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Q9CR08

- RPP29_MOUSE

UniProt

Q9CR08 - RPP29_MOUSE

Protein

Ribonuclease P protein subunit p29

Gene

Pop4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. mRNA cleavage Source: InterPro
    2. rRNA processing Source: InterPro
    3. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p29 (EC:3.1.26.5)
    Gene namesi
    Name:Pop4
    Synonyms:Rpp29
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1913411. Pop4.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolar ribonuclease P complex Source: InterPro
    2. ribonuclease MRP complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Ribonuclease P protein subunit p29PRO_0000128419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9CR08.
    PRIDEiQ9CR08.

    PTM databases

    PhosphoSiteiQ9CR08.

    Expressioni

    Gene expression databases

    BgeeiQ9CR08.
    GenevestigatoriQ9CR08.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CR08.
    SMRiQ9CR08. Positions 108-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG255667.
    GeneTreeiENSGT00390000010067.
    HOGENOMiHOG000007746.
    HOVERGENiHBG002676.
    InParanoidiQ9CR08.
    KOiK03538.
    OMAiMSQQACE.
    OrthoDBiEOG786H4B.
    PhylomeDBiQ9CR08.
    TreeFamiTF313883.

    Family and domain databases

    Gene3Di2.30.30.210. 1 hit.
    InterProiIPR002730. RNase_P/MRP_p29.
    IPR016848. RNase_P/MRP_p29-subunit.
    IPR023534. Rof/RNase_P-like.
    [Graphical view]
    PfamiPF01868. UPF0086. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
    SMARTiSM00538. POP4. 1 hit.
    [Graphical view]
    SUPFAMiSSF101744. SSF101744. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CR08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAAIYHAFS HKEAKDHDVQ ELGSQRAEAF VRAFLKQSIP HMSQEDCESH    50
    LQRKAVILEY FTRLKPRPRP KKKSKGLSAK QRRDMRLFDI KPEQQRYSLF 100
    LPLHELWKQY IRDLCNGLKP DTQPQMIQAK LLKADLHGAI ISVTKSKCPS 150
    YVGVTGILLQ ETKHVFKIIT REDHLKVIPK LNCVFTIEID DFISYIYGSK 200
    FQLRASERSA KKFKAKGSID L 221
    Length:221
    Mass (Da):25,637
    Last modified:June 1, 2001 - v1
    Checksum:i372E834DFC46A086
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002855 mRNA. Translation: BAB22410.1.
    AK003293 mRNA. Translation: BAB22696.1.
    AK150459 mRNA. Translation: BAE29579.1.
    AK152948 mRNA. Translation: BAE31617.1.
    BC011465 mRNA. Translation: AAH11465.1.
    CCDSiCCDS39915.1.
    RefSeqiNP_079666.1. NM_025390.4.
    UniGeneiMm.22284.

    Genome annotation databases

    EnsembliENSMUST00000032585; ENSMUSP00000032585; ENSMUSG00000030423.
    GeneIDi66161.
    KEGGimmu:66161.
    UCSCiuc009gkv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002855 mRNA. Translation: BAB22410.1 .
    AK003293 mRNA. Translation: BAB22696.1 .
    AK150459 mRNA. Translation: BAE29579.1 .
    AK152948 mRNA. Translation: BAE31617.1 .
    BC011465 mRNA. Translation: AAH11465.1 .
    CCDSi CCDS39915.1.
    RefSeqi NP_079666.1. NM_025390.4.
    UniGenei Mm.22284.

    3D structure databases

    ProteinModelPortali Q9CR08.
    SMRi Q9CR08. Positions 108-214.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CR08.

    Proteomic databases

    PaxDbi Q9CR08.
    PRIDEi Q9CR08.

    Protocols and materials databases

    DNASUi 66161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032585 ; ENSMUSP00000032585 ; ENSMUSG00000030423 .
    GeneIDi 66161.
    KEGGi mmu:66161.
    UCSCi uc009gkv.1. mouse.

    Organism-specific databases

    CTDi 10775.
    MGIi MGI:1913411. Pop4.

    Phylogenomic databases

    eggNOGi NOG255667.
    GeneTreei ENSGT00390000010067.
    HOGENOMi HOG000007746.
    HOVERGENi HBG002676.
    InParanoidi Q9CR08.
    KOi K03538.
    OMAi MSQQACE.
    OrthoDBi EOG786H4B.
    PhylomeDBi Q9CR08.
    TreeFami TF313883.

    Miscellaneous databases

    NextBioi 320810.
    PROi Q9CR08.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CR08.
    Genevestigatori Q9CR08.

    Family and domain databases

    Gene3Di 2.30.30.210. 1 hit.
    InterProi IPR002730. RNase_P/MRP_p29.
    IPR016848. RNase_P/MRP_p29-subunit.
    IPR023534. Rof/RNase_P-like.
    [Graphical view ]
    Pfami PF01868. UPF0086. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
    SMARTi SM00538. POP4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101744. SSF101744. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiRPP29_MOUSE
    AccessioniPrimary (citable) accession number: Q9CR08
    Secondary accession number(s): Q3U6V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3