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Protein

Vacuolar protein sorting-associated protein VTA1 homolog

Gene

Vta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR.By similarity1 Publication

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein VTA1 homolog
Alternative name(s):
SKD1-binding protein 1
Short name:
SBP1
Gene namesi
Name:Vta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1913451. Vta1.

Subcellular locationi

Cytoplasm 1 Publication. Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. endosome membrane Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 309308Vacuolar protein sorting-associated protein VTA1 homologPRO_0000089510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CR26.
PaxDbiQ9CR26.
PRIDEiQ9CR26.

PTM databases

PhosphoSiteiQ9CR26.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level).1 Publication

Gene expression databases

BgeeiQ9CR26.
CleanExiMM_VTA1.
ExpressionAtlasiQ9CR26. baseline and differential.
GenevestigatoriQ9CR26.

Interactioni

Subunit structurei

Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211293. 3 interactions.
DIPiDIP-54810N.
IntActiQ9CR26. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9CR26.
SMRiQ9CR26. Positions 13-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 186185Interaction with IST1By similarityAdd
BLAST
Regioni2 – 7574Interaction with CHMP5By similarityAdd
BLAST
Regioni198 – 309112Interaction with VPS4BAdd
BLAST

Sequence similaritiesi

Belongs to the VTA1 family.Curated

Phylogenomic databases

eggNOGiNOG127441.
GeneTreeiENSGT00390000011342.
HOVERGENiHBG050907.
InParanoidiQ9CR26.
KOiK12199.
OMAiTPQPGPI.
OrthoDBiEOG7JHM66.
PhylomeDBiQ9CR26.
TreeFamiTF105917.

Family and domain databases

Gene3Di1.25.40.270. 1 hit.
InterProiIPR023175. VPS_Vta1/CALS_N-dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID
60 70 80 90 100
SKTPECRKFL SKLMDQLEAL KKQLGDNEAV TQEIVGCAHL ENYALKMFLY
110 120 130 140 150
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT
160 170 180 190 200
YIHNCLKNGE TPQAGPVGIE EENDVEENED VGATSLPTQP PQPSSSSAYD
210 220 230 240 250
PSNLAPGSYS GIQIPPGAHA PANTPAEVPH STGVTSNAVQ PSPQTVPAAP
260 270 280 290 300
AVDPDLYTAS QGDIRLTPED FARAQKYCKY AGSALQYEDV GTAVQNLQKA

LRLLTTGRE
Length:309
Mass (Da):33,913
Last modified:June 1, 2001 - v1
Checksum:i2D37B56A571A0157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002611 mRNA. Translation: BAB22228.1.
AK009227 mRNA. Translation: BAB26150.1.
BC026752 mRNA. Translation: AAH26752.1.
CCDSiCCDS23705.1.
RefSeqiNP_079694.2. NM_025418.3.
UniGeneiMm.227983.

Genome annotation databases

EnsembliENSMUST00000154132; ENSMUSP00000119829; ENSMUSG00000019868.
GeneIDi66201.
KEGGimmu:66201.
UCSCiuc007ell.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002611 mRNA. Translation: BAB22228.1.
AK009227 mRNA. Translation: BAB26150.1.
BC026752 mRNA. Translation: AAH26752.1.
CCDSiCCDS23705.1.
RefSeqiNP_079694.2. NM_025418.3.
UniGeneiMm.227983.

3D structure databases

ProteinModelPortaliQ9CR26.
SMRiQ9CR26. Positions 13-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211293. 3 interactions.
DIPiDIP-54810N.
IntActiQ9CR26. 2 interactions.

PTM databases

PhosphoSiteiQ9CR26.

Proteomic databases

MaxQBiQ9CR26.
PaxDbiQ9CR26.
PRIDEiQ9CR26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154132; ENSMUSP00000119829; ENSMUSG00000019868.
GeneIDi66201.
KEGGimmu:66201.
UCSCiuc007ell.1. mouse.

Organism-specific databases

CTDi51534.
MGIiMGI:1913451. Vta1.

Phylogenomic databases

eggNOGiNOG127441.
GeneTreeiENSGT00390000011342.
HOVERGENiHBG050907.
InParanoidiQ9CR26.
KOiK12199.
OMAiTPQPGPI.
OrthoDBiEOG7JHM66.
PhylomeDBiQ9CR26.
TreeFamiTF105917.

Enzyme and pathway databases

ReactomeiREACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

NextBioi320943.
PROiQ9CR26.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR26.
CleanExiMM_VTA1.
ExpressionAtlasiQ9CR26. baseline and differential.
GenevestigatoriQ9CR26.

Family and domain databases

Gene3Di1.25.40.270. 1 hit.
InterProiIPR023175. VPS_Vta1/CALS_N-dom.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
    Fujita H., Umezuki Y., Imamura K., Ishikawa D., Uchimura S., Nara A., Yoshimori T., Hayashizaki Y., Kawai J., Ishidoh K., Tanaka Y., Himeno M.
    J. Cell Sci. 117:2997-3009(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VPS4B, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiVTA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.