Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Josephin-2

Gene

Josd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241NucleophilePROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC86.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Josephin-2 (EC:3.4.19.12)
Alternative name(s):
Josephin domain-containing protein 2
Gene namesi
Name:Josd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913374. Josd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Josephin-2PRO_0000053844Add
BLAST

Proteomic databases

PaxDbiQ9CR30.
PRIDEiQ9CR30.

Expressioni

Gene expression databases

BgeeiQ9CR30.
CleanExiMM_JOSD2.
ExpressionAtlasiQ9CR30. baseline and differential.
GenevisibleiQ9CR30. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048415.

Structurei

3D structure databases

ProteinModelPortaliQ9CR30.
SMRiQ9CR30. Positions 13-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 188178JosephinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG321724.
GeneTreeiENSGT00390000009228.
HOGENOMiHOG000005731.
HOVERGENiHBG039523.
InParanoidiQ9CR30.
KOiK15235.
OMAiDKRRTVQ.
OrthoDBiEOG75B871.
PhylomeDBiQ9CR30.
TreeFamiTF313660.

Family and domain databases

InterProiIPR006155. Josephin.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAPEARPS PPSVYHERQR LELCAVHALN NVLQEQLFSQ EAADEICKRL
60 70 80 90 100
APDSRLNPHR SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ
110 120 130 140 150
VLGLILNLPS PVSLGLLSLP LRRRHWVALR QVDGIYYNLD SKLRAPEALG
160 170 180
DEDGVRTFLA AALAQGLCEV LLVVTKEVEE AGCWLNTS
Length:188
Mass (Da):20,776
Last modified:June 1, 2001 - v1
Checksum:i2B2DE4BB1E9243F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003525 mRNA. Translation: BAB22837.1.
AK002872 mRNA. Translation: BAB22420.1.
CCDSiCCDS21208.1.
RefSeqiNP_001191999.1. NM_001205070.1.
NP_001192000.1. NM_001205071.1.
NP_001192001.1. NM_001205072.1.
NP_001192002.1. NM_001205073.1.
NP_079644.1. NM_025368.4.
XP_006541136.1. XM_006541073.2.
XP_006541137.1. XM_006541074.2.
UniGeneiMm.358691.

Genome annotation databases

EnsembliENSMUST00000035844; ENSMUSP00000048415; ENSMUSG00000038695.
ENSMUST00000117324; ENSMUSP00000113313; ENSMUSG00000038695.
ENSMUST00000118493; ENSMUSP00000113226; ENSMUSG00000038695.
ENSMUST00000118628; ENSMUSP00000113172; ENSMUSG00000038695.
ENSMUST00000120852; ENSMUSP00000114105; ENSMUSG00000038695.
GeneIDi66124.
KEGGimmu:66124.
UCSCiuc009gpl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003525 mRNA. Translation: BAB22837.1.
AK002872 mRNA. Translation: BAB22420.1.
CCDSiCCDS21208.1.
RefSeqiNP_001191999.1. NM_001205070.1.
NP_001192000.1. NM_001205071.1.
NP_001192001.1. NM_001205072.1.
NP_001192002.1. NM_001205073.1.
NP_079644.1. NM_025368.4.
XP_006541136.1. XM_006541073.2.
XP_006541137.1. XM_006541074.2.
UniGeneiMm.358691.

3D structure databases

ProteinModelPortaliQ9CR30.
SMRiQ9CR30. Positions 13-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048415.

Protein family/group databases

MEROPSiC86.005.

Proteomic databases

PaxDbiQ9CR30.
PRIDEiQ9CR30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035844; ENSMUSP00000048415; ENSMUSG00000038695.
ENSMUST00000117324; ENSMUSP00000113313; ENSMUSG00000038695.
ENSMUST00000118493; ENSMUSP00000113226; ENSMUSG00000038695.
ENSMUST00000118628; ENSMUSP00000113172; ENSMUSG00000038695.
ENSMUST00000120852; ENSMUSP00000114105; ENSMUSG00000038695.
GeneIDi66124.
KEGGimmu:66124.
UCSCiuc009gpl.2. mouse.

Organism-specific databases

CTDi126119.
MGIiMGI:1913374. Josd2.

Phylogenomic databases

eggNOGiNOG321724.
GeneTreeiENSGT00390000009228.
HOGENOMiHOG000005731.
HOVERGENiHBG039523.
InParanoidiQ9CR30.
KOiK15235.
OMAiDKRRTVQ.
OrthoDBiEOG75B871.
PhylomeDBiQ9CR30.
TreeFamiTF313660.

Miscellaneous databases

NextBioi320702.
PROiQ9CR30.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR30.
CleanExiMM_JOSD2.
ExpressionAtlasiQ9CR30. baseline and differential.
GenevisibleiQ9CR30. MM.

Family and domain databases

InterProiIPR006155. Josephin.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
    Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
    Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiJOS2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.