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Protein

ADP-ribosylation factor-like protein 8B

Gene

Arl8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 357GTPBy similarity
Nucleotide bindingi71 – 755GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8B
Alternative name(s):
ADP-ribosylation factor-like protein 10C
Novel small G protein indispensable for equal chromosome segregation 1
Gene namesi
Name:Arl8b
Synonyms:Arl10c, Gie1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914416. Arl8b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei1 – 1919Note=Mediates targeting to membranesBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186ADP-ribosylation factor-like protein 8BPRO_0000232923Add
BLAST

Proteomic databases

EPDiQ9CQW2.
MaxQBiQ9CQW2.
PaxDbiQ9CQW2.
PeptideAtlasiQ9CQW2.
PRIDEiQ9CQW2.
TopDownProteomicsiQ9CQW2.

PTM databases

iPTMnetiQ9CQW2.
PhosphoSiteiQ9CQW2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030105.
CleanExiMM_ARL8B.
ExpressionAtlasiQ9CQW2. baseline and differential.
GenevisibleiQ9CQW2. MM.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211990. 1 interaction.
STRINGi10090.ENSMUSP00000032196.

Structurei

3D structure databases

ProteinModelPortaliQ9CQW2.
SMRiQ9CQW2. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ9CQW2.
KOiK07955.
OMAiKNDLEGH.
OrthoDBiEOG091G0USZ.
PhylomeDBiQ9CQW2.
TreeFamiTF105470.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI
60 70 80 90 100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD
110 120 130 140 150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,539
Last modified:June 1, 2001 - v1
Checksum:i5030B01AFD749223
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471E → G in BAE30053 (PubMed:16141072).Curated
Sequence conflicti156 – 1561E → G in BAE31503 (PubMed:16141072).Curated
Sequence conflicti164 – 1641C → Y in BAE27063 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185206 mRNA. Translation: BAD30090.1.
AK009279 mRNA. Translation: BAB26190.1.
AK012024 mRNA. Translation: BAB27980.1.
AK030689 mRNA. Translation: BAC27079.1.
AK144177 mRNA. Translation: BAE25749.1.
AK146307 mRNA. Translation: BAE27063.1.
AK149822 mRNA. Translation: BAE29104.1.
AK151036 mRNA. Translation: BAE30053.1.
AK152798 mRNA. Translation: BAE31503.1.
AK159311 mRNA. Translation: BAE34979.1.
AK159348 mRNA. Translation: BAE35010.1.
AK169929 mRNA. Translation: BAE41467.1.
AK170645 mRNA. Translation: BAE41932.1.
CT010337 mRNA. Translation: CAJ18545.1.
BC013719 mRNA. Translation: AAH13719.1.
CCDSiCCDS39586.1.
RefSeqiNP_080287.1. NM_026011.3.
UniGeneiMm.271178.
Mm.466491.

Genome annotation databases

EnsembliENSMUST00000032196; ENSMUSP00000032196; ENSMUSG00000030105.
GeneIDi67166.
KEGGimmu:67166.
UCSCiuc009ddo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185206 mRNA. Translation: BAD30090.1.
AK009279 mRNA. Translation: BAB26190.1.
AK012024 mRNA. Translation: BAB27980.1.
AK030689 mRNA. Translation: BAC27079.1.
AK144177 mRNA. Translation: BAE25749.1.
AK146307 mRNA. Translation: BAE27063.1.
AK149822 mRNA. Translation: BAE29104.1.
AK151036 mRNA. Translation: BAE30053.1.
AK152798 mRNA. Translation: BAE31503.1.
AK159311 mRNA. Translation: BAE34979.1.
AK159348 mRNA. Translation: BAE35010.1.
AK169929 mRNA. Translation: BAE41467.1.
AK170645 mRNA. Translation: BAE41932.1.
CT010337 mRNA. Translation: CAJ18545.1.
BC013719 mRNA. Translation: AAH13719.1.
CCDSiCCDS39586.1.
RefSeqiNP_080287.1. NM_026011.3.
UniGeneiMm.271178.
Mm.466491.

3D structure databases

ProteinModelPortaliQ9CQW2.
SMRiQ9CQW2. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211990. 1 interaction.
STRINGi10090.ENSMUSP00000032196.

PTM databases

iPTMnetiQ9CQW2.
PhosphoSiteiQ9CQW2.

Proteomic databases

EPDiQ9CQW2.
MaxQBiQ9CQW2.
PaxDbiQ9CQW2.
PeptideAtlasiQ9CQW2.
PRIDEiQ9CQW2.
TopDownProteomicsiQ9CQW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032196; ENSMUSP00000032196; ENSMUSG00000030105.
GeneIDi67166.
KEGGimmu:67166.
UCSCiuc009ddo.1. mouse.

Organism-specific databases

CTDi55207.
MGIiMGI:1914416. Arl8b.

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ9CQW2.
KOiK07955.
OMAiKNDLEGH.
OrthoDBiEOG091G0USZ.
PhylomeDBiQ9CQW2.
TreeFamiTF105470.

Miscellaneous databases

ChiTaRSiArl8b. mouse.
PROiQ9CQW2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030105.
CleanExiMM_ARL8B.
ExpressionAtlasiQ9CQW2. baseline and differential.
GenevisibleiQ9CQW2. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL8B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQW2
Secondary accession number(s): Q3TXD7
, Q3U769, Q3UBB1, Q3UJU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.