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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

Ndufc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:Ndufc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913627. Ndufc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 5920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionBy similarityAdd
BLAST
Chaini28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialPRO_0000020050Add
BLAST

Proteomic databases

MaxQBiQ9CQY9.
PaxDbiQ9CQY9.
PRIDEiQ9CQY9.
TopDownProteomicsiQ9CQY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037152.
GenevisibleiQ9CQY9. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038463.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiQ9CQY9.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
PhylomeDBiQ9CQY9.
TreeFamiTF338333.

Family and domain databases

InterProiIPR026192. NDUFC1.
[Graphical view]
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSVVLRSF SRLLAPARLP SCSSTRSKFY VREPVNAKPN WLAVGLSVGA
60 70
SVFMWIYLIQ THNEDVLEYK RRNGLE
Length:76
Mass (Da):8,625
Last modified:June 1, 2001 - v1
Checksum:i3EF9EE9B8D2367F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003365 mRNA. Translation: BAB22739.1.
AK009393 mRNA. Translation: BAB26262.1.
AK018705 mRNA. Translation: BAB31356.1.
AK028011 mRNA. Translation: BAC25698.1.
BC092141 mRNA. Translation: AAH92141.1.
CCDSiCCDS38426.1.
RefSeqiNP_079799.1. NM_025523.1.
UniGeneiMm.331007.

Genome annotation databases

EnsembliENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
ENSMUST00000193279; ENSMUSP00000141933; ENSMUSG00000037152.
GeneIDi66377.
KEGGimmu:66377.
UCSCiuc008pdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003365 mRNA. Translation: BAB22739.1.
AK009393 mRNA. Translation: BAB26262.1.
AK018705 mRNA. Translation: BAB31356.1.
AK028011 mRNA. Translation: BAC25698.1.
BC092141 mRNA. Translation: AAH92141.1.
CCDSiCCDS38426.1.
RefSeqiNP_079799.1. NM_025523.1.
UniGeneiMm.331007.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038463.

Proteomic databases

MaxQBiQ9CQY9.
PaxDbiQ9CQY9.
PRIDEiQ9CQY9.
TopDownProteomicsiQ9CQY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
ENSMUST00000193279; ENSMUSP00000141933; ENSMUSG00000037152.
GeneIDi66377.
KEGGimmu:66377.
UCSCiuc008pdy.1. mouse.

Organism-specific databases

CTDi4717.
MGIiMGI:1913627. Ndufc1.

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiQ9CQY9.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
PhylomeDBiQ9CQY9.
TreeFamiTF338333.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufc1. mouse.
PROiQ9CQY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037152.
GenevisibleiQ9CQY9. MM.

Family and domain databases

InterProiIPR026192. NDUFC1.
[Graphical view]
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQY9
Secondary accession number(s): Q58DY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.