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Q9CQY9

- NDUC1_MOUSE

UniProt

Q9CQY9 - NDUC1_MOUSE

Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

Ndufc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Alternative name(s):
    Complex I-KFYI
    Short name:
    CI-KFYI
    NADH-ubiquinone oxidoreductase KFYI subunit
    Gene namesi
    Name:Ndufc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1913627. Ndufc1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: InterPro
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionBy similarityAdd
    BLAST
    Chaini28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialPRO_0000020050Add
    BLAST

    Proteomic databases

    MaxQBiQ9CQY9.
    PRIDEiQ9CQY9.

    Expressioni

    Gene expression databases

    BgeeiQ9CQY9.
    GenevestigatoriQ9CQY9.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.By similarity

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 5920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFC1 subunit family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43351.
    GeneTreeiENSGT00390000002565.
    HOGENOMiHOG000013086.
    HOVERGENiHBG006500.
    InParanoidiQ58DY9.
    KOiK03967.
    OMAiNAKPDWL.
    OrthoDBiEOG7T4MP8.
    PhylomeDBiQ9CQY9.
    TreeFamiTF338333.

    Family and domain databases

    InterProiIPR026192. NDUFC1.
    [Graphical view]
    PANTHERiPTHR17097. PTHR17097. 1 hit.
    PfamiPF15088. NADH_dh_m_C1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSVVLRSF SRLLAPARLP SCSSTRSKFY VREPVNAKPN WLAVGLSVGA   50
    SVFMWIYLIQ THNEDVLEYK RRNGLE 76
    Length:76
    Mass (Da):8,625
    Last modified:June 1, 2001 - v1
    Checksum:i3EF9EE9B8D2367F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003365 mRNA. Translation: BAB22739.1.
    AK009393 mRNA. Translation: BAB26262.1.
    AK018705 mRNA. Translation: BAB31356.1.
    AK028011 mRNA. Translation: BAC25698.1.
    BC092141 mRNA. Translation: AAH92141.1.
    CCDSiCCDS38426.1.
    RefSeqiNP_079799.1. NM_025523.1.
    UniGeneiMm.331007.

    Genome annotation databases

    EnsembliENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
    GeneIDi66377.
    KEGGimmu:66377.
    UCSCiuc008pdy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003365 mRNA. Translation: BAB22739.1 .
    AK009393 mRNA. Translation: BAB26262.1 .
    AK018705 mRNA. Translation: BAB31356.1 .
    AK028011 mRNA. Translation: BAC25698.1 .
    BC092141 mRNA. Translation: AAH92141.1 .
    CCDSi CCDS38426.1.
    RefSeqi NP_079799.1. NM_025523.1.
    UniGenei Mm.331007.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q9CQY9.
    PRIDEi Q9CQY9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038108 ; ENSMUSP00000038463 ; ENSMUSG00000037152 .
    GeneIDi 66377.
    KEGGi mmu:66377.
    UCSCi uc008pdy.1. mouse.

    Organism-specific databases

    CTDi 4717.
    MGIi MGI:1913627. Ndufc1.

    Phylogenomic databases

    eggNOGi NOG43351.
    GeneTreei ENSGT00390000002565.
    HOGENOMi HOG000013086.
    HOVERGENi HBG006500.
    InParanoidi Q58DY9.
    KOi K03967.
    OMAi NAKPDWL.
    OrthoDBi EOG7T4MP8.
    PhylomeDBi Q9CQY9.
    TreeFami TF338333.

    Miscellaneous databases

    ChiTaRSi NDUFC1. mouse.
    NextBioi 321493.
    PROi Q9CQY9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQY9.
    Genevestigatori Q9CQY9.

    Family and domain databases

    InterProi IPR026192. NDUFC1.
    [Graphical view ]
    PANTHERi PTHR17097. PTHR17097. 1 hit.
    Pfami PF15088. NADH_dh_m_C1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Kidney and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNDUC1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQY9
    Secondary accession number(s): Q58DY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3