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Protein

Synaptobrevin homolog YKT6

Gene

Ykt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: HGNC
  • exocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: MGI
  • vesicle docking involved in exocytosis Source: HGNC
  • vesicle fusion Source: GO_Central
  • vesicle targeting Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-)
Gene namesi
Name:Ykt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927550. Ykt6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807101 – 195Synaptobrevin homolog YKT6Add BLAST195
PropeptideiPRO_0000396662196 – 198Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1
Lipidationi194S-palmitoyl cysteineBy similarity1
Modified residuei195Cysteine methyl esterBy similarity1
Lipidationi195S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting (By similarity).By similarity
Farnesylation is required for Golgi targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9CQW1.
MaxQBiQ9CQW1.
PaxDbiQ9CQW1.
PeptideAtlasiQ9CQW1.
PRIDEiQ9CQW1.

PTM databases

iPTMnetiQ9CQW1.
PhosphoSitePlusiQ9CQW1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002741.
CleanExiMM_YKT6.
GenevisibleiQ9CQW1. MM.

Interactioni

Subunit structurei

Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207964. 4 interactors.
IntActiQ9CQW1. 1 interactor.
MINTiMINT-4613661.
STRINGi10090.ENSMUSP00000002818.

Structurei

3D structure databases

ProteinModelPortaliQ9CQW1.
SMRiQ9CQW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 131LonginPROSITE-ProRule annotationAdd BLAST124
Domaini138 – 198v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Domaini

The longin domain regulates palmitoylation and membrane targeting.By similarity

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
HOVERGENiHBG088939.
InParanoidiQ9CQW1.
KOiK08516.
OMAiKIILXAR.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ9CQW1.
TreeFamiTF105606.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYSLSVLY KGDPKAVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SGKGSRASVK EQEYLCHVYV RSDSLAGVVI ADSEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PVGSPATIQY TGLDDHLSKY QNPREADPMS KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGTQ SKAFYKTARK QNSCCAIM
Length:198
Mass (Da):22,314
Last modified:June 1, 2001 - v1
Checksum:i50A6E4EA7614592B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95E → D in AAC26834 (PubMed:11323436).Curated1
Sequence conflicti165E → V in AAC26834 (PubMed:11323436).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076956 mRNA. Translation: AAC26834.1.
AK002916 mRNA. Translation: BAB22455.1.
AK007486 mRNA. Translation: BAB25062.1.
AK147098 mRNA. Translation: BAE27674.1.
AK150472 mRNA. Translation: BAE29589.1.
AK159253 mRNA. Translation: BAE34934.1.
AL645469 Genomic DNA. Translation: CAI25267.1.
BC006760 mRNA. Translation: AAH06760.1.
CCDSiCCDS24410.1.
RefSeqiNP_062635.2. NM_019661.4.
UniGeneiMm.294821.

Genome annotation databases

EnsembliENSMUST00000002818; ENSMUSP00000002818; ENSMUSG00000002741.
GeneIDi56418.
KEGGimmu:56418.
UCSCiuc007hxp.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076956 mRNA. Translation: AAC26834.1.
AK002916 mRNA. Translation: BAB22455.1.
AK007486 mRNA. Translation: BAB25062.1.
AK147098 mRNA. Translation: BAE27674.1.
AK150472 mRNA. Translation: BAE29589.1.
AK159253 mRNA. Translation: BAE34934.1.
AL645469 Genomic DNA. Translation: CAI25267.1.
BC006760 mRNA. Translation: AAH06760.1.
CCDSiCCDS24410.1.
RefSeqiNP_062635.2. NM_019661.4.
UniGeneiMm.294821.

3D structure databases

ProteinModelPortaliQ9CQW1.
SMRiQ9CQW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207964. 4 interactors.
IntActiQ9CQW1. 1 interactor.
MINTiMINT-4613661.
STRINGi10090.ENSMUSP00000002818.

PTM databases

iPTMnetiQ9CQW1.
PhosphoSitePlusiQ9CQW1.

Proteomic databases

EPDiQ9CQW1.
MaxQBiQ9CQW1.
PaxDbiQ9CQW1.
PeptideAtlasiQ9CQW1.
PRIDEiQ9CQW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002818; ENSMUSP00000002818; ENSMUSG00000002741.
GeneIDi56418.
KEGGimmu:56418.
UCSCiuc007hxp.3. mouse.

Organism-specific databases

CTDi10652.
MGIiMGI:1927550. Ykt6.

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
HOVERGENiHBG088939.
InParanoidiQ9CQW1.
KOiK08516.
OMAiKIILXAR.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ9CQW1.
TreeFamiTF105606.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiQ9CQW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002741.
CleanExiMM_YKT6.
GenevisibleiQ9CQW1. MM.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKT6_MOUSE
AccessioniPrimary (citable) accession number: Q9CQW1
Secondary accession number(s): O88595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.