Reviewed,
UniProtKB/Swiss-Prot Q9CQX2 (CYB5B_MOUSE)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome b5 type B Alternative name(s): Cytochrome b5 outer mitochondrial membrane isoform | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 146 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases By similarity. |
| Subunit structure | Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2 By similarity. |
| Subcellular location | Mitochondrion outer membrane By similarity. |
| Sequence similarities | Belongs to the cytochrome b5 family. Contains 1 cytochrome b5 heme-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane |
| Ligand | Heme Iron Metal-binding |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membraneInferred from direct assay. Source: MGI mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | heme binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 11 | 11 | By similarity | PRO_0000006473 | |||||
| Chain | 12 – 146 | 135 | Cytochrome b5 type B | PRO_0000006474 | |||||
Regions | |||||||||
| Transmembrane | 119 – 136 | 18 | Potential | ||||||
| Domain | 20 – 96 | 77 | Cytochrome b5 heme-binding | ||||||
Sites | |||||||||
| Metal binding | 55 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Metal binding | 79 | 1 | Iron (heme axial ligand) By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 33 | 1 | Phosphoserine Ref.3 Ref.4 | ||||||
Experimental info | |||||||||
| Sequence conflict | 31 | 1 | R → E in BAB25251. Ref.1 | ||||||
| Sequence conflict | 142 | 1 | D → G in BAB22721. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Mammary gland, Pancreas and Thymus. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and FVB/N. Tissue: Brain and Colon. |
| [3] | "Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS." Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y. Mol. Cell. Proteomics 6:669-676(2007) [PubMed: 17208939] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, MASS SPECTROMETRY. Tissue: Liver. |
| [4] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, MASS SPECTROMETRY. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AK003333 mRNA. Translation: BAB22721.1. AK003815 mRNA. Translation: BAB23012.1. AK007780 mRNA. Translation: BAB25251.1. AK019263 mRNA. Translation: BAB31635.1. AK052810 mRNA. Translation: BAC35156.1. AK088970 mRNA. Translation: BAC40677.1. BC054749 mRNA. Translation: AAH54749.1. BC058812 mRNA. Translation: AAH58812.1. BC062980 mRNA. Translation: AAH62980.1. | |
| IPI | IPI00315794. |
| RefSeq | NP_079834.2. |
| UniGene | Mm.20242 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B5M based on UniProtKB P04166. |
| SMR | Q9CQX2. Positions 17-102. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9CQX2. |
Proteomic databases | |
| PRIDE | Q9CQX2. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000031924. Mus musculus. [Contig view] |
| GeneID | 66427. |
| KEGG | mmu:66427. |
Organism-specific databases | |
| MGI | MGI:1913677. Cyb5b. |
Phylogenomic databases | |
| HOVERGEN | Q9CQX2. |
| OMA | Q9CQX2. IGDVHPS. |
Gene expression databases | |
| ArrayExpress | Q9CQX2. |
| Bgee | Q9CQX2. |
| CleanEx | MM_CYB5B. |
| GermOnline | ENSMUSG00000031924. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001199. Cyt_B5. IPR018506. Cyt_B5_heme-BS. [Graphical view] |
| Gene3D | G3DSA:3.10.120.10. Cyt_B5. 1 hit. |
| Pfam | PF00173. Cyt-b5. 1 hit. [Graphical view] |
| PRINTS | PR00363. CYTOCHROMEB5. |
| ProDom | PD000612. Cyt_B5. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00191. CYTOCHROME_B5_1. 1 hit. PS50255. CYTOCHROME_B5_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 321663. |
| SOURCE | Search... |
Entry information
| Entry name | CYB5B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9CQX2 Secondary accession number(s): Q9D1M6, Q9D8R3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


