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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

Ndufa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:Ndufa6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914380. Ndufa6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6PRO_0000174303Add
BLAST

Proteomic databases

EPDiQ9CQZ5.
MaxQBiQ9CQZ5.
PaxDbiQ9CQZ5.
PRIDEiQ9CQZ5.

PTM databases

iPTMnetiQ9CQZ5.
PhosphoSiteiQ9CQZ5.

Expressioni

Gene expression databases

BgeeiQ9CQZ5.
GenevisibleiQ9CQZ5. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211963. 2 interactions.
IntActiQ9CQZ5. 3 interactions.
MINTiMINT-1838947.
STRINGi10090.ENSMUSP00000023085.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ9CQZ5.
KOiK03950.
OMAiNTVHQFQ.
OrthoDBiEOG708W1V.
PhylomeDBiQ9CQZ5.
TreeFamiTF105625.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAATGLRQ AAAAAASTSV KPIFSRDLNE AKRRVRELYR AWYREVPNTV
60 70 80 90 100
HLMQLDITVK QGRDKVREMF MKNAHVTDPR VVDLLVIKGK MELQETIKVW
110 120 130
KQRTHVMRFF HETETPRPKD FLSKFYMGHD P
Length:131
Mass (Da):15,283
Last modified:June 1, 2001 - v1
Checksum:i3D829A5BA1D42FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002749 mRNA. Translation: BAB22326.1.
AK010988 mRNA. Translation: BAB27308.1.
AK012328 mRNA. Translation: BAB28165.1.
BC048451 mRNA. Translation: AAH48451.1.
CCDSiCCDS27689.1.
RefSeqiNP_080263.1. NM_025987.3.
UniGeneiMm.27570.

Genome annotation databases

EnsembliENSMUST00000023085; ENSMUSP00000023085; ENSMUSG00000022450.
GeneIDi67130.
KEGGimmu:67130.
UCSCiuc007wzc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002749 mRNA. Translation: BAB22326.1.
AK010988 mRNA. Translation: BAB27308.1.
AK012328 mRNA. Translation: BAB28165.1.
BC048451 mRNA. Translation: AAH48451.1.
CCDSiCCDS27689.1.
RefSeqiNP_080263.1. NM_025987.3.
UniGeneiMm.27570.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211963. 2 interactions.
IntActiQ9CQZ5. 3 interactions.
MINTiMINT-1838947.
STRINGi10090.ENSMUSP00000023085.

PTM databases

iPTMnetiQ9CQZ5.
PhosphoSiteiQ9CQZ5.

Proteomic databases

EPDiQ9CQZ5.
MaxQBiQ9CQZ5.
PaxDbiQ9CQZ5.
PRIDEiQ9CQZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023085; ENSMUSP00000023085; ENSMUSG00000022450.
GeneIDi67130.
KEGGimmu:67130.
UCSCiuc007wzc.2. mouse.

Organism-specific databases

CTDi4700.
MGIiMGI:1914380. Ndufa6.

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ9CQZ5.
KOiK03950.
OMAiNTVHQFQ.
OrthoDBiEOG708W1V.
PhylomeDBiQ9CQZ5.
TreeFamiTF105625.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufa6. mouse.
NextBioi323666.
PROiQ9CQZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQZ5.
GenevisibleiQ9CQZ5. MM.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Embryonic liver and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-26; 45-60 AND 81-88, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUA6_MOUSE
AccessioniPrimary (citable) accession number: Q9CQZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.