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Q9CR26

- VTA1_MOUSE

UniProt

Q9CR26 - VTA1_MOUSE

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Protein

Vacuolar protein sorting-associated protein VTA1 homolog

Gene
Vta1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies By similarity. Involved in the sorting and down-regulation of EGFR.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein VTA1 homolog
Alternative name(s):
SKD1-binding protein 1
Short name:
SBP1
Gene namesi
Name:Vta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1913451. Vta1.

Subcellular locationi

Cytoplasm. Endosome membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 309308Vacuolar protein sorting-associated protein VTA1 homologPRO_0000089510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CR26.
PaxDbiQ9CR26.
PRIDEiQ9CR26.

PTM databases

PhosphoSiteiQ9CR26.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ9CR26.
BgeeiQ9CR26.
CleanExiMM_VTA1.
GenevestigatoriQ9CR26.

Interactioni

Subunit structurei

Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1 By similarity.1 Publication

Protein-protein interaction databases

BioGridi211293. 3 interactions.
DIPiDIP-54810N.
IntActiQ9CR26. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9CR26.
SMRiQ9CR26. Positions 13-163.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 186185Interaction with IST1 By similarityAdd
BLAST
Regioni2 – 7574Interaction with CHMP5 By similarityAdd
BLAST
Regioni198 – 309112Interaction with VPS4BAdd
BLAST

Sequence similaritiesi

Belongs to the VTA1 family.

Phylogenomic databases

eggNOGiNOG127441.
GeneTreeiENSGT00390000011342.
HOVERGENiHBG050907.
InParanoidiQ9CR26.
KOiK12199.
OMAiTPQPGPI.
OrthoDBiEOG7JHM66.
PhylomeDBiQ9CR26.
TreeFamiTF105917.

Family and domain databases

Gene3Di1.25.40.270. 1 hit.
InterProiIPR023175. VPS_Vta1/CALS_N-dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR26-1 [UniParc]FASTAAdd to Basket

« Hide

MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID    50
SKTPECRKFL SKLMDQLEAL KKQLGDNEAV TQEIVGCAHL ENYALKMFLY 100
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT 150
YIHNCLKNGE TPQAGPVGIE EENDVEENED VGATSLPTQP PQPSSSSAYD 200
PSNLAPGSYS GIQIPPGAHA PANTPAEVPH STGVTSNAVQ PSPQTVPAAP 250
AVDPDLYTAS QGDIRLTPED FARAQKYCKY AGSALQYEDV GTAVQNLQKA 300
LRLLTTGRE 309
Length:309
Mass (Da):33,913
Last modified:June 1, 2001 - v1
Checksum:i2D37B56A571A0157
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002611 mRNA. Translation: BAB22228.1.
AK009227 mRNA. Translation: BAB26150.1.
BC026752 mRNA. Translation: AAH26752.1.
CCDSiCCDS23705.1.
RefSeqiNP_079694.2. NM_025418.3.
UniGeneiMm.227983.

Genome annotation databases

EnsembliENSMUST00000154132; ENSMUSP00000119829; ENSMUSG00000019868.
GeneIDi66201.
KEGGimmu:66201.
UCSCiuc007ell.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002611 mRNA. Translation: BAB22228.1 .
AK009227 mRNA. Translation: BAB26150.1 .
BC026752 mRNA. Translation: AAH26752.1 .
CCDSi CCDS23705.1.
RefSeqi NP_079694.2. NM_025418.3.
UniGenei Mm.227983.

3D structure databases

ProteinModelPortali Q9CR26.
SMRi Q9CR26. Positions 13-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211293. 3 interactions.
DIPi DIP-54810N.
IntActi Q9CR26. 2 interactions.

PTM databases

PhosphoSitei Q9CR26.

Proteomic databases

MaxQBi Q9CR26.
PaxDbi Q9CR26.
PRIDEi Q9CR26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000154132 ; ENSMUSP00000119829 ; ENSMUSG00000019868 .
GeneIDi 66201.
KEGGi mmu:66201.
UCSCi uc007ell.1. mouse.

Organism-specific databases

CTDi 51534.
MGIi MGI:1913451. Vta1.

Phylogenomic databases

eggNOGi NOG127441.
GeneTreei ENSGT00390000011342.
HOVERGENi HBG050907.
InParanoidi Q9CR26.
KOi K12199.
OMAi TPQPGPI.
OrthoDBi EOG7JHM66.
PhylomeDBi Q9CR26.
TreeFami TF105917.

Enzyme and pathway databases

Reactomei REACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

NextBioi 320943.
PROi Q9CR26.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CR26.
Bgeei Q9CR26.
CleanExi MM_VTA1.
Genevestigatori Q9CR26.

Family and domain databases

Gene3Di 1.25.40.270. 1 hit.
InterProi IPR023175. VPS_Vta1/CALS_N-dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
    Fujita H., Umezuki Y., Imamura K., Ishikawa D., Uchimura S., Nara A., Yoshimori T., Hayashizaki Y., Kawai J., Ishidoh K., Tanaka Y., Himeno M.
    J. Cell Sci. 117:2997-3009(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VPS4B, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiVTA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi