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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

Ndufa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Curated
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:Ndufa6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914380 Ndufa6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001743031 – 131NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Add BLAST131

Proteomic databases

EPDiQ9CQZ5
MaxQBiQ9CQZ5
PaxDbiQ9CQZ5
PeptideAtlasiQ9CQZ5
PRIDEiQ9CQZ5

PTM databases

iPTMnetiQ9CQZ5
PhosphoSitePlusiQ9CQZ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022450
GenevisibleiQ9CQZ5 MM

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211963, 2 interactors
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiQ9CQZ5
IntActiQ9CQZ5, 3 interactors
MINTiQ9CQZ5
STRINGi10090.ENSMUSP00000023085

Structurei

3D structure databases

SMRiQ9CQZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426 Eukaryota
ENOG4111S2F LUCA
GeneTreeiENSGT00390000018898
HOGENOMiHOG000200993
HOVERGENiHBG002032
InParanoidiQ9CQZ5
KOiK03950
OMAiEWIRAAP
OrthoDBiEOG091G0UGT
PhylomeDBiQ9CQZ5
TreeFamiTF105625

Family and domain databases

InterProiView protein in InterPro
IPR008011 Complex1_LYR
IPR016488 NADH_Ub_cplx-1_asu_su-6
PANTHERiPTHR12964 PTHR12964, 1 hit
PfamiView protein in Pfam
PF05347 Complex1_LYR, 1 hit
PIRSFiPIRSF006643 NDUA6, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAATGLRQ AAAAAASTSV KPIFSRDLNE AKRRVRELYR AWYREVPNTV
60 70 80 90 100
HLMQLDITVK QGRDKVREMF MKNAHVTDPR VVDLLVIKGK MELQETIKVW
110 120 130
KQRTHVMRFF HETETPRPKD FLSKFYMGHD P
Length:131
Mass (Da):15,283
Last modified:June 1, 2001 - v1
Checksum:i3D829A5BA1D42FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002749 mRNA Translation: BAB22326.1
AK010988 mRNA Translation: BAB27308.1
AK012328 mRNA Translation: BAB28165.1
BC048451 mRNA Translation: AAH48451.1
CCDSiCCDS27689.1
RefSeqiNP_080263.1, NM_025987.3
UniGeneiMm.27570

Genome annotation databases

EnsembliENSMUST00000023085; ENSMUSP00000023085; ENSMUSG00000022450
GeneIDi67130
KEGGimmu:67130
UCSCiuc007wzc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUA6_MOUSE
AccessioniPrimary (citable) accession number: Q9CQZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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