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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

Ndufc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:Ndufc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913627. Ndufc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 59HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000002005028 – 76NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialAdd BLAST49

Proteomic databases

MaxQBiQ9CQY9.
PaxDbiQ9CQY9.
PRIDEiQ9CQY9.
TopDownProteomicsiQ9CQY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037152.
GenevisibleiQ9CQY9. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038463.

Structurei

3D structure databases

SMRiQ9CQY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiQ9CQY9.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
PhylomeDBiQ9CQY9.
TreeFamiTF338333.

Family and domain databases

InterProiView protein in InterPro
IPR026192. NDUFC1.
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiView protein in Pfam
PF15088. NADH_dh_m_C1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSVVLRSF SRLLAPARLP SCSSTRSKFY VREPVNAKPN WLAVGLSVGA
60 70
SVFMWIYLIQ THNEDVLEYK RRNGLE
Length:76
Mass (Da):8,625
Last modified:June 1, 2001 - v1
Checksum:i3EF9EE9B8D2367F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003365 mRNA. Translation: BAB22739.1.
AK009393 mRNA. Translation: BAB26262.1.
AK018705 mRNA. Translation: BAB31356.1.
AK028011 mRNA. Translation: BAC25698.1.
BC092141 mRNA. Translation: AAH92141.1.
CCDSiCCDS38426.1.
RefSeqiNP_079799.1. NM_025523.1.
UniGeneiMm.331007.

Genome annotation databases

EnsembliENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
ENSMUST00000193279; ENSMUSP00000141933; ENSMUSG00000037152.
GeneIDi66377.
KEGGimmu:66377.
UCSCiuc008pdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003365 mRNA. Translation: BAB22739.1.
AK009393 mRNA. Translation: BAB26262.1.
AK018705 mRNA. Translation: BAB31356.1.
AK028011 mRNA. Translation: BAC25698.1.
BC092141 mRNA. Translation: AAH92141.1.
CCDSiCCDS38426.1.
RefSeqiNP_079799.1. NM_025523.1.
UniGeneiMm.331007.

3D structure databases

SMRiQ9CQY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038463.

Proteomic databases

MaxQBiQ9CQY9.
PaxDbiQ9CQY9.
PRIDEiQ9CQY9.
TopDownProteomicsiQ9CQY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
ENSMUST00000193279; ENSMUSP00000141933; ENSMUSG00000037152.
GeneIDi66377.
KEGGimmu:66377.
UCSCiuc008pdy.1. mouse.

Organism-specific databases

CTDi4717.
MGIiMGI:1913627. Ndufc1.

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiQ9CQY9.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
PhylomeDBiQ9CQY9.
TreeFamiTF338333.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufc1. mouse.
PROiPR:Q9CQY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037152.
GenevisibleiQ9CQY9. MM.

Family and domain databases

InterProiView protein in InterPro
IPR026192. NDUFC1.
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiView protein in Pfam
PF15088. NADH_dh_m_C1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQY9
Secondary accession number(s): Q58DY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.