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Protein

Acyl carrier protein, mitochondrial

Gene

Ndufab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-389661. Glyoxylate metabolism and glycine degradation.
R-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
CI-SDAP
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:Ndufab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917566. Ndufab1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6868MitochondrionBy similarityAdd
BLAST
Chaini69 – 15688Acyl carrier protein, mitochondrialPRO_0000000562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881N6-acetyllysineCombined sources
Modified residuei112 – 1121O-(pantetheine 4'-phosphoryl)serineSequence analysis

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

EPDiQ9CR21.
MaxQBiQ9CR21.
PaxDbiQ9CR21.
PeptideAtlasiQ9CR21.
PRIDEiQ9CR21.
TopDownProteomicsiQ9CR21.

PTM databases

iPTMnetiQ9CR21.
PhosphoSiteiQ9CR21.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030869.
ExpressionAtlasiQ9CR21. baseline and differential.
GenevisibleiQ9CR21. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.

Protein-protein interaction databases

IntActiQ9CR21. 1 interaction.
MINTiMINT-1861124.
STRINGi10090.ENSMUSP00000033157.

Structurei

3D structure databases

ProteinModelPortaliQ9CR21.
SMRiQ9CR21. Positions 69-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiQ9CR21.
KOiK03955.
OMAiTHLCRQY.
OrthoDBiEOG091G0UIC.
PhylomeDBiQ9CR21.
TreeFamiTF314361.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVLCACV RRLPAAFAPL PRLPTLALAR PLSTTLCPEG IRRRPGALQS
60 70 80 90 100
ALALAQVPGT VTHLCRQYSD APPLTLDGIK DRVLYVLKLY DKIDPEKLSV
110 120 130 140 150
NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD

KKDVYE
Length:156
Mass (Da):17,370
Last modified:June 1, 2001 - v1
Checksum:i2FC53044FE0902C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381L → F in BAB26446 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008788 mRNA. No translation available.
AK009698 mRNA. Translation: BAB26446.1.
AK010307 mRNA. Translation: BAB26840.1.
AK011302 mRNA. Translation: BAB27528.1.
AK018688 mRNA. Translation: BAB31346.1.
AK018717 mRNA. Translation: BAB31363.1.
AK089103 mRNA. Translation: BAC40751.1.
BC060951 mRNA. Translation: AAH60951.1.
CCDSiCCDS21809.1.
RefSeqiNP_082453.2. NM_028177.3.
XP_006508263.1. XM_006508200.2.
UniGeneiMm.3014.
Mm.347976.

Genome annotation databases

EnsembliENSMUST00000033157; ENSMUSP00000033157; ENSMUSG00000030869.
ENSMUST00000123296; ENSMUSP00000116177; ENSMUSG00000030869.
GeneIDi70316.
KEGGimmu:70316.
UCSCiuc009joh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008788 mRNA. No translation available.
AK009698 mRNA. Translation: BAB26446.1.
AK010307 mRNA. Translation: BAB26840.1.
AK011302 mRNA. Translation: BAB27528.1.
AK018688 mRNA. Translation: BAB31346.1.
AK018717 mRNA. Translation: BAB31363.1.
AK089103 mRNA. Translation: BAC40751.1.
BC060951 mRNA. Translation: AAH60951.1.
CCDSiCCDS21809.1.
RefSeqiNP_082453.2. NM_028177.3.
XP_006508263.1. XM_006508200.2.
UniGeneiMm.3014.
Mm.347976.

3D structure databases

ProteinModelPortaliQ9CR21.
SMRiQ9CR21. Positions 69-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CR21. 1 interaction.
MINTiMINT-1861124.
STRINGi10090.ENSMUSP00000033157.

PTM databases

iPTMnetiQ9CR21.
PhosphoSiteiQ9CR21.

Proteomic databases

EPDiQ9CR21.
MaxQBiQ9CR21.
PaxDbiQ9CR21.
PeptideAtlasiQ9CR21.
PRIDEiQ9CR21.
TopDownProteomicsiQ9CR21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033157; ENSMUSP00000033157; ENSMUSG00000030869.
ENSMUST00000123296; ENSMUSP00000116177; ENSMUSG00000030869.
GeneIDi70316.
KEGGimmu:70316.
UCSCiuc009joh.1. mouse.

Organism-specific databases

CTDi4706.
MGIiMGI:1917566. Ndufab1.

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiQ9CR21.
KOiK03955.
OMAiTHLCRQY.
OrthoDBiEOG091G0UIC.
PhylomeDBiQ9CR21.
TreeFamiTF314361.

Enzyme and pathway databases

ReactomeiR-MMU-389661. Glyoxylate metabolism and glycine degradation.
R-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CR21.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030869.
ExpressionAtlasiQ9CR21. baseline and differential.
GenevisibleiQ9CR21. MM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACPM_MOUSE
AccessioniPrimary (citable) accession number: Q9CR21
Secondary accession number(s): Q9D726, Q9D7V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.