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Protein

ADP-ribosylation factor-like protein 8B

Gene

Arl8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in lysosome motility. May play a role in chromosome segregation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35GTPBy similarity7
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8B
Alternative name(s):
ADP-ribosylation factor-like protein 10C
Novel small G protein indispensable for equal chromosome segregation 1
Gene namesi
Name:Arl8b
Synonyms:Arl10c, Gie1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914416 Arl8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei1 – 19Note=Mediates targeting to membranesBy similarityAdd BLAST19

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329231 – 186ADP-ribosylation factor-like protein 8BAdd BLAST186

Proteomic databases

EPDiQ9CQW2
MaxQBiQ9CQW2
PaxDbiQ9CQW2
PeptideAtlasiQ9CQW2
PRIDEiQ9CQW2
TopDownProteomicsiQ9CQW2

PTM databases

iPTMnetiQ9CQW2
PhosphoSitePlusiQ9CQW2
SwissPalmiQ9CQW2

Expressioni

Gene expression databases

BgeeiENSMUSG00000030105
CleanExiMM_ARL8B
ExpressionAtlasiQ9CQW2 baseline and differential
GenevisibleiQ9CQW2 MM

Interactioni

Subunit structurei

Interacts with tubulin. Interacts with BORCS5; recruits ARL8B to lysosomes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211990, 2 interactors
STRINGi10090.ENSMUSP00000032196

Structurei

3D structure databases

ProteinModelPortaliQ9CQW2
SMRiQ9CQW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075 Eukaryota
ENOG410XNUK LUCA
GeneTreeiENSGT00910000144027
HOGENOMiHOG000163692
HOVERGENiHBG105214
InParanoidiQ9CQW2
KOiK07955
OMAiSCYSCSM
OrthoDBiEOG091G0USZ
PhylomeDBiQ9CQW2
TreeFamiTF105470

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI
60 70 80 90 100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD
110 120 130 140 150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,539
Last modified:June 1, 2001 - v1
Checksum:i5030B01AFD749223
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47E → G in BAE30053 (PubMed:16141072).Curated1
Sequence conflicti156E → G in BAE31503 (PubMed:16141072).Curated1
Sequence conflicti164C → Y in BAE27063 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185206 mRNA Translation: BAD30090.1
AK009279 mRNA Translation: BAB26190.1
AK012024 mRNA Translation: BAB27980.1
AK030689 mRNA Translation: BAC27079.1
AK144177 mRNA Translation: BAE25749.1
AK146307 mRNA Translation: BAE27063.1
AK149822 mRNA Translation: BAE29104.1
AK151036 mRNA Translation: BAE30053.1
AK152798 mRNA Translation: BAE31503.1
AK159311 mRNA Translation: BAE34979.1
AK159348 mRNA Translation: BAE35010.1
AK169929 mRNA Translation: BAE41467.1
AK170645 mRNA Translation: BAE41932.1
CT010337 mRNA Translation: CAJ18545.1
BC013719 mRNA Translation: AAH13719.1
CCDSiCCDS39586.1
RefSeqiNP_080287.1, NM_026011.3
UniGeneiMm.271178
Mm.466491

Genome annotation databases

EnsembliENSMUST00000032196; ENSMUSP00000032196; ENSMUSG00000030105
GeneIDi67166
KEGGimmu:67166
UCSCiuc009ddo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARL8B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQW2
Secondary accession number(s): Q3TXD7
, Q3U769, Q3UBB1, Q3UJU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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