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Q9CR26

- VTA1_MOUSE

UniProt

Q9CR26 - VTA1_MOUSE

Protein

Vacuolar protein sorting-associated protein VTA1 homolog

Gene

Vta1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies By similarity. Involved in the sorting and down-regulation of EGFR.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein VTA1 homolog
    Alternative name(s):
    SKD1-binding protein 1
    Short name:
    SBP1
    Gene namesi
    Name:Vta1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1913451. Vta1.

    Subcellular locationi

    Cytoplasm 1 Publication. Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 309308Vacuolar protein sorting-associated protein VTA1 homologPRO_0000089510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CR26.
    PaxDbiQ9CR26.
    PRIDEiQ9CR26.

    PTM databases

    PhosphoSiteiQ9CR26.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9CR26.
    BgeeiQ9CR26.
    CleanExiMM_VTA1.
    GenevestigatoriQ9CR26.

    Interactioni

    Subunit structurei

    Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211293. 3 interactions.
    DIPiDIP-54810N.
    IntActiQ9CR26. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR26.
    SMRiQ9CR26. Positions 13-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 186185Interaction with IST1By similarityAdd
    BLAST
    Regioni2 – 7574Interaction with CHMP5By similarityAdd
    BLAST
    Regioni198 – 309112Interaction with VPS4BAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VTA1 family.Curated

    Phylogenomic databases

    eggNOGiNOG127441.
    GeneTreeiENSGT00390000011342.
    HOVERGENiHBG050907.
    InParanoidiQ9CR26.
    KOiK12199.
    OMAiTPQPGPI.
    OrthoDBiEOG7JHM66.
    PhylomeDBiQ9CR26.
    TreeFamiTF105917.

    Family and domain databases

    Gene3Di1.25.40.270. 1 hit.
    InterProiIPR023175. VPS_Vta1/CALS_N-dom.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CR26-1 [UniParc]FASTAAdd to Basket

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    MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID    50
    SKTPECRKFL SKLMDQLEAL KKQLGDNEAV TQEIVGCAHL ENYALKMFLY 100
    ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT 150
    YIHNCLKNGE TPQAGPVGIE EENDVEENED VGATSLPTQP PQPSSSSAYD 200
    PSNLAPGSYS GIQIPPGAHA PANTPAEVPH STGVTSNAVQ PSPQTVPAAP 250
    AVDPDLYTAS QGDIRLTPED FARAQKYCKY AGSALQYEDV GTAVQNLQKA 300
    LRLLTTGRE 309
    Length:309
    Mass (Da):33,913
    Last modified:June 1, 2001 - v1
    Checksum:i2D37B56A571A0157
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002611 mRNA. Translation: BAB22228.1.
    AK009227 mRNA. Translation: BAB26150.1.
    BC026752 mRNA. Translation: AAH26752.1.
    CCDSiCCDS23705.1.
    RefSeqiNP_079694.2. NM_025418.3.
    UniGeneiMm.227983.

    Genome annotation databases

    EnsembliENSMUST00000154132; ENSMUSP00000119829; ENSMUSG00000019868.
    GeneIDi66201.
    KEGGimmu:66201.
    UCSCiuc007ell.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002611 mRNA. Translation: BAB22228.1 .
    AK009227 mRNA. Translation: BAB26150.1 .
    BC026752 mRNA. Translation: AAH26752.1 .
    CCDSi CCDS23705.1.
    RefSeqi NP_079694.2. NM_025418.3.
    UniGenei Mm.227983.

    3D structure databases

    ProteinModelPortali Q9CR26.
    SMRi Q9CR26. Positions 13-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211293. 3 interactions.
    DIPi DIP-54810N.
    IntActi Q9CR26. 2 interactions.

    PTM databases

    PhosphoSitei Q9CR26.

    Proteomic databases

    MaxQBi Q9CR26.
    PaxDbi Q9CR26.
    PRIDEi Q9CR26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000154132 ; ENSMUSP00000119829 ; ENSMUSG00000019868 .
    GeneIDi 66201.
    KEGGi mmu:66201.
    UCSCi uc007ell.1. mouse.

    Organism-specific databases

    CTDi 51534.
    MGIi MGI:1913451. Vta1.

    Phylogenomic databases

    eggNOGi NOG127441.
    GeneTreei ENSGT00390000011342.
    HOVERGENi HBG050907.
    InParanoidi Q9CR26.
    KOi K12199.
    OMAi TPQPGPI.
    OrthoDBi EOG7JHM66.
    PhylomeDBi Q9CR26.
    TreeFami TF105917.

    Enzyme and pathway databases

    Reactomei REACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

    Miscellaneous databases

    NextBioi 320943.
    PROi Q9CR26.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CR26.
    Bgeei Q9CR26.
    CleanExi MM_VTA1.
    Genevestigatori Q9CR26.

    Family and domain databases

    Gene3Di 1.25.40.270. 1 hit.
    InterProi IPR023175. VPS_Vta1/CALS_N-dom.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
      Fujita H., Umezuki Y., Imamura K., Ishikawa D., Uchimura S., Nara A., Yoshimori T., Hayashizaki Y., Kawai J., Ishidoh K., Tanaka Y., Himeno M.
      J. Cell Sci. 117:2997-3009(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VPS4B, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiVTA1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3