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Q9CR08

- RPP29_MOUSE

UniProt

Q9CR08 - RPP29_MOUSE

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Protein

Ribonuclease P protein subunit p29

Gene

Pop4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. ribonuclease P RNA binding Source: RefGenome

GO - Biological processi

  1. mRNA cleavage Source: InterPro
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  4. rRNA processing Source: RefGenome
  5. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p29 (EC:3.1.26.5)
Gene namesi
Name:Pop4
Synonyms:Rpp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1913411. Pop4.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolar ribonuclease P complex Source: InterPro
  2. ribonuclease MRP complex Source: RefGenome
  3. ribonuclease P complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Ribonuclease P protein subunit p29PRO_0000128419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CR08.
PaxDbiQ9CR08.
PRIDEiQ9CR08.

PTM databases

PhosphoSiteiQ9CR08.

Expressioni

Gene expression databases

BgeeiQ9CR08.
GenevestigatoriQ9CR08.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CR08.
SMRiQ9CR08. Positions 108-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG255667.
GeneTreeiENSGT00390000010067.
HOGENOMiHOG000007746.
HOVERGENiHBG002676.
InParanoidiQ9CR08.
KOiK03538.
OMAiMSQQACE.
OrthoDBiEOG786H4B.
PhylomeDBiQ9CR08.
TreeFamiTF313883.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
InterProiIPR002730. RNase_P/MRP_p29.
IPR016848. RNase_P/MRP_p29-subunit.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamiPF01868. UPF0086. 1 hit.
[Graphical view]
PIRSFiPIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMARTiSM00538. POP4. 1 hit.
[Graphical view]
SUPFAMiSSF101744. SSF101744. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CR08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAAIYHAFS HKEAKDHDVQ ELGSQRAEAF VRAFLKQSIP HMSQEDCESH
60 70 80 90 100
LQRKAVILEY FTRLKPRPRP KKKSKGLSAK QRRDMRLFDI KPEQQRYSLF
110 120 130 140 150
LPLHELWKQY IRDLCNGLKP DTQPQMIQAK LLKADLHGAI ISVTKSKCPS
160 170 180 190 200
YVGVTGILLQ ETKHVFKIIT REDHLKVIPK LNCVFTIEID DFISYIYGSK
210 220
FQLRASERSA KKFKAKGSID L
Length:221
Mass (Da):25,637
Last modified:June 1, 2001 - v1
Checksum:i372E834DFC46A086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002855 mRNA. Translation: BAB22410.1.
AK003293 mRNA. Translation: BAB22696.1.
AK150459 mRNA. Translation: BAE29579.1.
AK152948 mRNA. Translation: BAE31617.1.
BC011465 mRNA. Translation: AAH11465.1.
CCDSiCCDS39915.1.
RefSeqiNP_079666.1. NM_025390.4.
UniGeneiMm.22284.

Genome annotation databases

EnsembliENSMUST00000032585; ENSMUSP00000032585; ENSMUSG00000030423.
GeneIDi66161.
KEGGimmu:66161.
UCSCiuc009gkv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002855 mRNA. Translation: BAB22410.1 .
AK003293 mRNA. Translation: BAB22696.1 .
AK150459 mRNA. Translation: BAE29579.1 .
AK152948 mRNA. Translation: BAE31617.1 .
BC011465 mRNA. Translation: AAH11465.1 .
CCDSi CCDS39915.1.
RefSeqi NP_079666.1. NM_025390.4.
UniGenei Mm.22284.

3D structure databases

ProteinModelPortali Q9CR08.
SMRi Q9CR08. Positions 108-214.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CR08.

Proteomic databases

MaxQBi Q9CR08.
PaxDbi Q9CR08.
PRIDEi Q9CR08.

Protocols and materials databases

DNASUi 66161.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032585 ; ENSMUSP00000032585 ; ENSMUSG00000030423 .
GeneIDi 66161.
KEGGi mmu:66161.
UCSCi uc009gkv.1. mouse.

Organism-specific databases

CTDi 10775.
MGIi MGI:1913411. Pop4.

Phylogenomic databases

eggNOGi NOG255667.
GeneTreei ENSGT00390000010067.
HOGENOMi HOG000007746.
HOVERGENi HBG002676.
InParanoidi Q9CR08.
KOi K03538.
OMAi MSQQACE.
OrthoDBi EOG786H4B.
PhylomeDBi Q9CR08.
TreeFami TF313883.

Miscellaneous databases

NextBioi 320810.
PROi Q9CR08.
SOURCEi Search...

Gene expression databases

Bgeei Q9CR08.
Genevestigatori Q9CR08.

Family and domain databases

Gene3Di 2.30.30.210. 1 hit.
InterProi IPR002730. RNase_P/MRP_p29.
IPR016848. RNase_P/MRP_p29-subunit.
IPR023534. Rof/RNase_P-like.
[Graphical view ]
Pfami PF01868. UPF0086. 1 hit.
[Graphical view ]
PIRSFi PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMARTi SM00538. POP4. 1 hit.
[Graphical view ]
SUPFAMi SSF101744. SSF101744. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRPP29_MOUSE
AccessioniPrimary (citable) accession number: Q9CR08
Secondary accession number(s): Q3U6V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3