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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

Ndufa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:Ndufa6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914380. Ndufa6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001743031 – 131NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Add BLAST131

Proteomic databases

EPDiQ9CQZ5.
MaxQBiQ9CQZ5.
PaxDbiQ9CQZ5.
PeptideAtlasiQ9CQZ5.
PRIDEiQ9CQZ5.

PTM databases

iPTMnetiQ9CQZ5.
PhosphoSitePlusiQ9CQZ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022450.
GenevisibleiQ9CQZ5. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211963. 2 interactors.
IntActiQ9CQZ5. 3 interactors.
MINTiMINT-1838947.
STRINGi10090.ENSMUSP00000023085.

Structurei

3D structure databases

ProteinModelPortaliQ9CQZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ9CQZ5.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
PhylomeDBiQ9CQZ5.
TreeFamiTF105625.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAATGLRQ AAAAAASTSV KPIFSRDLNE AKRRVRELYR AWYREVPNTV
60 70 80 90 100
HLMQLDITVK QGRDKVREMF MKNAHVTDPR VVDLLVIKGK MELQETIKVW
110 120 130
KQRTHVMRFF HETETPRPKD FLSKFYMGHD P
Length:131
Mass (Da):15,283
Last modified:June 1, 2001 - v1
Checksum:i3D829A5BA1D42FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002749 mRNA. Translation: BAB22326.1.
AK010988 mRNA. Translation: BAB27308.1.
AK012328 mRNA. Translation: BAB28165.1.
BC048451 mRNA. Translation: AAH48451.1.
CCDSiCCDS27689.1.
RefSeqiNP_080263.1. NM_025987.3.
UniGeneiMm.27570.

Genome annotation databases

EnsembliENSMUST00000023085; ENSMUSP00000023085; ENSMUSG00000022450.
GeneIDi67130.
KEGGimmu:67130.
UCSCiuc007wzc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002749 mRNA. Translation: BAB22326.1.
AK010988 mRNA. Translation: BAB27308.1.
AK012328 mRNA. Translation: BAB28165.1.
BC048451 mRNA. Translation: AAH48451.1.
CCDSiCCDS27689.1.
RefSeqiNP_080263.1. NM_025987.3.
UniGeneiMm.27570.

3D structure databases

ProteinModelPortaliQ9CQZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211963. 2 interactors.
IntActiQ9CQZ5. 3 interactors.
MINTiMINT-1838947.
STRINGi10090.ENSMUSP00000023085.

PTM databases

iPTMnetiQ9CQZ5.
PhosphoSitePlusiQ9CQZ5.

Proteomic databases

EPDiQ9CQZ5.
MaxQBiQ9CQZ5.
PaxDbiQ9CQZ5.
PeptideAtlasiQ9CQZ5.
PRIDEiQ9CQZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023085; ENSMUSP00000023085; ENSMUSG00000022450.
GeneIDi67130.
KEGGimmu:67130.
UCSCiuc007wzc.2. mouse.

Organism-specific databases

CTDi4700.
MGIiMGI:1914380. Ndufa6.

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ9CQZ5.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
PhylomeDBiQ9CQZ5.
TreeFamiTF105625.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufa6. mouse.
PROiQ9CQZ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022450.
GenevisibleiQ9CQZ5. MM.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA6_MOUSE
AccessioniPrimary (citable) accession number: Q9CQZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.