 90 100
APDSRLNPHR SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ
110 120 130 140 150
VLGLILNLPS PVSLGLLSLP LRRRHWVALR QVDGIYYNLD SKLRAPEALG
160 170 180
DEDGVRTFLA AALAQGLCEV LLVVTKEVEE AGCWLNTS
Length:188
Mass (Da):20,776
Last modified:June 1, 2001 - v1
Checksum:i2B2DE4BB1E9243F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003525 mRNA. Translation: BAB22837.1.
AK002872 mRNA. Translation: BAB22420.1.
CCDSiCCDS21208.1.
RefSeqiNP_001191999.1. NM_001205070.1.
NP_001192000.1. NM_001205071.1.
NP_001192001.1. NM_001205072.1.
NP_001192002.1. NM_001205073.1.
NP_079644.1. NM_025368.4.
XP_006541136.1. XM_006541073.1.
XP_006541137.1. XM_006541074.1.
UniGeneiMm.358691.

Genome annotation databases

EnsembliENSMUST00000035844; ENSMUSP00000048415; ENSMUSG00000038695.
ENSMUST00000117324; ENSMUSP00000113313; ENSMUSG00000038695.
ENSMUST00000118493; ENSMUSP00000113226; ENSMUSG00000038695.
ENSMUST00000118628; ENSMUSP00000113172; ENSMUSG00000038695.
ENSMUST00000120852; ENSMUSP00000114105; ENSMUSG00000038695.
GeneIDi66124.
KEGGimmu:66124.
UCSCiuc009gpl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003525 mRNA. Translation: BAB22837.1 .
AK002872 mRNA. Translation: BAB22420.1 .
CCDSi CCDS21208.1.
RefSeqi NP_001191999.1. NM_001205070.1.
NP_001192000.1. NM_001205071.1.
NP_001192001.1. NM_001205072.1.
NP_001192002.1. NM_001205073.1.
NP_079644.1. NM_025368.4.
XP_006541136.1. XM_006541073.1.
XP_006541137.1. XM_006541074.1.
UniGenei Mm.358691.

3D structure databases

ProteinModelPortali Q9CR30.
SMRi Q9CR30. Positions 13-165.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C86.005.

Proteomic databases

PaxDbi Q9CR30.
PRIDEi Q9CR30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035844 ; ENSMUSP00000048415 ; ENSMUSG00000038695 .
ENSMUST00000117324 ; ENSMUSP00000113313 ; ENSMUSG00000038695 .
ENSMUST00000118493 ; ENSMUSP00000113226 ; ENSMUSG00000038695 .
ENSMUST00000118628 ; ENSMUSP00000113172 ; ENSMUSG00000038695 .
ENSMUST00000120852 ; ENSMUSP00000114105 ; ENSMUSG00000038695 .
GeneIDi 66124.
KEGGi mmu:66124.
UCSCi uc009gpl.2. mouse.

Organism-specific databases

CTDi 126119.
MGIi MGI:1913374. Josd2.

Phylogenomic databases

eggNOGi NOG321724.
GeneTreei ENSGT00390000009228.
HOGENOMi HOG000005731.
HOVERGENi HBG039523.
InParanoidi Q9CR30.
KOi K15235.
OMAi AVWWDRR.
OrthoDBi EOG75B871.
PhylomeDBi Q9CR30.
TreeFami TF313660.

Miscellaneous databases

NextBioi 320702.
PROi Q9CR30.
SOURCEi Search...

Gene expression databases

Bgeei Q9CR30.
CleanExi MM_JOSD2.
ExpressionAtlasi Q9CR30. baseline and differential.
Genevestigatori Q9CR30.

Family and domain databases

InterProi IPR006155. Josephin.
[Graphical view ]
Pfami PF02099. Josephin. 1 hit.
[Graphical view ]
PRINTSi PR01233. JOSEPHIN.
PROSITEi PS50957. JOSEPHIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
    Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
    Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiJOS2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3