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Protein

Vacuolar protein sorting-associated protein VTA1 homolog

Gene

Vta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein VTA1 homolog
Alternative name(s):
SKD1-binding protein 1
Short name:
SBP1
Gene namesi
Name:Vta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913451. Vta1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000895102 – 309Vacuolar protein sorting-associated protein VTA1 homologAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR26.
MaxQBiQ9CR26.
PaxDbiQ9CR26.
PeptideAtlasiQ9CR26.
PRIDEiQ9CR26.

PTM databases

iPTMnetiQ9CR26.
PhosphoSitePlusiQ9CR26.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000019868.
CleanExiMM_VTA1.
ExpressionAtlasiQ9CR26. baseline and differential.
GenevisibleiQ9CR26. MM.

Interactioni

Subunit structurei

Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211293. 3 interactors.
DIPiDIP-54810N.
IntActiQ9CR26. 3 interactors.
STRINGi10090.ENSMUSP00000119829.

Structurei

3D structure databases

ProteinModelPortaliQ9CR26.
SMRiQ9CR26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 186Interaction with IST1By similarityAdd BLAST185
Regioni2 – 75Interaction with CHMP5By similarityAdd BLAST74
Regioni198 – 309Interaction with VPS4B1 PublicationAdd BLAST112

Sequence similaritiesi

Belongs to the VTA1 family.Curated

Phylogenomic databases

eggNOGiKOG0917. Eukaryota.
ENOG4111H3M. LUCA.
GeneTreeiENSGT00390000011342.
HOVERGENiHBG050907.
InParanoidiQ9CR26.
KOiK12199.
OMAiQTADTFQ.
OrthoDBiEOG091G0QW9.
PhylomeDBiQ9CR26.
TreeFamiTF105917.

Family and domain databases

Gene3Di1.25.40.270. 1 hit.
InterProiView protein in InterPro
IPR023175. VPS_Vta1/CALS_N.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID
60 70 80 90 100
SKTPECRKFL SKLMDQLEAL KKQLGDNEAV TQEIVGCAHL ENYALKMFLY
110 120 130 140 150
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT
160 170 180 190 200
YIHNCLKNGE TPQAGPVGIE EENDVEENED VGATSLPTQP PQPSSSSAYD
210 220 230 240 250
PSNLAPGSYS GIQIPPGAHA PANTPAEVPH STGVTSNAVQ PSPQTVPAAP
260 270 280 290 300
AVDPDLYTAS QGDIRLTPED FARAQKYCKY AGSALQYEDV GTAVQNLQKA

LRLLTTGRE
Length:309
Mass (Da):33,913
Last modified:June 1, 2001 - v1
Checksum:i2D37B56A571A0157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002611 mRNA. Translation: BAB22228.1.
AK009227 mRNA. Translation: BAB26150.1.
BC026752 mRNA. Translation: AAH26752.1.
CCDSiCCDS23705.1.
RefSeqiNP_079694.2. NM_025418.3.
UniGeneiMm.227983.

Genome annotation databases

EnsembliENSMUST00000154132; ENSMUSP00000119829; ENSMUSG00000019868.
GeneIDi66201.
KEGGimmu:66201.
UCSCiuc007ell.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiVTA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families