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Protein

YEATS domain-containing protein 4

Gene

Yeats4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 4
Gene namesi
Name:Yeats4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1927224. Yeats4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: UniProtKB
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227YEATS domain-containing protein 4PRO_0000066205Add
BLAST

Proteomic databases

EPDiQ9CR11.
MaxQBiQ9CR11.
PaxDbiQ9CR11.
PRIDEiQ9CR11.

PTM databases

iPTMnetiQ9CR11.
PhosphoSiteiQ9CR11.

Expressioni

Gene expression databases

BgeeiQ9CR11.
CleanExiMM_YEATS4.
GenevisibleiQ9CR11. MM.

Interactioni

Subunit structurei

Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211018. 4 interactions.
IntActiQ9CR11. 3 interactions.
STRINGi10090.ENSMUSP00000020382.

Structurei

3D structure databases

ProteinModelPortaliQ9CR11.
SMRiQ9CR11. Positions 13-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 126105YEATSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 22765Interaction with MLLT10By similarityAdd
BLAST
Regioni168 – 22760Interaction with TACC1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili178 – 22649Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000190181.
HOVERGENiHBG061271.
InParanoidiQ9CR11.
KOiK11341.
OMAiVIKIYFH.
OrthoDBiEOG73FQNN.
PhylomeDBiQ9CR11.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CR11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY
60 70 80 90 100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII
110 120 130 140 150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM
160 170 180 190 200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER
210 220
LKASRETINC LKNEIRKLEE DDQTKDI
Length:227
Mass (Da):26,530
Last modified:June 1, 2001 - v1
Checksum:i34C46937527A7B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002839 mRNA. Translation: BAB22396.1.
AK012096 mRNA. Translation: BAB28027.1.
AK010522 mRNA. Translation: BAB27003.1.
BC020043 mRNA. Translation: AAH20043.1.
CCDSiCCDS24191.1.
RefSeqiNP_080846.1. NM_026570.4.
UniGeneiMm.233529.

Genome annotation databases

EnsembliENSMUST00000020382; ENSMUSP00000020382; ENSMUSG00000020171.
GeneIDi64050.
KEGGimmu:64050.
UCSCiuc007hcx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002839 mRNA. Translation: BAB22396.1.
AK012096 mRNA. Translation: BAB28027.1.
AK010522 mRNA. Translation: BAB27003.1.
BC020043 mRNA. Translation: AAH20043.1.
CCDSiCCDS24191.1.
RefSeqiNP_080846.1. NM_026570.4.
UniGeneiMm.233529.

3D structure databases

ProteinModelPortaliQ9CR11.
SMRiQ9CR11. Positions 13-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211018. 4 interactions.
IntActiQ9CR11. 3 interactions.
STRINGi10090.ENSMUSP00000020382.

PTM databases

iPTMnetiQ9CR11.
PhosphoSiteiQ9CR11.

Proteomic databases

EPDiQ9CR11.
MaxQBiQ9CR11.
PaxDbiQ9CR11.
PRIDEiQ9CR11.

Protocols and materials databases

DNASUi64050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020382; ENSMUSP00000020382; ENSMUSG00000020171.
GeneIDi64050.
KEGGimmu:64050.
UCSCiuc007hcx.2. mouse.

Organism-specific databases

CTDi8089.
MGIiMGI:1927224. Yeats4.

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000190181.
HOVERGENiHBG061271.
InParanoidiQ9CR11.
KOiK11341.
OMAiVIKIYFH.
OrthoDBiEOG73FQNN.
PhylomeDBiQ9CR11.

Miscellaneous databases

NextBioi319871.
PROiQ9CR11.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CR11.
CleanExiMM_YEATS4.
GenevisibleiQ9CR11. MM.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiYETS4_MOUSE
AccessioniPrimary (citable) accession number: Q9CR11
Secondary accession number(s): Q9CW86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.